IkB zeta Monoclonal Antibody (hft2nap), PE, eBioscience | Invitrogen 12-9853-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IkB zeta Monoclonal Antibody (hft2nap), PE, eBioscience

catalog :

12-9853-42

quantity :

100 Tests

price :

US 429.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

hft2nap

reactivity :

human

application :

flow cytometry

citations: 5

Reference
Kannan Y, Yu J, RAICES R, Seshadri S, Wei M, Caligiuri M, et al. I?B? augments IL-12- and IL-18-mediated IFN-? production in human NK cells. Blood. 2011;117:2855-63 pubmed publisher
Miyake T, Satoh T, Kato H, Matsushita K, Kumagai Y, Vandenbon A, et al. I?B? is essential for natural killer cell activation in response to IL-12 and IL-18. Proc Natl Acad Sci U S A. 2010;107:17680-5 pubmed publisher
Okamoto K, Iwai Y, Oh Hora M, Yamamoto M, Morio T, Aoki K, et al. IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature. 2010;464:1381-5 pubmed publisher
Seshadri S, Kannan Y, Mitra S, Parker Barnes J, Wewers M. MAIL regulates human monocyte IL-6 production. J Immunol. 2009;183:5358-68 pubmed publisher
RAICES R, Kannan Y, Bellamkonda Athmaram V, Seshadri S, Wang H, Guttridge D, et al. A novel role for IkappaBzeta in the regulation of IFNgamma production. PLoS ONE. 2009;4:e6776 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IkB zeta Monoclonal Antibody (hft2nap), PE, eBioscience

Catalog # :

12-9853-42

Quantity :

100 Tests

Price :

US 429.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.25 ug)/test

Species :

Human

Clone :

hft2nap

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

I-kappa-B-zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.

Immunogen :

Human IkBz N-terminal Fragment (1-200)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.25 ug)/test

Aliases :

AA408868; FLJ30225; FLJ34463; Ikappa B-zeta variant 3; ikappaBzeta; I-kappa-B-zeta; IkappaB-zeta; IKBZ; ikB-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; Mail; molecule possessing ankyrin repeats induced by lipopolysaccharide; molecule possessing ankyrin-repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; NFKB inhibitor zeta; NFKBIZ; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta; OTTHUMP00000214340; RGD1310834