product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
E-cadherin Monoclonal Antibody (ECCD-2)
catalog :
13-1900
quantity :
100 µg
price :
US 455.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
ECCD-2
reactivity :
hamsters, human, mouse, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation, immunohistochemistry knockout validation
more info or order :
Invitrogen product webpage
citations: 254
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; 1:250; fig s1a
  • western blot knockout validation; mouse; 1:1000; fig s1a
  • immunohistochemistry - frozen section; mouse; fig s1f
Shamir E, Pappalardo E, Jorgens D, Coutinho K, Tsai W, Aziz K, et al. Twist1-induced dissemination preserves epithelial identity and requires E-cadherin. J Cell Biol. 2014;204:839-56 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s2b
Osborne J, Kinney M, Han A, Akinnola K, Yermalovich A, Vo L, et al. Lin28 paralogs regulate lung branching morphogenesis. Cell Rep. 2021;36:109408 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 3k
Carter P, Schnell U, Chaney C, TONG B, Pan X, ye J, et al. Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma. J Clin Invest. 2021;131: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 1s3a
Zhang K, Yao E, Lin C, Chou Y, Wong J, Li J, et al. A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis. elife. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 3d
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, et al. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity. Nat Commun. 2020;11:1310 pubmed publisher
  • immunohistochemistry; mouse; fig 1j
Sozen B, Cox A, De Jonghe J, Bao M, Hollfelder F, Glover D, et al. Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid. Dev Cell. 2019;51:698-712.e8 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s4p
Ouadah Y, Rojas E, Riordan D, Capostagno S, Kuo C, Krasnow M. Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch. Cell. 2019;179:403-416.e23 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Padmanaban V, Krol I, Suhail Y, Szczerba B, Aceto N, Bader J, et al. E-cadherin is required for metastasis in multiple models of breast cancer. Nature. 2019;573:439-444 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4s3b
Saatcioglu H, Kano M, Horn H, Zhang L, Samore W, Nagykery N, et al. Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility. elife. 2019;8: pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 6c
Li L, Kang H, Zhang Q, D Agati V, Al Awqati Q, Lin F. FoxO3 activation in hypoxic tubules prevents chronic kidney disease. J Clin Invest. 2019;129:2374-2389 pubmed publisher
  • immunocytochemistry; dogs; 1:500; fig s1a
Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine K. Tension-dependent regulation of mammalian Hippo signaling through LIMD1. J Cell Sci. 2018;131: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 2n
Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson Peer K, et al. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. elife. 2017;6: pubmed publisher
  • flow cytometry; human; fig 1b
Jiang F, Li K, Archer M, Mehta M, Jamieson E, Charles A, et al. Differentiation of Islet Progenitors Regulated by Nicotinamide into Transcriptome-Verified β Cells That Ameliorate Diabetes. Stem Cells. 2017;35:1341-1354 pubmed publisher
  • immunohistochemistry; mouse; 1:250; loading ...; fig 5c
Maatouk D, Natarajan A, Shibata Y, Song L, Crawford G, Ohler U, et al. Genome-wide identification of regulatory elements in Sertoli cells. Development. 2017;144:720-730 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig s2a
  • western blot; human; 1:500; loading ...; fig s2e
Priya R, Liang X, Teo J, Duszyc K, Yap A, Gomez G. ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens. Mol Biol Cell. 2017;28:12-20 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig e1d
Nonomura K, Woo S, Chang R, Gillich A, Qiu Z, Francisco A, et al. Piezo2 senses airway stretch and mediates lung inflation-induced apnoea. Nature. 2017;541:176-181 pubmed publisher
  • immunocytochemistry; mouse; fig 5g
Lin J, Khan M, Zapiec B, Mombaerts P. Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos. Sci Rep. 2016;6:39457 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 4d
Platet N, Hinkel I, Richert L, Murdamoothoo D, Moufok Sadoun A, Vanier M, et al. The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton. Cancer Lett. 2017;386:57-64 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 5d
Yousefi M, Li N, Nakauka Ddamba A, Wang S, Davidow K, Schoenberger J, et al. Msi RNA-binding proteins control reserve intestinal stem cell quiescence. J Cell Biol. 2016;215:401-413 pubmed
  • immunocytochemistry; dogs; loading ...; fig 4d
Cheng H, Burroughs Garcia J, Birkness J, Trinidad J, Deans M. Disparate Regulatory Mechanisms Control Fat3 and P75NTR Protein Transport through a Conserved Kif5-Interaction Domain. PLoS ONE. 2016;11:e0165519 pubmed publisher
  • immunocytochemistry; human; fig 1d
Rouzaire M, Comptour A, Belville C, Bouvier D, Clairefond G, Ponelle F, et al. All-trans retinoic acid promotes wound healing of primary amniocytes through the induction of LOXL4, a member of the lysyl oxidase family. Int J Biochem Cell Biol. 2016;81:10-19 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 3
Ren S, Luo Y, Chen H, Warburton D, Lam H, Wang L, et al. Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization. Am J Pathol. 2016;186:3261-3272 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 1a
Priya R, Wee K, Budnar S, Gomez G, Yap A, Michael M. Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II. Cell Cycle. 2016;15:3033-3041 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4a
Bain V, Gordon J, O Neil J, Ramos I, Richie E, Manley N. Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate. Development. 2016;143:4027-4037 pubmed
  • immunohistochemistry - paraffin section; human; loading ...; fig 4g
Coburn L, Lopez H, Caldwell B, Moussa E, Yap C, Priya R, et al. Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates. Mol Biol Cell. 2016;27:3436-3448 pubmed
  • immunohistochemistry; mouse; 1:1000; fig 1
Laresgoiti U, Nikolić M, Rao C, Brady J, Richardson R, Batchen E, et al. Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate. Development. 2016;143:3686-3699 pubmed
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4a
Belinson H, Savage A, Fadrosh D, Kuo Y, Lin D, Valladares R, et al. Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. JCI Insight. 2016;1: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...
Freddo A, Shoffner S, Shao Y, Taniguchi K, Grosse A, Guysinger M, et al. Coordination of signaling and tissue mechanics during morphogenesis of murine intestinal villi: a role for mitotic cell rounding. Integr Biol (Camb). 2016;8:918-28 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:2000; fig s5
Perdigoto C, Dauber K, Bar C, Tsai P, Valdes V, Cohen I, et al. Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLoS Genet. 2016;12:e1006151 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 7
Cox A, Barrandon O, Cai E, Rios J, Chavez J, Bonnyman C, et al. Resolving Discrepant Findings on ANGPTL8 in ?-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy. PLoS ONE. 2016;11:e0159276 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...
  • immunocytochemistry; mouse; 1:200; fig 5c
Cantú A, Altshuler Keylin S, Laird D. Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling. J Cell Biol. 2016;214:215-29 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 2
  • flow cytometry; mouse; fig 2
Li N, Yousefi M, Nakauka Ddamba A, Tobias J, Jensen S, Morrisey E, et al. Heterogeneity in readouts of canonical wnt pathway activity within intestinal crypts. Dev Dyn. 2016;245:822-33 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 2
Bai H, Zhu Q, Surcel A, Luo T, Ren Y, Guan B, et al. Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization. Am J Physiol Gastrointest Liver Physiol. 2016;311:G396-411 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig s3
  • immunocytochemistry; dogs; 1:200; loading ...; fig 1a
  • immunocytochemistry; hamsters; 1:200; loading ...; fig 4d
Chen C, Wang S, Chan P, Shen M, Chen H. Phosphorylation of E-cadherin at threonine 790 by protein kinase C? reduces ?-catenin binding and suppresses the function of E-cadherin. Oncotarget. 2016;7:37260-37276 pubmed publisher
  • immunohistochemistry; mouse; fig 5
Benjamin J, Van Der Meer R, Im A, Plosa E, Zaynagetdinov R, Burman A, et al. Epithelial-Derived Inflammation Disrupts Elastin Assembly and Alters Saccular Stage Lung Development. Am J Pathol. 2016;186:1786-1800 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 1
Rios A, Fu N, Jamieson P, Pal B, Whitehead L, Nicholas K, et al. Essential role for a novel population of binucleated mammary epithelial cells in lactation. Nat Commun. 2016;7:11400 pubmed publisher
  • western blot; human; 1:100; fig 2
Choi V, Herrou J, Hecht A, Teoh W, Turner J, Crosson S, et al. Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice. Nat Med. 2016;22:563-7 pubmed publisher
  • immunocytochemistry; mouse; 1:3000; fig 4
Balasooriya G, Johnson J, Basson M, Rawlins E. An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. Dev Cell. 2016;37:85-97 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 1
Tan S, Krasnow M. Developmental origin of lung macrophage diversity. Development. 2016;143:1318-27 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; fig 2
  • western blot; mouse; 1:800; fig 2
Thakur A, Nigri J, Lac S, Leca J, Bressy C, Berthezene P, et al. TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma. Cell Death Differ. 2016;23:1358-70 pubmed publisher
  • immunohistochemistry; mouse; 3:1000; fig 1
Loebel D, Plageman T, Tang T, Jones V, Muccioli M, Tam P. Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction. Biol Open. 2016;5:130-9 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 6
Gao X, Bali A, Randell S, Hogan B. GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. J Cell Biol. 2015;211:669-82 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 6
Eisses J, Criscimanna A, Dionise Z, Orabi A, Javed T, Sarwar S, et al. Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol. 2015;185:3304-15 pubmed publisher
  • immunocytochemistry; mouse
Gamat M, Malinowski R, Parkhurst L, Steinke L, Marker P. Ornithine Decarboxylase Activity Is Required for Prostatic Budding in the Developing Mouse Prostate. PLoS ONE. 2015;10:e0139522 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 2
Buchert M, Rohde F, Eissmann M, Tebbutt N, Williams B, Tan C, et al. A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations. Dis Model Mech. 2015;8:1361-73 pubmed publisher
  • immunocytochemistry; human; 1:500; fig s3
  • western blot; human; 1:500; fig s1h
Priya R, Gomez G, Budnar S, Verma S, Cox H, Hamilton N, et al. Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nat Cell Biol. 2015;17:1282-93 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 2h
Tan C, Hirokawa Y, Burgess A. Analysis of Wnt signalling dynamics during colon crypt development in 3D culture. Sci Rep. 2015;5:11036 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 3
Causton B, Ramadas R, CHO J, Jones K, Pardo Saganta A, Rajagopal J, et al. CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation. J Immunol. 2015;195:683-94 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 3
Liu C, Dubé P, Girish N, Reddy A, Polk D. Optical reconstruction of murine colorectal mucosa at cellular resolution. Am J Physiol Gastrointest Liver Physiol. 2015;308:G721-35 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 3
Guillaumond F, Bidaut G, Ouaissi M, Servais S, Gouirand V, Olivares O, et al. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112:2473-8 pubmed publisher
  • immunohistochemistry; mouse; 1:200
WANG Y, McAllister F, Bailey J, Scott S, Hendley A, Leach S, et al. Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. PLoS ONE. 2014;9:e113127 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 6
Plosa E, Young L, Gulleman P, Polosukhin V, Zaynagetdinov R, Benjamin J, et al. Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization. Development. 2014;141:4751-62 pubmed publisher
  • immunohistochemistry - frozen section; mouse
  • western blot; mouse
DiTommaso T, Cottle D, Pearson H, Schlüter H, Kaur P, Humbert P, et al. Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet. 2014;10:e1004706 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 4
Yoshida T, Iwata T, Takai Y, Birchmeier W, Yamato M, Okano T. Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice. Genes Cells. 2014;19:842-52 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 7b
Alanis D, Chang D, Akiyama H, Krasnow M, Chen J. Two nested developmental waves demarcate a compartment boundary in the mouse lung. Nat Commun. 2014;5:3923 pubmed publisher
  • immunohistochemistry; mouse
Baluk P, Phillips K, Yao L, Adams A, Nitschké M, McDonald D. Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways. Am J Pathol. 2014;184:1877-89 pubmed publisher
  • immunocytochemistry; mouse
Huang T, Rivera Perez J. Senescence-associated ?-galactosidase activity marks the visceral endoderm of mouse embryos but is not indicative of senescence. Genesis. 2014;52:300-8 pubmed publisher
  • western blot; mouse
Hirokawa Y, Yip K, Tan C, Burgess A. Colonic myofibroblast cell line stimulates colonoid formation. Am J Physiol Gastrointest Liver Physiol. 2014;306:G547-56 pubmed publisher
  • immunohistochemistry - paraffin section; human
Fantozzi A, Gruber D, Pisarsky L, Heck C, Kunita A, Yilmaz M, et al. VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation. Cancer Res. 2014;74:1566-75 pubmed publisher
  • immunocytochemistry; mouse; fig 4
  • western blot; mouse; fig 4
Shahbazi M, Megias D, Epifano C, Akhmanova A, Gundersen G, Fuchs E, et al. CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions. J Cell Biol. 2013;203:1043-61 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 7
Tan C, Hirokawa Y, Gardiner B, Smith D, Burgess A. Colon cryptogenesis: asymmetric budding. PLoS ONE. 2013;8:e78519 pubmed publisher
  • immunohistochemistry; mouse; fig 6
Castelli M, Boca M, Chiaravalli M, Ramalingam H, Rowe I, Distefano G, et al. Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis. Nat Commun. 2013;4:2658 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Tan F, Vladar E, Ma L, Fuentealba L, Hoh R, Espinoza F, et al. Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development. 2013;140:4277-86 pubmed publisher
  • immunocytochemistry; human
Judson R, Greve T, Parchem R, Blelloch R. MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Nat Struct Mol Biol. 2013;20:1227-35 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Mann E, Harmel Laws E, Cohen M, Steinbrecher K. Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen. BMC Gastroenterol. 2013;13:135 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 6
Das A, Tanigawa S, Karner C, Xin M, Lum L, Chen C, et al. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol. 2013;15:1035-44 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
Cedervall J, Zhang Y, Ringvall M, Thulin A, Moustakas A, Jahnen Dechent W, et al. HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment. Angiogenesis. 2013;16:889-902 pubmed publisher
  • western blot; mouse; fig 2
Tsai Y, Disson O, Bierne H, Lecuit M. Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses. PLoS Pathog. 2013;9:e1003381 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 2
Biehs B, Hu J, Strauli N, Sangiorgi E, Jung H, Heber R, et al. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013;15:846-52 pubmed publisher
  • immunocytochemistry; human; fig 1
Xu X, Jin D, Durgan J, Hall A. LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation. Mol Cell Biol. 2013;33:2671-82 pubmed publisher
  • immunocytochemistry; human; fig 1
Priya R, Yap A, Gomez G. E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens. Differentiation. 2013;86:133-40 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 1
  • western blot; mouse; 1:1000
Correia A, Mori H, Chen E, Schmitt F, Bissell M. The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90?. Genes Dev. 2013;27:805-17 pubmed publisher
  • western blot; human; fig 4
Tiwari N, Meyer Schaller N, Arnold P, Antoniadis H, Pachkov M, van Nimwegen E, et al. Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). PLoS ONE. 2013;8:e57329 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig S8
Chou J, Lin J, Brenot A, Kim J, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol. 2013;15:201-13 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig S1
Chen J, Krasnow M. Integrin Beta 1 suppresses multilayering of a simple epithelium. PLoS ONE. 2012;7:e52886 pubmed publisher
  • immunohistochemistry; mouse; fig 4
Waldmeier L, Meyer Schaller N, Diepenbruck M, Christofori G. Py2T murine breast cancer cells, a versatile model of TGF?-induced EMT in vitro and in vivo. PLoS ONE. 2012;7:e48651 pubmed publisher
  • immunohistochemistry; human; 1:500; fig 5
Magudia K, Lahoz A, Hall A. K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc. J Cell Biol. 2012;198:185-94 pubmed publisher
  • immunocytochemistry; dogs; fig 3
Wei C, Bhattaram V, Igwe J, Fleming E, Tirnauer J. The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells. PLoS ONE. 2012;7:e41118 pubmed publisher
  • western blot; mouse; fig 3
Chavez M, Yu W, Biehs B, Harada H, Snead M, Lee J, et al. Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms. Tissue Eng Part C Methods. 2013;19:15-24 pubmed publisher
  • immunocytochemistry; mouse; 1:250; fig 5
Jameson S, Lin Y, Capel B. Testis development requires the repression of Wnt4 by Fgf signaling. Dev Biol. 2012;370:24-32 pubmed publisher
  • immunocytochemistry; human; fig 3
Stoll S, Rittie L, Johnson J, Elder J. Heparin-binding EGF-like growth factor promotes epithelial-mesenchymal transition in human keratinocytes. J Invest Dermatol. 2012;132:2148-57 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; fig 1
Heaney J, Anderson E, Michelson M, Zechel J, Conrad P, Page D, et al. Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice. Development. 2012;139:1577-86 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig 1
Hajduk P, May A, Puri P, Murphy P. The effect of adriamycin exposure on the notochord of mouse embryos. Birth Defects Res B Dev Reprod Toxicol. 2012;95:175-83 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig 4
Le T, Conley K, Mead T, Rowan S, Yutzey K, Brown N. Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn. 2012;241:493-504 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250; fig 2
Mork L, Tang H, Batchvarov I, Capel B. Mouse germ cell clusters form by aggregation as well as clonal divisions. Mech Dev. 2012;128:591-6 pubmed publisher
  • immunohistochemistry; mouse; 1:250
Stubbs J, Vladar E, Axelrod J, Kintner C. Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. Nat Cell Biol. 2012;14:140-7 pubmed publisher
  • western blot; mouse; 1:200; fig 1
Laird D, Altshuler Keylin S, Kissner M, Zhou X, Anderson K. Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011;7:e1002428 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 4
Zakariyah A, Hou W, Slim R, Jerome Majewska L. TMED2/p24?1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines. Placenta. 2012;33:214-9 pubmed publisher
  • immunocytochemistry; mouse; fig 4
Saravanamuthu S, Le T, Gao C, Cojocaru R, Pandiyan P, Liu C, et al. Conditional ablation of the Notch2 receptor in the ocular lens. Dev Biol. 2012;362:219-29 pubmed publisher
  • immunocytochemistry; dogs; fig 4
Rodríguez Rigueiro T, Valladares Ayerbes M, Haz Conde M, Aparicio L, Figueroa A. Hakai reduces cell-substratum adhesion and increases epithelial cell invasion. BMC Cancer. 2011;11:474 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; fig 1
  • flow cytometry; human; 1:400; fig 2
Paca A, Séguin C, Clements M, Ryczko M, Rossant J, Rodriguez T, et al. BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm. Dev Biol. 2012;361:90-102 pubmed publisher
  • immunohistochemistry; mouse; fig 2
Nikitas G, Deschamps C, Disson O, Niault T, Cossart P, Lecuit M. Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin. J Exp Med. 2011;208:2263-77 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 6 ug/ml; fig 4
Loebel D, Studdert J, Power M, Radziewic T, Jones V, Coultas L, et al. Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm. Development. 2011;138:4511-22 pubmed publisher
  • immunohistochemistry; mouse; fig 5
Chawengsaksophak K, Svingen T, Ng E, Epp T, Spiller C, Clark C, et al. Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice. Biol Reprod. 2012;86:1-12 pubmed publisher
  • immunohistochemistry; mouse; fig 1
Grosse A, Pressprich M, Curley L, Hamilton K, Margolis B, Hildebrand J, et al. Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis. Development. 2011;138:4423-32 pubmed publisher
  • immunocytochemistry; mouse; fig 2
Collado M, Thiede B, Baker W, Askew C, Igbani L, Corwin J. The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organs. J Neurosci. 2011;31:11855-66 pubmed publisher
  • immunohistochemistry; mouse; fig 2
Musselmann K, Green J, Sone K, Hsu J, Bothwell I, Johnson S, et al. Salivary gland gene expression atlas identifies a new regulator of branching morphogenesis. J Dent Res. 2011;90:1078-84 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000
Sun Z, Shushanov S, LeRoith D, Wood T. Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2. Endocrinology. 2011;152:3233-45 pubmed publisher
  • immunohistochemistry; mouse
Silvis M, Kreger B, Lien W, Klezovitch O, Rudakova G, Camargo F, et al. ?-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal. 2011;4:ra33 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 3
  • western blot; mouse; fig 4
Kovtun I, Harris K, Jatoi A, Jevremovic D. Increased incidence of endometrioid tumors caused by aberrations in E-cadherin promoter of mismatch repair-deficient mice. Carcinogenesis. 2011;32:1085-92 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 7
Kobayashi A, Stewart C, Wang Y, Fujioka K, Thomas N, Jamin S, et al. ?-Catenin is essential for Müllerian duct regression during male sexual differentiation. Development. 2011;138:1967-75 pubmed publisher
  • immunohistochemistry; mouse; fig 8
Jovov B, Que J, Tobey N, Djukic Z, Hogan B, Orlando R. Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol. 2011;106:1039-47 pubmed publisher
  • western blot; human; fig 5
Staal J, Driege Y, Bekaert T, Demeyer A, Muyllaert D, Van Damme P, et al. T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. EMBO J. 2011;30:1742-52 pubmed publisher
  • immunocytochemistry; human; 1:200; fig s2
Durgan J, Kaji N, Jin D, Hall A. Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis. J Biol Chem. 2011;286:12461-74 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 5
