product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD140a (PDGFRA) Monoclonal Antibody (APA5), Biotin, eBioscience
catalog :
13-1401-82
quantity :
100 ug
price :
US 229.00
clonality :
monoclonal
host :
rat
conjugate :
biotin
clone name :
APA5
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 132
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; loading ...; fig s7a
Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577:676-681 pubmed publisher
  • flow cytometry; mouse; loading ...
Mukhopadhyay C, Triplett A, Bargar T, HECKMAN C, Wagner K, Naramura M. Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation. Proc Natl Acad Sci U S A. 2016;113:E8228-E8237 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Patenaude J, Perreault C. Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile. J Immunol. 2016;196:4760-70 pubmed publisher
  • flow cytometry; mouse; fig 1g
Sun L, Sun C, Liang Z, Li H, Chen L, Luo H, et al. FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells. Sci Rep. 2015;5:14871 pubmed publisher
  • flow cytometry; mouse
Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, et al. Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development. Dev Cell. 2014;29:340-9 pubmed publisher
  • flow cytometry; mouse
Osada M, Singh V, Wu K, Sant Angelo D, Pezzano M. Label retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus. PLoS ONE. 2013;8:e83024 pubmed publisher
Burdick L, DelVichio A, Hanson L, Griffith B, Bouchard K, Hunter J, et al. Sex as a Critical Variable in Basic and Pre-Clinical Studies of Fibrodysplasia Ossificans Progressiva. Biomolecules. 2024;14: pubmed publisher
Athanasouli P, Balli M, de Jaime Soguero A, Boel A, Papanikolaou S, van der Veer B, et al. The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency. Nat Commun. 2023;14:1210 pubmed publisher
Mitchell C, Verovskaya E, Calero Nieto F, Olson O, Swann J, Wang X, et al. Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing. Nat Cell Biol. 2023;25:30-41 pubmed publisher
Qin G, Park E, Chen X, Han S, Xiang D, Ren F, et al. Distinct niche structures and intrinsic programs of fallopian tube and ovarian surface epithelial cells. iScience. 2023;26:105861 pubmed publisher
Geng Y, Li L, Yan J, Liu K, Yang A, Zhang L, et al. PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis. Nat Commun. 2022;13:7114 pubmed publisher
Wang Y, Elsherbiny A, Kessler L, Cordero J, Shi H, Serke H, et al. Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function. Nat Commun. 2022;13:6663 pubmed publisher
Roy I, Anu P, Zaunz S, Reddi S, Giri A, Sankar R, et al. Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function. iScience. 2022;25:105171 pubmed publisher
Kanazawa S, Okada H, Riu D, Mabuchi Y, Akazawa C, Iwata J, et al. Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells. Int J Mol Sci. 2022;23: pubmed publisher
Potluri T, Taylor M, Stulberg J, Lieber R, Zhao H, Bulun S. An estrogen-sensitive fibroblast population drives abdominal muscle fibrosis in an inguinal hernia mouse model. JCI Insight. 2022;7: pubmed publisher
Limbad C, Doi R, McGirr J, Ciotlos S, Perez K, Clayton Z, et al. Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. iScience. 2022;25:103848 pubmed publisher
Bizen N, Bepari A, Zhou L, Abe M, Sakimura K, Ono K, et al. Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression. Cell Death Differ. 2022;: pubmed publisher
Mo C, Guo J, Qin J, Zhang X, Sun Y, Wei H, et al. Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools. EMBO J. 2022;41:e108415 pubmed publisher
Minakawa T, Matoba T, Ishidate F, Fujiwara T, Takehana S, Tabata Y, et al. Extracellular vesicles synchronize cellular phenotypes of differentiating cells. J Extracell Vesicles. 2021;10:e12147 pubmed publisher
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Prados B, del Toro R, MacGrogan D, G xf3 mez Api xf1 xe1 niz P, Papoutsi T, Mu xf1 oz C xe1 noves P, et al. Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages. Cell Death Dis. 2021;12:729 pubmed publisher
Westcott G, Emont M, Li J, Jacobs C, Tsai L, Rosen E. Mesothelial cells are not a source of adipocytes in mice. Cell Rep. 2021;36:109388 pubmed publisher
Usui N, Berto S, Konishi A, Kondo M, Konopka G, Matsuzaki H, et al. Zbtb16 regulates social cognitive behaviors and neocortical development. Transl Psychiatry. 2021;11:242 pubmed publisher
Nishina T, Deguchi Y, Ohshima D, Takeda W, Ohtsuka M, Shichino S, et al. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021;12:2281 pubmed publisher
He H, Snowball J, Sun F, Na C, Whitsett J. IGF1R controls mechanosignaling in myofibroblasts required for pulmonary alveologenesis. JCI Insight. 2021;6: pubmed publisher
Ma S, McGuire M, Mangala L, Lee S, Stur E, Hu W, et al. Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype. Cell Rep. 2021;34:108726 pubmed publisher
Vu T, Takechi M, Shimizu M, Kitazawa T, Higashiyama H, Iwase A, et al. Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme. Sci Rep. 2021;11:2092 pubmed publisher
Redente E, Chakraborty S, Sajuthi S, Black B, Edelman B, Seibold M, et al. Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis. JCI Insight. 2020;6: pubmed publisher
Wu R, Ma F, Tosevska A, Farrell C, Pellegrini M, Deb A. Cardiac fibroblast proliferation rates and collagen expression mature early and are unaltered with advancing age. JCI Insight. 2020;5: pubmed publisher
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Ma S, Zhang B, Lafave L, Earl A, Chiang Z, Hu Y, et al. Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin. Cell. 2020;183:1103-1116.e20 pubmed publisher
Wei H, Xu Y, Wang Y, Xu L, Mo C, Li L, et al. Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target. Cell Rep. 2020;33:108252 pubmed publisher
Kondo J, Huh W, Franklin J, Heinrich M, Rubin B, Coffey R. A smooth muscle-derived, Braf-driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell-of-origin. J Pathol. 2020;252:441-450 pubmed publisher
Jiang M, Ye J, Wang X, Li N, Wang Y, Shi Y. Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals. Cell Biosci. 2020;10:65 pubmed publisher
Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, et al. Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nat Commun. 2020;11:2303 pubmed publisher
Farabaugh S, Litzenburger B, Elangovan A, Pecar G, Walheim L, Atkinson J, et al. IGF1R constitutive activation expands luminal progenitors and influences lineage differentiation during breast tumorigenesis. Dev Biol. 2020;463:77-87 pubmed publisher
Falero Perez J, Sheibani N, Sorenson C. Bim expression modulates the pro-inflammatory phenotype of retinal astroglial cells. PLoS ONE. 2020;15:e0232779 pubmed publisher
Fortin J, Tian R, Zarrabi I, Hill G, Williams E, Sanchez Duffhues G, et al. Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas. Cancer Cell. 2020;37:308-323.e12 pubmed publisher
McCarthy N, Manieri E, Storm E, Saadatpour A, Luoma A, Kapoor V, et al. Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020;: pubmed publisher
Vila Ellis L, Cain M, Hutchison V, Flodby P, Crandall E, Borok Z, et al. Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell. 2020;52:617-630.e6 pubmed publisher
Santini M, Malide D, Hoffman G, Pandey G, D Escamard V, Nomura Kitabayashi A, et al. Tissue-Resident PDGFRα+ Progenitor Cells Contribute to Fibrosis versus Healing in a Context- and Spatiotemporally Dependent Manner. Cell Rep. 2020;30:555-570.e7 pubmed publisher
Dokoshi T, Zhang L, Li F, Nakatsuji T, Butcher A, Yoshida H, et al. Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection. Cell Rep. 2020;30:61-68.e4 pubmed publisher
Naipauer J, Rosario S, Gupta S, Premer C, Méndez Solís O, Schlesinger M, et al. PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment. PLoS Pathog. 2019;15:e1008221 pubmed publisher
Goldstein J, Tabebordbar M, Zhu K, Wang L, Messemer K, Peacker B, et al. In Situ Modification of Tissue Stem and Progenitor Cell Genomes. Cell Rep. 2019;27:1254-1264.e7 pubmed publisher
Huang X, Feng T, Jiang Z, Meng J, Kou S, Lu Z, et al. Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes. J Biol Chem. 2019;294:8894-8906 pubmed publisher
Camps J, Grosemans H, Gijsbers R, Maes C, Sampaolesi M. Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells. Int J Mol Sci. 2019;20: pubmed publisher
Han Y, Feng H, Sun J, Liang X, Wang Z, Xing W, et al. Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation. J Clin Invest. 2019;130: pubmed publisher
Zhao M, Tao F, Venkatraman A, Li Z, Smith S, Unruh J, et al. N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells. Cell Rep. 2019;26:652-669.e6 pubmed publisher
Chagraoui H, Kristiansen M, Ruiz J, Serra Barros A, Richter J, Hall Ponsele E, et al. SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells. Nat Commun. 2018;9:5375 pubmed publisher
Higashi A, Aronow B, Dressler G. Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis. J Am Soc Nephrol. 2019;30:80-94 pubmed publisher
Chaudhury S, O Connor C, Cañete A, Bittencourt Silvestre J, Sarrou E, Prendergast Á, et al. Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias. Nat Commun. 2018;9:5280 pubmed publisher
Raz Y, Cohen N, Shani O, Bell R, Novitskiy S, Abramovitz L, et al. Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer. J Exp Med. 2018;215:3075-3093 pubmed publisher
Phua Y, Clugston A, Chen K, Kostka D, Ho J. Small non-coding RNA expression in mouse nephrogenic mesenchymal progenitors. Sci Data. 2018;5:180218 pubmed publisher
Li R, Bernau K, Sandbo N, Gu J, Preissl S, Sun X. Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response. elife. 2018;7: pubmed publisher
Maryanovich M, Zahalka A, Pierce H, Pinho S, Nakahara F, Asada N, et al. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nat Med. 2018;24:782-791 pubmed publisher
Yoon C, Song H, Yin T, Bausch Fluck D, Frei A, Kattman S, et al. FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors. Stem Cell Reports. 2018;10:87-100 pubmed publisher
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Brown J, Yonekubo Y, Hanson N, Sastre Perona A, Basin A, Rytlewski J, et al. TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma. Cell Stem Cell. 2017;21:650-664.e8 pubmed publisher
Fogarty N, McCarthy A, Snijders K, Powell B, Kubikova N, Blakeley P, et al. Genome editing reveals a role for OCT4 in human embryogenesis. Nature. 2017;550:67-73 pubmed publisher
Oak P, Pritzke T, Thiel I, Koschlig M, Mous D, Windhorst A, et al. Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease. EMBO Mol Med. 2017;9:1504-1520 pubmed publisher
Quattrocelli M, Salamone I, Page P, Warner J, Demonbreun A, McNally E. Intermittent Glucocorticoid Dosing Improves Muscle Repair and Function in Mice with Limb-Girdle Muscular Dystrophy. Am J Pathol. 2017;187:2520-2535 pubmed publisher
He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, et al. Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest. 2017;127:2968-2981 pubmed publisher
Hong S, Song S, Cho S, Lee S, Koh B, Bae H, et al. Generation of PDGFRα+ Cardioblasts from Pluripotent Stem Cells. Sci Rep. 2017;7:41840 pubmed publisher
Yue R, Shen B, Morrison S. Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton. elife. 2016;5: pubmed publisher
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Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, et al. Pericyte-fibroblast transition promotes tumor growth and metastasis. Proc Natl Acad Sci U S A. 2016;113:E5618-27 pubmed publisher
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Lu J, Wu P, Zhang X, Feng L, Dong B, Chu X, et al. Immunopotentiators Improve the Efficacy of Oil-Emulsion-Inactivated Avian Influenza Vaccine in Chickens, Ducks and Geese. PLoS ONE. 2016;11:e0156573 pubmed publisher
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Pallangyo C, Ziegler P, Greten F. IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. J Exp Med. 2015;212:2253-66 pubmed publisher
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Zomerman W, Plasschaert S, Diks S, Lourens H, Meeuwsen de Boer T, Hoving E, et al. Exogenous HGF Bypasses the Effects of ErbB Inhibition on Tumor Cell Viability in Medulloblastoma Cell Lines. PLoS ONE. 2015;10:e0141381 pubmed publisher
Bayindir I, Babaeikelishomi R, Kocanova S, Sousa I, Lerch S, Hardt O, et al. Transcriptional Pathways in cPGI2-Induced Adipocyte Progenitor Activation for Browning. Front Endocrinol (Lausanne). 2015;6:129 pubmed publisher
