CD28 Monoclonal Antibody (37.51), Biotin, eBioscience™ | Invitrogen 13-0281-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD28 Monoclonal Antibody (37.51), Biotin, eBioscience™

catalog :

13-0281-81

quantity :

50 µg

price :

US 309.00

clonality :

monoclonal

host :

Syrian golden hamster

conjugate :

biotin

clone name :

37.51

reactivity :

mouse

application :

flow cytometry

citations: 14

Reference
Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
Moretti F, Klapproth S, Ruppert R, Margraf A, Weber J, Pick R, et al. Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus. elife. 2018;7: pubmed publisher
Villadiego J, Labrador Garrido A, Franco J, Leal Lasarte M, De Genst E, Dobson C, et al. Immunization with ?-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model. Glia. 2018;66:191-205 pubmed publisher
Akhter N, Takeda Y, Nara H, Araki A, Ishii N, Asao N, et al. Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses. J Biol Chem. 2016;291:23672-23680 pubmed
Xu Y, Zhao F, Qiu Q, Chen K, Wei J, Kong Q, et al. The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity. Nat Commun. 2016;7:12073 pubmed publisher
Farez M, Mascanfroni I, MÃ©ndez Huergo S, Yeste A, Murugaiyan G, Garo L, et al. Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell. 2015;162:1338-52 pubmed publisher
Gillgrass A, Chew M, Krneta T, Ashkar A. Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model. BMC Cancer. 2015;15:293 pubmed publisher
Christo S, Diener K, Nordon R, Brown M, Griesser H, Vasilev K, et al. Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus. Sci Rep. 2015;5:7760 pubmed publisher
Shindo Y, Unsinger J, Burnham C, Green J, Hotchkiss R. Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression. Shock. 2015;43:334-43 pubmed publisher
Ribot J, deBarros A, Mancio Silva L, Pamplona A, Silva Santos B. B7-CD28 costimulatory signals control the survival and proliferation of murine and human ?? T cells via IL-2 production. J Immunol. 2012;189:1202-8 pubmed publisher
Vaitaitis G, Wagner D. Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity. PLoS ONE. 2012;7:e38708 pubmed publisher
Grabner R, Lotzer K, Döpping S, Hildner M, Radke D, Beer M, et al. Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice. J Exp Med. 2009;206:233-48 pubmed publisher
Kawamura T, Takeda K, Kaneda H, Matsumoto H, Hayakawa Y, Raulet D, et al. NKG2A inhibits invariant NKT cell activation in hepatic injury. J Immunol. 2009;182:250-8 pubmed
Zeng H, Di L, Fu G, Chen Y, Gao X, Xu L, et al. Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation. Mol Cell Biol. 2007;27:5235-45 pubmed

product information

Product Type :

Antibody

Product Name :

CD28 Monoclonal Antibody (37.51), Biotin, eBioscience™

Catalog # :

13-0281-81

Quantity :

50 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Syrian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Mouse

Clone :

37.51

Isotype :

IgG

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

antigen CD28; Cd28; CD28 antigen; CD28 antigen (Tp44); CD28 isoform; CD28 isoform 2; CD28 molecule; CD28 precursor protein; CD28 protein; CD28 protein precursor; CD28RNA; cell surface protein; CHT28; contains partial extracellular domain; costimulatory molecule B7 receptor CD28; EGK_04709; MGC138290; sCD28; soluble CD28; T44; T-cell costimulatory molecule CD28; T-cell costimulatory molecule Tp44; T-cell-specific surface glycoprotein CD28; T-cell-specific surface glycoprotein CD28 homolog; TP44