P-cadherin Monoclonal Antibody (PCD-1) | Invitrogen 13-2000Z product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

P-cadherin Monoclonal Antibody (PCD-1)

catalog :

13-2000Z

quantity :

100 µg

price :

449 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

PCD-1

reactivity :

hamsters, human, mouse, bovine

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 24

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; bovine; loading ...; fig 9b	Domke L, Franke W. The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system. Cell Tissue Res. 2019;375:451-482 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 7d immunohistochemistry - paraffin section; mouse; loading ...; fig 4c western blot; mouse; loading ...; fig 5c	Mescher M, Jeong P, Knapp S, Rübsam M, Saynisch M, Kranen M, et al. The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma. J Exp Med. 2017;214:339-358 pubmed publisher
immunohistochemistry; mouse; 1:500; fig 5	Iwai Takekoshi L, Ramos A, Schaler A, Weinreb S, Blazeski R, Mason C. Retinal pigment epithelial integrity is compromised in the developing albino mouse retina. J Comp Neurol. 2016;524:3696-3716 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 2c	Tomann P, Paus R, Millar S, Scheidereit C, Schmidt Ullrich R. Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth. Development. 2016;143:1512-22 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:1000; fig 2	Biehs B, Hu J, Strauli N, Sangiorgi E, Jung H, Heber R, et al. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013;15:846-52 pubmed publisher
immunohistochemistry - frozen section; mouse; 10 ug/ml; fig 6	Nagao K, Zhu J, Heneghan M, Hanson J, Morasso M, Tessarollo L, et al. Abnormal placental development and early embryonic lethality in EpCAM-null mice. PLoS ONE. 2009;4:e8543 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:100; fig 2	Shimomura Y, Wajid M, Shapiro L, Christiano A. P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle. Development. 2008;135:743-53 pubmed publisher
flow cytometry; mouse	Jia D, DaJusta D, Foty R. Tissue surface tensions guide in vitro self-assembly of rodent pancreatic islet cells. Dev Dyn. 2007;236:2039-49 pubmed
immunohistochemistry; mouse	Kashiwagi M, Morgan B, Georgopoulos K. The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Development. 2007;134:1571-82 pubmed
immunohistochemistry; mouse	Akins M, Benson D, Greer C. Cadherin expression in the developing mouse olfactory system. J Comp Neurol. 2007;501:483-97 pubmed
flow cytometry; mouse	Duguay D, Foty R, Steinberg M. Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants. Dev Biol. 2003;253:309-23 pubmed
immunohistochemistry; mouse	Dahl U, Sjödin A, Larue L, Radice G, Cajander S, Takeichi M, et al. Genetic dissection of cadherin function during nephrogenesis. Mol Cell Biol. 2002;22:1474-87 pubmed
western blot; mouse	Scholl F, Gamallo C, Quintanilla M. Ectopic expression of PA2.26 antigen in epidermal keratinocytes leads to destabilization of adherens junctions and malignant progression. Lab Invest. 2000;80:1749-59 pubmed
immunohistochemistry; mouse; 1:200	Danjo Y, Gipson I. Actin 'purse string' filaments are anchored by E-cadherin-mediated adherens junctions at the leading edge of the epithelial wound, providing coordinated cell movement. J Cell Sci. 1998;111 ( Pt 22):3323-32 pubmed
	Li K, Jain P, He C, Eun F, Kang S, Tumbar T. Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis. elife. 2019;8: pubmed publisher
	Cohen J, Raviv S, Adir O, Padmanabhan K, Soffer A, Luxenburg C. The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling. J Cell Biol. 2019;218:1390-1406 pubmed publisher
	Miroshnikova Y, Le H, Schneider D, Thalheim T, Rübsam M, Bremicker N, et al. Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification. Nat Cell Biol. 2018;20:69-80 pubmed publisher
	Grudzien Nogalska E, Reed B, Rhoads R. CPEB1 promotes differentiation and suppresses EMT in mammary epithelial cells. J Cell Sci. 2014;127:2326-38 pubmed publisher
	Veniaminova N, Vagnozzi A, Kopinke D, Do T, Murtaugh L, Maillard I, et al. Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development. 2013;140:4870-80 pubmed publisher
	Rico M, Mukherjee A, Konieczkowski M, Bruggeman L, Miller R, Khan S, et al. WT1-interacting protein and ZO-1 translocate into podocyte nuclei after puromycin aminonucleoside treatment. Am J Physiol Renal Physiol. 2005;289:F431-41 pubmed
	Tinkle C, Lechler T, Pasolli H, Fuchs E. Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A. 2004;101:552-7 pubmed
	Liu G, Kaw B, Kurfis J, Rahmanuddin S, Kanwar Y, Chugh S. Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability. J Clin Invest. 2003;112:209-21 pubmed
	Jamora C, DasGupta R, Kocieniewski P, Fuchs E. Links between signal transduction, transcription and adhesion in epithelial bud development. Nature. 2003;422:317-22 pubmed
	Takeichi M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development. 1988;102:639-55 pubmed

product information

Product Type :

Antibody

Product Name :

P-cadherin Monoclonal Antibody (PCD-1)

Catalog # :

13-2000Z

Quantity :

100 µg

Price :

449 USD

Clonality :

Monoclonal

Purity :

Ion-exchange chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Immunohistochemistry (Frozen): Assay Dependent, Inhibition Assays: 60 µg/mL, Western Blot: 10 µg/mL

Species :

Mouse

Clone :

PCD-1

Isotype :

IgG2a

Storage :

4° C

Description :

P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.

Immunogen :

Mouse endoderm cell line PSA5-E.

Format :

Lyophilized

Applications w/Dilutions :

Immunohistochemistry (Frozen): Assay Dependent, Inhibition Assays: 60 µg/mL, Western Blot: 10 µg/mL

Aliases :

AI385538; CADH3; cadherin 15, M-cadherin (myotubule); cadherin 3; cadherin 3, type 1, P-cadherin (placental); cadherin-3; Cadp; calcium-dependent adhesion protein, placental; CDH15; CDH3; CDHP; HJMD; PCAD; P-cadherin; Placental cadherin; Placental-cadherin; RPE-specific cadherin

more info or order :

Invitrogen product webpage