This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD281 (TLR1) Monoclonal Antibody (GD2.F4), PE, eBioscience
catalog :
12-9911-42
quantity :
100 Tests
price :
US 396.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
GD2.F4

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
citations: 11
Reference
He Q, Yu C, Wu G, Wang K, Ni Y, Guo X, et al. A novel alternative for pyrogen detection based on a transgenic cell line. Signal Transduct Target Ther. 2024;9:33 pubmed publisher
da Rocha Sobrinho H, Saar Gomes R, da Silva D, Quixabeira V, Joosten L, Ribeiro De Barros Cardoso C, et al. Toll-like receptor 10 controls TLR2-induced cytokine production in monocytes from patients with Parkinson's disease. J Neurosci Res. 2021;99:2511-2524 pubmed publisher
Steiner M, Hawranek T, Schneider M, Ferreira F, Horejs Hoeck J, Harrer A, et al. Elevated Toll-Like Receptor-Induced CXCL8 Secretion in Human Blood Basophils from Allergic Donors Is Independent of Toll-Like Receptor Expression Levels. PLoS ONE. 2016;11:e0149275 pubmed publisher
Judge C, Reyes Aviles E, Conry S, Sieg S, Feng Z, Weinberg A, et al. HBD-3 induces NK cell activation, IFN-γ secretion and mDC dependent cytolytic function. Cell Immunol. 2015;297:61-8 pubmed publisher
Conrad K, Wu P, Sieper J, Syrbe U. In vivo pre-activation of monocytes in patients with axial spondyloarthritis. Arthritis Res Ther. 2015;17:179 pubmed publisher
Juthani Mehta M, Guo X, Shaw A, Towle V, Ning Y, Wang X, et al. Innate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders. J Aging Sci. 2014;2: pubmed
Novis C, Archin N, Buzon M, Verdin E, Round J, Lichterfeld M, et al. Reactivation of latent HIV-1 in central memory CD4? T cells through TLR-1/2 stimulation. Retrovirology. 2013;10:119 pubmed publisher
Harman A, Bye C, Nasr N, Sandgren K, Kim M, Mercier S, et al. Identification of lineage relationships and novel markers of blood and skin human dendritic cells. J Immunol. 2013;190:66-79 pubmed publisher
Funderburg N, Sieg S. Diminished responsiveness to human β-defensin-3 and decreased TLR1 expression on monocytes and mDCs from HIV-1-infected patients. J Leukoc Biol. 2012;92:1103-9 pubmed publisher
Oberg H, Ly T, Ussat S, Meyer T, Kabelitz D, Wesch D. Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands. J Immunol. 2010;184:4733-40 pubmed publisher
Peiser M, Koeck J, Kirschning C, Wittig B, Wanner R. Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity. J Leukoc Biol. 2008;83:1118-27 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD281 (TLR1) Monoclonal Antibody (GD2.F4), PE, eBioscience
Catalog # :
12-9911-42
Quantity :
100 Tests
Price :
US 396.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (1 ug)/test
Species :
Human
Clone :
GD2.F4
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (1 ug)/test
Aliases :
CD281; KIAA0012; rsc786; TIL; TIL. LPRS5; TLR1; toll like receptor 1; Toll/interleukin-1 receptor-like protein; toll-like receptor 1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA