TCR gamma/delta Monoclonal Antibody (B1.1), PE, eBioscience™ | Invitrogen 12-9959-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR gamma/delta Monoclonal Antibody (B1.1), PE, eBioscience™

catalog :

12-9959-42

quantity :

100 Tests

price :

US 293

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

B1.1

reactivity :

African green monkey, baboons, human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
flow cytometry; African green monkey flow cytometry; baboons	Conrad M, Davis W, Koop B. TCR and CD3 antibody cross-reactivity in 44 species. Cytometry A. 2007;71:925-33 pubmed
	Beatson R, Parente Pereira A, Halim L, Cozzetto D, Hull C, Whilding L, et al. TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer. Cell Rep Med. 2021;2:100473 pubmed publisher
	Rana I, Badarinath K, Zirmire R, Jamora C. Isolation and Quantification of Mouse γδT-cells in vitro and in vivo. Bio Protoc. 2021;11:e4148 pubmed publisher
	Sangaletti S, Botti L, Gulino A, Lecis D, Bassani B, Portararo P, et al. SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis. iScience. 2021;24:102510 pubmed publisher
	Ben Othman R, Cai B, Liu A, Varankovich N, He D, Blimkie T, et al. Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults. Front Immunol. 2020;11:580373 pubmed publisher
	Wang R, Wen Q, He W, Yang J, Zhou C, Xiong W, et al. Optimized protocols for γδ T cell expansion and lentiviral transduction. Mol Med Rep. 2019;19:1471-1480 pubmed publisher
	Sairafi D, Stikvoort A, Gertow J, Mattsson J, Uhlin M. Donor Cell Composition and Reactivity Predict Risk of Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. J Immunol Res. 2016;2016:5601204 pubmed
	Xu X, Tan C, Li P, Zhang S, Pang X, Liu H, et al. Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest. PLoS ONE. 2013;8:e77401 pubmed publisher
	Siegers G, Felizardo T, Mathieson A, Kosaka Y, Wang X, Medin J, et al. Anti-leukemia activity of in vitro-expanded human gamma delta T cells in a xenogeneic Ph+ leukemia model. PLoS ONE. 2011;6:e16700 pubmed publisher
	Deetz C, Hebbeler A, Propp N, Cairo C, Tikhonov I, Pauza C. Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonist Pam3Cys. Infect Immun. 2006;74:4505-11 pubmed
	Walrath J, Zukowski L, Krywiak A, Silver R. Resident Th1-like effector memory cells in pulmonary recall responses to Mycobacterium tuberculosis. Am J Respir Cell Mol Biol. 2005;33:48-55 pubmed

product information

Product Type :

Antibody

Product Name :

TCR gamma/delta Monoclonal Antibody (B1.1), PE, eBioscience™

Catalog # :

12-9959-42

Quantity :

100 Tests

Price :

US 293

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (4 µg)/test

Species :

Human

Clone :

B1.1

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (4 µg)/test

Aliases :

T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@

more info or order :

Invitrogen product webpage