CD360 (IL-21 Receptor) Monoclonal Antibody (eBio4A9), Biotin, eBioscience | Invitrogen 13-1219-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD360 (IL-21 Receptor) Monoclonal Antibody (eBio4A9), Biotin, eBioscience

catalog :

13-1219-81

quantity :

50 ug

price :

US 118.00

clonality :

monoclonal

host :

rat

conjugate :

biotin

clone name :

eBio4A9

reactivity :

mouse

application :

flow cytometry

citations: 9

Reference
Carter M, Cox K, Blakemore S, Turaj A, Oldham R, Dahal L, et al. PI3K? inhibition elicits anti-leukemic effects through Bim-dependent apoptosis. Leukemia. 2017;31:1423-1433 pubmed publisher
Ding Y, Li J, Wu Q, Yang P, Luo B, Xie S, et al. IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells. J Immunol. 2013;191:1614-24 pubmed publisher
Schmitz I, Schneider C, Fröhlich A, Frebel H, Christ D, Leonard W, et al. IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog. 2013;9:e1003362 pubmed publisher
Ligons D, Tuncer C, Linowes B, Akcay I, Kurtulus S, Deniz E, et al. CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1. J Biol Chem. 2012;287:34386-99 pubmed publisher
Corfe S, Rottapel R, Paige C. Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells. J Immunol. 2011;187:3499-510 pubmed publisher
Simard N, Konforte D, Tran A, Esufali J, Leonard W, Paige C. Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow. J Immunol. 2011;186:5244-53 pubmed publisher
DeKoter R, Geadah M, Khoosal S, Xu L, Thillainadesan G, Torchia J, et al. Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C. J Immunol. 2010;185:7374-84 pubmed publisher
Piao W, Jee Y, Liu R, Coons S, Kala M, Collins M, et al. IL-21 modulates CD4+ CD25+ regulatory T-cell homeostasis in experimental autoimmune encephalomyelitis. Scand J Immunol. 2008;67:37-46 pubmed
Vosshenrich C, Ranson T, Samson S, Corcuff E, Colucci F, Rosmaraki E, et al. Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J Immunol. 2005;174:1213-21 pubmed

product information

Product Type :

Antibody

Product Name :

CD360 (IL-21 Receptor) Monoclonal Antibody (eBio4A9), Biotin, eBioscience

Catalog # :

13-1219-81

Quantity :

50 ug

Price :

US 118.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Mouse

Clone :

eBio4A9

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

CD360; IL-21 receptor; Il21r; IL-21R; interleukin 21 receptor; interleukin-21 receptor; LR-beta; lymphocyte receptor beta; MGC10967; NILR; novel cytokine receptor 8; Novel interleukin receptor; NR8; UNQ3121/PRO10273