This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-17F Monoclonal Antibody (eBio18F10), PE, eBioscience
catalog :
12-7471-82
quantity :
100 ug
price :
US 416.00
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
eBio18F10
reactivity :
mouse
application :
flow cytometry
citations: 22
Reference
Faust H, Zhang H, Han J, Wolf M, Jeon O, Sadtler K, et al. IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis. J Clin Invest. 2020;130:5493-5507 pubmed publisher
Hrdý J, Alard J, Couturier Maillard A, Boulard O, Boutillier D, Delacre M, et al. Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses. Sci Rep. 2020;10:5345 pubmed publisher
Amir M, Chaudhari S, Wang R, Campbell S, Mosure S, Chopp L, et al. REV-ERBα Regulates TH17 Cell Development and Autoimmunity. Cell Rep. 2018;25:3733-3749.e8 pubmed publisher
Giles D, Moreno Fernandez M, Stankiewicz T, Graspeuntner S, Cappelletti M, Wu D, et al. Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Nat Med. 2017;23:829-838 pubmed publisher
Giles D, Moreno Fernandez M, Stankiewicz T, Cappelletti M, Huppert S, Iwakura Y, et al. Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. PLoS ONE. 2016;11:e0149783 pubmed publisher
Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, et al. p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice. Eur J Immunol. 2016;46:212-22 pubmed publisher
Maciel B, Lima Maciel B, Valverde J, Rodrigues Neto J, Freire Neto F, Keesen T, et al. Dual immune modulatory effect of vitamin A in human visceral leishmaniasis. PLoS ONE. 2014;9:e107564 pubmed publisher
Bi Y, Zhou J, Yang H, Wang X, Zhang X, Wang Q, et al. IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-?-activated macrophage programming. J Immunol. 2014;192:704-13 pubmed publisher
Kim H, Lee H, Chang Y, Pichavant M, Shore S, Fitzgerald K, et al. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med. 2014;20:54-61 pubmed publisher
Corsetti P, de Almeida L, Carvalho N, Azevedo V, Silva T, Teixeira H, et al. Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice. PLoS ONE. 2013;8:e74729 pubmed publisher
Russell S, Stefanska A, Kubica M, Horan R, Mantovani A, Garlanda C, et al. Toll IL-1R8/single Ig IL-1-related receptor regulates psoriasiform inflammation through direct inhibition of innate IL-17A expression by ?? T cells. J Immunol. 2013;191:3337-46 pubmed publisher
Liu H, Yao S, Dann S, Qin H, Elson C, Cong Y. ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis. Eur J Immunol. 2013;43:1716-26 pubmed publisher
Russell S, Moore A, Fallon P, Walsh P. Soluble IL-2R? (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice. PLoS ONE. 2012;7:e47748 pubmed publisher
Gangaplara A, Massilamany C, Brown D, Delhon G, Pattnaik A, Chapman N, et al. Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-?-reactive CD4 T cells in A/J mice. Clin Immunol. 2012;144:237-49 pubmed publisher
Robb R, Lineburg K, Kuns R, Wilson Y, Raffelt N, Olver S, et al. Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation. Blood. 2012;119:5898-908 pubmed publisher
Carvalho N, Oliveira F, Durães F, de Almeida L, Flórido M, Prata L, et al. Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses. Infect Immun. 2011;79:1638-46 pubmed publisher
Ghoreschi K, Laurence A, Yang X, Tato C, McGeachy M, Konkel J, et al. Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature. 2010;467:967-71 pubmed publisher
Singh T, Schön M, Wallbrecht K, Michaelis K, Rinner B, Mayer G, et al. 8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder. J Immunol. 2010;184:7257-67 pubmed publisher
Tan A, Lam K. Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation. J Immunol. 2010;184:1849-57 pubmed publisher
Sonnenberg G, Mangan P, Bezman N, Sekiguchi D, Luning Prak E, Erikson J, et al. Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production. Blood. 2010;115:2186-95 pubmed publisher
Jäger A, Dardalhon V, Sobel R, Bettelli E, Kuchroo V. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol. 2009;183:7169-77 pubmed publisher
Lee Y, Turner H, Maynard C, Oliver J, Chen D, Elson C, et al. Late developmental plasticity in the T helper 17 lineage. Immunity. 2009;30:92-107 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IL-17F Monoclonal Antibody (eBio18F10), PE, eBioscience
Catalog # :
12-7471-82
Quantity :
100 ug
Price :
US 416.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse
Clone :
eBio18F10
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production. IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells. IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
C87042; CANDF6; cytokine ML-1; IL17F; IL-17F; IL-24; ILN; Interleukin; interleukin 17F; Interleukin17F; interleukin-17F; interleukin-24; ML1; ML-1; mutant IL-17F
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA