E-cadherin Monoclonal Antibody (ECCD-1) | Invitrogen 13-1800 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

E-cadherin Monoclonal Antibody (ECCD-1)

catalog :

13-1800

quantity :

100 µg

price :

449 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

ECCD-1

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1e	Kress T, Pellanda P, Pellegrinet L, Bianchi V, Nicoli P, Doni M, et al. Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors. Cancer Res. 2016;76:3463-72 pubmed publisher
immunohistochemistry - frozen section; mouse; fig 7	Boddupally K, Wang G, Chen Y, Kobielak A. Lgr5 Marks Neural Crest Derived Multipotent Oral Stromal Stem Cells. Stem Cells. 2016;34:720-31 pubmed publisher
blocking or activating experiments; human; 200 ug/ml; fig 1 immunocytochemistry; human; 10 ug/ml; fig 1	Moore R, Cherry J, Mathur V, Cohen R, Grumet M, Moghe P. E-cadherin-expressing feeder cells promote neural lineage restriction of human embryonic stem cells. Stem Cells Dev. 2012;21:30-41 pubmed publisher
blocking or activating experiments; mouse; 1.0 ug/ml; fig 5a	Karpowicz P, Willaime Morawek S, Balenci L, DeVeale B, Inoue T, van der Kooy D. E-Cadherin regulates neural stem cell self-renewal. J Neurosci. 2009;29:3885-96 pubmed publisher
blocking or activating experiments; mouse; fig 4	Wei C, Larsen M, Hoffman M, Yamada K. Self-organization and branching morphogenesis of primary salivary epithelial cells. Tissue Eng. 2007;13:721-35 pubmed
blocking or activating experiments; mouse flow cytometry; mouse	Duguay D, Foty R, Steinberg M. Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants. Dev Biol. 2003;253:309-23 pubmed
western blot; human	Schmeiser K, Grand R. The fate of E- and P-cadherin during the early stages of apoptosis. Cell Death Differ. 1999;6:377-86 pubmed
	Gao X, Acharya B, Engl W, de Mets R, Thiery J, Yap A, et al. Probing compression versus stretch activated recruitment of cortical actin and apical junction proteins using mechanical stimulations of suspended doublets. APL Bioeng. 2018;2:026111 pubmed publisher
	Wang H, Tong D, El Gehani F, Tekpetey F, Kidder G. Connexin expression and gap junctional coupling in human cumulus cells: contribution to embryo quality. J Cell Mol Med. 2009;13:972-84 pubmed publisher
	Sevilla L, Nachat R, Groot K, Klement J, Uitto J, Djian P, et al. Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. J Cell Biol. 2007;179:1599-612 pubmed publisher
	Tinkle C, Lechler T, Pasolli H, Fuchs E. Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A. 2004;101:552-7 pubmed
	Takeichi M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development. 1988;102:639-55 pubmed

product information

Product Type :

Antibody

Product Name :

E-cadherin Monoclonal Antibody (ECCD-1)

Catalog # :

13-1800

Quantity :

100 µg

Price :

449 USD

Clonality :

Monoclonal

Purity :

purified

Host :

Rat

Reactivity :

Mouse

Applications :

Inhibition Assays: 200 µg/mL

Species :

Mouse

Clone :

ECCD-1

Isotype :

IgG2b

Storage :

4° C

Description :

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

Immunogen :

Mouse teratocarcinoma cell line F9.

Format :

Lyophilized

Applications w/Dilutions :

Inhibition Assays: 200 µg/mL

Aliases :

AA960649; Arc-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; Cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-Cadherin phospho; Epithelial cadherin; hab; half baked; LCAM; L-CAM; phospho cadherin 1; phospho E-Cadherin; phospho LCAM; phospho S838; phospho UVO; S840; S840 E-Cadherin; Ser840; Ser840 E-Cadherin; Um; UVO; Uvomorulin

more info or order :

Invitrogen product webpage