Phospho-STAT5 (Tyr694) Monoclonal Antibody (SRBCZX), PE, eBioscience | Invitrogen 12-9010-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-STAT5 (Tyr694) Monoclonal Antibody (SRBCZX), PE, eBioscience

catalog :

12-9010-42

quantity :

100 Tests

price :

US 380

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

SRBCZX

reactivity :

human, mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2g	Webb L, Fra Bido S, Innocentin S, Matheson L, Attaf N, Bignon A, et al. Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ. Aging Cell. 2021;20:e13295 pubmed publisher
	Cao W, Fan W, Wang F, Zhang Y, Wu G, Shi X, et al. GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages. J Transl Med. 2022;20:11 pubmed publisher
	Yang C, Wang Z, Li L, Zhang Z, Jin X, Wu P, et al. Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis. J Immunother Cancer. 2021;9: pubmed publisher
	Chu Y, Nayyar G, Kham Su N, Rosenblum J, Soon Shiong P, Lee J, et al. Novel cytokine-antibody fusion protein, N-820, to enhance the functions of ex vivo expanded natural killer cells against Burkitt lymphoma. J Immunother Cancer. 2020;8: pubmed publisher
	Hu M, Lu Y, Qi Y, Zhang Z, Wang S, Xu Y, et al. SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells. Cancer Immunol Res. 2020;8:1150-1162 pubmed publisher
	Hong J, Lim J, Carvalho F, Cho J, Vaidyanathan B, Yu S, et al. Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids. Cell. 2020;180:847-861.e15 pubmed publisher
	Eken A, Cansever M, Okus F, Erdem S, Nain E, Azizoglu Z, et al. ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients. Allergy. 2020;75:921-932 pubmed publisher
	Ferrao R, Wallweber H, Lupardus P. Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation. elife. 2018;7: pubmed publisher
	Seyfarth J, Ahlert H, Rosenbauer J, Baechle C, Roden M, Holl R, et al. CISH promoter polymorphism effects on T cell cytokine receptor signaling and type 1 diabetes susceptibility. Mol Cell Pediatr. 2018;5:2 pubmed publisher
	Gilboa D, Haim Ohana Y, Deshet Unger N, Ben Califa N, Hiram Bab S, Reuveni D, et al. Erythropoietin enhances Kupffer cell number and activity in the challenged liver. Sci Rep. 2017;7:10379 pubmed publisher
	Lundtoft C, Afum Adjei Awuah A, Rimpler J, Harling K, Nausch N, Kohns M, et al. Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. PLoS Pathog. 2017;13:e1006425 pubmed publisher
	Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel M, et al. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016;7:292-305 pubmed publisher
	Fu R, Ding S, Liu Y, Li L, Liu H, Wang H, et al. Expression and function of hematopoiesis-stimulating factor receptors on the GPI- and GPI+ hematopoietic stem cells of patients with paroxysmal nocturnal hemoglobinuria/aplastic anemia syndrome. Exp Ther Med. 2016;11:1668-1672 pubmed
	Xu H, Lauer F, Liu K, Hudson L, Burchiel S. Environmentally relevant concentrations of arsenite and monomethylarsonous acid inhibit IL-7/STAT5 cytokine signaling pathways in mouse CD3+CD4-CD8- double negative thymus cells. Toxicol Lett. 2016;247:62-8 pubmed publisher
	Ezeh P, Xu H, Lauer F, Liu K, Hudson L, Burchiel S. Monomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells. Toxicol Sci. 2016;149:289-99 pubmed publisher
	Beider K, Darash Yahana M, Blaier O, Koren Michowitz M, Abraham M, Wald H, et al. Combination of imatinib with CXCR4 antagonist BKT140 overcomes the protective effect of stroma and targets CML in vitro and in vivo. Mol Cancer Ther. 2014;13:1155-69 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-STAT5 (Tyr694) Monoclonal Antibody (SRBCZX), PE, eBioscience

Catalog # :

12-9010-42

Quantity :

100 Tests

Price :

US 380

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 5 µL (0.25 µg)/test

Species :

Human, Mouse

Clone :

SRBCZX

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.25 µg)/test

Aliases :

AA959963; mammary gland factor; mammary gland factor STAT5A; mammary gland factor; transcription factor; Mgf; Mpf; signal transducer and activator of transcription 5; signal transducer and activator of transcription 5a; signal transducer and activator of transcription factor 5A; STAT; STAT5; STAT5A; STAT5A, Mammary Gland Factor; STAT5A/MGF; STAT5B; STATA5

more info or order :

Invitrogen product webpage