product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-17A Monoclonal Antibody (eBio64DEC17), PE, eBioscience
catalog :
12-7179-41
quantity :
25 Tests
price :
US 149.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
eBio64DEC17
reactivity :
human, bovine, domestic sheep
application :
flow cytometry
more info or order :
citations: 181
Published Application/Species/Sample/DilutionReference
  • flow cytometry; bovine; loading ...; fig 4b
  • flow cytometry; domestic sheep; loading ...; fig 4b
Wattegedera S, Corripio Miyar Y, Pang Y, Frew D, McNeilly T, Palarea Albaladejo J, et al. Enhancing the toolbox to study IL-17A in cattle and sheep. Vet Res. 2017;48:20 pubmed publisher
  • flow cytometry; human; loading ...; fig 4a
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed publisher
  • flow cytometry; human; 1:10; loading ...; tbl 2
Moreira M, Costa Pereira C, Alves M, Marteleto B, Ribeiro V, Peruhype Magalhães V, et al. Vaccination against canine leishmaniosis increases the phagocytic activity, nitric oxide production and expression of cell activation/migration molecules in neutrophils and monocytes. Vet Parasitol. 2016;220:33-45 pubmed publisher
  • flow cytometry; human; fig 7
Cleret Buhot A, Zhang Y, Planas D, Goulet J, Monteiro P, Gosselin A, et al. Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach. Retrovirology. 2015;12:102 pubmed publisher
  • flow cytometry; human; fig 7
Scottà C, Fanelli G, Hoong S, Romano M, Lamperti E, Sukthankar M, et al. Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells. Haematologica. 2016;101:91-100 pubmed publisher
  • flow cytometry; human; fig 1
Wang W, Yen M, Liu K, Hsu P, Lin M, Chen P, et al. Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses. Stem Cell Reports. 2015;5:392-404 pubmed publisher
  • flow cytometry; human; loading ...; fig 3b
Weist B, Wehler P, El Ahmad L, Schmueck Henneresse M, Millward J, Nienen M, et al. A revised strategy for monitoring BKV-specific cellular immunity in kidney transplant patients. Kidney Int. 2015;88:1293-1303 pubmed publisher
  • flow cytometry; human; tbl s5
Dimova T, Brouwer M, Gosselin F, Tassignon J, Leo O, Donner C, et al. Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire. Proc Natl Acad Sci U S A. 2015;112:E556-65 pubmed publisher
  • flow cytometry; human
Heninger A, Wentrup S, Al Saeedi M, Schiessling S, Giese T, Wartha F, et al. Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex®. Immun Inflamm Dis. 2014;2:166-80 pubmed publisher
  • flow cytometry; human; fig 1
Kim K, Chung B, Kim B, Cho M, Yang C. The effect of mammalian target of rapamycin inhibition on T helper type 17 and regulatory T cell differentiation in vitro and in vivo in kidney transplant recipients. Immunology. 2015;144:68-78 pubmed publisher
  • flow cytometry; human
Sereti I, Estes J, Thompson W, Morcock D, Fischl M, Croughs T, et al. Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. PLoS Pathog. 2014;10:e1003890 pubmed publisher
  • flow cytometry; human; fig 2
Melis L, Van Praet L, Pircher H, Venken K, Elewaut D. Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-? production by interaction with its soluble E-cadherin ligand in chronically inflamed joints. Ann Rheum Dis. 2014;73:1223-31 pubmed publisher
  • flow cytometry; human; fig 3
Magalhaes I, Vudattu N, Ahmed R, Kuhlmann Berenzon S, Ngo Y, Sizemore D, et al. High content cellular immune profiling reveals differences between rhesus monkeys and men. Immunology. 2010;131:128-40 pubmed publisher
Lee A, Lee S, Choi J, Um I, Na H, Lee J, et al. Establishment of a humanized mouse model of keloid diseases following the migration of patient immune cells to the lesion: Patient-derived keloid xenograft (PDKX) model. Exp Mol Med. 2023;55:1713-1719 pubmed publisher
Peng H, Lv Y, Li C, Cheng Z, He S, Wang C, et al. Cathepsin S inhibition in dendritic cells prevents Th17 cell differentiation in perivascular adipose tissues following vascular injury in diabetic rats. J Biochem Mol Toxicol. 2023;37:e23419 pubmed publisher
