TLR4/MD-2 Complex Monoclonal Antibody (MTS510), PE, eBioscience™ | Invitrogen 12-9924-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TLR4/MD-2 Complex Monoclonal Antibody (MTS510), PE, eBioscience™

catalog :

12-9924-82

quantity :

100 µg

price :

US 366

clonality :

monoclonal

host :

rat

conjugate :

clone name :

MTS510

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 93

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Berger S, Romero X, Ma C, Wang G, Faubion W, Liao G, et al. SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol. 2010;11:920-7 pubmed publisher
flow cytometry; mouse	Gomariz R, Arranz A, Abad C, Torroba M, Martinez C, Rosignoli F, et al. Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP. J Leukoc Biol. 2005;78:491-502 pubmed
	Xue J, Yu Y, Zhang X, Zhang C, Zhao Y, Liu B, et al. Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll-Like Receptor 4 to Lipid Rafts. J Am Heart Assoc. 2019;8:e012885 pubmed publisher
	Ball D, Al Riyami L, Harnett W, Harnett M. IL-33/ST2 signalling and crosstalk with FcÎµRI and TLR4 is targeted by the parasitic worm product, ES-62. Sci Rep. 2018;8:4497 pubmed publisher
	Schappe M, Szteyn K, Stremska M, Mendu S, Downs T, Seegren P, et al. Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation. Immunity. 2018;48:59-74.e5 pubmed publisher
	Schweighoffer E, Nys J, Vanes L, Smithers N, Tybulewicz V. TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK. J Exp Med. 2017;214:1269-1280 pubmed publisher
	Kumazoe M, Nakamura Y, Yamashita M, Suzuki T, Takamatsu K, Huang Y, et al. Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216. J Biol Chem. 2017;292:4077-4088 pubmed publisher
	Wezel A, De Vries M, Maassen J, Kip P, Peters E, Karper J, et al. Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response. Sci Rep. 2016;6:24248 pubmed publisher
	Wilensky A, Tzach Nahman R, Potempa J, Shapira L, Nussbaum G. Porphyromonas gingivalis gingipains selectively reduce CD14 expression, leading to macrophage hyporesponsiveness to bacterial infection. J Innate Immun. 2015;7:127-135 pubmed publisher
	Xue J, Habtezion A. Carbon monoxide-based therapy ameliorates acute pancreatitis via TLR4 inhibition. J Clin Invest. 2014;124:437-47 pubmed publisher
	Lee S, Park H, Park S, Kim N, Hong S. Immunomodulatory effect of poly-?-glutamic acid derived from Bacillus subtilis on natural killer dendritic cells. Biochem Biophys Res Commun. 2014;443:413-21 pubmed publisher
	Wang C, Luo H, Zhu L, Yang F, Chu Z, Tian H, et al. Microgravity inhibition of lipopolysaccharide-induced tumor necrosis factor-? expression in macrophage cells. Inflamm Res. 2014;63:91-8 pubmed publisher
	Deguchi A, Tomita T, Omori T, Komatsu A, Ohto U, Takahashi S, et al. Serum amyloid A3 binds MD-2 to activate p38 and NF-?B pathways in a MyD88-dependent manner. J Immunol. 2013;191:1856-64 pubmed publisher
	Casella C, Mitchell T. Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A. PLoS ONE. 2013;8:e62622 pubmed publisher
	Seillet C, Rouquié N, Foulon E, Douin Echinard V, Krust A, Chambon P, et al. Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor ?. J Immunol. 2013;190:5459-70 pubmed publisher
	Liu B, Fu Y, Feng S, Zhang X, Liu Z, Cao Y, et al. Involvement of RP105 and toll-like receptors in the activation of mouse peritoneal macrophages by Staphylococcus aureus. Scand J Immunol. 2013;78:8-16 pubmed publisher
	Corbitt N, Kimura S, Isse K, Specht S, Chedwick L, Rosborough B, et al. Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantation. Am J Pathol. 2013;182:180-91 pubmed publisher
	Kuan Y, Lee W, Hung C, Yang C, Sheu F. Investigating the function of a novel protein from Anoectochilus formosanus which induced macrophage differentiation through TLR4-mediated NF-?B activation. Int Immunopharmacol. 2012;14:114-20 pubmed publisher
	Chen G, Hwang S, Su H, Kuo C, Luo W, Lo K, et al. Defective antiviral responses of induced pluripotent stem cells to baculoviral vector transduction. J Virol. 2012;86:8041-9 pubmed publisher
	Paul J, Karmakar S, De T. TLR-mediated distinct IFN-?/IL-10 pattern induces protective immunity against murine visceral leishmaniasis. Eur J Immunol. 2012;42:2087-99 pubmed publisher
	Ohtaki H, Ito H, Hoshi M, Osawa Y, Takamatsu M, Hara A, et al. High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice. Sci Rep. 2012;2:367 pubmed publisher
	Honda H, Nagai Y, Matsunaga T, Saitoh S, Akashi Takamura S, Hayashi H, et al. Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner. J Leukoc Biol. 2012;91:967-76 pubmed publisher
	Chen M, Chang W, Kuan Y, Lin S, Hsu H, Lee C. Resveratrol inhibits LPS-induced epithelial-mesenchymal transition in mouse melanoma model. Innate Immun. 2012;18:685-93 pubmed
	Tsukiyama T, Matsuda Tsukiyama M, Bohgaki M, Terai S, Tanaka S, Hatakeyama S. Ymer acts as a multifunctional regulator in nuclear factor-?B and Fas signaling pathways. Mol Med. 2012;18:587-97 pubmed publisher
	Bain C, Mowat A. CD200 receptor and macrophage function in the intestine. Immunobiology. 2012;217:643-51 pubmed publisher
	Kobayashi F, Watanabe E, Nakagawa Y, Yamanishi S, Norose Y, Fukunaga Y, et al. Production of autoantibodies by murine B-1a cells stimulated with Helicobacter pylori urease through toll-like receptor 2 signaling. Infect Immun. 2011;79:4791-801 pubmed publisher
	Kim E, Hong H, Cho D, Han J, Kim S, Kim T. Enhancement of toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells. Immunology. 2011;134:73-81 pubmed publisher
	Xing Q, de Vos P, Faas M, Ye Q, Ren Y. LPS promotes pre-osteoclast activity by up-regulating CXCR4 via TLR-4. J Dent Res. 2011;90:157-62 pubmed publisher
	Mendez M, Monroy Y, Du M, Preston A, Tolle L, Lin Y, et al. Overexpression of sICAM-1 in the alveolar epithelial space results in an exaggerated inflammatory response and early death in Gram negative pneumonia. Respir Res. 2011;12:12 pubmed publisher
	Fan J, Edsen Moore M, Turner L, Cook R, Legge K, Waldschmidt T, et al. Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation. Alcohol Clin Exp Res. 2011;35:47-59 pubmed publisher
	Gomez C, Karavitis J, Palmer J, Faunce D, Ramirez L, Nomellini V, et al. Interleukin-6 contributes to age-related alteration of cytokine production by macrophages. Mediators Inflamm. 2010;2010:475139 pubmed publisher
	Rettew J, McCall S, Marriott I. GPR30/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages. Mol Cell Endocrinol. 2010;328:87-92 pubmed publisher
	Zhang Z, Li W, Sun D, Zhao L, Zhang R, Wang Y, et al. Toll-like receptor 4 signaling in dysfunction of cardiac microvascular endothelial cells under hypoxia/reoxygenation. Inflamm Res. 2011;60:37-45 pubmed publisher
	Zhu X, Owen J, Wilson M, Li H, Griffiths G, Thomas M, et al. Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. J Lipid Res. 2010;51:3196-206 pubmed publisher
	Suzuki K, Maruya M, Kawamoto S, Sitnik K, Kitamura H, Agace W, et al. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity. 2010;33:71-83 pubmed publisher
	Anthony D, Andrews D, Chow M, Watt S, House C, Akira S, et al. A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol. 2010;185:1794-803 pubmed publisher
	Calippe B, Douin Echinard V, Delpy L, Laffargue M, Lélu K, Krust A, et al. 17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo. J Immunol. 2010;185:1169-76 pubmed publisher
	Price L, Wenner C, Sloper D, Slaton J, Novack J. Role for toll-like receptor 4 in TNF-alpha secretion by murine macrophages in response to polysaccharide Krestin, a Trametes versicolor mushroom extract. Fitoterapia. 2010;81:914-9 pubmed publisher
	Davies J, Macsharry J, Shanahan F. Differential regulation of Toll-like receptor signalling in spleen and Peyer's patch dendritic cells. Immunology. 2010;131:438-48 pubmed publisher
	Burton O, Gibbs S, Miller N, Jones F, Wen L, Dunne D, et al. Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens. Eur J Immunol. 2010;40:2221-9 pubmed publisher
	Loser K, Vogl T, Voskort M, Lueken A, Kupas V, Nacken W, et al. The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nat Med. 2010;16:713-7 pubmed publisher
	Ohkusu Tsukada K, Ohta S, Kawakami Y, Toda M. Adjuvant effects of formalin-inactivated HSV through activation of dendritic cells and inactivation of myeloid-derived suppressor cells in cancer immunotherapy. Int J Cancer. 2011;128:119-31 pubmed publisher
	Taylor T, Kim Y, Ou X, DERBIGNY W, Broxmeyer H. Toll-like receptor 2 mediates proliferation, survival, NF-kappaB translocation, and cytokine mRNA expression in LIF-maintained mouse embryonic stem cells. Stem Cells Dev. 2010;19:1333-41 pubmed publisher
	Saunders S, Barlow J, Walsh C, Bellsoi A, Smith P, McKenzie A, et al. C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide. J Immunol. 2010;184:2627-37 pubmed publisher
	Kurowska Stolarska M, Stolarski B, Kewin P, Murphy G, Corrigan C, Ying S, et al. IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol. 2009;183:6469-77 pubmed publisher
	Bauernfeind F, Horvath G, Stutz A, Alnemri E, MacDonald K, Speert D, et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol. 2009;183:787-91 pubmed publisher
	Takashima K, Matsunaga N, Yoshimatsu M, Hazeki K, Kaisho T, Uekata M, et al. Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model. Br J Pharmacol. 2009;157:1250-62 pubmed publisher
	Lee S, Hong B, Sharabi A, Huang X, Chen S. Embryonic stem cells and mammary luminal progenitors directly sense and respond to microbial products. Stem Cells. 2009;27:1604-15 pubmed publisher
	Rettew J, Huet Y, Marriott I. Estrogens augment cell surface TLR4 expression on murine macrophages and regulate sepsis susceptibility in vivo. Endocrinology. 2009;150:3877-84 pubmed publisher
	Zhang H, Rosenberg S, Coffey F, He Y, Manser T, Hardy R, et al. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol. 2009;182:207-15 pubmed
	Tsuji M, Suzuki K, Kitamura H, Maruya M, Kinoshita K, Ivanov I, et al. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity. 2008;29:261-71 pubmed publisher
	Turnquist H, Sumpter T, Tsung A, Zahorchak A, Nakao A, Nau G, et al. IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells. J Immunol. 2008;181:62-72 pubmed
	Cross J, Kott K, Miletic T, Johnson P. CD45 regulates TLR-induced proinflammatory cytokine and IFN-beta secretion in dendritic cells. J Immunol. 2008;180:8020-9 pubmed
	Arranz A, Juarranz Y, Leceta J, Gomariz R, Martinez C. VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4. Peptides. 2008;29:948-56 pubmed publisher
	Treese C, Mittag A, Lange F, Tarnok A, Loesche A, Emmrich F, et al. Characterization of fibroblasts responsible for cartilage destruction in arthritis. Cytometry A. 2008;73:351-60 pubmed publisher
	Milne C, Corfe S, Paige C. Heparan sulfate and heparin enhance ERK phosphorylation and mediate preBCR-dependent events during B lymphopoiesis. J Immunol. 2008;180:2839-47 pubmed
	Rettew J, Huet Hudson Y, Marriott I. Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod. 2008;78:432-7 pubmed
	Ukai T, Yumoto H, Gibson F, Genco C. Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production. Infect Immun. 2008;76:812-9 pubmed
	Kitazawa T, Fukushima A, Okugawa S, Yanagimoto S, Tsukada K, Tatsuno K, et al. Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase. Microbes Infect. 2007;9:1410-4 pubmed
	Elftman M, Norbury C, Bonneau R, Truckenmiller M. Corticosterone impairs dendritic cell maturation and function. Immunology. 2007;122:279-90 pubmed
	Ribeiro Gomes F, Moniz de Souza M, Alexandre Moreira M, Dias W, Lopes M, Nunes M, et al. Neutrophils activate macrophages for intracellular killing of Leishmania major through recruitment of TLR4 by neutrophil elastase. J Immunol. 2007;179:3988-94 pubmed
	Shu S, Lian Z, Chuang Y, Yang G, Moritoki Y, Comstock S, et al. The role of CD11c(+) hepatic dendritic cells in the induction of innate immune responses. Clin Exp Immunol. 2007;149:335-43 pubmed
	Liu X, Ukai T, Yumoto H, Davey M, Goswami S, Gibson F, et al. Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Atherosclerosis. 2008;196:146-54 pubmed
	Eguchi M, Sekiya Y, Suzuki M, Yamamoto T, Matsui H. An oral Salmonella vaccine promotes the down-regulation of cell surface Toll-like receptor 4 (TLR4) and TLR2 expression in mice. FEMS Immunol Med Microbiol. 2007;50:300-8 pubmed
	Petursdottir D, Hardardottir I. Dietary fish oil increases the number of splenic macrophages secreting TNF-alpha and IL-10 but decreases the secretion of these cytokines by splenic T cells from mice. J Nutr. 2007;137:665-70 pubmed
	Nemoto E, Darveau R, Foster B, Nogueira Filho G, Somerman M. Regulation of cementoblast function by P. gingivalis lipopolysaccharide via TLR2. J Dent Res. 2006;85:733-8 pubmed
	Turner J, Langley R, Johnston K, Egerton G, Wanji S, Taylor M. Wolbachia endosymbiotic bacteria of Brugia malayi mediate macrophage tolerance to TLR- and CD40-specific stimuli in a MyD88/TLR2-dependent manner. J Immunol. 2006;177:1240-9 pubmed
	Lin K, Kao Y, Kuo H, Yang W, Chou A, Lin H, et al. Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1. J Biol Chem. 2006;281:24111-23 pubmed
	Lin Y, Xie M, Chen Y, Di J, Zeng Y. Preterm delivery induced by LPS in syngeneically impregnated BALB/c and NOD/SCID mice. J Reprod Immunol. 2006;71:87-101 pubmed
	Jou I, Lee J, Park S, Yoon H, Joe E, Park E. Gangliosides trigger inflammatory responses via TLR4 in brain glia. Am J Pathol. 2006;168:1619-30 pubmed
	Kajita E, Nishiya T, Miwa S. The transmembrane domain directs TLR9 to intracellular compartments that contain TLR3. Biochem Biophys Res Commun. 2006;343:578-84 pubmed
	Chabot S, Wagner J, Farrant S, Neutra M. TLRs regulate the gatekeeping functions of the intestinal follicle-associated epithelium. J Immunol. 2006;176:4275-83 pubmed
	Huber M, Kalis C, Keck S, Jiang Z, Georgel P, Du X, et al. R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells. Eur J Immunol. 2006;36:701-11 pubmed
	Nishiya T, Kajita E, Miwa S. Ligand-independent oligomerization of TLR4 regulated by a short hydrophobic region adjacent to the transmembrane domain. Biochem Biophys Res Commun. 2006;341:1128-34 pubmed
	Viriyakosol S, Matthias M, Swancutt M, Kirkland T, Vinetz J. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun. 2006;74:887-95 pubmed
	Mortaz E, Redegeld F, Nijkamp F, Wong H, Engels F. Acetylsalicylic acid-induced release of HSP70 from mast cells results in cell activation through TLR pathway. Exp Hematol. 2006;34:8-18 pubmed
	Sun D, Chen D, Du B, Pan J. Heat shock response inhibits NF-kappaB activation and cytokine production in murine Kupffer cells. J Surg Res. 2005;129:114-21 pubmed
	Mao A, Paharkova Vatchkova V, Hardy J, Miller M, Kovats S. Estrogen selectively promotes the differentiation of dendritic cells with characteristics of Langerhans cells. J Immunol. 2005;175:5146-51 pubmed
	Qi H, Shelhamer J. Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages. J Biol Chem. 2005;280:38969-75 pubmed
	Boehmer E, Meehan M, Cutro B, Kovacs E. Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev. 2005;126:1305-13 pubmed
	Nishiya T, Kajita E, Miwa S, DeFranco A. TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chem. 2005;280:37107-17 pubmed
	Nalbandian G, Paharkova Vatchkova V, Mao A, Nale S, Kovats S. The selective estrogen receptor modulators, tamoxifen and raloxifene, impair dendritic cell differentiation and activation. J Immunol. 2005;175:2666-75 pubmed
	Andonegui G, Kerfoot S, McNagny K, Ebbert K, Patel K, Kubes P. Platelets express functional Toll-like receptor-4. Blood. 2005;106:2417-23 pubmed
	Yang R, Murillo F, Delannoy M, Blosser R, Yutzy W, Uematsu S, et al. B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88. J Immunol. 2005;174:7912-9 pubmed
	Nagaoka K, Takahara K, Tanaka K, Yoshida H, Steinman R, Saitoh S, et al. Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria. Int Immunol. 2005;17:827-36 pubmed
	Mu H, Pennock N, Humphreys J, Kirschning C, Cole B. Engagement of Toll-like receptors by mycoplasmal superantigen: downregulation of TLR2 by MAM/TLR4 interaction. Cell Microbiol. 2005;7:789-97 pubmed
	Chen D, Texada D, Duggan C, Liang C, Reden T, Kooragayala L, et al. Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells. J Biol Chem. 2005;280:22425-36 pubmed
	Araki A, Kanai T, Ishikura T, Makita S, Uraushihara K, Iiyama R, et al. MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis. J Gastroenterol. 2005;40:16-23 pubmed
	Shimura H, Nitahara A, Ito A, Tomiyama K, Ito M, Kawai K. Up-regulation of cell surface Toll-like receptor 4-MD2 expression on dendritic epidermal T cells after the emigration from epidermis during cutaneous inflammation. J Dermatol Sci. 2005;37:101-10 pubmed
	Chelvarajan R, Collins S, Van Willigen J, Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol. 2005;77:503-12 pubmed
	Mou H, Lin M, Cen H, Yu J, Meng X. TGF-beta1 treated murine dendritic cells are maturation resistant and down-regulate Toll-like receptor 4 expression. J Zhejiang Univ Sci. 2004;5:1239-44 pubmed
	Nishiya T, DeFranco A. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem. 2004;279:19008-17 pubmed
	Boehmer E, Goral J, Faunce D, Kovacs E. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol. 2004;75:342-9 pubmed

product information

Product Type :

Antibody

Product Name :

TLR4/MD-2 Complex Monoclonal Antibody (MTS510), PE, eBioscience™

Catalog # :

12-9924-82

Quantity :

100 µg

Price :

US 366

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Mouse

Clone :

MTS510

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

ARMD10; CD284; Esop1; ESOP-1; hToll; lipopolysaccharide response; Lps; Ly87; Ly96; Ly-96; lymphocyte antigen 96; MD2; MD-2; myeloid differentiation factor-2; myeloid differentiation protein-2; protein MD-2; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll-like receptor 4

more info or order :

Invitrogen product webpage