CD217 (IL-17Ra) Monoclonal Antibody (PAJ-17R), PE, eBioscience | Invitrogen 12-7182-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD217 (IL-17Ra) Monoclonal Antibody (PAJ-17R), PE, eBioscience

catalog :

12-7182-80

quantity :

25 µg

price :

US 165.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

PAJ-17R

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 6b	Vuckovic S, Minnie S, Smith D, Gartlan K, Watkins T, Markey K, et al. Bone marrow transplantation generates T cell-dependent control of myeloma in mice. J Clin Invest. 2019;129:106-121 pubmed publisher
	Jondle C, Tarakanova V. T Cell-Intrinsic Interleukin 17 Receptor A Signaling Supports the Establishment of Chronic Murine Gammaherpesvirus 68 Infection. J Virol. 2022;96:e0063922 pubmed publisher
	McGinley A, Sutton C, Edwards S, Leane C, Decourcey J, Teijeiro A, et al. Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells. Immunity. 2020;52:342-356.e6 pubmed publisher
	Hamour S, Gan P, Pepper R, Florez Barros F, Wang H, O Sullivan K, et al. Local IL-17 Production Exerts a Protective Role in Murine Experimental Glomerulonephritis. PLoS ONE. 2015;10:e0136238 pubmed publisher
	Chen S, Shimada K, Zhang W, Huang G, Crother T, Arditi M. IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice. J Immunol. 2010;185:5619-27 pubmed publisher
	Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, et al. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol. 2006;177:36-9 pubmed

product information

Product Type :

Antibody

Product Name :

CD217 (IL-17Ra) Monoclonal Antibody (PAJ-17R), PE, eBioscience

Catalog # :

12-7182-80

Quantity :

25 µg

Price :

US 165.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Mouse

Clone :

PAJ-17R

Isotype :

IgG2a

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

AW538159; CANDF5; CD127; CD217; CDw217; hIL-17R; IL-17 receptor A; IL17R; Il17ra; IL-17RA; interleukin 17 receptor A; interleukin-17 receptor A; MGC10262; VDw217

more info or order :

Invitrogen product webpage