CD338 (ABCG2) Monoclonal Antibody (5D3), PE, eBioscience™ | Invitrogen 12-8888-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD338 (ABCG2) Monoclonal Antibody (5D3), PE, eBioscience™

catalog :

12-8888-41

quantity :

25 Tests

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

5D3

reactivity :

human

application :

flow cytometry

citations: 22

Reference
Ito D, Childress M, Mason N, Winter A, O BRIEN T, Henson M, et al. A double blinded, placebo-controlled pilot study to examine reduction of CD34 +/CD117 +/CD133 + lymphoma progenitor cells and duration of remission induced by neoadjuvant valspodar in dogs with large B-cell lymphoma. F1000Res. 2015;4:42 pubmed publisher
Feng D, Yan K, Zhou Y, Liang H, Liang J, Zhao W, et al. Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis. Oncotarget. 2016;7:64575-64588 pubmed publisher
Weidner L, Fung K, Kannan P, Moen J, Kumar J, Mulder J, et al. Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein. Drug Metab Dispos. 2016;44:275-82 pubmed publisher
GORDEN B, Saha J, Khammanivong A, Schwartz G, Dickerson E. Lysosomal drug sequestration as a mechanism of drug resistance in vascular sarcoma cells marked by high CSF-1R expression. Vasc Cell. 2014;6:20 pubmed publisher
Marriott S, Baskir R, Gaskill C, Menon S, Carrier E, Williams J, et al. ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am J Physiol Cell Physiol. 2014;307:C684-98 pubmed publisher
To K, Tomlinson B. Targeting the ABCG2-overexpressing multidrug resistant (MDR) cancer cells by PPAR? agonists. Br J Pharmacol. 2013;170:1137-51 pubmed publisher
Yang W, Song M, Park E, Lee J, Park J, Park K, et al. Transcription factors Sp1 and Sp3 regulate expression of human ABCG2 gene and chemoresistance phenotype. Mol Cells. 2013;36:368-75 pubmed publisher
Cannon C, Pozniak J, Scott M, Ito D, Gorden B, Graef A, et al. Canine osteosarcoma cells exhibit resistance to aurora kinase inhibitors. Vet Comp Oncol. 2015;13:48-59 pubmed publisher
Foster B, Gangavarapu K, Mathew G, Azabdaftari G, Morrison C, Miller A, et al. Human prostate side population cells demonstrate stem cell properties in recombination with urogenital sinus mesenchyme. PLoS ONE. 2013;8:e55062 pubmed publisher
Das S, Hermanson D, Bleeker N, Lowman X, Li Y, Kelekar A, et al. Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy. ACS Chem Biol. 2013;8:327-35 pubmed publisher
Padmanabhan R, Chen K, Gillet J, Handley M, Mallon B, Hamilton R, et al. Regulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells. Stem Cells. 2012;30:2175-87 pubmed publisher
Cheng G, To K. Adverse Cell Culture Conditions Mimicking the Tumor Microenvironment Upregulate ABCG2 to Mediate Multidrug Resistance and a More Malignant Phenotype. ISRN Oncol. 2012;2012:746025 pubmed publisher
Wei Y, Ma Y, Zhao Q, Ren Z, Li Y, Hou T, et al. New use for an old drug: inhibiting ABCG2 with sorafenib. Mol Cancer Ther. 2012;11:1693-702 pubmed publisher
Dhanasekaran M, Indumathi S, Kanmani A, Poojitha R, Revathy K, Rajkumar J, et al. Surface antigenic profiling of stem cells from human omentum fat in comparison with subcutaneous fat and bone marrow. Cytotechnology. 2012;: pubmed
Ni Z, Bikadi Z, Shuster D, Zhao C, Rosenberg M, Mao Q. Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity. Biochemistry. 2011;50:8057-66 pubmed publisher
Goler Baron V, Assaraf Y. Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance. PLoS ONE. 2011;6:e16007 pubmed publisher
Ni Z, Bikadi Z, Cai X, Rosenberg M, Mao Q. Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport. Am J Physiol Cell Physiol. 2010;299:C1100-9 pubmed publisher
Cai X, Bikadi Z, Ni Z, Lee E, Wang H, Rosenberg M, et al. Role of basic residues within or near the predicted transmembrane helix 2 of the human breast cancer resistance protein in drug transport. J Pharmacol Exp Ther. 2010;333:670-81 pubmed publisher
Polgar O, Ediriwickrema L, Robey R, Sharma A, Hegde R, Li Y, et al. Arginine 383 is a crucial residue in ABCG2 biogenesis. Biochim Biophys Acta. 2009;1788:1434-43 pubmed publisher
Bram E, Adar Y, Mesika N, Sabisz M, Skladanowski A, Assaraf Y. Structural determinants of imidazoacridinones facilitating antitumor activity are crucial for substrate recognition by ABCG2. Mol Pharmacol. 2009;75:1149-59 pubmed publisher
Robey R, Obrzut T, Shukla S, Polgar O, Macalou S, Bahr J, et al. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol. 2009;64:575-83 pubmed publisher
Wang J, Guo L, Chen L, Zeng Y, Lu S. Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Cancer Res. 2007;67:3716-24 pubmed

product information

Product Type :

Antibody

Product Name :

CD338 (ABCG2) Monoclonal Antibody (5D3), PE, eBioscience™

Catalog # :

12-8888-41

Quantity :

25 Tests

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.25 µg)/test

Species :

Human

Clone :

5D3

Isotype :

IgG2b, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

ABCG2, is also known as placenta-specific ABC transporter and breast cancer resistance protein (BCRP1). ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Under normal conditions, ABCG2 may serve a protective function by removing toxins from the cell, and plays an important role in regulating stem cell differentiation. ABCG2 is responsible for the side population (SP) phenotype and is widely expressed in a large variety of stem cells, making it an important stem cell marker. ABCG2 may have N-linked glycosylation and may dimerize in vivo. ABCG2 is abundantly expressed in placenta, liver, intestine and stem cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.25 µg)/test

Aliases :

ABC transporter; ABC15; ABCG2; ABCP; ATP binding cassette subfamily G member 2 (Junior blood group); ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group); BCRP; BCRP1; BMDP; Breast cancer resistance protein; Broad substrate specificity ATP-binding cassette transporter ABCG2; CD338; CDw338; EST157481; GOUT1; Mitoxantrone resistance-associated protein; MRX; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2; MXR; MXR1; MXR-1; placenta specific MDR protein; placenta-specific ATP-binding cassette transporter; UAQTL1; Urate exporter