product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
E-cadherin Monoclonal Antibody (HECD-1)
catalog :
13-1700
quantity :
100 µg
price :
425 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HECD-1
reactivity :
hamsters, guinea pig, human, mouse, rat, dogs, bovine, domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
Invitrogen product webpage
citations: 287
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; fig 5g
Benedicto I, Lehmann G, Ginsberg M, Nolan D, Bareja R, Elemento O, et al. Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors. Nat Commun. 2017;8:15374 pubmed publisher
  • immunohistochemistry; human; fig 1c
Gibier J, Hemon B, Fanchon M, Gaudelot K, Pottier N, Ringot B, et al. Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1336-1349 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...
  • western blot; human; loading ...; fig 3c
Day K, Lorenzatti Hiles G, Kozminsky M, Dawsey S, Paul A, Broses L, et al. HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone. Cancer Res. 2017;77:74-85 pubmed publisher
  • immunohistochemistry; human; 1:1000; fig 1a
Varga E, Nemes C, Táncos Z, Bock I, Berzsenyi S, Lévay G, et al. Establishment of EHMT1 mutant induced pluripotent stem cell (iPSC) line from a 11-year-old Kleefstra syndrome (KS) patient with autism and normal intellectual performance. Stem Cell Res. 2016;17:531-533 pubmed publisher
  • immunocytochemistry; human; 2 ug/ml; loading ...; fig 4e
  • western blot; human; loading ...; fig 4b
Matos M, Lapyckyj L, Rosso M, Besso M, Mencucci M, Briggiler C, et al. Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events. J Cell Physiol. 2017;232:1368-1386 pubmed publisher
  • western blot; human; fig 1a
Runge T, Shaheen N, Djukic Z, Hallquist S, Orlando R. Cleavage of E-Cadherin Contributes to Defective Barrier Function in Neosquamous Epithelium. Dig Dis Sci. 2016;61:3169-3175 pubmed
  • immunocytochemistry; human; 1:1000; fig 1A
Tancos Z, Varga E, Kovacs E, Dinnyes A, Kobolak J. Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Res. 2016;17:81-83 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 1A
Chandrasekaran A, Varga E, Nemes C, Tancos Z, Kobolak J, Dinnyes A. Establishment of induced pluripotent stem cell (iPSC) line from a 63-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Res. 2016;17:78-80 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 1A
Tancos Z, Varga E, Kovacs E, Dinnyes A, Kobolak J. Establishment of induced pluripotent stem cell (iPSC) line from an 84-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Res. 2016;17:75-77 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 1A
Ochalek A, Nemes C, Varga E, Tancos Z, Kobolak J, Dinnyes A. Establishment of induced pluripotent stem cell (iPSC) line from a 57-year old patient with sporadic Alzheimer's disease. Stem Cell Res. 2016;17:72-74 pubmed publisher
  • western blot; human; fig 2
Morton P, Hicks A, Ortiz Zapater E, Raghavan S, Pike R, Noble A, et al. TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers. Sci Rep. 2016;6:26321 pubmed publisher
  • immunocytochemistry; human; fig 2
  • immunohistochemistry; human; 1:500; fig 5
  • western blot; human; fig 2
Teo W, Merino V, Cho S, Korangath P, Liang X, Wu R, et al. HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24. Oncogene. 2016;35:5539-5551 pubmed publisher
  • immunocytochemistry; human; 1:300; fig 2
Bell C, Hendriks D, Moro S, Ellis E, Walsh J, Renblom A, et al. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Sci Rep. 2016;6:25187 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig s2
Nummela P, Leinonen H, Järvinen P, Thiel A, Jarvinen H, Lepistö A, et al. Expression of CEA, CA19-9, CA125, and EpCAM in pseudomyxoma peritonei. Hum Pathol. 2016;54:47-54 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:7000; fig 2
  • western blot; human; fig 4
Wang O, Azizian N, Guo M, Capello M, Deng D, Zang F, et al. Prognostic and Functional Significance of MAP4K5 in Pancreatic Cancer. PLoS ONE. 2016;11:e0152300 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:7000; fig 7
Huo L, Wang Y, Gong Y, Krishnamurthy S, Wang J, Diao L, et al. MicroRNA expression profiling identifies decreased expression of miR-205 in inflammatory breast cancer. Mod Pathol. 2016;29:330-46 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 4
Tato Costa J, Casimiro S, Pacheco T, Pires R, Fernandes A, Alho I, et al. Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer. Clin Colorectal Cancer. 2016;15:170-178.e3 pubmed publisher
  • immunocytochemistry; human
Lizalek J, McKenna T, Huegel K, Marsh S, Carolan A, Kobliska A, et al. Lysophosphatidic Acid Stimulates Urokinase Receptor (uPAR/CD87) in Ovarian Epithelial Cancer Cells. Anticancer Res. 2015;35:5263-70 pubmed
  • western blot; mouse
Wei Q, Chen Z, Wang L, Zhang T, Duan L, Behrens C, et al. LZTFL1 suppresses lung tumorigenesis by maintaining differentiation of lung epithelial cells. Oncogene. 2016;35:2655-63 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig 3
Ko A, Bekaii Saab T, Van Ziffle J, Mirzoeva O, Joseph N, Talasaz A, et al. A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma. Clin Cancer Res. 2016;22:61-8 pubmed publisher
  • immunocytochemistry; human
Burkhalter R, Westfall S, Liu Y, Stack M. Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma. J Biol Chem. 2015;290:22143-54 pubmed publisher
  • western blot; mouse
Barber A, Castillo Martin M, Bonal D, Jia A, Rybicki B, Christiano A, et al. PI3K/AKT pathway regulates E-cadherin and Desmoglein 2 in aggressive prostate cancer. Cancer Med. 2015;4:1258-71 pubmed publisher
  • immunohistochemistry - paraffin section; human; tbl 2
Savci Heijink C, Halfwerk H, Hooijer G, Horlings H, Wesseling J, van de Vijver M. Retrospective analysis of metastatic behaviour of breast cancer subtypes. Breast Cancer Res Treat. 2015;150:547-57 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
  • western blot; human; 1:500
Nguyen D, Rubinstein L, Takebe N, Miele L, Tomaszewski J, Ivy P, et al. Notch1 phenotype and clinical stage progression in non-small cell lung cancer. J Hematol Oncol. 2015;8:9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 1
Nykopp T, Pasonen Seppänen S, Tammi M, Tammi R, Kosma V, Anttila M, et al. Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer. Gynecol Oncol. 2015;137:152-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:3000
Davidson B, Holth A, Hellesylt E, Tan T, Huang R, Tropé C, et al. The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions. Hum Pathol. 2015;46:1-8 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 4
Akoury E, Zhang L, Ao A, Slim R. NLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton. Hum Reprod. 2015;30:159-69 pubmed publisher
  • immunocytochemistry; human
Hagos Y, Wegner W, Kuehne A, Floerl S, Marada V, Burckhardt G, et al. HNF4α induced chemosensitivity to oxaliplatin and 5-FU mediated by OCT1 and CNT3 in renal cell carcinoma. J Pharm Sci. 2014;103:3326-34 pubmed publisher
  • immunohistochemistry; human; 1:3000
Wennerström A, Lothe I, Sandhu V, Kure E, Myklebost O, Munthe E. Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines. PLoS ONE. 2014;9:e103873 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2500; tbl 3
Lindström A, Hellberg D. Immunohistochemical LRIG3 expression in cervical intraepithelial neoplasia and invasive squamous cell cervical cancer: association with expression of tumor markers, hormones, high-risk HPV-infection, smoking and patient outcome. Eur J Histochem. 2014;58:2227 pubmed publisher
  • immunohistochemistry; mouse
Costales M, Lopez F, García Inclán C, Fernandez S, Marcos C, Llorente J, et al. Establishment and characterization of an orthotopic sinonasal squamous cell carcinoma mouse model. Head Neck. 2015;37:1769-75 pubmed publisher
  • western blot; human; fig 3
McEwen A, Maher M, Mo R, Gottardi C. E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion. Mol Biol Cell. 2014;25:2365-74 pubmed publisher
  • flow cytometry; human; 1:50
Bassagañas S, Carvalho S, Dias A, Pérez Garay M, Ortiz M, Figueras J, et al. Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of ?2?1 integrin and E-cadherin function. PLoS ONE. 2014;9:e98595 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Moiola C, De Luca P, Zalazar F, Cotignola J, Rodríguez Seguí S, Gardner K, et al. Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice. Clin Cancer Res. 2014;20:4086-95 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Zhang C, Zhang H, Yu L, Cao Y. Helicobacter pylori dwelling on the apical surface of gastrointestinal epithelium damages the mucosal barrier through direct contact. Helicobacter. 2014;19:330-42 pubmed publisher
  • western blot; human
Wojtalewicz N, Sadeqzadeh E, Weiß J, Tehrani M, Klein Scory S, Hahn S, et al. A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding. PLoS ONE. 2014;9:e90461 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2000
Agoston A, Odze R. Evidence that gastric pit dysplasia-like atypia is a neoplastic precursor lesion. Hum Pathol. 2014;45:446-55 pubmed publisher
  • immunohistochemistry; human; 1:100; fig 7
Hesami P, Holzapfel B, Taubenberger A, Roudier M, Fazli L, Sieh S, et al. A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone. Clin Exp Metastasis. 2014;31:435-46 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 5
Grivas P, Day K, Karatsinides A, Paul A, Shakir N, Owainati I, et al. Evaluation of the antitumor activity of dacomitinib in models of human bladder cancer. Mol Med. 2013;19:367-76 pubmed publisher
  • immunohistochemistry; human; 1:200; fig 9
Haisler W, Timm D, Gage J, Tseng H, Killian T, Souza G. Three-dimensional cell culturing by magnetic levitation. Nat Protoc. 2013;8:1940-9 pubmed publisher
  • western blot; mouse; fig 1
Shields M, Ebine K, Sahai V, Kumar K, Siddiqui K, Hwang R, et al. Snail cooperates with KrasG12D to promote pancreatic fibrosis. Mol Cancer Res. 2013;11:1078-87 pubmed publisher
  • western blot; mouse; fig 2
Tsai Y, Disson O, Bierne H, Lecuit M. Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses. PLoS Pathog. 2013;9:e1003381 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Shi Y, Wu H, Zhang M, Ding L, Meng F, Fan X. Expression of the epithelial-mesenchymal transition-related proteins and their clinical significance in lung adenocarcinoma. Diagn Pathol. 2013;8:89 pubmed publisher
  • immunohistochemistry; human; 1:100; fig 1
Rakha E, Teoh T, Lee A, Nolan C, Ellis I, Green A. Further evidence that E-cadherin is not a tumour suppressor gene in invasive ductal carcinoma of the breast: an immunohistochemical study. Histopathology. 2013;62:695-701 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 3
Majewski I, Kluijt I, Cats A, Scerri T, de Jong D, Kluin R, et al. An ?-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. J Pathol. 2013;229:621-9 pubmed publisher
  • western blot; human; fig 1
Gordon K, Kochkodan J, Blatt H, Lin S, Kaplan N, Johnston A, et al. Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis. J Invest Dermatol. 2013;133:712-722 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 4
de Toledo M, Anguille C, Roger L, Roux P, Gadea G. Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity. PLoS ONE. 2012;7:e48344 pubmed publisher
  • western blot; human; 2 ug/ml
Visciano P, Schirone M, Tofalo R, Berti M, Luciani M, Ferri N, et al. Detection of yessotoxin by three different methods in Mytilus galloprovincialis of Adriatic Sea, Italy. Chemosphere. 2013;90:1077-82 pubmed publisher
  • immunohistochemistry; human; fig s3
Takahashi Y, Kupferman M, Bell D, Jiffar T, Lee J, Xie T, et al. Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. Clin Cancer Res. 2012;18:6178-87 pubmed publisher
  • immunocytochemistry; human; fig 4
Langer M, Duggan E, Booth J, Patel V, Zander R, Silasi Mansat R, et al. Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infect Immun. 2012;80:4374-87 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 6
Piao Y, Liang J, Holmes L, Zurita A, Henry V, Heymach J, et al. Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype. Neuro Oncol. 2012;14:1379-92 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 4
Peramo A, Marcelo C. Visible effects of rapamycin (sirolimus) on human skin explants in vitro. Arch Dermatol Res. 2013;305:163-71 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
Veschi S, Lattanzio R, Aceto G, Curia M, Magnasco S, Angelucci D, et al. Alterations of MEN1 and E-cadherin/?-catenin complex in sporadic pulmonary carcinoids. Int J Oncol. 2012;41:1221-8 pubmed publisher
  • immunohistochemistry - paraffin section; dogs; fig 2
Mackowiak I, Gentile L, Chaible L, Nagamine M, Guerra J, Mota E, et al. E-cadherin in canine mast cell tumors: decreased expression and altered subcellular localization in Grade 3 tumors. Vet J. 2012;194:405-11 pubmed publisher
  • immunocytochemistry; human; fig 4
Stamp L, Braxton D, Wu J, Akopian V, Hasegawa K, Chandrasoma P, et al. The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin. Stem Cells. 2012;30:1999-2009 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; tbl 1
Jang S, Han H, Jun Y, Jang S, Min K, Sim J, et al. Clinicopathological significance of CADM4 expression, and its correlation with expression of E-cadherin and Ki-67 in colorectal adenocarcinomas. J Clin Pathol. 2012;65:902-6 pubmed
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 2
Raiko L, Siljamäki E, Mahoney M, Putaala H, Suominen E, Peltonen J, et al. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes. Exp Dermatol. 2012;21:586-91 pubmed publisher
  • immunocytochemistry; human; fig 1
Liu Y, Burkhalter R, Symowicz J, Chaffin K, Ellerbroek S, Stack M. Lysophosphatidic Acid disrupts junctional integrity and epithelial cohesion in ovarian cancer cells. J Oncol. 2012;2012:501492 pubmed publisher
  • immunocytochemistry; human; 1:2500; tbl 1
Karlsson H, Fryknäs M, Larsson R, Nygren P. Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system. Exp Cell Res. 2012;318:1577-85 pubmed publisher
  • flow cytometry; mouse; 1:100
Simões Correia J, Figueiredo J, Lopes R, Stricher F, Oliveira C, Serrano L, et al. E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer. PLoS ONE. 2012;7:e33783 pubmed publisher
  • immunocytochemistry; human; fig 1
DesRochers T, Shamis Y, Alt Holland A, Kudo Y, Takata T, Wang G, et al. The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma. Epigenetics. 2012;7:34-46 pubmed publisher
  • immunohistochemistry - frozen section; human; fig 3
Nguyen Hoang A, Chen P, Juarez J, Sachamitr P, Billing B, Bosnjak L, et al. Dendritic cell functional properties in a three-dimensional tissue model of human lung mucosa. Am J Physiol Lung Cell Mol Physiol. 2012;302:L226-37 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2500; tbl 3
Samir R, Asplund A, Tot T, Pekar G, Hellberg D. Oral contraceptive and progestin-only use correlates to tissue tumor marker expression in women with cervical intraepithelial neoplasia. Contraception. 2012;85:288-93 pubmed publisher
  • western blot; human; fig 1
Grabowska M, Sandhu B, Day M. EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells. Cell Signal. 2012;24:532-8 pubmed publisher
  • immunocytochemistry; mouse; fig 5
Schneider D, Wu M, Le T, Cho S, Brenner M, Blackburn M, et al. Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-? production and epithelial to mesenchymal transition. FASEB J. 2012;26:503-12 pubmed publisher
  • immunohistochemistry; mouse; fig 1
Nikitas G, Deschamps C, Disson O, Niault T, Cossart P, Lecuit M. Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin. J Exp Med. 2011;208:2263-77 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 6
  • western blot; human; 1:500; fig 3
Sigurdsson V, Hilmarsdottir B, Sigmundsdottir H, Fridriksdottir A, Ringner M, Villadsen R, et al. Endothelial induced EMT in breast epithelial cells with stem cell properties. PLoS ONE. 2011;6:e23833 pubmed publisher
  • western blot; human; 1:1000; fig 1
de Wit M, Jimenez C, Carvalho B, Belien J, Delis van Diemen P, Mongera S, et al. Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression. Gut. 2012;61:855-64 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:300; tbl 1
Holbrook E, Wu E, Curry W, Lin D, Schwob J. Immunohistochemical characterization of human olfactory tissue. Laryngoscope. 2011;121:1687-701 pubmed publisher
  • immunocytochemistry; human; fig 2
Lacher M, Shiina M, Chang P, Keller D, Tiirikainen M, Korn W. ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor. Mol Cancer. 2011;10:91 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2500; tbl 1
Lindström A, Asplund A, Hellberg D. Correlation between LRIG1 and LRIG2 expressions and expression of 11 tumor markers, with special reference to tumor suppressors, in CIN and normal cervical epithelium. Gynecol Oncol. 2011;122:372-6 pubmed publisher
  • immunohistochemistry; human; fig 4
Jovov B, Que J, Tobey N, Djukic Z, Hogan B, Orlando R. Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol. 2011;106:1039-47 pubmed publisher
  • western blot; human; 1:1000; fig 5
Diehl H, Stühler K, Klein Scory S, Volmer M, Schöneck A, Bieling C, et al. A catalogue of proteins released by colorectal cancer cells in vitro as an alternative source for biomarker discovery. Proteomics Clin Appl. 2007;1:47-61 pubmed publisher
  • immunocytochemistry; human; tbl 1
Ingthorsson S, Halldorsson T, Sigurdsson V, Friðriksdottir A, Bodvarsdottir S, Steinarsdottir M, et al. Selection for EGFR gene amplification in a breast epithelial cell line with basal-like phenotype and hereditary background. In Vitro Cell Dev Biol Anim. 2011;47:139-48 pubmed publisher
  • immunocytochemistry; human; fig 1
  • immunohistochemistry; human; fig 1
Ye Y, Tellez J, Durazo M, Belcher M, Yearsley K, Barsky S. E-cadherin accumulation within the lymphovascular embolus of inflammatory breast cancer is due to altered trafficking. Anticancer Res. 2010;30:3903-10 pubmed
  • immunohistochemistry; human; 1:200; fig 1
Rakha E, Patel A, Powe D, Benhasouna A, Green A, Lambros M, et al. Clinical and biological significance of E-cadherin protein expression in invasive lobular carcinoma of the breast. Am J Surg Pathol. 2010;34:1472-9 pubmed publisher
  • immunocytochemistry; human; 1:200; fig s1
Loessner D, Stok K, Lutolf M, Hutmacher D, Clements J, Rizzi S. Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. Biomaterials. 2010;31:8494-506 pubmed publisher
  • western blot; human; fig 4
Dangi Garimella S, Redig A, Shields M, Siddiqui M, Munshi H. Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes. J Biol Chem. 2010;285:28363-72 pubmed publisher
  • immunohistochemistry; human; 0.2 ug/ul; fig 1
Brusevold I, Husvik C, Schreurs O, Schenck K, Bryne M, Søland T. Induction of invasion in an organotypic oral cancer model by CoCl2, a hypoxia mimetic. Eur J Oral Sci. 2010;118:168-76 pubmed publisher
  • western blot; human; fig 3
Maher M, Mo R, Flozak A, Peled O, Gottardi C. Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling. PLoS ONE. 2010;5:e10184 pubmed publisher
  • western blot; human; fig 6
Wen T, Zhang Z, Yu Y, Qu H, Koch M, Aumailley M. Integrin alpha3 subunit regulates events linked to epithelial repair, including keratinocyte migration and protein expression. Wound Repair Regen. 2010;18:325-34 pubmed publisher
  • immunocytochemistry; human; fig 7
Blank F, Wehrli M, Lehmann A, Baum O, Gehr P, von Garnier C, et al. Macrophages and dendritic cells express tight junction proteins and exchange particles in an in vitro model of the human airway wall. Immunobiology. 2011;216:86-95 pubmed publisher
  • immunohistochemistry; human; 1:100; tbl 1
Flatmark K, Davidson B, Kristian A, Stavnes H, Førsund M, Reed W. Exploring the peritoneal surface malignancy phenotype--a pilot immunohistochemical study of human pseudomyxoma peritonei and derived animal models. Hum Pathol. 2010;41:1109-19 pubmed publisher
  • flow cytometry; human; 1:100
Ghosh S, Koblinski J, Johnson J, Liu Y, Ericsson A, Davis J, et al. Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression. Mol Cancer Res. 2010;8:145-58 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; tbl 2
Kaarteenaho R, Sormunen R, Paakko P. Variable expression of tenascin-C, osteopontin and fibronectin in inflammatory myofibroblastic tumour of the lung. APMIS. 2010;118:91-100 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2500; tbl 1
Samir R, Asplund A, Tot T, Pekar G, Hellberg D. Tissue tumor marker expression in smokers, including serum cotinine concentrations, in women with cervical intraepithelial neoplasia or normal squamous cervical epithelium. Am J Obstet Gynecol. 2010;202:579.e1-7 pubmed publisher
  • blocking or activating experiments; human
Morales J, Alpaugh M. Gain in cellular organization of inflammatory breast cancer: A 3D in vitro model that mimics the in vivo metastasis. BMC Cancer. 2009;9:462 pubmed publisher
  • immunohistochemistry - frozen section; human; fig 2
  • western blot; human; fig 1
Maher M, Flozak A, Stocker A, Chenn A, Gottardi C. Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion. J Cell Biol. 2009;186:219-28 pubmed publisher
  • immunocytochemistry; human
Kim J, Kushiro K, Graham N, Asthagiri A. Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth. Proc Natl Acad Sci U S A. 2009;106:11149-53 pubmed publisher
  • immunocytochemistry; human; fig 4a
Agnarsson B, Ingthorsson S, Gudjonsson T, Leosson K. Evanescent-wave fluorescence microscopy using symmetric planar waveguides. Opt Express. 2009;17:5075-82 pubmed
  • immunocytochemistry; human; fig 1b
Sarrio D, Palacios J, Hergueta Redondo M, Gomez Lopez G, Cano A, Moreno Bueno G. Functional characterization of E- and P-cadherin in invasive breast cancer cells. BMC Cancer. 2009;9:74 pubmed publisher
  • western blot; human; fig 2
Rogers S, Box C, Chambers P, Barbachano Y, Nutting C, Rhys Evans P, et al. Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck. J Pathol. 2009;218:122-30 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 5
  • western blot; human; 1:1000; fig 3
Jiang H, Guan G, Zhang R, Liu G, Cheng J, Hou X, et al. Identification of urinary soluble E-cadherin as a novel biomarker for diabetic nephropathy. Diabetes Metab Res Rev. 2009;25:232-41 pubmed publisher
  • western blot; human
Li Z, Zhou Z, Welch D, Donahue H. Expressing connexin 43 in breast cancer cells reduces their metastasis to lungs. Clin Exp Metastasis. 2008;25:893-901 pubmed publisher
  • immunocytochemistry; human; 20 ug/ml; fig 4
  • western blot; human; fig 3
Marín Briggiler C, Veiga M, Matos M, Echeverría M, Furlong L, Vazquez Levin M. Expression of epithelial cadherin in the human male reproductive tract and gametes and evidence of its participation in fertilization. Mol Hum Reprod. 2008;14:561-71 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Klein E, Campbell L, Kothapalli D, Fournier A, Assoian R. Joint requirement for Rac and ERK activities underlies the mid-G1 phase induction of cyclin D1 and S phase entry in both epithelial and mesenchymal cells. J Biol Chem. 2008;283:30911-8 pubmed publisher
  • immunocytochemistry; human; 1:200
Van Hoof D, Braam S, Dormeyer W, Ward van Oostwaard D, Heck A, Krijgsveld J, et al. Feeder-free monolayer cultures of human embryonic stem cells express an epithelial plasma membrane protein profile. Stem Cells. 2008;26:2777-81 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • flow cytometry; human; 1:200
  • western blot; human; 1:2000
Caberg J, Hubert P, Begon D, Herfs M, Roncarati P, Boniver J, et al. Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes. Carcinogenesis. 2008;29:1441-7 pubmed publisher
  • immunohistochemistry; human; 1:200; tbl 2
Marchio C, Iravani M, Natrajan R, Lambros M, Savage K, Tamber N, et al. Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast. J Pathol. 2008;215:398-410 pubmed publisher
  • immunoprecipitation; human
  • western blot; human
Najy A, Day K, Day M. The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation. J Biol Chem. 2008;283:18393-401 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Rakha E, El Sheikh S, Kandil M, El Sayed M, Green A, Ellis I. Expression of BRCA1 protein in breast cancer and its prognostic significance. Hum Pathol. 2008;39:857-65 pubmed publisher
  • western blot; human; fig 3c
Agarwal S, Lee D, Kiener H, Brenner M. Coexpression of two mesenchymal cadherins, cadherin 11 and N-cadherin, on murine fibroblast-like synoviocytes. Arthritis Rheum. 2008;58:1044-54 pubmed publisher
  • immunohistochemistry; human; tbl 2
McClelland R, Wauthier E, Uronis J, Reid L. Gradients in the liver's extracellular matrix chemistry from periportal to pericentral zones: influence on human hepatic progenitors. Tissue Eng Part A. 2008;14:59-70 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:20; fig 1a
  • western blot; human; fig 3a
Fanelli M, Montt Guevara M, Diblasi A, Gago F, Tello O, Cuello Carrión F, et al. P-cadherin and beta-catenin are useful prognostic markers in breast cancer patients; beta-catenin interacts with heat shock protein Hsp27. Cell Stress Chaperones. 2008;13:207-20 pubmed publisher
  • flow cytometry; human; 2.5 ug/ml
Ivascu A, Kubbies M. Diversity of cell-mediated adhesions in breast cancer spheroids. Int J Oncol. 2007;31:1403-13 pubmed
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 6
Akat K, Bleck C, Lee Y, Haselmann Weiss U, Kartenbeck J. Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52. Cell Tissue Res. 2008;331:401-12 pubmed
  • blocking or activating experiments; human
  • western blot; human; 1:1000
Haga T, Uchide N, Tugizov S, Palefsky J. Role of E-cadherin in the induction of apoptosis of HPV16-positive CaSki cervical cancer cells during multicellular tumor spheroid formation. Apoptosis. 2008;13:97-108 pubmed
  • western blot; human; 1:5000
Xie J, Haslam S. Extracellular matrix, Rac1 signaling, and estrogen-induced proliferation in MCF-7 breast cancer cells. Breast Cancer Res Treat. 2008;110:257-68 pubmed
  • immunocytochemistry; human; fig 5
Troyanovsky R, Laur O, Troyanovsky S. Stable and unstable cadherin dimers: mechanisms of formation and roles in cell adhesion. Mol Biol Cell. 2007;18:4343-52 pubmed
  • immunohistochemistry - paraffin section; human; 1:200
Chung Y, Lam A, Luk J, Law S, Chan K, Lee P, et al. Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma. Ann Surg Oncol. 2007;14:3260-7 pubmed
  • immunohistochemistry - paraffin section; human; fig 1
Mahomed F, Altini M, Meer S. Altered E-cadherin/beta-catenin expression in oral squamous carcinoma with and without nodal metastasis. Oral Dis. 2007;13:386-92 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Canavese G, Bernardi A, Candelaresi G, Lovadina P, Amerio S, Rossetti V, et al. Expression of the E-cadherin-catenins complex in sentinel node is related to tumor morphology but not to spread to nonsentinel nodes. Pathol Res Pract. 2007;203:517-23 pubmed
  • western blot; human; 1:4000; fig 1
Symowicz J, Adley B, Gleason K, Johnson J, Ghosh S, Fishman D, et al. Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res. 2007;67:2030-9 pubmed
  • immunocytochemistry; human
Chang Y, Marlin J, Chance T, Jakobi R. RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. Cancer Res. 2006;66:11700-8 pubmed
  • immunohistochemistry; human; 1:100; tbl 1
Rakha E, El Sayed M, Green A, Lee A, Robertson J, Ellis I. Prognostic markers in triple-negative breast cancer. Cancer. 2007;109:25-32 pubmed
  • immunohistochemistry; human; fig 2h
Murao K, Kubo Y, Ohtani N, Hara E, Arase S. Epigenetic abnormalities in cutaneous squamous cell carcinomas: frequent inactivation of the RB1/p16 and p53 pathways. Br J Dermatol. 2006;155:999-1005 pubmed
  • immunohistochemistry; human; 1:100
  • ELISA; human
  • western blot; human; 1:500
Sonne S, Hoei Hansen C, Nielsen J, Herlihy A, Andersson A, Almstrup K, et al. CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours. APMIS. 2006;114:549-58 pubmed
  • immunocytochemistry; human
Robert G, Gaggioli C, Bailet O, Chavey C, Abbe P, Aberdam E, et al. SPARC represses E-cadherin and induces mesenchymal transition during melanoma development. Cancer Res. 2006;66:7516-23 pubmed
  • immunohistochemistry - paraffin section; human
Rodriguez Sanjuan J, Fontalba A, Mayorga M, Bordin M, Hyland S, Trugeda S, et al. A novel mutation in the E-cadherin gene in the first family with hereditary diffuse gastric cancer reported in Spain. Eur J Surg Oncol. 2006;32:1110-3 pubmed
  • immunocytochemistry; human; fig 6
  • immunohistochemistry; human; fig 1
Bacani J, Soares M, Zwingerman R, Di Nicola N, Senz J, Riddell R, et al. CDH1/E-cadherin germline mutations in early-onset gastric cancer. J Med Genet. 2006;43:867-72 pubmed
  • immunocytochemistry; human; 20 ug/ml; fig 5
Katso R, Pardo O, Palamidessi A, Franz C, Marinov M, De Laurentiis A, et al. Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. Mol Biol Cell. 2006;17:3729-44 pubmed
  • immunoprecipitation; human; fig 5
  • immunocytochemistry; human; fig 4
Troyanovsky R, Sokolov E, Troyanovsky S. Endocytosis of cadherin from intracellular junctions is the driving force for cadherin adhesive dimer disassembly. Mol Biol Cell. 2006;17:3484-93 pubmed
  • immunocytochemistry; hamsters; fig 2
  • western blot; hamsters; fig 2
  • immunocytochemistry; human; fig 1
Fujita Y, Hogan C, Braga V. Regulation of cell-cell adhesion by Rap1. Methods Enzymol. 2006;407:359-72 pubmed
  • immunohistochemistry - paraffin section; human; 1:300
Rao K, Alper O, Opheim K, Bonnet G, Wolfe K, Bryant E, et al. Cytogenetic characterization and H-ras associated transformation of immortalized human mammary epithelial cells. Cancer Cell Int. 2006;6:15 pubmed
  • immunohistochemistry - paraffin section; human; 1:600
Lascombe I, Clairotte A, Fauconnet S, Bernardini S, Wallerand H, Kantelip B, et al. N-cadherin as a novel prognostic marker of progression in superficial urothelial tumors. Clin Cancer Res. 2006;12:2780-7 pubmed
  • western blot; human; 1:1000; fig 1
Lombaerts M, van Wezel T, Philippo K, Dierssen J, Zimmerman R, Oosting J, et al. E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Br J Cancer. 2006;94:661-71 pubmed
  • immunohistochemistry - paraffin section; human; 1:100; tbl 2
Voutilainen K, Anttila M, Sillanpää S, Ropponen K, Saarikoski S, Juhola M, et al. Prognostic significance of E-cadherin-catenin complex in epithelial ovarian cancer. J Clin Pathol. 2006;59:460-7 pubmed
  • immunohistochemistry; human; 1:100; tbl 7
Rakha E, Putti T, Abd El Rehim D, Paish C, Green A, Powe D, et al. Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation. J Pathol. 2006;208:495-506 pubmed
  • immunohistochemistry - paraffin section; human; 1:400; fig 1
Harigopal M, Shin S, Murray M, Tickoo S, Brogi E, Rosen P. Aberrant E-cadherin staining patterns in invasive mammary carcinoma. World J Surg Oncol. 2005;3:73 pubmed
  • immunocytochemistry; human; 1:200; fig 4B
  • western blot; human; 1:1000; fig 3B
Taylor D, Watt N, Perera W, Hooper N. Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J Cell Sci. 2005;118:5141-53 pubmed
  • immunohistochemistry - paraffin section; human; fig 1C
  • immunocytochemistry; human; fig 4Ac
  • western blot; human; fig 3B
Han S, Lee H, Lee J, Kim W, Nam H, Kim H, et al. Modulation of E-cadherin by hepatocyte growth factor induces aggressiveness of gastric carcinoma. Ann Surg. 2005;242:676-83 pubmed
  • immunohistochemistry - paraffin section; human; 1:1000
Asioli S, Marucci G, Ficarra G, Stephens M, Foschini M, Ellis I, et al. Polymorphous adenocarcinoma of the breast. Report of three cases. Virchows Arch. 2006;448:29-34 pubmed
  • immunocytochemistry; human; fig 5
Veveris Lowe T, Lawrence M, Collard R, Bui L, Herington A, Nicol D, et al. Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells. Endocr Relat Cancer. 2005;12:631-43 pubmed
  • western blot; rat; 1:1000
  • immunocytochemistry; human; 1:400
  • western blot; human; 1:1000
Schmidt C, Gi Y, Patel T, Coffey R, Beauchamp R, Pearson A. E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. Surgery. 2005;138:306-12 pubmed
  • immunohistochemistry; human; fig 2
Margulis A, Zhang W, Alt Holland A, Pawagi S, Prabhu P, Cao J, et al. Loss of intercellular adhesion activates a transition from low- to high-grade human squamous cell carcinoma. Int J Cancer. 2006;118:821-31 pubmed
  • western blot; human; fig 2
Köbel M, Pohl G, Schmitt W, Hauptmann S, Wang T, Shih I. Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor. Am J Pathol. 2005;167:879-85 pubmed
  • immunohistochemistry - paraffin section; human; 1:1000
Bassarova A, Torlakovic E, Sedloev T, Hristova S, Trifonov D, Nesland J. Simultaneous bilateral breast carcinoma: Histopathological characteristics and CD44/catenin-cadherin profile. Histol Histopathol. 2005;20:791-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Rakha E, Abd El Rehim D, Pinder S, Lewis S, Ellis I. E-cadherin expression in invasive non-lobular carcinoma of the breast and its prognostic significance. Histopathology. 2005;46:685-93 pubmed
  • immunohistochemistry - paraffin section; human; fig 1
Vongwiwatana A, Tasanarong A, Rayner D, Melk A, Halloran P. Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant. 2005;5:1367-74 pubmed
  • ELISA; human; fig 1
Kuefer R, Hofer M, Zorn C, Engel O, Volkmer B, Juarez Brito M, et al. Assessment of a fragment of e-cadherin as a serum biomarker with predictive value for prostate cancer. Br J Cancer. 2005;92:2018-23 pubmed
  • immunohistochemistry; human; 1:10-1:20
Abd El Rehim D, Ball G, Pinder S, Rakha E, Paish C, Robertson J, et al. High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer. 2005;116:340-50 pubmed
  • immunohistochemistry - paraffin section; human; 1:300; fig 1
Bendardaf R, Elzagheid A, Lamlum H, Ristamaki R, Collan Y, Pyrhonen S. E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer. Oncol Rep. 2005;13:831-5 pubmed
  • immunocytochemistry; human
Ivanov A, Hunt D, Utech M, Nusrat A, Parkos C. Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. Mol Biol Cell. 2005;16:2636-50 pubmed
  • immunohistochemistry - paraffin section; human; 1:400; tbl 2
Pelosi G, Scarpa A, Puppa G, Veronesi G, Spaggiari L, Pasini F, et al. Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids. Cancer. 2005;103:1154-64 pubmed
  • immunohistochemistry; human; 1:1000; fig 1
van Velthuysen M, Taal B, van der Hoeven J, Peterse J. Expression of oestrogen receptor and loss of E-cadherin are diagnostic for gastric metastasis of breast carcinoma. Histopathology. 2005;46:153-7 pubmed
  • immunocytochemistry; human; 1:300; fig 3
Rothen Rutishauser B, Kiama S, Gehr P. A three-dimensional cellular model of the human respiratory tract to study the interaction with particles. Am J Respir Cell Mol Biol. 2005;32:281-9 pubmed
  • immunohistochemistry - paraffin section; human; 1:100; tbl 1
Rakha E, Armour J, Pinder S, Paish C, Ellis I. High-resolution analysis of 16q22.1 in breast carcinoma using DNA amplifiable probes (multiplex amplifiable probe hybridization technique) and immunohistochemistry. Int J Cancer. 2005;114:720-9 pubmed
  • immunohistochemistry - paraffin section; human
Bane A, Tjan S, Parkes R, Andrulis I, O Malley F. Invasive lobular carcinoma: to grade or not to grade. Mod Pathol. 2005;18:621-8 pubmed
  • immunocytochemistry; human; fig 3
  • western blot; human; fig 1
Rios Doria J, Day M. Truncated E-cadherin potentiates cell death in prostate epithelial cells. Prostate. 2005;63:259-68 pubmed
  • immunohistochemistry - paraffin section; human; 1:600
Eriksen J, Buffa F, Alsner J, Steiniche T, Bentzen S, Overgaard J. Molecular profiles as predictive marker for the effect of overall treatment time of radiotherapy in supraglottic larynx squamous cell carcinomas. Radiother Oncol. 2004;72:275-82 pubmed
  • immunohistochemistry - frozen section; human; 1:300
  • immunohistochemistry - paraffin section; human; 1:300
Honecker F, Kersemaekers A, Molier M, Van Weeren P, Stoop H, de Krijger R, et al. Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development. J Pathol. 2004;204:167-74 pubmed
  • immunocytochemistry; human; fig 3
  • western blot; human; 1:1000; fig 1
Schmidt C, Gi Y, Coffey R, Beauchamp R, Pearson A. Oncogenic Ras dominates overexpression of E-cadherin in malignant transformation of intestinal epithelial cells. Surgery. 2004;136:303-9 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; tbl 1
Marques F, Fonsechi Carvasan G, de Angelo Andrade L, Bottcher Luiz F. Immunohistochemical patterns for alpha- and beta-catenin, E- and N-cadherin expression in ovarian epithelial tumors. Gynecol Oncol. 2004;94:16-24 pubmed
  • western blot; human; fig 4
Kapoor P, Saunders M, Li Z, Zhou Z, Sheaffer N, Kunze E, et al. Breast cancer metastatic potential: correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells. Int J Cancer. 2004;111:693-7 pubmed
  • immunohistochemistry - paraffin section; human; 1:1000
Andersen K, Nesland J, Holm R, Flørenes V, Fodstad Ø, Maelandsmo G. Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant melanoma. Mod Pathol. 2004;17:990-7 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Song S, Kim S, Kim D, Son H, Rhee J, Kim Y. Abnormal expression of E-cadherin in early gastric carcinoma: its relationship with macroscopic growth patterns and catenin alpha and beta. J Clin Gastroenterol. 2004;38:252-9 pubmed
  • immunohistochemistry - paraffin section; human; fig 2A
Graziano F, Arduini F, Ruzzo A, Bearzi I, Humar B, More H, et al. Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. Clin Cancer Res. 2004;10:2784-9 pubmed
  • immunohistochemistry; human; 1:75; tbl 2
Bassarova A, Nesland J, Sedloev T, Danielsen H, Christova S. Pilomatrix carcinoma with lymph node metastases. J Cutan Pathol. 2004;31:330-5 pubmed
  • immunohistochemistry - paraffin section; human; 1:100
Graziano F, Arduini F, Ruzzo A, Mandolesi A, Bearzi I, Silva R, et al. Combined analysis of E-cadherin gene (CDH1) promoter hypermethylation and E-cadherin protein expression in patients with gastric cancer: implications for treatment with demethylating drugs. Ann Oncol. 2004;15:489-92 pubmed
  • immunoprecipitation; human; fig 4
  • western blot; human; 2.0 ug/ml; fig 2
Chunthapong J, Seftor E, Khalkhali Ellis Z, Seftor R, Amir S, Lubaroff D, et al. Dual roles of E-cadherin in prostate cancer invasion. J Cell Biochem. 2004;91:649-61 pubmed
  • western blot; human; fig 1
Chen Q, Lipkina G, Song Q, Kramer R. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun. 2004;315:850-6 pubmed
  • immunohistochemistry - paraffin section; domestic rabbit; fig 7
Tobey N, Argote C, Hosseini S, Orlando R. Calcium-switch technique and junctional permeability in native rabbit esophageal epithelium. Am J Physiol Gastrointest Liver Physiol. 2004;286:G1042-9 pubmed
  • western blot; human
Kuefer R, Hofer M, Gschwend J, Pienta K, Sanda M, Chinnaiyan A, et al. The role of an 80 kDa fragment of E-cadherin in the metastatic progression of prostate cancer. Clin Cancer Res. 2003;9:6447-52 pubmed
  • western blot; human
Han S, Kim H, Seong D, Kim Y, Park Y, Bang Y, et al. Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer. Oncogene. 2004;23:1333-41 pubmed
  • western blot; human; 1:10000; fig 3
Gottardi C, Gumbiner B. Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions. Am J Physiol Cell Physiol. 2004;286:C747-56 pubmed
  • western blot; human; fig 2
Troyanovsky R, Sokolov E, Troyanovsky S. Adhesive and lateral E-cadherin dimers are mediated by the same interface. Mol Cell Biol. 2003;23:7965-72 pubmed
  • immunohistochemistry; human; 1:20; fig 1
Ordonez N. Value of E-cadherin and N-cadherin immunostaining in the diagnosis of mesothelioma. Hum Pathol. 2003;34:749-55 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Palacios J, Sarrio D, García Macias M, Bryant B, Sobel M, Merino M. Frequent E-cadherin gene inactivation by loss of heterozygosity in pleomorphic lobular carcinoma of the breast. Mod Pathol. 2003;16:674-8 pubmed
  • immunohistochemistry; human; 1:200; tbl 1
Rocha A, Soares P, Fonseca E, Cameselle Teijeiro J, Oliveira M, Sobrinho Simoes M. E-cadherin loss rather than beta-catenin alterations is a common feature of poorly differentiated thyroid carcinomas. Histopathology. 2003;42:580-7 pubmed
  • immunocytochemistry; human; fig 3a
  • western blot; human; fig 3b
McGuire J, Li Q, Parks W. Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium. Am J Pathol. 2003;162:1831-43 pubmed
  • western blot; human; 1:1000
Kokenyesi R, Murray K, Benshushan A, Huntley E, Kao M. Invasion of interstitial matrix by a novel cell line from primary peritoneal carcinosarcoma, and by established ovarian carcinoma cell lines: role of cell-matrix adhesion molecules, proteinases, and E-cadherin expression. Gynecol Oncol. 2003;89:60-72 pubmed
  • flow cytometry; human; tbl 3
  • immunocytochemistry; human; fig 5
  • western blot; human; 0.5 ug/ml; fig 8
Offterdinger M, Schneider S, Grunt T. Heregulin and retinoids synergistically induce branching morphogenesis of breast cancer cells cultivated in 3D collagen gels. J Cell Physiol. 2003;195:260-75 pubmed
  • immunohistochemistry - paraffin section; human
Impola U, Toriseva M, Suomela S, Jeskanen L, Hieta N, Jahkola T, et al. Matrix metalloproteinase-19 is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation. Int J Cancer. 2003;103:709-16 pubmed
  • immunohistochemistry - paraffin section; human
Carpenter P, Al Kuran R, Theuer C. Paranuaclear E-cadherin in gastric adenocarcinoma. Am J Clin Pathol. 2002;118:887-94 pubmed
  • immunohistochemistry; human
Kuijper A, Preisler Adams S, Rahusen F, Gille J, van der Wall E, van Diest P. Multiple fibroadenomas harbouring carcinoma in situ in a woman with a family history of breast/ovarian cancer. J Clin Pathol. 2002;55:795-7 pubmed
  • immunohistochemistry - paraffin section; human; 1:2000; tbl 2
Karbova E, Davidson B, Metodiev K, Trope C, Nesland J. Adenomatous polyposis coli (APC) protein expression in primary and metastatic serous ovarian carcinoma. Int J Surg Pathol. 2002;10:175-80 pubmed
  • immunohistochemistry - paraffin section; human; 1:1000; fig 6
Damiani S, Eusebi V, Peterse J. Malignant neoplasms infiltrating pseudoangiomatous' stromal hyperplasia of the breast: an unrecognized pathway of tumour spread. Histopathology. 2002;41:208-15 pubmed
  • western blot; human
Jamal S, Schneider R. UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells. J Clin Invest. 2002;110:443-52 pubmed
  • immunohistochemistry - paraffin section; human; 1:1000; tbl 1
  • western blot; human; tbl 3
Khorram Manesh A, Ahlman H, Jansson S, Nilsson O. N-cadherin expression in adrenal tumors: upregulation in malignant pheochromocytoma and downregulation in adrenocortical carcinoma. Endocr Pathol. 2002;13:99-110 pubmed
  • immunohistochemistry - paraffin section; human; fig 3
Elzagheid A, Kuopio T, Ilmen M, Collan Y. Prognostication of invasive ductal breast cancer by quantification of E-cadherin immunostaining: the methodology and clinical relevance. Histopathology. 2002;41:127-33 pubmed
  • western blot; human; fig 4
Tran N, Adams D, Vaillancourt R, Heimark R. Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization. J Biol Chem. 2002;277:32905-14 pubmed
  • blocking or activating experiments; human
Kim J, Joo C. Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1. J Biol Chem. 2002;277:31938-48 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Rocha A, Soares P, Machado J, Máximo V, Fonseca E, Franssila K, et al. Mucoepidermoid carcinoma of the thyroid: a tumour histotype characterised by P-cadherin neoexpression and marked abnormalities of E-cadherin/catenins complex. Virchows Arch. 2002;440:498-504 pubmed
  • immunocytochemistry; human; 1:100; fig 1
  • western blot; human; 1:1000; fig 1
Sahai E, Marshall C. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol. 2002;4:408-15 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; fig 2
Paredes J, Milanezi F, Viegas L, Amendoeira I, Schmitt F. P-cadherin expression is associated with high-grade ductal carcinoma in situ of the breast. Virchows Arch. 2002;440:16-21 pubmed
  • immunohistochemistry; human
Mert G. National action plan on Breast Cancer Workshop on Multicultural Aspects of Breast Cancer Etiology: recommendations of the workshop. Cancer. 2002;94:2113 pubmed
  • blocking or activating experiments; human
Hegerfeldt Y, Tusch M, Brocker E, Friedl P. Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies. Cancer Res. 2002;62:2125-30 pubmed
  • western blot; human; 1:5000
Hajra K, Chen D, Fearon E. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 2002;62:1613-8 pubmed
  • immunohistochemistry - paraffin section; human
Laskin W, Miettinen M. Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues. Arch Pathol Lab Med. 2002;126:425-31 pubmed
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 2
Schreider C, Peignon G, Thenet S, Chambaz J, Pincon Raymond M. Integrin-mediated functional polarization of Caco-2 cells through E-cadherin--actin complexes. J Cell Sci. 2002;115:543-52 pubmed
  • immunocytochemistry; human; 1:100
Fetsch P, Simsir A, Brosky K, Abati A. Comparison of three commonly used cytologic preparations in effusion immunocytochemistry. Diagn Cytopathol. 2002;26:61-6 pubmed
  • western blot; human; fig 5
Gregoire L, Rabah R, Schmelz E, Munkarah A, Roberts P, Lancaster W. Spontaneous malignant transformation of human ovarian surface epithelial cells in vitro. Clin Cancer Res. 2001;7:4280-7 pubmed
  • immunohistochemistry - paraffin section; human
Parker C, Rampaul R, Pinder S, Bell J, Wencyk P, Blamey R, et al. E-cadherin as a prognostic indicator in primary breast cancer. Br J Cancer. 2001;85:1958-63 pubmed
  • immunohistochemistry - paraffin section; human; fig 3
Pummi K, Malminen M, Aho H, Karvonen S, Peltonen J, Peltonen S. Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes. J Invest Dermatol. 2001;117:1050-8 pubmed
  • immunohistochemistry - frozen section; human; 1:200
Ascaño J, Frierson H, Moskaluk C, Harper J, Roviello F, Jackson C, et al. Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer. Mod Pathol. 2001;14:942-9 pubmed
  • immunohistochemistry - paraffin section; human; 1:1000
Kapiteijn E, Liefers G, Los L, Kranenbarg E, Hermans J, Tollenaar R, et al. Mechanisms of oncogenesis in colon versus rectal cancer. J Pathol. 2001;195:171-8 pubmed
  • immunohistochemistry - paraffin section; human; 1:20; fig 1
  • western blot; human; fig 2
Krill D, Thomas A, Wu S, Dhir R, Becich M. E-cadherin expression and PSA secretion in human prostate epithelial cells. Urol Res. 2001;29:287-92 pubmed
  • immunohistochemistry - paraffin section; human; tbl 1
Wheelock M, Soler A, Knudsen K. Cadherin junctions in mammary tumors. J Mammary Gland Biol Neoplasia. 2001;6:275-85 pubmed
  • immunohistochemistry; human; 1:800
Noci I, Borri P, Bonfirraro G, Chieffi O, Arcangeli A, Cherubini A, et al. Longstanding survival without cancer progression in a patient affected by endometrial carcinoma treated primarily with leuprolide. Br J Cancer. 2001;85:333-6 pubmed
  • immunohistochemistry - paraffin section; human; fig 1
Rubin M, Mucci N, Figurski J, Fecko A, Pienta K, Day M. E-cadherin expression in prostate cancer: a broad survey using high-density tissue microarray technology. Hum Pathol. 2001;32:690-7 pubmed
  • immunohistochemistry; human; fig 1
Rocha A, Soares P, Seruca R, Máximo V, Matias Guiu X, Cameselle Teijeiro J, et al. Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant. J Pathol. 2001;194:358-66 pubmed
  • blocking or activating experiments; human
  • immunoprecipitation; human; fig 3d
  • immunohistochemistry; human; fig 3f
  • western blot; human; fig 2
Tomlinson J, Alpaugh M, Barsky S. An intact overexpressed E-cadherin/alpha,beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma. Cancer Res. 2001;61:5231-41 pubmed
  • immunohistochemistry - frozen section; human; 1:10
Hentula M, Peltonen J, Peltonen S. Expression profiles of cell-cell and cell-matrix junction proteins in developing human epidermis. Arch Dermatol Res. 2001;293:259-67 pubmed
  • immunohistochemistry - paraffin section; human; 1:200
Rahn J, Dabbagh L, Pasdar M, Hugh J. The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literature. Cancer. 2001;91:1973-82 pubmed
  • western blot; human
Gottardi C, Wong E, Gumbiner B. E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol. 2001;153:1049-60 pubmed
  • immunohistochemistry - paraffin section; human; 1:2000; fig 2
Spina D, Vindigni C, Presenti L, Schurfeld K, Stumpo M, Tosi P. Cell proliferation, cell death, E-cadherin, metalloproteinase expression and angiogenesis in gastric cancer precursors and early cancer of the intestinal type. Int J Oncol. 2001;18:1251-8 pubmed
  • immunohistochemistry; human; 1:100
Leong A, Sormunen R, Vinyuvat S, Hamdani R, Suthipintawong C. Biologic markers in ductal carcinoma in situ and concurrent infiltrating carcinoma. A comparison of eight contemporary grading systems. Am J Clin Pathol. 2001;115:709-18 pubmed
  • immunohistochemistry - paraffin section; human; 1:500
Rieger Christ K, Pezza J, Dugan J, Braasch J, Hughes K, Summerhayes I. Disparate E-cadherin mutations in LCIS and associated invasive breast carcinomas. Mol Pathol. 2001;54:91-7 pubmed
  • immunohistochemistry - paraffin section; human; 1:1000; fig 1
Etzell J, DeVries S, Chew K, Florendo C, Molinaro A, Ljung B, et al. Loss of chromosome 16q in lobular carcinoma in situ. Hum Pathol. 2001;32:292-6 pubmed
  • immunohistochemistry; human; 1:1000; tbl 3
Waldman F, Hwang E, Etzell J, Eng C, DeVries S, Bennington J, et al. Genomic alterations in tubular breast carcinomas. Hum Pathol. 2001;32:222-6 pubmed
  • western blot; human
Rashid M, Sanda M, Vallorosi C, Rios Doria J, Rubin M, Day M. Posttranslational truncation and inactivation of human E-cadherin distinguishes prostate cancer from matched normal prostate. Cancer Res. 2001;61:489-92 pubmed
  • immunohistochemistry - paraffin section; human; 1:200
Acs G, Lawton T, Rebbeck T, LiVolsi V, Zhang P. Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications. Am J Clin Pathol. 2001;115:85-98 pubmed
  • immunohistochemistry; human; 1:100; fig 5
Maluf H, Swanson P, Koerner F. Solid low-grade in situ carcinoma of the breast: role of associated lesions and E-cadherin in differential diagnosis. Am J Surg Pathol. 2001;25:237-44 pubmed
  • immunohistochemistry; human; 1:200
Acs G, LiVolsi V. Loss of membrane expression of E-cadherin in leukemic erythroblasts. Arch Pathol Lab Med. 2001;125:198-201 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:100
Luo Y, Ferreira Cornwell M, Baldwin H, Kostetskii I, Lenox J, Lieberman M, et al. Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin. Development. 2001;128:459-69 pubmed
  • immunohistochemistry - paraffin section; human
Kolby L, Bernhardt P, Ahlman H, Wangberg B, Johanson V, Wigander A, et al. A transplantable human carcinoid as model for somatostatin receptor-mediated and amine transporter-mediated radionuclide uptake. Am J Pathol. 2001;158:745-55 pubmed
  • western blot; human
Corn P, Smith B, Ruckdeschel E, Douglas D, Baylin S, Herman J. E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia. Clin Cancer Res. 2000;6:4243-8 pubmed
  • immunohistochemistry; human
Rechardt O, Elomaa O, Vaalamo M, Pääkkönen K, Jahkola T, Hook Nikanne J, et al. Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines. J Invest Dermatol. 2000;115:778-87 pubmed
  • immunocytochemistry; human
  • western blot; human; fig 2
Kaida M, Cao F, Skumatz C, Irving P, Burke J. Time at confluence for human RPE cells: effects on the adherens junction and in vitro wound closure. Invest Ophthalmol Vis Sci. 2000;41:3215-24 pubmed
  • immunohistochemistry - frozen section; bovine
  • immunohistochemistry; bovine
Burke J, Cao F, Irving P. High levels of E-/P-cadherin: correlation with decreased apical polarity of Na/K ATPase in bovine RPE cells in situ. Invest Ophthalmol Vis Sci. 2000;41:1945-52 pubmed
  • flow cytometry; human
Hsu M, Meier F, Nesbit M, Hsu J, Van Belle P, Elder D, et al. E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors. Am J Pathol. 2000;156:1515-25 pubmed
  • immunohistochemistry - paraffin section; human; 1:500; tbl 1
Bukholm I, Nesland J. Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas. Virchows Arch. 2000;436:224-8 pubmed
  • immunohistochemistry - paraffin section; human; fig 1
Halachmi S, Demarzo A, Chow N, Halachmi N, Smith A, Linn J, et al. Genetic alterations in urinary bladder carcinosarcoma: evidence of a common clonal origin. Eur Urol. 2000;37:350-7 pubmed
  • immunohistochemistry - frozen section; human
Spirin K, Ljubimov A, Castellon R, Wiedoeft O, Marano M, Sheppard D, et al. Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA. Invest Ophthalmol Vis Sci. 1999;40:3108-15 pubmed
  • immunohistochemistry - paraffin section; human
Huiping C, Sigurgeirsdottir J, Jonasson J, Eiriksdottir G, Johannsdottir J, Egilsson V, et al. Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer. Br J Cancer. 1999;81:1103-10 pubmed
  • immunocytochemistry; human; 1:400
Gomez S, del Mont Llosas M, Verdu J, Roura S, Lloreta J, Fabre M, et al. Independent regulation of adherens and tight junctions by tyrosine phosphorylation in Caco-2 cells. Biochim Biophys Acta. 1999;1452:121-32 pubmed
  • immunocytochemistry; human
Burke J, Cao F, Irving P, Skumatz C. Expression of E-cadherin by human retinal pigment epithelium: delayed expression in vitro. Invest Ophthalmol Vis Sci. 1999;40:2963-70 pubmed
  • immunohistochemistry - paraffin section; human; fig 3
Peralta Soler A, Knudsen K, Salazar H, Han A, Keshgegian A. P-cadherin expression in breast carcinoma indicates poor survival. Cancer. 1999;86:1263-72 pubmed
  • immunohistochemistry - frozen section; human; fig 1
Peltonen S, Hentula M, Hagg P, Ylä Outinen H, Tuukkanen J, Lakkakorpi J, et al. A novel component of epidermal cell-matrix and cell-cell contacts: transmembrane protein type XIII collagen. J Invest Dermatol. 1999;113:635-42 pubmed
  • immunoprecipitation; human; fig 2
  • immunocytochemistry; human; fig 3
  • western blot; human; fig 2
Tran N, Nagle R, Cress A, Heimark R. N-Cadherin expression in human prostate carcinoma cell lines. An epithelial-mesenchymal transformation mediating adhesion withStromal cells. Am J Pathol. 1999;155:787-98 pubmed
  • immunohistochemistry - paraffin section; human; 1:800; fig 1
Blok P, Craanen M, Dekker W, Tytgat G. Loss of E-cadherin expression in early gastric cancer. Histopathology. 1999;34:410-5 pubmed
  • immunocytochemistry; human
Wong A, Maines Bandiera S, Rosen B, Wheelock M, Johnson K, Leung P, et al. Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: influence of family history of ovarian cancer. Int J Cancer. 1999;81:180-8 pubmed
  • western blot; human
Day M, Zhao X, Vallorosi C, Putzi M, Powell C, Lin C, et al. E-cadherin mediates aggregation-dependent survival of prostate and mammary epithelial cells through the retinoblastoma cell cycle control pathway. J Biol Chem. 1999;274:9656-64 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; fig 2
Montonen O, Ezer S, Laurikkala J, Karjalainen Lindsberg M, Thesleff I, Kere J, et al. Expression of the anhidrotic ectodermal dysplasia gene is reduced in skin cancer coinciding with reduced E-cadherin. Exp Dermatol. 1998;7:168-74 pubmed
  • immunocytochemistry; human
Sancho E, Vila M, Sanchez Pulido L, Lozano J, Paciucci R, Nadal M, et al. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. Mol Cell Biol. 1998;18:576-89 pubmed
  • flow cytometry; human; 1:1000; fig 2
Laihia J, Jansen C. Up-regulation of human epidermal Langerhans' cell B7-1 and B7-2 co-stimulatory molecules in vivo by solar-simulating irradiation. Eur J Immunol. 1997;27:984-9 pubmed
  • immunohistochemistry - paraffin section; human
Songun I, van de Velde C, Hermans J, Pals S, Verspaget H, Vis A, et al. Expression of oncoproteins and the amount of eosinophilic and lymphocytic infiltrates can be used as prognostic factors in gastric cancer. Dutch Gastric Cancer Group (DGCG). Br J Cancer. 1996;74:1783-8 pubmed
  • immunohistochemistry - paraffin section; human; 5 ug/ml
Cheng L, Nagabhushan M, Pretlow T, Amini S, Pretlow T. Expression of E-cadherin in primary and metastatic prostate cancer. Am J Pathol. 1996;148:1375-80 pubmed
  • flow cytometry; human
Rokhlin O, Cohen M. Expression of cellular adhesion molecules on human prostate tumor cell lines. Prostate. 1995;26:205-12 pubmed
Carneiro P, Moreira A, Figueiredo J, Barros R, Oliveira P, Fernandes M, et al. S100P is a molecular determinant of E-cadherin function in gastric cancer. Cell Commun Signal. 2019;17:155 pubmed publisher
Palangat M, Anastasakis D, Fei D, Lindblad K, Bradley R, Hourigan C, et al. The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation. Genes Dev. 2019;33:482-497 pubmed publisher
Saxena S, Purohit A, Varney M, Hayashi Y, Singh R. Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells. BMC Cancer. 2018;18:1283 pubmed publisher
Song J, Miermont A, Lim C, Kamm R. A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines. Sci Rep. 2018;8:17949 pubmed publisher
Papoff G, Presutti D, Lalli C, Bolasco G, Santini S, Manelfi C, et al. CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion. Sci Rep. 2018;8:17705 pubmed publisher
Wolf G, Winter W, Bellile E, Nguyen A, Donnelly C, McHugh J, et al. Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck. Oral Oncol. 2018;87:29-35 pubmed publisher
Motawea H, Chotani M, Ali M, Ackerman W, Zhao G, Ahmed A, et al. Human Placenta Expresses α2-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction. Am J Pathol. 2018;188:2774-2785 pubmed publisher
Tang M, Yue P, Ip P, Huang R, Lai H, Cheung A, et al. Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface. Nat Commun. 2018;9:2270 pubmed publisher
Chang J, Hu S, Wang W, Li Y, Zhi W, Lu S, et al. Matrine inhibits prostate cancer via activation of the unfolded protein response/endoplasmic reticulum stress signaling and reversal of epithelial to mesenchymal transition. Mol Med Rep. 2018;18:945-957 pubmed publisher
Ottaviani S, Stebbing J, Frampton A, Zagorac S, Krell J, de Giorgio A, et al. TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Nat Commun. 2018;9:1845 pubmed publisher
Indra I, Choi J, Chen C, Troyanovsky R, Shapiro L, Honig B, et al. Spatial and temporal organization of cadherin in punctate adherens junctions. Proc Natl Acad Sci U S A. 2018;115:E4406-E4415 pubmed publisher
Hareza A, Bakun M, Åšwiderska B, Dudkiewicz M, Koscielny A, Bajur A, et al. Phosphoproteomic insights into processes influenced by the kinase-like protein DIA1/C3orf58. Peerj. 2018;6:e4599 pubmed publisher
Warthan M, Washington S, Franzese S, Ramus R, Kim K, York T, et al. The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma. Biol Reprod. 2018;98:309-322 pubmed publisher
Li T, Wang L. Riparsaponin isolated from Homonoia riparia Lour induces apoptosis of oral cancer cells. Oncol Lett. 2017;14:6841-6846 pubmed publisher
Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, et al. Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells in Periodontitis. J Immunol. 2017;199:4023-4035 pubmed publisher
Aström P, Juurikka K, Hadler Olsen E, Svineng G, Cervigne N, Coletta R, et al. The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma. Br J Cancer. 2017;117:1007-1016 pubmed publisher
Al Khalaf H, Amir M, Al Mohanna F, Tulbah A, Al Sayed A, Aboussekhra A. Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity. Mol Cell Biol. 2017;37: pubmed publisher
Bays J, Campbell H, Heidema C, Sebbagh M, DeMali K. Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK. Nat Cell Biol. 2017;19:724-731 pubmed publisher
Meng J, Zhou P, Liu Y, Liu F, Yi X, Liu S, et al. The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling. PLoS ONE. 2013;8:e82373 pubmed publisher
Araki K, Shimura T, Suzuki H, Tsutsumi S, Wada W, Yajima T, et al. E/N-cadherin switch mediates cancer progression via TGF-?-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma. Br J Cancer. 2011;105:1885-93 pubmed publisher
Ferreira A, Suriano G, Mendes N, Gomes B, Wen X, Carneiro F, et al. E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2. Hum Mol Genet. 2012;21:334-43 pubmed publisher
Yin L, Castagnino P, Assoian R. ABCG2 expression and side population abundance regulated by a transforming growth factor beta-directed epithelial-mesenchymal transition. Cancer Res. 2008;68:800-7 pubmed publisher
Fournier A, Campbell L, Castagnino P, Liu W, Chung B, Weaver V, et al. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. J Cell Sci. 2008;121:226-33 pubmed publisher
Villadsen R, Fridriksdottir A, Rønnov Jessen L, Gudjonsson T, Rank F, Labarge M, et al. Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol. 2007;177:87-101 pubmed
Yanagisawa M, Anastasiadis P. p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness. J Cell Biol. 2006;174:1087-96 pubmed
Burke J, Hong J. Fate of E-cadherin in early RPE cultures: transient accumulation of truncated peptides at nonjunctional sites. Invest Ophthalmol Vis Sci. 2006;47:3635-43 pubmed
Liu W, Nelson C, Pirone D, Chen C. E-cadherin engagement stimulates proliferation via Rac1. J Cell Biol. 2006;173:431-41 pubmed
Peignon G, Thenet S, Schreider C, Fouquet S, Ribeiro A, Dussaulx E, et al. E-cadherin-dependent transcriptional control of apolipoprotein A-IV gene expression in intestinal epithelial cells: a role for the hepatic nuclear factor 4. J Biol Chem. 2006;281:3560-8 pubmed
Gottardi C, Gumbiner B. Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. J Cell Biol. 2004;167:339-49 pubmed
Seveau S, Bierne H, Giroux S, Prevost M, Cossart P. Role of lipid rafts in E-cadherin-- and HGF-R/Met--mediated entry of Listeria monocytogenes into host cells. J Cell Biol. 2004;166:743-53 pubmed
Ivanov A, McCall I, Parkos C, Nusrat A. Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex. Mol Biol Cell. 2004;15:2639-51 pubmed
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Conacci Sorrell M, Simcha I, Ben Yedidia T, Blechman J, Savagner P, Ben Ze ev A. Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol. 2003;163:847-57 pubmed
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product information
Product Type :
Antibody
Product Name :
E-cadherin Monoclonal Antibody (HECD-1)
Catalog # :
13-1700
Quantity :
100 µg
Price :
425 USD
Clonality :
Monoclonal
Purity :
Ion-exchange chromatography
Host :
Mouse
Reactivity :
Guinea Pig, Human
Applications :
ELISA: 2-10 µg/mL, Flow Cytometry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunohistochemistry (Frozen): 2-10 µg/mL, Immunohistochemistry (Paraffin): 2-10 µg/mL, Inhibition Assays: 100 µg/mL, Western Blot: 2-10 µg/mL
Species :
Guinea Pig, Human
Clone :
HECD-1
Isotype :
IgG1
Storage :
4° C
Description :
E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
Immunogen :
Human breast tumor cell line MCF-7.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: 2-10 µg/mL, Flow Cytometry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunohistochemistry (Frozen): 2-10 µg/mL, Immunohistochemistry (Paraffin): 2-10 µg/mL, Inhibition Assays: 100 µg/mL, Western Blot: 2-10 µg/mL
Aliases :
AA960649; Arc-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; Cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-Cadherin phospho; Epithelial cadherin; hab; half baked; LCAM; L-CAM; phospho cadherin 1; phospho E-Cadherin; phospho LCAM; phospho S838; phospho UVO; S840; S840 E-Cadherin; Ser840; Ser840 E-Cadherin; Um; UVO; Uvomorulin
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA