CD324 (E-Cadherin) Monoclonal Antibody (DECMA-1), Biotin, eBioscience™ | Invitrogen 13-3249-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD324 (E-Cadherin) Monoclonal Antibody (DECMA-1), Biotin, eBioscience™

catalog :

13-3249-80

quantity :

25 µg

price :

US 140

clonality :

monoclonal

host :

rat

conjugate :

biotin

clone name :

DECMA-1

reactivity :

human, mouse, dogs

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 19

Reference
Bornes L, van Scheppingen R, Beerling E, Schelfhorst T, Ellenbroek S, Seinstra D, et al. Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT. Cell Rep. 2019;29:2565-2569.e3 pubmed publisher
Tran K, Pietrzak S, Zaidan N, Siahpirani A, McCalla S, Zhou A, et al. Defining Reprogramming Checkpoints from Single-Cell Analyses of Induced Pluripotency. Cell Rep. 2019;27:1726-1741.e5 pubmed publisher
Ostrin E, Little D, Gerner Mauro K, Sumner E, Ríos Corzo R, Ambrosio E, et al. β-Catenin maintains lung epithelial progenitors after lung specification. Development. 2018;145: pubmed publisher
Chua C, Epsi N, Leung E, Xuan S, Lei M, Li B, et al. Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation. elife. 2018;7: pubmed publisher
Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian T, et al. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell Stem Cell. 2017;21:791-805.e9 pubmed publisher
Lyons Cohen M, Thomas S, Cook D, Nakano H. Precision-cut Mouse Lung Slices to Visualize Live Pulmonary Dendritic Cells. J Vis Exp. 2017;: pubmed publisher
Wuidart A, Ousset M, Rulands S, Simons B, Van Keymeulen A, Blanpain C. Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells. Genes Dev. 2016;30:1261-77 pubmed publisher
Oren B, Urosevic J, Mertens C, Mora J, Guiu M, Gomis R, et al. Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis. J Pathol. 2016;239:274-85 pubmed publisher
Jackson S, Olufs Z, Tran K, Zaidan N, Sridharan R. Alternative Routes to Induced Pluripotent Stem Cells Revealed by Reprogramming of the Neural Lineage. Stem Cell Reports. 2016;6:302-11 pubmed publisher
Zheng X, Carstens J, Kim J, Scheible M, Kaye J, Sugimoto H, et al. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 2015;527:525-530 pubmed publisher
Chantzoura E, Skylaki S, Menendez S, Kim S, Johnsson A, Linnarsson S, et al. Reprogramming Roadblocks Are System Dependent. Stem Cell Reports. 2015;5:350-64 pubmed publisher
Lovisa S, LeBleu V, Tampe B, Sugimoto H, Vadnagara K, Carstens J, et al. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat Med. 2015;21:998-1009 pubmed publisher
Liang S, Marti T, Dorn P, Froment L, Hall S, Berezowska S, et al. Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer. Cell Death Dis. 2015;6:e1824 pubmed publisher
Wang S, Wang B, Pan N, Fu L, Wang C, Song G, et al. Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons. Sci Rep. 2015;5:9232 pubmed publisher
Chua C, Shibata M, Lei M, Toivanen R, Barlow L, Bergren S, et al. Single luminal epithelial progenitors can generate prostate organoids in culture. Nat Cell Biol. 2014;16:951-61, 1-4 pubmed publisher
Kaanta A, Virtanen C, Selfors L, Brugge J, Neel B. Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Res. 2013;15:R65 pubmed
Oda M, Kumaki Y, Shigeta M, Jakt L, Matsuoka C, Yamagiwa A, et al. DNA methylation restricts lineage-specific functions of transcription factor Gata4 during embryonic stem cell differentiation. PLoS Genet. 2013;9:e1003574 pubmed publisher
O MALLEY J, Skylaki S, Iwabuchi K, Chantzoura E, Ruetz T, Johnsson A, et al. High-resolution analysis with novel cell-surface markers identifies routes to iPS cells. Nature. 2013;499:88-91 pubmed publisher
Kobayashi A, Donaldson D, Kanaya T, Fukuda S, Baillie J, Freeman T, et al. Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations. DNA Res. 2012;19:407-22 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD324 (E-Cadherin) Monoclonal Antibody (DECMA-1), Biotin, eBioscience™

Catalog # :

13-3249-80

Quantity :

25 µg

Price :

US 140

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Canine, Human, Mouse

Applications :

Flow Cytometry: 0.25 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent

Species :

Canine, Human, Mouse

Clone :

DECMA-1

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent

Aliases :

AA960649; Arc-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; Cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-Cadherin phospho; Epithelial cadherin; hab; half baked; LCAM; L-CAM; phospho cadherin 1; phospho E-Cadherin; phospho LCAM; phospho S838; phospho UVO; S840; S840 E-Cadherin; Ser840; Ser840 E-Cadherin; Um; UVO; Uvomorulin