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Chang C, Zhang M, Rajapakshe K, Coarfa C, Edwards D, Huang S, et al. Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage. Stem Cell Reports. 2015;5:378-91 pubmed publisher
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Kondo J, Powell A, Wang Y, Musser M, Southard Smith E, Franklin J, et al. LRIG1 Regulates Ontogeny of Smooth Muscle-Derived Subsets of Interstitial Cells of Cajal in Mice. Gastroenterology. 2015;149:407-19.e8 pubmed publisher
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Sohn J, Lu A, Tang Y, Wang B, Huard J. Activation of non-myogenic mesenchymal stem cells during the disease progression in dystrophic dystrophin/utrophin knockout mice. Hum Mol Genet. 2015;24:3814-29 pubmed publisher
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Qin Y, Zhou P, Zhou C, Li J, Gao W. The adipose-derived lineage-negative cells are enriched mesenchymal stem cells and promote limb ischemia recovery in mice. Stem Cells Dev. 2014;23:363-71 pubmed publisher
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Groneberg D, Konig P, Koesling D, Friebe A. Nitric oxide-sensitive guanylyl cyclase is dispensable for nitrergic signaling and gut motility in mouse intestinal smooth muscle. Gastroenterology. 2011;140:1608-17 pubmed publisher
Kurahashi M, Zheng H, Dwyer L, Ward S, Koh S, Sanders K. A functional role for the 'fibroblast-like cells' in gastrointestinal smooth muscles. J Physiol. 2011;589:697-710 pubmed publisher
Gao J, Yan X, Li R, Liu Y, He W, Sun S, et al. Characterization of OP9 as authentic mesenchymal stem cell line. J Genet Genomics. 2010;37:475-82 pubmed publisher
Era T. Mesoderm cell development from ES cells. Methods Mol Biol. 2010;636:87-103 pubmed publisher
Bénézech C, White A, Mader E, Serre K, Parnell S, Pfeffer K, et al. Ontogeny of stromal organizer cells during lymph node development. J Immunol. 2010;184:4521-30 pubmed publisher
LaMarca H, Visbal A, Creighton C, Liu H, Zhang Y, Behbod F, et al. CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland. Stem Cells. 2010;28:535-44 pubmed publisher
Iino S, Nojyo Y. Immunohistochemical demonstration of c-Kit-negative fibroblast-like cells in murine gastrointestinal musculature. Arch Histol Cytol. 2009;72:107-15 pubmed
Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Del Bo R, et al. Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1). J Neurosci. 2009;29:11761-71 pubmed publisher
Zhang H, Fraser S, Papazoglu C, Hoatlin M, Baron M. Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells. Stem Cells. 2009;27:2884-95 pubmed publisher
Sher F, van Dam G, Boddeke E, Copray S. Bioluminescence imaging of Olig2-neural stem cells reveals improved engraftment in a demyelination mouse model. Stem Cells. 2009;27:1582-91 pubmed publisher
Iino S, Horiguchi K, Horiguchi S, Nojyo Y. c-Kit-negative fibroblast-like cells express platelet-derived growth factor receptor alpha in the murine gastrointestinal musculature. Histochem Cell Biol. 2009;131:691-702 pubmed publisher
Odaka C. Localization of mesenchymal cells in adult mouse thymus: their abnormal distribution in mice with disorganization of thymic medullary epithelium. J Histochem Cytochem. 2009;57:373-82 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD140a (PDGFRA) Monoclonal Antibody (APA5), Biotin, eBioscience
Catalog # :
13-1401-82
Quantity :
100 ug
Price :
US 229.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 ug/test
Species :
Mouse
Clone :
APA5
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test
Aliases :
AI115593; alpha platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); alpha-type platelet-derived growth factor receptor; APDGFR; CD140 antigen-like family member A; CD140A; CD140a antigen; GAS9; MGC74795; OTTHUMP00000218656; PDGF A-chain; PDGF alpha chain; PDGF Receptor alpha; PDGF subunit A; PDGF-1; PDGFACE; PDGFR2; Pdgfr-2; PDGFRA; pdgfr-a; PDGFRA/BCR fusion; PDGF-R-alpha; PDGFR-alpha; platelet derived growth factor receptor alpha; platelet derived growth factor receptor, alpha polypeptide; platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor, alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; RHEPDGFRA
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA