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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-21 Monoclonal Antibody (eBio3A3-N2 (3A3-N2)), PE, eBioscience
catalog :
12-7219-41
quantity :
25 Tests
price :
US 203.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
eBio3A3-N2 (3A3-N2)
reactivity :
human
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 28
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 1a
Rasmussen T, Andersen T, Bak R, Yiu G, Sørensen C, Stengaard Pedersen K, et al. Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. Arthritis Res Ther. 2015;17:154 pubmed publisher
  • flow cytometry; human
Gironi M, Saresella M, Rovaris M, Vaghi M, Nemni R, Clerici M, et al. A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis. Immun Ageing. 2013;10:1 pubmed publisher
Rosain J, Neehus A, Manry J, Yang R, Le Pen J, Daher W, et al. Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria. Cell. 2023;186:621-645.e33 pubmed publisher
Webb L, Fra Bido S, Innocentin S, Matheson L, Attaf N, Bignon A, et al. Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ. Aging Cell. 2021;20:e13295 pubmed publisher
Rodda L, Netland J, Shehata L, Pruner K, Morawski P, Thouvenel C, et al. Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell. 2021;184:169-183.e17 pubmed publisher
Pallikkuth S, Chaudhury S, Lu P, Pan L, Jongert E, Wille Reece U, et al. A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses. elife. 2020;9: pubmed publisher
Verghese D, Chun N, Paz K, Fribourg M, Woodruff T, Flynn R, et al. C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans. JCI Insight. 2018;3: pubmed publisher
Lagou V, Garcia Perez J, Smets I, Van Horebeek L, Vandebergh M, Chen L, et al. Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators. Cell Rep. 2018;25:798-810.e6 pubmed publisher
Dige A, Magnusson M, Uhrenholt C, Rasmussen T, Kragstrup T, Ohman L, et al. Effects of Anti-TNFα Treatment on Mucosal Expression of IL-17A, IL-21, and IL-22 and Cytokine-Producing T Cell Subsets in Crohn's Disease. Mediators Inflamm. 2018;2018:3279607 pubmed publisher
Cárdeno A, Magnusson M, Quiding Järbrink M, Lundgren A. Activated T follicular helper-like cells are released into blood after oral vaccination and correlate with vaccine specific mucosal B-cell memory. Sci Rep. 2018;8:2729 pubmed publisher
Catakovic K, Gassner F, Ratswohl C, Zaborsky N, Rebhandl S, Schubert M, et al. TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia. Oncoimmunology. 2017;7:e1371399 pubmed publisher
Yamada H, Haraguchi A, Sakuraba K, Okazaki K, Fukushi J, Mizu uchi H, et al. Th1 is the predominant helper T cell subset that produces GM-CSF in the joint of rheumatoid arthritis. RMD Open. 2017;3:e000487 pubmed publisher
Cobb D, Kim O, Golden Mason L, Rosen H, Hahn Y. Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection. Hepatology. 2017;: pubmed publisher
Vinton C, Ortiz A, Calantone N, Mudd J, Deléage C, Morcock D, et al. Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4+ T Cells in African Green Monkeys. J Immunol. 2017;198:4403-4412 pubmed publisher
Bekele Y, Amu S, Bobosha K, Lantto R, Nilsson A, Endale B, et al. Impaired Phenotype and Function of T Follicular Helper Cells in HIV-1-Infected Children Receiving ART. Medicine (Baltimore). 2015;94:e1125 pubmed publisher
Azzopardi L, Thompson S, Harding K, Cossburn M, Robertson N, Compston A, et al. Predicting autoimmunity after alemtuzumab treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2014;85:795-8 pubmed publisher
Kared H, Fabre T, Bedard N, Bruneau J, Shoukry N. Galectin-9 and IL-21 mediate cross-regulation between Th17 and Treg cells during acute hepatitis C. PLoS Pathog. 2013;9:e1003422 pubmed publisher
Abdulahad W, Lepse N, Stegeman C, Huitema M, Doornbos van der Meer B, Tadema H, et al. Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA). Arthritis Res Ther. 2013;15:R70 pubmed
Somanchi S, Somanchi A, Cooper L, Lee D. Engineering lymph node homing of ex vivo-expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7. Blood. 2012;119:5164-72 pubmed publisher
Kamburova E, Koenen H, Boon L, Hilbrands L, Joosten I. In vitro?effects of rituximab on the proliferation, activation and differentiation of human B cells. Am J Transplant. 2012;12:341-50 pubmed publisher
Dolff S, Abdulahad W, Westra J, Doornbos van der Meer B, Limburg P, Kallenberg C, et al. Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus. Arthritis Res Ther. 2011;13:R157 pubmed publisher
Karnell J, Karnell F, Stephens G, Rajan B, Morehouse C, Li Y, et al. Mycophenolic acid differentially impacts B cell function depending on the stage of differentiation. J Immunol. 2011;187:3603-12 pubmed publisher
Singh H, Figliola M, Dawson M, Huls H, Olivares S, Switzer K, et al. Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies. Cancer Res. 2011;71:3516-27 pubmed publisher
Hovhannisyan Z, Treatman J, Littman D, Mayer L. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011;140:957-65 pubmed publisher
Batten M, Ramamoorthi N, Kljavin N, Ma C, Cox J, Dengler H, et al. IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med. 2010;207:2895-906 pubmed publisher
Moser J, Sassano E, Leistritz D, Eatrides J, Phogat S, Koff W, et al. Optimization of a dendritic cell-based assay for the in vitro priming of naïve human CD4+ T cells. J Immunol Methods. 2010;353:8-19 pubmed publisher
Jeffery L, Burke F, Mura M, Zheng Y, Qureshi O, Hewison M, et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol. 2009;183:5458-67 pubmed publisher
Chen M, Chen G, Nie H, Zhang X, Niu X, Zang Y, et al. Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS. Eur J Immunol. 2009;39:2525-36 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IL-21 Monoclonal Antibody (eBio3A3-N2 (3A3-N2)), PE, eBioscience
Catalog # :
12-7219-41
Quantity :
25 Tests
Price :
US 203.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 µL (0.5 µg)/test
Species :
Human
Clone :
eBio3A3-N2 (3A3-N2)
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.5 µg)/test
Aliases :
CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA