CD10 Monoclonal Antibody (SN5c), Biotin, eBioscience | Invitrogen 13-0108-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD10 Monoclonal Antibody (SN5c), Biotin, eBioscience

catalog :

13-0108-82

quantity :

100 µg

price :

US 195

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

SN5c

reactivity :

human

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; tbl 4	Fromm J, Tagliente D, Shaver A, Neppalli V, Craig F. Case study interpretation: Report from the ICCS Annual Meeting, Seattle, 2014. Cytometry B Clin Cytom. 2015;88:413-24 pubmed publisher
	Mukhopadhyay C, Zhao X, Maroni D, Band V, Naramura M. Distinct effects of EGFR ligands on human mammary epithelial cell differentiation. PLoS ONE. 2013;8:e75907 pubmed publisher
	Labuda L, Ateba Ngoa U, Feugap E, Heeringa J, van der Vlugt L, Pires R, et al. Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. PLoS Negl Trop Dis. 2013;7:e2094 pubmed publisher
	Khamis Z, Sahab Z, Byers S, Sang Q. Novel stromal biomarkers in human breast cancer tissues provide evidence for the more malignant phenotype of estrogen receptor-negative tumors. J Biomed Biotechnol. 2011;2011:723650 pubmed publisher
	Khamis Z, Iczkowski K, Sahab Z, Sang Q. Protein profiling of isolated leukocytes, myofibroblasts, epithelial, Basal, and endothelial cells from normal, hyperplastic, cancerous, and inflammatory human prostate tissues. J Cancer. 2010;1:70-9 pubmed
	Biddle W, Haruta Y, Seon B, Henderson E, Sarcione E. In vitro and in vivo cytotoxic activity of anti-human leukemia monoclonal antibodies SN5c and SN6 daunorubicin conjugates. Leuk Res. 1989;13:699-707 pubmed
	Matsuzaki H, Haruta Y, Fukukawa T, Barcos M, Seon B. Unique epitopes of common acute lymphoblastic leukemia antigen detected by new monoclonal antibodies. Cancer Res. 1987;47:2160-6 pubmed

product information

Product Type :

Antibody

Product Name :

CD10 Monoclonal Antibody (SN5c), Biotin, eBioscience

Catalog # :

13-0108-82

Quantity :

100 µg

Price :

US 195

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.25 µg/test, Immunohistochemistry (Frozen): Assay-Dependent

Species :

Human

Clone :

SN5c

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. CD10 is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. Further, CD10 is a 100 kDa type II transmembrane glycoprotein that exists in a single copy of greater than 45 kb. The 5' untranslated region of the CD10 gene is alternatively spliced, resulting in four separate mRNA transcripts and the coding region is not affected by alternative splicing. Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie tooth Disease.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test, Immunohistochemistry (Frozen): Assay-Dependent

Aliases :

6030454K05Rik; Atriopeptidase; C85356; CALLA; CD10; CMT2T; common acute lymphoblastic leukemia antigen; common acute lymphocytic leukemia antigen; Enkephalinase; EPN; membrane metallo endopeptidase; membrane metalloendopeptidase; membrane metallo-endopeptidase; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase); membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; MME; NEP; neprilysin; neprilysin-390; neprilysin-411; neutral endopeptidase 24.11; SFE; Skin fibroblast elastase

more info or order :

Invitrogen product webpage