product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD171 Monoclonal Antibody (eBio5G3 (5G3)), Biotin, eBioscience
catalog :
13-1719-82
quantity :
100 ug
price :
US 290.00
clonality :
monoclonal
host :
mouse
conjugate :
biotin
clone name :
eBio5G3 (5G3)
reactivity :
human, mouse
application :
western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 24
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000
Kapogiannis D, Boxer A, Schwartz J, Abner E, Biragyn A, Masharani U, et al. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB J. 2015;29:589-96 pubmed publisher
Wang L, Lu Z, Teng Y, Pan W, Li Y, Su S, et al. Cognitive impairment is associated with BDNF-TrkB signaling mediating synaptic damage and reduction of amino acid neurotransmitters in heart failure. FASEB J. 2024;38:e23351 pubmed publisher
You Y, Zhang Z, Sultana N, Ericsson M, Martens Y, Sun M, et al. ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids. Sci Adv. 2023;9:eadi3647 pubmed publisher
Dunlop R, Banack S, Cox P. L1CAM immunocapture generates a unique extracellular vesicle population with a reproducible miRNA fingerprint. RNA Biol. 2023;20:140-148 pubmed publisher
Winston C, Sukreet S, Lynch H, Lee V, Wilcock D, Nelson P, et al. Evaluation of blood-based, extracellular vesicles as biomarkers for aging-related TDP-43 pathology. Alzheimers Dement (Amst). 2022;14:e12365 pubmed publisher
Goetzl E, Srihari V, Mustapic M, Kapogiannis D, Heninger G. Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron-derived extracellular vesicles of early schizophrenia. FASEB J. 2022;36:e22466 pubmed publisher
Burrows K, Figueroa Hall L, Kuplicki R, Stewart J, Alarbi A, Ramesh R, et al. Neuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial. Sci Rep. 2022;12:861 pubmed publisher
You Y, Muraoka S, Jedrychowski M, Hu J, McQuade A, Young Pearse T, et al. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. J Extracell Vesicles. 2022;11:e12183 pubmed publisher
Delgado Peraza F, Nogueras Ortiz C, Volpert O, Liu D, Goetzl E, Mattson M, et al. Neuronal and Astrocytic Extracellular Vesicle Biomarkers in Blood Reflect Brain Pathology in Mouse Models of Alzheimer's Disease. Cells. 2021;10: pubmed publisher
Lee E, Winston Gray C, Barlow J, Rissman R, Jeste D. Plasma Levels of Neuron- and Astrocyte-Derived Exosomal Amyloid Beta1-42, Amyloid Beta1-40, and Phosphorylated Tau Levels in Schizophrenia Patients and Non-psychiatric Comparison Subjects: Relationships With Cognitive Functioning and Psychopathology. Front Psychiatry. 2020;11:532624 pubmed publisher
Sun B, Tang N, Peluso M, Iyer N, Torres L, Donatelli J, et al. Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations. Cells. 2021;10: pubmed publisher
Banack S, Dunlop R, Cox P. An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease. Open Biol. 2020;10:200116 pubmed publisher
Nasca C, Dobbin J, Bigio B, Watson K, De Angelis P, Kautz M, et al. Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance. Mol Psychiatry. 2021;26:5140-5149 pubmed publisher
Winston C, Romero H, Ellisman M, Nauss S, Julovich D, Conger T, et al. Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity. Front Neurosci. 2019;13:1005 pubmed publisher
Zhao Z, Chen Z, Zhou R, Zhang X, Ye Q, Wang Y. Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson's Disease. Front Aging Neurosci. 2018;10:438 pubmed publisher
Er E, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, et al. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol. 2018;20:966-978 pubmed publisher
Guix F, Corbett G, Cha D, Mustapic M, Liu W, Mengel D, et al. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. Int J Mol Sci. 2018;19: pubmed publisher
Mustapic M, Eitan E, Werner J, Berkowitz S, Lazaropoulos M, Tran J, et al. Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes. Front Neurosci. 2017;11:278 pubmed publisher
Mullins R, Mustapic M, Goetzl E, Kapogiannis D. Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease. Hum Brain Mapp. 2017;38:1933-1940 pubmed publisher
Winston C, Goetzl E, Akers J, Carter B, Rockenstein E, Galasko D, et al. Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile. Alzheimers Dement (Amst). 2016;3:63-72 pubmed publisher
Abner E, Jicha G, Shaw L, Trojanowski J, Goetzl E. Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging. Ann Clin Transl Neurol. 2016;3:399-403 pubmed publisher
Goetzl E, Boxer A, Schwartz J, Abner E, Petersen R, Miller B, et al. Low neural exosomal levels of cellular survival factors in Alzheimer's disease. Ann Clin Transl Neurol. 2015;2:769-73 pubmed publisher
Goetzl E, Boxer A, Schwartz J, Abner E, Petersen R, Miller B, et al. Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. Neurology. 2015;85:40-7 pubmed publisher
Valiente M, Obenauf A, Jin X, Chen Q, Zhang X, Lee D, et al. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 2014;156:1002-16 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD171 Monoclonal Antibody (eBio5G3 (5G3)), Biotin, eBioscience
Catalog # :
13-1719-82
Quantity :
100 ug
Price :
US 290.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 0.5 ug/test, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent
Species :
Human
Clone :
eBio5G3 (5G3)
Isotype :
IgG2a
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
antigen identified by monoclonal antibody R1; CAML1; CD 171; CD171; CD171 molecule; HSAS; HSAS1; Hyd; L1; L1 cell adhesion molecule; L1CAM; MASA; MIC5; N-CAM L1; NCAML1; N-CAML1; N-CAM-L1; NCAM-L1; Nerve-growth factor-inducible large external glycoprotein; neural cell adhesion molecule L1; NILE; S10; sCD171; sL1 CAM; sL1CAM; soluble CD 171; soluble CD171; soluble L1 CAM; soluble L1CAM; SPG1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA