HLA-E Monoclonal Antibody (3D12HLA-E), PE, eBioscience | Invitrogen 12-9953-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HLA-E Monoclonal Antibody (3D12HLA-E), PE, eBioscience

catalog :

12-9953-42

quantity :

100 Tests

price :

US 394

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

3D12HLA-E

reactivity :

human

application :

flow cytometry

citations: 17

Reference
Carré T, Thiery J, Janji B, Terry S, Gros G, Meurice G, et al. Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress. Oncol Rep. 2021;45:582-594 pubmed publisher
Laplagne C, Meddour S, Figarol S, Michelas M, Calvayrac O, Favre G, et al. Vγ9Vδ2 T Cells Activation Through Phosphoantigens Can Be Impaired by a RHOB Rerouting in Lung Cancer. Front Immunol. 2020;11:1396 pubmed publisher
McWilliams E, Mele J, Cheney C, Timmerman E, Fiazuddin F, Strattan E, et al. Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia. Oncoimmunology. 2016;5:e1226720 pubmed
Andersson E, Poschke I, Villabona L, Carlson J, Lundqvist A, Kiessling R, et al. Non-classical HLA-class I expression in serous ovarian carcinoma: Correlation with the HLA-genotype, tumor infiltrating immune cells and prognosis. Oncoimmunology. 2016;5:e1052213 pubmed
Ruggeri L, Urbani E, AndrÃ© P, Mancusi A, Tosti A, Topini F, et al. Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells. Haematologica. 2016;101:626-33 pubmed publisher
Harrer A, Wipfler P, Pilz G, Oppermann K, Haschke Becher E, Afazel S, et al. Adaptive Immune Responses in a Multiple Sclerosis Patient with Acute Varicella-Zoster Virus Reactivation during Treatment with Fingolimod. Int J Mol Sci. 2015;16:21832-45 pubmed publisher
Pasero C, Gravis G, Granjeaud S, Guerin M, Thomassin Piana J, Rocchi P, et al. Highly effective NK cells are associated with good prognosis in patients with metastatic prostate cancer. Oncotarget. 2015;6:14360-73 pubmed
SÃ¡nchez MartÃnez D, Azaceta G, Muntasell A, AguilÃ³ N, NÃºÃ±ez D, GÃ¡lvez E, et al. Human NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells. Oncoimmunology. 2015;4:e991613 pubmed
Braun M, BjÃ¶rkstrÃ¶m N, Gupta S, SundstrÃ¶m K, Ahlm C, KlingstrÃ¶m J, et al. NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15RÎ± expression. PLoS Pathog. 2014;10:e1004521 pubmed publisher
Lim D, Yawata N, Selva K, Li N, Tsai C, Yeong L, et al. The combination of type I IFN, TNF-Î±, and cell surface receptor engagement with dendritic cells enables NK cells to overcome immune evasion by dengue virus. J Immunol. 2014;193:5065-75 pubmed publisher
Rygh C, Wang J, Thuen M, Gras Navarro A, Huuse E, Thorsen F, et al. Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLoS ONE. 2014;9:e108414 pubmed publisher
Cheent K, Jamil K, Cassidy S, Liu M, Mbiribindi B, Mulder A, et al. Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94. Proc Natl Acad Sci U S A. 2013;110:16981-6 pubmed publisher
Jacobs S, Plessers J, Pinxteren J, Roobrouck V, Verfaillie C, Van Gool S. Mutual interaction between human multipotent adult progenitor cells and NK cells. Cell Transplant. 2014;23:1099-110 pubmed publisher
Sloan R, Kuhl B, Donahue D, Roland A, Bar Magen T, Wainberg M. Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef. J Virol. 2011;85:2828-36 pubmed publisher
Takao S, Ishikawa T, Yamashita K, Uchiyama T. The rapid induction of HLA-E is essential for the survival of antigen-activated naive CD4 T cells from attack by NK cells. J Immunol. 2010;185:6031-40 pubmed publisher
Wooden S, Kalb S, Cotter R, Soloski M. Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis. J Immunol. 2005;175:1383-7 pubmed
Strong R, Holmes M, Li P, Braun L, Lee N, Geraghty D. HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities. J Biol Chem. 2003;278:5082-90 pubmed

product information

Product Type :

Antibody

Product Name :

HLA-E Monoclonal Antibody (3D12HLA-E), PE, eBioscience

Catalog # :

12-9953-42

Quantity :

100 Tests

Price :

US 394

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.5 µg)/test

Species :

Human

Clone :

3D12HLA-E

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.5 µg)/test

Aliases :

A29 protein; antigen presenting molecule; Aw-33; Aw-74; DAMA-277I14.1; DAQB-90C11.16; DKFZp686P19218; EA1.2; EA2.1; FLJ26655; HLA A; HLA class I antigen; HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLA class I histocompatibility antigen, A-30 alpha chain; HLA class I histocompatibility antigen, A-33 alpha chain; HLA class I histocompatibility antigen, A-74 alpha chain; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, E alpha chain; HLA locus; HLA-6.2; HLAA; HLA-A; HLA-A locus alpha 2 domain; HLA-A null; HLA-A11; HLA-A33; HLA-Aw33.1; HLA-DQB1; HLA-DRB1; HLAE; HLA-E; Human leukocyte antigen A; leukocyte antigen class I-A; lymphocyte antigen; major histocompatibility complex, class I, A; major histocompatibility complex, class I, E; MCH class I antigen; MHC; MHC 1; MHC class 1 antigen; MHC class I anti; MHC Class I antigen; MHC class I antigen A*30; MHC class I antigen A*33; MHC class I antigen A*74; MHC class I antigen E; MHC class I antigen heavy chain; MHC class I antigen HLA-A heavy chain; MHC class I antigen HLA-A33; MHC class I antigen null protein; MHC class I antigene; MHC class II antigen; MHC classI antigen; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC1; QA1; sHLA-E; Soluble HLA class I histocompatibility antigen, alpha chain E; truncated MHC class I antigen