Sand F, Hörnblad A, Johansson J, Lorén C, Edsbagge J, Ståhlberg A, et al. Growth-limiting role of endothelial cells in endoderm development. Dev Biol. 2011;352:267-77 pubmed publisher
  • immunohistochemistry; mouse; fig 4
  • western blot; mouse; fig 4
Kirschner N, Haftek M, Niessen C, Behne M, Furuse M, Moll I, et al. CD44 regulates tight-junction assembly and barrier function. J Invest Dermatol. 2011;131:932-43 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 5
Yoshida T, Miyoshi J, Takai Y, Thesleff I. Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth. Dev Dyn. 2010;239:2558-69 pubmed publisher
  • western blot; human; fig 3
Wallace S, Magalhaes A, Hall A. The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol Cell Biol. 2011;31:81-91 pubmed publisher
  • immunohistochemistry; human; 1:50; fig 1
Lim M, Adsay N, Grignon D, Osunkoya A. E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma. Mod Pathol. 2011;24:241-7 pubmed publisher
  • immunocytochemistry; human; fig 5
Wallace S, Durgan J, Jin D, Hall A. Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B. Mol Biol Cell. 2010;21:2996-3006 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:2000; fig 1
Kopinke D, Murtaugh L. Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol. 2010;10:38 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 4
Wiley L, Dattilo L, Kang K, Giovannini M, Beebe D. The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens. Invest Ophthalmol Vis Sci. 2010;51:3611-8 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 10 ug/ml; fig 6
Nagao K, Zhu J, Heneghan M, Hanson J, Morasso M, Tessarollo L, et al. Abnormal placental development and early embryonic lethality in EpCAM-null mice. PLoS ONE. 2009;4:e8543 pubmed publisher
  • western blot; mouse; fig 3a
MANICONE A, Huizar I, McGuire J. Matrilysin (Matrix Metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alpha(E)beta(7)-integrin). Am J Pathol. 2009;175:2319-31 pubmed publisher
  • flow cytometry; mouse; fig 2b
Banh C, Fugere C, Brossay L. Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling. Blood. 2009;114:5299-306 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250; fig 9
Cattin A, Le Beyec J, Barreau F, Saint Just S, Houllier A, Gonzalez F, et al. Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium. Mol Cell Biol. 2009;29:6294-308 pubmed publisher
  • western blot; mouse; fig 6
Wenderfer S, Dubinsky W, Hernandez Sanabria M, Braun M. Urine proteome analysis in murine nephrotoxic serum nephritis. Am J Nephrol. 2009;30:450-8 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 3A
  • immunocytochemistry; dogs; 1:200; fig 2A
den Elzen N, Buttery C, Maddugoda M, Ren G, Yap A. Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia. Mol Biol Cell. 2009;20:3740-50 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 3
Le T, Conley K, Brown N. Jagged 1 is necessary for normal mouse lens formation. Dev Biol. 2009;328:118-26 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Cook M, Coveney D, Batchvarov I, Nadeau J, Capel B. BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. Dev Biol. 2009;328:377-83 pubmed publisher
  • flow cytometry; mouse; 1:500
Karpowicz P, Willaime Morawek S, Balenci L, DeVeale B, Inoue T, van der Kooy D. E-Cadherin regulates neural stem cell self-renewal. J Neurosci. 2009;29:3885-96 pubmed publisher
  • western blot; mouse
Rhee K, Wu S, Wu X, Huso D, Karim B, Franco A, et al. Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice. Infect Immun. 2009;77:1708-18 pubmed publisher
  • flow cytometry; mouse; 1:100
  • immunocytochemistry; mouse; 1:100
Lim S, Pereira L, Wong M, Hirst C, Van Vranken B, Pick M, et al. Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation. Stem Cells. 2009;27:363-74 pubmed publisher
  • immunocytochemistry; human
Jaffe A, Kaji N, Durgan J, Hall A. Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis. J Cell Biol. 2008;183:625-33 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Morel E, Fouquet S, Strup Perrot C, Pichol Thievend C, Thievend C, Petit C, et al. The cellular prion protein PrP(c) is involved in the proliferation of epithelial cells and in the distribution of junction-associated proteins. PLoS ONE. 2008;3:e3000 pubmed publisher
  • immunohistochemistry; mouse; fig 3
Singh P, Chen C, Pal Ghosh S, Stepp M, Sheppard D, Van De Water L. Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. J Invest Dermatol. 2009;129:217-28 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 3
Rowan S, Conley K, Le T, Donner A, Maas R, Brown N. Notch signaling regulates growth and differentiation in the mammalian lens. Dev Biol. 2008;321:111-22 pubmed publisher
  • western blot; mouse; fig 3a
Agarwal S, Lee D, Kiener H, Brenner M. Coexpression of two mesenchymal cadherins, cadherin 11 and N-cadherin, on murine fibroblast-like synoviocytes. Arthritis Rheum. 2008;58:1044-54 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 2
Hebbard L, Garlatti M, Young L, Cardiff R, Oshima R, Ranscht B. T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. Cancer Res. 2008;68:1407-16 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 5
Marose T, Merkel C, McMahon A, Carroll T. Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol. 2008;314:112-26 pubmed publisher
  • immunocytochemistry; mouse; fig 4C
Kaimori A, Potter J, Kaimori J, Wang C, Mezey E, Koteish A. Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem. 2007;282:22089-101 pubmed
  • immunohistochemistry; mouse; fig 6
Perrin Tricaud C, Rutishauser U, Tricaud N. P120 catenin is required for thickening of Schwann cell myelin. Mol Cell Neurosci. 2007;35:120-9 pubmed
  • immunohistochemistry; mouse
Kashiwagi M, Morgan B, Georgopoulos K. The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Development. 2007;134:1571-82 pubmed
  • immunocytochemistry; mouse; 1:100; fig 7E
  • immunohistochemistry; mouse; 1:100; fig 7F
Wei C, Larsen M, Hoffman M, Yamada K. Self-organization and branching morphogenesis of primary salivary epithelial cells. Tissue Eng. 2007;13:721-35 pubmed
  • immunohistochemistry; mouse; fig 3
Rivera Perez J, Diefes H, Magnuson T. A simple enzymatic method for parietal yolk sac removal in early postimplantation mouse embryos. Dev Dyn. 2007;236:489-93 pubmed
  • immunohistochemistry; mouse
Suh J, Yu C, Tang K, Tanaka T, Kodama T, Tsai M, et al. The expression profiles of nuclear receptors in the developing and adult kidney. Mol Endocrinol. 2006;20:3412-20 pubmed
  • immunocytochemistry; mouse
Larsen M, Wei C, Yamada K. Cell and fibronectin dynamics during branching morphogenesis. J Cell Sci. 2006;119:3376-84 pubmed
  • immunocytochemistry; mouse
McCloskey K, Stice S, Nerem R. In vitro derivation and expansion of endothelial cells from embryonic stem cells. Methods Mol Biol. 2006;330:287-301 pubmed
  • immunoprecipitation; mouse; fig 7
  • immunocytochemistry; mouse; fig 6
Janda E, Nevolo M, Lehmann K, Downward J, Beug H, Grieco M. Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin. Oncogene. 2006;25:7117-30 pubmed
  • flow cytometry; mouse
Keino H, Masli S, Sasaki S, Streilein J, Stein Streilein J. CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance. Invest Ophthalmol Vis Sci. 2006;47:1533-42 pubmed
  • immunohistochemistry; mouse; fig 4
Ormestad M, Astorga J, Landgren H, Wang T, Johansson B, Miura N, et al. Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development. 2006;133:833-43 pubmed
  • flow cytometry; mouse; fig 1
Gründemann C, Bauer M, Schweier O, von Oppen N, Lässing U, Saudan P, et al. Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1. J Immunol. 2006;176:1311-5 pubmed
  • immunohistochemistry - frozen section; mouse; 1:500; fig 1
Rivera Perez J, Magnuson T. Primitive streak formation in mice is preceded by localized activation of Brachyury and Wnt3. Dev Biol. 2005;288:363-71 pubmed
  • immunohistochemistry - paraffin section; mouse; 5 ug/ml; fig 3
Naim E, Bernstein A, Bertram J, Caruana G. Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney. Kidney Int. 2005;68:955-65 pubmed
  • immunohistochemistry - paraffin section; human; 1:200
Schuetz A, Rubin B, Goldblum J, Shehata B, Weiss S, Liu W, et al. Intercellular junctions in Ewing sarcoma/primitive neuroectodermal tumor: additional evidence of epithelial differentiation. Mod Pathol. 2005;18:1403-10 pubmed
  • flow cytometry; mouse; fig 4
  • western blot; mouse; fig 1
Ng E, Azzola L, Sourris K, Robb L, Stanley E, Elefanty A. The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells. Development. 2005;132:873-84 pubmed
  • flow cytometry; human; fig 3
  • immunocytochemistry; human; fig 1
Shen X, Kramer R. Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol. 2004;165:1315-29 pubmed
  • immunohistochemistry; mouse; 1:250; fig 5
  • western blot; mouse; 1:2500; fig 4
Fouquet S, Lugo Martínez V, Faussat A, Renaud F, Cardot P, Chambaz J, et al. Early loss of E-cadherin from cell-cell contacts is involved in the onset of Anoikis in enterocytes. J Biol Chem. 2004;279:43061-9 pubmed
  • immunohistochemistry; mouse; fig 1
Chang Rodriguez S, Ecker R, Stingl G, Elbe Bürger A. Autocrine IL-10 partially prevents differentiation of neonatal dendritic epidermal leukocytes into Langerhans cells. J Leukoc Biol. 2004;76:657-66 pubmed
  • flow cytometry; mouse; fig 3
McCloskey K, Lyons I, Rao R, Stice S, Nerem R. Purified and proliferating endothelial cells derived and expanded in vitro from embryonic stem cells. Endothelium. 2003;10:329-36 pubmed
  • immunohistochemistry; mouse; fig 5h
  • western blot; mouse; fig 6
McGuire J, Li Q, Parks W. Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium. Am J Pathol. 2003;162:1831-43 pubmed
  • immunoprecipitation; mouse; 2 ug
  • immunocytochemistry; mouse; 1:250
Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey A. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev. 2003;17:1090-100 pubmed
  • western blot; mouse; 2 ug/ml
Davis J, Duncan M, Robison W, Piatigorsky J. Requirement for Pax6 in corneal morphogenesis: a role in adhesion. J Cell Sci. 2003;116:2157-67 pubmed
  • immunohistochemistry - paraffin section; mouse
Tong W, Cortes U, Hande M, Ohgaki H, Cavalli L, Lansdorp P, et al. Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Res. 2002;62:6990-6 pubmed
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  • western blot; dogs; fig 7
Contreras R, Shoshani L, Flores Maldonado C, Lazaro A, Monroy A, Roldán M, et al. E-Cadherin and tight junctions between epithelial cells of different animal species. Pflugers Arch. 2002;444:467-75 pubmed
  • immunohistochemistry - frozen section; mouse; 1:800
Lopez T, Hanahan D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell. 2002;1:339-53 pubmed
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  • western blot; mouse; fig 2
Carothers A, Melstrom K, Mueller J, Weyant M, Bertagnolli M. Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice. J Biol Chem. 2001;276:39094-102 pubmed
  • immunohistochemistry - frozen section; mouse
Feng C, Britton W, Palendira U, Groat N, Briscoe H, Bean A. Up-regulation of VCAM-1 and differential expansion of beta integrin-expressing T lymphocytes are associated with immunity to pulmonary Mycobacterium tuberculosis infection. J Immunol. 2000;164:4853-60 pubmed
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Ong A, Maines Bandiera S, Roskelley C, Auersperg N. An ovarian adenocarcinoma line derived from SV40/E-cadherin-transfected normal human ovarian surface epithelium. Int J Cancer. 2000;85:430-7 pubmed
  • flow cytometry; mouse
Anderson R, Fassler R, Georges Labouesse E, Hynes R, Bader B, Kreidberg J, et al. Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads. Development. 1999;126:1655-64 pubmed
  • immunohistochemistry; mouse; 1:200
Danjo Y, Gipson I. Actin 'purse string' filaments are anchored by E-cadherin-mediated adherens junctions at the leading edge of the epithelial wound, providing coordinated cell movement. J Cell Sci. 1998;111 ( Pt 22):3323-32 pubmed
  • flow cytometry; mouse
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  • western blot; human; fig 1
Mbalaviele G, Dunstan C, Sasaki A, Williams P, Mundy G, Yoneda T. E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. Cancer Res. 1996;56:4063-70 pubmed
  • immunocytochemistry; mouse
Wesseling J, van der Valk S, Hilkens J. A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1. Mol Biol Cell. 1996;7:565-77 pubmed
  • immunoprecipitation; mouse; fig 1
  • western blot; mouse; fig 1
Fannon A, Sherman D, Ilyina Gragerova G, Brophy P, Friedrich V, Colman D. Novel E-cadherin-mediated adhesion in peripheral nerve: Schwann cell architecture is stabilized by autotypic adherens junctions. J Cell Biol. 1995;129:189-202 pubmed
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product information
Product Type :
Antibody
Product Name :
E-cadherin Monoclonal Antibody (ECCD-2)
Catalog # :
13-1900
Quantity :
100 µg
Price :
US 455.00
Clonality :
Monoclonal
Purity :
Ion-exchange chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Immunohistochemistry (Frozen): 10 µg/mL, Western Blot: 10 µg/mL
Species :
Mouse
Clone :
ECCD-2
Isotype :
IgG2a
Storage :
4° C
Description :
E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
Immunogen :
Mouse liver E-cadherin fragment.
Format :
Lyophilized
Applications w/Dilutions :
Immunohistochemistry (Frozen): 10 µg/mL, Western Blot: 10 µg/mL
Aliases :
AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-Cadherin phospho; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; phospho cadherin 1; phospho E-Cadherin; phospho LCAM; phospho S838; phospho UVO; S840; S840 E-Cadherin; Ser840; Ser840 E-Cadherin; Um; UVO; Uvomorulin
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA