product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-4 Monoclonal Antibody (11B11), PE, eBioscience
catalog :
12-7041-82
quantity :
100 µg
price :
US 306
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
11B11
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 229
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 4c
Cheng Y, Zhu X, Wang X, Zhuang Q, Huyan X, Sun X, et al. Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation. Front Immunol. 2018;9:1566 pubmed publisher
  • flow cytometry; mouse; 1:300; loading ...; fig 1i
Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed publisher
  • flow cytometry; mouse; fig 2B
Veinotte L, Gebremeskel S, Johnston B. CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFN? production and tumor control. Oncoimmunology. 2016;5:e1160979 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2d
Gabunia K, Ellison S, Kelemen S, Kako F, Cornwell W, Rogers T, et al. IL-19 Halts Progression of Atherosclerotic Plaque, Polarizes, and Increases Cholesterol Uptake and Efflux in Macrophages. Am J Pathol. 2016;186:1361-74 pubmed publisher
  • flow cytometry; mouse
Schwartz C, Turqueti Neves A, Hartmann S, Yu P, Nimmerjahn F, Voehringer D. Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion. Proc Natl Acad Sci U S A. 2014;111:E5169-77 pubmed publisher
Kalim K, Yang J, Modur V, Nguyen P, Li Y, Zheng Y, et al. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Front Immunol. 2021;12:726393 pubmed publisher
Makino A, Shibata T, Nagayasu M, Hosoya I, Nishimura T, Nakano C, et al. RSV infection-elicited high MMP-12-producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration. iScience. 2021;24:103201 pubmed publisher
Tsai S, Atai N, Cacciottolo M, Nice J, Salehi A, Guo C, et al. Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity. J Biol Chem. 2021;297:101266 pubmed publisher
Chen J, Ding Y, Huang F, Lan R, Wang Z, Huang W, et al. Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells. Oncol Lett. 2021;21:409 pubmed publisher
Pang L, Yu P, Liu X, Fan Y, Shi Y, Zou S. Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice. Mol Med Rep. 2021;23: pubmed publisher
Shi Y, Fu Y, Zhang X, Zhao G, Yao Y, Guo Y, et al. Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer. Cancer Immunol Immunother. 2021;70:61-73 pubmed publisher
Jaeger N, McDonough R, Rosen A, Hernandez Leyva A, Wilson N, Lint M, et al. Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation. Cell Rep. 2020;33:108331 pubmed publisher
Wu J, Wei Z, Cheng P, Qian C, Xu F, Yang Y, et al. Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis. Theranostics. 2020;10:10665-10679 pubmed publisher
Xue F, Yu M, Li L, Zhang W, Ma Y, Dong L, et al. Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma. Int J Biol Sci. 2020;16:2072-2083 pubmed publisher
LUCAS B, White A, Cosway E, Parnell S, James K, Jones N, et al. Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells. Nat Commun. 2020;11:2198 pubmed publisher
Zhu F, Qiu T, Zhu S, Zhao K, Chen C, Qiao J, et al. TIRC7 inhibits Th1 cells by upregulating the expression of CTLA‑4 and STAT3 in mice with acute graft‑versus‑host disease. Oncol Rep. 2020;44:43-54 pubmed publisher
Zhu X, Zhang W, Guo J, Zhang X, Li L, Wang T, et al. Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells. Cell Rep. 2019;27:1205-1220.e4 pubmed publisher
Pramanik J, Chen X, Kar G, Henriksson J, Gomes T, Park J, et al. Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation. Genome Med. 2018;10:76 pubmed publisher
Pang P, Zheng K, Wu S, Xü H, Deng L, Shi Y, et al. Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis. Evid Based Complement Alternat Med. 2018;2018:4923062 pubmed publisher
Gabryšová L, Alvarez Martinez M, Luisier R, Cox L, Sodenkamp J, Hosking C, et al. c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells. Nat Immunol. 2018;19:497-507 pubmed publisher
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172:517-533.e20 pubmed publisher
Lee S, Charmoy M, Romano A, Paun A, Chaves M, Cope F, et al. Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment. J Exp Med. 2018;215:357-375 pubmed publisher
Hu X, Li X, Hu C, Qin L, He R, Luo L, et al. Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4+T cells Immune Responses. Sci Rep. 2017;7:15207 pubmed publisher
Entwistle L, Pelly V, Coomes S, Kannan Y, Perez Lloret J, Czieso S, et al. Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic. Cell Host Microbe. 2017;22:484-493.e5 pubmed publisher
Chu F, Hu Y, Zhou Y, Guo M, Lu J, Zheng W, et al. MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway. Clin Exp Immunol. 2017;: pubmed publisher
Bock C, Babu S, Breloer M, Rajamanickam A, Boothra Y, Brunn M, et al. Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells. Front Cell Infect Microbiol. 2017;7:261 pubmed publisher
Chen P, Hsieh M, Kuo W, Kao H, Hsu C, Wang J. Water-soluble chitosan inhibits nerve growth factor and attenuates allergic inflammation in mite allergen-induced allergic rhinitis. J Allergy Clin Immunol. 2017;140:1146-1149.e8 pubmed publisher
Benson M, Manzanero S, Borges K. The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus. Epilepsia. 2017;58:e54-e58 pubmed publisher
Yu H, Park M, Kang S, Cho K, Mun S, Roh H. Culture supernatant of adipose stem cells can ameliorate allergic airway inflammation via recruitment of CD4+CD25+Foxp3 T cells. Stem Cell Res Ther. 2017;8:8 pubmed publisher
Xue D, Kaufman G, Dembele M, Beland M, Massoud A, Mindt B, et al. Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells. J Immunol. 2017;198:71-81 pubmed
Coomes S, Kannan Y, Pelly V, Entwistle L, Guidi R, Perez Lloret J, et al. CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation. Mucosal Immunol. 2017;10:150-161 pubmed publisher
Qi X, Gurung P, Malireddi R, Karmaus P, Sharma D, Vogel P, et al. Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunol. 2017;10:128-138 pubmed publisher
Lu G, Teng X, Zheng Z, Zhang R, Peng L, Zheng F, et al. Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus. Gene Ther. 2016;23:323-9 pubmed publisher
Zhong Y, Tang H, Wang X, Zeng Q, Liu Y, Zhao X, et al. Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis. Clin Exp Immunol. 2016;183:452-68 pubmed publisher
Coomes S, Pelly V, Kannan Y, Okoye I, Czieso S, Entwistle L, et al. IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells. PLoS Pathog. 2015;11:e1004994 pubmed publisher
Li X, Xu J, Lv Z, Wang J, Sun S, Zhu W, et al. Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice. Hum Vaccin Immunother. 2015;11:1735-43 pubmed publisher
Siggs O, Miosge L, Daley S, Asquith K, Foster P, Liston A, et al. Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation. J Immunol. 2015;194:2587-95 pubmed publisher
Cui Y, Dahlin J, Feinstein R, Bankova L, Xing W, Shin K, et al. Mouse mast cell protease-6 and MHC are involved in the development of experimental asthma. J Immunol. 2014;193:4783-4789 pubmed publisher
Tousif S, Singh D, Ahmad S, Moodley P, Bhattacharyya M, Van Kaer L, et al. Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection. J Biol Chem. 2014;289:30190-5 pubmed publisher
Burger M, Leung K, Bennett M, Winoto A. T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity. elife. 2014;3: pubmed publisher
Draleau K, Maddula S, Slaiby A, Nutile McMenemy N, De Leo J, Cao L. Phenotypic Identification of Spinal Cord-Infiltrating CD4+ T Lymphocytes in a Murine Model of Neuropathic Pain. J Pain Relief. 2014;Suppl 3:003 pubmed
Monk J, Turk H, Fan Y, Callaway E, Weeks B, Yang P, et al. Antagonizing arachidonic acid-derived eicosanoids reduces inflammatory Th17 and Th1 cell-mediated inflammation and colitis severity. Mediators Inflamm. 2014;2014:917149 pubmed publisher
Prajeeth C, Löhr K, Floess S, Zimmermann J, Ulrich R, Gudi V, et al. Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia. Brain Behav Immun. 2014;37:248-59 pubmed publisher
Kim S, Karasuyama H, Lopez A, Ouyang W, Li X, Le Gros G, et al. IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses. Immune Netw. 2013;13:249-56 pubmed publisher
Adachi K, Osada Y, Nakamura R, Tamada K, Hamano S. Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection. PLoS ONE. 2013;8:e82698 pubmed publisher
Kahlfuß S, Simma N, Mankiewicz J, Bose T, Lowinus T, Klein Hessling S, et al. Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells. Mol Cell Biol. 2014;34:820-31 pubmed publisher
Kim K, Srikanth S, Tan Y, Yee M, Jew M, Damoiseaux R, et al. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014;192:110-22 pubmed publisher
Farhadi N, Lambert L, Triulzi C, Openshaw P, Guerra N, Culley F. Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation. J Allergy Clin Immunol. 2014;133:827-35.e3 pubmed publisher
Lee P, Puppi M, Schluns K, Yu Lee L, Dong C, Lacorazza H. The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage. J Immunol. 2014;192:178-88 pubmed publisher
Wang S, Wu B, Xue J, Wang M, Chen R, Wang B. Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge. Hum Vaccin Immunother. 2014;10:461-8 pubmed publisher
Mollo S, Zajac A, Harrington L. Temporal requirements for B cells in the establishment of CD4 T cell memory. J Immunol. 2013;191:6052-9 pubmed publisher
Nakanishi W, Yamaguchi S, Matsuda A, Suzukawa M, Shibui A, Nambu A, et al. IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. PLoS ONE. 2013;8:e78099 pubmed publisher
Wong L, HATFIELD J, Brown M. Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development. J Biol Chem. 2013;288:35170-9 pubmed publisher
Zhou Q, Hu Y, Howard O, Oppenheim J, Chen X. In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo. Cytokine. 2014;65:56-64 pubmed publisher
Boué J, Basso L, Cenac N, Blanpied C, Rolli Derkinderen M, Neunlist M, et al. Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice. Gastroenterology. 2014;146:166-75 pubmed publisher
Murakami R, Denda Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T. A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS ONE. 2013;8:e73270 pubmed publisher
Gangaplara A, Massilamany C, Steffen D, Reddy J. Mimicry epitope from Ehrlichia canis for interphotoreceptor retinoid-binding protein 201-216 prevents autoimmune uveoretinitis by acting as altered peptide ligand. J Neuroimmunol. 2013;263:98-107 pubmed publisher
Yu K, Zhu P, Dong Q, Zhong Y, Zhu Z, Lin Y, et al. Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice. J Am Heart Assoc. 2013;2:e000391 pubmed publisher
Wu B, Zou Q, Hu Y, Wang B. Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice. Hum Vaccin Immunother. 2013;9:2133-41 pubmed publisher
Yousefi M, Duplay P. CD28 controls the development of innate-like CD8+ T cells by promoting the functional maturation of NKT cells. Eur J Immunol. 2013;43:3017-27 pubmed publisher
González García C, Bravo B, Ballester A, Gomez Perez R, Eguiluz C, Redondo M, et al. Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis. Br J Pharmacol. 2013;170:602-13 pubmed publisher
Monk J, Hou T, Turk H, McMurray D, Chapkin R. n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells. J Nutr. 2013;143:1501-8 pubmed publisher
Debock I, Jaworski K, Chadlaoui H, Delbauve S, Passon N, Twyffels L, et al. Neonatal follicular Th cell responses are impaired and modulated by IL-4. J Immunol. 2013;191:1231-9 pubmed publisher
Yeh L, Miaw S, Lin M, Chou F, Shieh S, Chuang Y, et al. Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice. J Immunol. 2013;191:594-607 pubmed publisher
Ohta S, Imamura M, Xing W, Boyce J, Balestrieri B. Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. J Immunol. 2013;190:5927-38 pubmed publisher
Kong F, Chen W, He S, Lin Z, Li X, Zhang X, et al. Mycophenolic acid derivative 118 improves outcome of skin grafts by suppressing IL-17 production. Acta Pharmacol Sin. 2013;34:921-9 pubmed publisher
Shin K, Chung H, Kim D, Hwang J, Lee S. Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma. Life Sci. 2013;92:1093-9 pubmed publisher
Barron L, Smith A, El Kasmi K, Qualls J, Huang X, Cheever A, et al. Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS ONE. 2013;8:e61961 pubmed publisher
Suzuki J, Kuwahara M, Tofukuji S, Imamura M, Kato F, Nakayama T, et al. A novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus. PLoS ONE. 2013;8:e61785 pubmed publisher
Yao C, Hirata T, Soontrapa K, Ma X, Takemori H, Narumiya S. Prostaglandin E? promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase. Nat Commun. 2013;4:1685 pubmed publisher
Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M. Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands. Eur J Immunol. 2013;43:1727-34 pubmed publisher
Natividad K, Junankar S, Mohd Redzwan N, Nair R, Wirasinha R, King C, et al. Interleukin-27 signaling promotes immunity against endogenously arising murine tumors. PLoS ONE. 2013;8:e57469 pubmed publisher
Ferreira I, Smyth D, Gaze S, Aziz A, Giacomin P, Ruyssers N, et al. Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis. Infect Immun. 2013;81:2104-11 pubmed publisher
Manzke N, Akhmetzyanova I, Hasenkrug K, Trilling M, Zelinskyy G, Dittmer U. CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells. J Virol. 2013;87:6306-13 pubmed publisher
Othy S, Hegde P, Topçu S, Sharma M, Maddur M, Lacroix Desmazes S, et al. Intravenous gammaglobulin inhibits encephalitogenic potential of pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine-1 phosphate receptor 1-mammalian target of rapamycin axis. J Immunol. 2013;190:4535-41 pubmed publisher
Helmersson S, Sundstedt A, Deronic A, Leanderson T, Ivars F. Amelioration of experimental autoimmune encephalomyelitis by the quinoline-3-carboxamide paquinimod: reduced priming of proinflammatory effector CD4(+) T cells. Am J Pathol. 2013;182:1671-80 pubmed publisher
Park S, Jing X, Gupta D, Dziarski R. Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses. J Immunol. 2013;190:3480-92 pubmed publisher
Faustino L, da Fonseca D, Takenaka M, Mirotti L, Florsheim E, Guereschi M, et al. Regulatory T cells migrate to airways via CCR4 and attenuate the severity of airway allergic inflammation. J Immunol. 2013;190:2614-21 pubmed publisher
Yamamoto M, Seki Y, Iwai K, Ko I, Martin A, Tsuji N, et al. Ontogeny and localization of the cells produce IL-2 in healthy animals. Cytokine. 2013;61:831-41 pubmed publisher
Khan T, Wong E, Soni C, Rahman Z. Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4+ Th cell responses leading to autoantibody production. J Immunol. 2013;190:1433-46 pubmed publisher
Wan W, Lionakis M, Liu Q, Roffe E, Murphy P. Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice. Cardiovasc Res. 2013;97:580-8 pubmed publisher
Monk J, Hou T, Turk H, Weeks B, Wu C, McMurray D, et al. Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis. PLoS ONE. 2012;7:e49739 pubmed publisher
Donaldson D, Apostolaki M, Bone H, Richards C, Williams N. The Escherichia coli heat-labile enterotoxin B subunit protects from allergic airway disease development by inducing CD4+ regulatory T cells. Mucosal Immunol. 2013;6:535-46 pubmed publisher
Antvorskov J, Fundova P, Buschard K, Funda D. Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice. Immunology. 2013;138:23-33 pubmed publisher
Zhao D, Zhang M, Wang M, Liu B, Wang X, Yang J, et al. Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4+ T-cell subsets. Immunobiology. 2013;218:602-8 pubmed publisher
Bajwa A, Huang L, Ye H, Dondeti K, Song S, Rosin D, et al. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol. 2012;189:2584-96 pubmed publisher
Gangaplara A, Massilamany C, Brown D, Delhon G, Pattnaik A, Chapman N, et al. Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-?-reactive CD4 T cells in A/J mice. Clin Immunol. 2012;144:237-49 pubmed publisher
Shah H, Devera T, Rampuria P, Lang G, Lang M. Type II NKT cells facilitate Alum-sensing and humoral immunity. J Leukoc Biol. 2012;92:883-93 pubmed publisher
Besin G, Yousefi M, Saba I, Klinck R, Pandolfi P, Duplay P. Dok-1 overexpression promotes development of ?? natural killer T cells. Eur J Immunol. 2012;42:2491-504 pubmed publisher
Qu Z, Fu J, Ma H, Zhou J, Jin M, Mapara M, et al. PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease. Cell Biosci. 2012;2:23 pubmed publisher
Jung K, Kang M, Park C, Hyun Choi Y, Jeon Y, Park S, et al. Protective role of V-set and immunoglobulin domain-containing 4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liver T- and natural killer T-cells. Hepatology. 2012;56:1838-48 pubmed publisher
Carrier Y, Whitters M, Miyashiro J, LaBranche T, Ramon H, Benoit S, et al. Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells. Eur J Immunol. 2012;42:1393-404 pubmed publisher
Lischke T, Hegemann A, Gurka S, Vu Van D, Burmeister Y, Lam K, et al. Comprehensive analysis of CD4+ T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS. J Immunol. 2012;189:234-44 pubmed publisher
Young J, Wu T, Chen Y, Zhao D, Liu H, Yi T, et al. Donor B cells in transplants augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like chronic graft-versus-host disease. J Immunol. 2012;189:222-33 pubmed publisher
Kwon M, Ma J, Ding Y, Wang R, Sun Z. Protein kinase C-? promotes Th17 differentiation via upregulation of Stat3. J Immunol. 2012;188:5887-97 pubmed publisher
Zhong Y, Wang X, Ji Q, Mao X, Tang H, Yi G, et al. CD4+LAP + and CD4 +CD25 +Foxp3 + regulatory T cells induced by nasal oxidized low-density lipoprotein suppress effector T cells response and attenuate atherosclerosis in ApoE-/- mice. J Clin Immunol. 2012;32:1104-17 pubmed publisher
Mizutani N, Goshima H, Nabe T, Yoshino S. Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice. J Immunol. 2012;188:5694-705 pubmed publisher
Ueda A, Zhou L, Stein P. Fyn promotes Th17 differentiation by regulating the kinetics of ROR?t and Foxp3 expression. J Immunol. 2012;188:5247-56 pubmed publisher
Pereira P, Boucontet L. Innate NKT?? and NKT?? cells exert similar functions and compete for a thymic niche. Eur J Immunol. 2012;42:1272-81 pubmed publisher
Sharma A, Chen Q, Nguyen T, Yu Q, Sen J. T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes. J Immunol. 2012;188:3859-68 pubmed publisher
McNamara J, Schramm C, Singh A, Secor E, Guernsey L, Lefrancois L, et al. Phenotypic changes to the endogenous antigen-specific CD8+ T cell response correlates with the development and resolution of allergic airway disease. Am J Pathol. 2012;180:1991-2000 pubmed publisher
Attridge K, Wang C, Wardzinski L, Kenefeck R, Chamberlain J, Manzotti C, et al. IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis. Blood. 2012;119:4656-64 pubmed publisher
Ramon H, Beal A, Liu Y, Worthen G, Oliver P. The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J Immunol. 2012;188:4023-31 pubmed publisher
Bai L, Constantinides M, Thomas S, Reboulet R, Meng F, Koentgen F, et al. Distinct APCs explain the cytokine bias of ?-galactosylceramide variants in vivo. J Immunol. 2012;188:3053-61 pubmed publisher
Inamine A, Sakurai D, Horiguchi S, Yonekura S, Hanazawa T, Hosokawa H, et al. Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells. Clin Immunol. 2012;143:170-9 pubmed publisher
Kadri N, Korpos E, Gupta S, Briet C, Löfbom L, Yagita H, et al. CD4(+) type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes. J Immunol. 2012;188:3138-49 pubmed publisher
Muller U, Piehler D, Stenzel W, Kohler G, Frey O, Held J, et al. Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis. Mucosal Immunol. 2012;5:299-310 pubmed publisher
Leonhardt F, Zirlik K, Buchner M, Prinz G, Hechinger A, Gerlach U, et al. Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels. Leukemia. 2012;26:1617-29 pubmed publisher
Iseki M, Omori Miyake M, Xu W, Sun X, Takaki S, Rawlings D, et al. Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4. Int Immunol. 2012;24:183-95 pubmed publisher
Boué J, Blanpied C, Djata Cabral M, Pelletier L, Vergnolle N, Dietrich G. Immune conditions associated with CD4+ T effector-induced opioid release and analgesia. Pain. 2012;153:485-93 pubmed publisher
Goswami R, Jabeen R, Yagi R, Pham D, Zhu J, Goenka S, et al. STAT6-dependent regulation of Th9 development. J Immunol. 2012;188:968-75 pubmed publisher
Nie X, Cai G, Zhang W, Wang H, Wu B, Li Q, et al. Lipopolysaccharide mediated mast cells induce IL-10 producing regulatory T cells through the ICOSL/ICOS axis. Clin Immunol. 2012;142:269-79 pubmed publisher
Tsakiri N, Papadopoulos D, Denis M, Mitsikostas D, Kollias G. TNFR2 on non-haematopoietic cells is required for Foxp3+ Treg-cell function and disease suppression in EAE. Eur J Immunol. 2012;42:403-12 pubmed publisher
Massilamany C, Asojo O, Gangaplara A, Steffen D, Reddy J. Identification of a second mimicry epitope from Acanthamoeba castellanii that induces CNS autoimmunity by generating cross-reactive T cells for MBP 89-101 in SJL mice. Int Immunol. 2011;23:729-39 pubmed publisher
Park S, Gupta D, Hurwich R, Kim C, Dziarski R. Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses. J Immunol. 2011;187:5813-23 pubmed publisher
Iguchi Hashimoto M, Usui T, Yoshifuji H, Shimizu M, Kobayashi S, Ito Y, et al. Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-?B and increased STAT5 signals. PLoS ONE. 2011;6:e27020 pubmed publisher
Nakahira M, Nakanishi K. Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells. Int Immunol. 2011;23:761-72 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
IL-4 Monoclonal Antibody (11B11), PE, eBioscience
Catalog # :
12-7041-82
Quantity :
100 µg
Price :
US 306
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.125 µg/test
Species :
Mouse
Clone :
11B11
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.125 µg/test
Aliases :
B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA