EBI3 (IL-27 subunit) Monoclonal Antibody (ebic6), PE, eBioscience | Invitrogen 12-7358-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

EBI3 (IL-27 subunit) Monoclonal Antibody (ebic6), PE, eBioscience

catalog :

12-7358-42

quantity :

100 Tests

price :

US 418.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

ebic6

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Zhang N, Dai H, Dong X, Liu W, Jiang H, Zhao Q, et al. Level of interleukin-35 in patients with idiopathic membranous nephropathy and its predictive value for remission time. Front Immunol. 2022;13:926368 pubmed publisher
Wang W, Wei C, Cheng Z, Yang J. Aberrant Th2 Immune Responses Are Associated With a Reduced Frequency of IL-35-Induced Regulatory T Cells After Allergen Exposure in Patients With Allergic Asthma. Allergy Asthma Immunol Res. 2020;12:1029-1045 pubmed publisher
Tovar Salazar A, Weinberg A. Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity. PLoS ONE. 2017;12:e0180691 pubmed publisher

product information

Product Type :

Antibody

Product Name :

EBI3 (IL-27 subunit) Monoclonal Antibody (ebic6), PE, eBioscience

Catalog # :

12-7358-42

Quantity :

100 Tests

Price :

US 418.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.03 ug)/test

Species :

Human

Clone :

ebic6

Isotype :

IgG2b, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

EBI3 (Epstein-Barr virus Induced-3) is a secreted glycoprotein of the hematopoietin receptor family. It plays a critical regulatory role in the induction of Th2-type immune responses and the development of Th2-mediated tissue inflammation in vivo, which may be mediated through the control of iNKT cell function. EBI3 dimerizes with p28 and p35 subunits of IL-12 to form new proteins IL-27 and IL-35, respectively. IL-27 is an early product of activated antigen presenting cell that is produced upon TLR ligation. It negatively regulates Th17 cell differentiation. EBI3 is widely expressed and its expression in dendritic cell is transcriptionally regulated by TLR signaling via MyD88 and NF-kappaB during innate immune responses preceding cytokine driven Th cell development. EBI3 signal inhibits delayed-type hypersensitivity responses by suppressing IL-17 production and inducing IL-10 hyperproduction. EBI3 may play a novel role in controlling tumor metastasis via lung CD8+ T cells, and its deficiency is associated with a diminished production of Th2 cytokines which are known to regulate allergic airway inflammation in asthma. Targeted deletion of EBI3 protects mice from lung metastasis.

Immunogen :

Human IL-27 recombinant protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.03 ug)/test

Aliases :

cytokine receptor; EBI3; EBI-3; EBV-induced gene 3 protein; Epstein-Barr virus induced 3; Epstein-Barr virus induced gene 3; Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor); epstein-Barr virus-induced gene 3 protein; Epstein-Barr virus-induced gene 3 protein homolog; IL-27; IL27 subunit; IL-27 subunit beta; IL27B; IL-27B; IL35 subunit; interleukin-27 subunit beta