Huang T, Cheng L, Jiang Y, Zhang L, Qian L. Indole-3-pyruvic acid alleviates rheumatoid arthritis via the aryl hydrocarbon receptor pathway. Ann Transl Med. 2023;11:213 pubmed publisher
Park J, Yang S, Jeong H, Lee S, Ryu J, Choi J, et al. EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis. Arthritis Res Ther. 2022;24:254 pubmed publisher
Hu Y, Chen Y, Chen Z, Zhang X, Guo C, Yu Z, et al. Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients. Front Cell Dev Biol. 2021;9:799560 pubmed publisher
Teshima T, Yuchi Y, Suzuki R, Matsumoto H, Koyama H. Immunomodulatory Effects of Canine Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles on Stimulated CD4+ T Cells Isolated from Peripheral Blood Mononuclear Cells. J Immunol Res. 2021;2021:2993043 pubmed publisher
Arra A, Pech M, Fu H, Lingel H, Braun F, Beyer C, et al. Immune-checkpoint blockade of CTLA-4 (CD152) in antigen-specific human T-cell responses differs profoundly between neonates, children, and adults. Oncoimmunology. 2021;10:1938475 pubmed publisher
Minns D, Smith K, Alessandrini V, Hardisty G, Melrose L, Jackson Jones L, et al. The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation. Nat Commun. 2021;12:1285 pubmed publisher
Chen Y, Eskandarpour M, Zhang X, Galatowicz G, Greenwood J, Lightman S, et al. Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis. J Neuroinflammation. 2021;18:49 pubmed publisher
Renavikar P, Sinha S, Brate A, Borcherding N, Crawford M, Steward Tharp S, et al. IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation. Front Immunol. 2020;11:568630 pubmed publisher
Sekine T, Perez Potti A, Rivera Ballesteros O, Stralin K, Gorin J, Olsson A, et al. Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19. Cell. 2020;183:158-168.e14 pubmed publisher
Malais xe9 Y, Le Mentec H, Sparfel L, Guzylack Piriou L. Differential influences of the BPA, BPS and BPF on in vitro IL-17 secretion by mouse and human T cells. Toxicol In Vitro. 2020;69:104993 pubmed publisher
Lu M, Qin X, Yao J, Yang Y, Zhao M, Sun L. Th17/Treg imbalance modulates rat myocardial fibrosis and heart failure by regulating LOX expression. Acta Physiol (Oxf). 2020;230:e13537 pubmed publisher
Bartolom xe9 Casado R, Landsverk O, Chauhan S, S xe6 tre F, Hagen K, Yaqub S, et al. CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile. Mucosal Immunol. 2021;14:402-410 pubmed publisher
Lee J, Hall J, Kroehling L, Wu L, Najar T, Nguyen H, et al. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. 2020;180:79-91.e16 pubmed publisher
Fania L, Morelli M, Scarponi C, Mercurio L, Scopelliti F, Cattani C, et al. Paradoxical psoriasis induced by TNF-α blockade shows immunological features typical of the early phase of psoriasis development. J Pathol Clin Res. 2020;6:55-68 pubmed publisher
Gramlich R, Aliahmadi E, Peiser M. In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists. Int J Mol Sci. 2019;20: pubmed publisher
Ahlmanner F, Sundström P, Akeus P, Eklöf J, Borjesson L, Gustavsson B, et al. CD39+ regulatory T cells accumulate in colon adenocarcinomas and display markers of increased suppressive function. Oncotarget. 2018;9:36993-37007 pubmed publisher
Ricciardi S, Manfrini N, Alfieri R, Calamita P, Crosti M, Gallo S, et al. The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling. Cell Metab. 2018;28:895-906.e5 pubmed publisher
Luo J, Ming B, Zhang C, Deng X, Li P, Wei Z, et al. IL-2 Inhibition of Th17 Generation Rather Than Induction of Treg Cells Is Impaired in Primary Sjögren's Syndrome Patients. Front Immunol. 2018;9:1755 pubmed publisher
Oh C, Lee J, Yoon T, Seo E, Park H, Piao L, et al. Effect of Equipotent Doses of Propofol versus Sevoflurane Anesthesia on Regulatory T Cells after Breast Cancer Surgery. Anesthesiology. 2018;129:921-931 pubmed publisher
Hammer A, Waschbisch A, Kuhbandner K, Bayas A, Lee D, Duscha A, et al. The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis. Ann Clin Transl Neurol. 2018;5:668-676 pubmed publisher
Chen X, Wang Y, Wang J, Wen J, Jia X, Wang X, et al. Accumulation of T-helper 22 cells, interleukin-22 and myeloid-derived suppressor cells promotes gastric cancer progression in elderly patients. Oncol Lett. 2018;16:253-261 pubmed publisher
Ohl K, Nickel H, Moncrieffe H, Klemm P, Scheufen A, Föll D, et al. The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2018;16:39 pubmed publisher
Li Q, Ding S, Wang Y, Xu X, Shen Z, Fu R, et al. Age-associated alteration in Th17 cell response is related to endothelial cell senescence and atherosclerotic cerebral infarction. Am J Transl Res. 2017;9:5160-5168 pubmed
Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang T, et al. Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis. Nat Commun. 2017;8:1600 pubmed publisher
Tischner D, Grimm M, Kaur H, Staudenraus D, Carvalho J, Looso M, et al. Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation. JCI Insight. 2017;2: pubmed publisher
West N, Hegazy A, Owens B, Bullers S, Linggi B, Buonocore S, et al. Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease. Nat Med. 2017;23:579-589 pubmed publisher
Feldhoff L, Rueda C, Moreno Fernandez M, Sauer J, Jackson C, Chougnet C, et al. IL-1? induced HIF-1? inhibits the differentiation of human FOXP3+ T cells. Sci Rep. 2017;7:465 pubmed publisher
Effner R, Hiller J, Eyerich S, Traidl Hoffmann C, Brockow K, Triggiani M, et al. Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop. Sci Rep. 2017;7:44005 pubmed publisher
Chung B, Kim B, Doh K, Cho M, Kim K, Yang C. Protective effect of 1?,25-dihydroxyvitamin D3 on effector CD4+ T cell induced injury in human renal proximal tubular epithelial cells. PLoS ONE. 2017;12:e0172536 pubmed publisher
Elias S, Schmidt A, Kannan V, Andersson J, Tegner J. TGF-? Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner. Front Immunol. 2016;7:603 pubmed publisher
Yang Y, Wang Q, Xie M, Liu P, Qi X, Liu X, et al. Berberine exerts an anti-inflammatory role in ocular Behcet's disease. Mol Med Rep. 2017;15:97-102 pubmed publisher
Zhu H, Hu F, Sun X, Zhang X, Zhu L, Liu X, et al. CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus. Front Immunol. 2016;7:512 pubmed
Zhang J, Chen X, Liu T, Jiang S. FOXP3+ associated with the pro-inflammatory regulatory T and T helper 17 effector cells in asthma patients. Exp Ther Med. 2016;12:2753-2758 pubmed
Grasse M, Meryk A, Schirmer M, Grubeck Loebenstein B, Weinberger B. Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults. Immun Ageing. 2016;13:26 pubmed publisher
Noack M, Ndongo Thiam N, Miossec P. Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion. Arthritis Res Ther. 2016;18:148 pubmed publisher
Loiseau C, Requena M, Mavigner M, Cazabat M, Carrere N, Suc B, et al. CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected individuals. Mucosal Immunol. 2016;9:1137-50 pubmed publisher
Dyring Andersen B, Nielsen M, Geisler C, Bonefeld C, Skov L. IL-17A- and IFNγ-Producing T Cells in Healthy Skin. Scand J Immunol. 2016;83:297-9 pubmed publisher
Pearson C, Thornton E, McKenzie B, Schaupp A, Huskens N, Griseri T, et al. ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation. elife. 2016;5:e10066 pubmed publisher
Chung B, Kim K, Kim B, Doh K, Cho M, Yang C. Increase of Th17 Cell Phenotype in Kidney Transplant Recipients with Chronic Allograft Dysfunction. PLoS ONE. 2015;10:e0145258 pubmed publisher
Kim K, Moon S, Park M, Kim B, Kim E, Lee S, et al. Optimization of adipose tissue-derived mesenchymal stem cells by rapamycin in a murine model of acute graft-versus-host disease. Stem Cell Res Ther. 2015;6:202 pubmed publisher
Volk T, Pannicke U, Reisli I, Bulashevska A, Ritter J, Björkman A, et al. DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency. Hum Mol Genet. 2015;24:7361-72 pubmed publisher
Moreira M, Dorneles E, Soares R, Magalhães C, Costa Pereira C, Lage A, et al. Cross-reactivity of commercially available anti-human monoclonal antibodies with canine cytokines: establishment of a reliable panel to detect the functional profile of peripheral blood lymphocytes by intracytoplasmic staining. Acta Vet Scand. 2015;57:51 pubmed publisher
Sundström P, Ahlmanner F, Akéus P, Sundquist M, Alsén S, Yrlid U, et al. Human Mucosa-Associated Invariant T Cells Accumulate in Colon Adenocarcinomas but Produce Reduced Amounts of IFN-γ. J Immunol. 2015;195:3472-81 pubmed publisher
Ortiz A, Klase Z, DiNapoli S, Vujkovic Cvijin I, Carmack K, Perkins M, et al. IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal Immunol. 2016;9:458-67 pubmed publisher
Chen J, Dawoodji A, Tarlton A, Gnjatic S, Tajar A, Karydis I, et al. NY-ESO-1 specific antibody and cellular responses in melanoma patients primed with NY-ESO-1 protein in ISCOMATRIX and boosted with recombinant NY-ESO-1 fowlpox virus. Int J Cancer. 2015;136:E590-601 pubmed publisher
Perez Bercoff L, Valentini D, Gaseitsiwe S, Mahdavifar S, Schutkowski M, Poiret T, et al. Whole CMV proteome pattern recognition analysis after HSCT identifies unique epitope targets associated with the CMV status. PLoS ONE. 2014;9:e89648 pubmed publisher
Shan M, You R, Yuan X, Frazier M, Porter P, Seryshev A, et al. Agonistic induction of PPAR? reverses cigarette smoke-induced emphysema. J Clin Invest. 2014;124:1371-81 pubmed publisher
Salerno Goncalves R, Rezwan T, Sztein M. B cells modulate mucosal associated invariant T cell immune responses. Front Immunol. 2014;4:511 pubmed publisher
Gui T, Chen C, Zhang Z, Tang W, Qian R, Ma X, et al. The disturbance of TH17-Treg cell balance in adenomyosis. Fertil Steril. 2014;101:506-14 pubmed publisher
Galindo Albarrán A, Ramirez Pliego O, Labastida Conde R, Melchy Pérez E, Liquitaya Montiel A, Esquivel Guadarrama F, et al. CD43 signals prepare human T cells to receive cytokine differentiation signals. J Cell Physiol. 2014;229:172-80 pubmed
Zhang L, Wang T, Wang X, Du R, Zhang K, Liu X, et al. Elevated frequencies of circulating Th22 cell in addition to Th17 cell and Th17/Th1 cell in patients with acute coronary syndrome. PLoS ONE. 2013;8:e71466 pubmed publisher
Prodger J, Hirbod T, Gray R, Kigozi G, Nalugoda F, Galiwango R, et al. HIV Infection in Uncircumcised Men Is Associated With Altered CD8 T-cell Function But Normal CD4 T-cell Numbers in the Foreskin. J Infect Dis. 2014;209:1185-94 pubmed publisher
Kosmaczewska A, Swierkot J, Ciszak L, Szteblich A, Chrobak A, Karabon L, et al. Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement. Rheumatol Int. 2014;34:243-53 pubmed publisher
Prodger J, Hirbod T, Kigozi G, Nalugoda F, Reynolds S, Galiwango R, et al. Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda. Mucosal Immunol. 2014;7:634-44 pubmed publisher
Boisson B, Wang C, Pedergnana V, Wu L, Cypowyj S, Rybojad M, et al. An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. Immunity. 2013;39:676-86 pubmed publisher
Bharadwaj A, Schewitz Bowers L, Wei L, Lee R, Smith J. Intercellular adhesion molecule 1 mediates migration of Th1 and Th17 cells across human retinal vascular endothelium. Invest Ophthalmol Vis Sci. 2013;54:6917-25 pubmed publisher
Takahashi Y, Mayne A, Khowawisetsut L, Pattanapanyasat K, Little D, Villinger F, et al. In vivo administration of a JAK3 inhibitor to chronically siv infected rhesus macaques leads to NK cell depletion associated with transient modest increase in viral loads. PLoS ONE. 2013;8:e70992 pubmed publisher
Covassin L, Jangalwe S, Jouvet N, Laning J, Burzenski L, Shultz L, et al. Human immune system development and survival of non-obese diabetic (NOD)-scid IL2r?(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells. Clin Exp Immunol. 2013;174:372-88 pubmed publisher
Jamshidian A, Shaygannejad V, Pourazar A, Zarkesh Esfahani S, Gharagozloo M. Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms. J Neuroimmunol. 2013;262:106-12 pubmed publisher
Geherin S, Lee M, Wilson R, Debes G. Ovine skin-recirculating ?? T cells express IFN-? and IL-17 and exit tissue independently of CCR7. Vet Immunol Immunopathol. 2013;155:87-97 pubmed publisher
Abdulahad W, Lepse N, Stegeman C, Huitema M, Doornbos van der Meer B, Tadema H, et al. Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA). Arthritis Res Ther. 2013;15:R70 pubmed
Obermajer N, Wong J, Edwards R, Chen K, Scott M, KHADER S, et al. Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling. J Exp Med. 2013;210:1433-445 pubmed
Liu X, Gao N, Li M, Xu D, Hou Y, Wang Q, et al. Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction. PLoS ONE. 2013;8:e64531 pubmed publisher
Li Q, Wang Y, Yu F, Wang Y, Zhang C, Hu C, et al. Peripheral Th17/Treg imbalance in patients with atherosclerotic cerebral infarction. Int J Clin Exp Pathol. 2013;6:1015-27 pubmed
Khowawisetsut L, Pattanapanyasat K, Onlamoon N, Mayne A, Little D, Villinger F, et al. Relationships between IL-17(+) subsets, Tregs and pDCs that distinguish among SIV infected elite controllers, low, medium and high viral load rhesus macaques. PLoS ONE. 2013;8:e61264 pubmed publisher
Chen Z, Ding J, Pang N, Du R, Meng W, Zhu Y, et al. The Th17/Treg balance and the expression of related cytokines in Uygur cervical cancer patients. Diagn Pathol. 2013;8:61 pubmed publisher
Lin W, Vilalta A, Adams R, Rolland A, Sullivan S, Griffin D. Vaxfectin adjuvant improves antibody responses of juvenile rhesus macaques to a DNA vaccine encoding the measles virus hemagglutinin and fusion proteins. J Virol. 2013;87:6560-8 pubmed publisher
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker R, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013;496:518-22 pubmed publisher
Tang X, Jo J, Tan A, Sandalova E, Chia A, Tan K, et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol. 2013;190:3142-52 pubmed publisher
Perreau M, Rozot V, Welles H, Belluti Enders F, Vigano S, Maillard M, et al. Lack of Mycobacterium tuberculosis-specific interleukin-17A-producing CD4+ T cells in active disease. Eur J Immunol. 2013;43:939-48 pubmed publisher
McArthur M, Sztein M. Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans. Clin Immunol. 2013;146:140-52 pubmed publisher
Li Q, Wang Y, Wang Y, Zhou Q, Chen K, Wang Y, et al. Distinct different sensitivity of Treg and Th17 cells to Fas-mediated apoptosis signaling in patients with acute coronary syndrome. Int J Clin Exp Pathol. 2013;6:297-307 pubmed
Hanai H, Iida T, Ikeya K, Abe J, Maruyama Y, Shimura T, et al. A new paradigm in ulcerative colitis: regulatory T cells are key factor which induces/exacerbates UC through an immune imbalance. Mol Immunol. 2013;54:173-80 pubmed publisher
Badot V, Luijten R, van Roon J, Depresseux G, Aydin S, van den Eynde B, et al. Serum soluble interleukin 7 receptor is strongly associated with lupus nephritis in patients with systemic lupus erythematosus. Ann Rheum Dis. 2013;72:453-6 pubmed publisher
Scotta C, Esposito M, Fazekasova H, Fanelli G, Edozie F, Ali N, et al. Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations. Haematologica. 2013;98:1291-9 pubmed publisher
Duran Aniotz C, Segal G, Salazar L, Pereda C, Falcón C, Tempio F, et al. The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses. Cancer Immunol Immunother. 2013;62:761-72 pubmed publisher
Dutra M, Béla S, Peixoto Rangel A, Fakiola M, Cruz A, Gazzinelli A, et al. Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis. J Infect Dis. 2013;207:152-63 pubmed publisher
Bautista Caro M, Arroyo Villa I, Castillo Gallego C, de Miguel E, Peiteado D, Puig Kröger A, et al. Decreased Th17 and Th1 cells in the peripheral blood of patients with early non-radiographic axial spondyloarthritis: a marker of disease activity in HLA-B27? patients. Rheumatology (Oxford). 2013;52:352-62 pubmed publisher
Micci L, Cervasi B, Ende Z, Iriele R, Reyes Aviles E, Vinton C, et al. Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques. Blood. 2012;120:3925-35 pubmed publisher
Arroyo Villa I, Bautista Caro M, Balsa A, Aguado Acín P, Nuño L, Bonilla Hernán M, et al. Frequency of Th17 CD4+ T cells in early rheumatoid arthritis: a marker of anti-CCP seropositivity. PLoS ONE. 2012;7:e42189 pubmed publisher
Vicetti Miguel R, Maryak S, Cherpes T. Brefeldin A, but not monensin, enables flow cytometric detection of interleukin-4 within peripheral T cells responding to ex vivo stimulation with Chlamydia trachomatis. J Immunol Methods. 2012;384:191-5 pubmed publisher
Chung B, Kim K, Kim B, Piao S, Lim S, Choi B, et al. Dysregulation of Th17 cells during the early post-transplant period in patients under calcineurin inhibitor based immunosuppression. PLoS ONE. 2012;7:e42011 pubmed publisher
Chan Y, Chen K, Duncan S, Lathrop K, Latoche J, Logar A, et al. Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes. J Allergy Clin Immunol. 2013;131:1117-29, 1129.e1-5 pubmed publisher
McArthur M, Sztein M. Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization. PLoS ONE. 2012;7:e38408 pubmed publisher
Feyler S, Scott G, Parrish C, Jarmin S, Evans P, Short M, et al. Tumour cell generation of inducible regulatory T-cells in multiple myeloma is contact-dependent and antigen-presenting cell-independent. PLoS ONE. 2012;7:e35981 pubmed publisher
Li Y, Zhao L, Tong L, Qian S, Ren Y, Zhang L, et al. Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity. Arthritis Res Ther. 2012;14:R123 pubmed publisher
Lundgren A, Bhuiyan T, Novak D, Kaim J, Reske A, Lu Y, et al. Characterization of Th17 responses to Streptococcus pneumoniae in humans: comparisons between adults and children in a developed and a developing country. Vaccine. 2012;30:3897-907 pubmed publisher
Zhang L, Li Y, Li Y, Qi L, Liu X, Yuan C, et al. Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis. PLoS ONE. 2012;7:e31000 pubmed publisher
Wacleche V, Chomont N, Gosselin A, Monteiro P, Goupil M, Kared H, et al. The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin ?7 but not CCR6 and regulated by retinoic acid. PLoS ONE. 2012;7:e32964 pubmed publisher
Velden J, Paust H, Hoxha E, Turner J, Steinmetz O, Wolf G, et al. Renal IL-17 expression in human ANCA-associated glomerulonephritis. Am J Physiol Renal Physiol. 2012;302:F1663-73 pubmed publisher
Müller A, Jun E, Conlon H, Sadiq S. Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis. BMC Neurosci. 2012;13:30 pubmed publisher
Gertow J, Berglund S, Okas M, Kärre K, Remberger M, Mattsson J, et al. Expansion of T-cells from the cord blood graft as a predictive tool for complications and outcome of cord blood transplantation. Clin Immunol. 2012;143:134-44 pubmed publisher
Kanai Y, Satoh T, Igawa K, Yokozeki H. Impaired expression of Tim-3 on Th17 and Th1 cells in psoriasis. Acta Derm Venereol. 2012;92:367-71 pubmed publisher
Shan M, Yuan X, Song L, Roberts L, Zarinkamar N, Seryshev A, et al. Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Sci Transl Med. 2012;4:117ra9 pubmed publisher
Khoo A, Koenen H, Chai L, Sweep F, Netea M, van der Ven A, et al. Seasonal variation in vitamin D? levels is paralleled by changes in the peripheral blood human T cell compartment. PLoS ONE. 2012;7:e29250 pubmed publisher
Saito A, Yokohama A, Osaki Y, Ogawa Y, Nakahashi H, Toyama K, et al. Circulating plasmacytoid dendritic cells in patients with primary and Helicobacter pylori-associated immune thrombocytopenia. Eur J Haematol. 2012;88:340-9 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
IL-17A Monoclonal Antibody (eBio64DEC17), PE, eBioscience
Catalog # :
12-7179-41
Quantity :
25 Tests
Price :
US 149.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.25 ug)/test
Species :
Human
Clone :
eBio64DEC17
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.25 ug)/test
Aliases :
Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA