CD273 (B7-DC) Monoclonal Antibody (TY25), PE, eBioscience™ | Invitrogen 12-5986-83 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD273 (B7-DC) Monoclonal Antibody (TY25), PE, eBioscience™

catalog :

12-5986-83

quantity :

200 µg

price :

US 309.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

TY25

reactivity :

mouse

application :

flow cytometry

citations: 25

Reference
LagassÃ© H, Anidi I, Craig J, Limjunyawong N, Poupore A, Mitzner W, et al. Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes. J Leukoc Biol. 2016;99:659-71 pubmed publisher
Laidlaw B, Cui W, Amezquita R, Gray S, Guan T, Lu Y, et al. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nat Immunol. 2015;16:871-9 pubmed publisher
Yang L, Lewkowich I, Apsley K, Fritz J, Wills Karp M, Weaver T. Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin. J Immunol. 2015;194:5635-43 pubmed publisher
Fujiwara H, Maeda Y, Kobayashi K, Nishimori H, Matsuoka K, Fujii N, et al. Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease. J Immunol. 2014;193:2565-73 pubmed publisher
Forghani P, Harris W, Giver C, Mirshafiey A, Galipeau J, Waller E. Properties of immature myeloid progenitors with nitric-oxide-dependent immunosuppressive activity isolated from bone marrow of tumor-free mice. PLoS ONE. 2013;8:e64837 pubmed publisher
Bonne Annee S, Kerepesi L, Hess J, O Connell A, Lok J, Nolan T, et al. Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis. Infect Immun. 2013;81:3346-55 pubmed publisher
Van Der Werf N, Redpath S, Azuma M, Yagita H, Taylor M. Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection. PLoS Pathog. 2013;9:e1003215 pubmed publisher
Lewkowich I, Lajoie S, Stoffers S, Suzuki Y, Richgels P, Dienger K, et al. PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production. Mucosal Immunol. 2013;6:728-39 pubmed publisher
Yokosuka T, Takamatsu M, Kobayashi Imanishi W, Hashimoto Tane A, Azuma M, Saito T. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med. 2012;209:1201-17 pubmed publisher
Girard Madoux M, Kel J, Reizis B, Clausen B. IL-10 controls dendritic cell-induced T-cell reactivation in the skin to limit contact hypersensitivity. J Allergy Clin Immunol. 2012;129:143-50.e1-10 pubmed publisher
Lages C, Lewkowich I, Sproles A, Wills Karp M, Chougnet C. Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/?PD-L1 pathway. Aging Cell. 2010;9:785-98 pubmed publisher
Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, et al. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol. 2010;184:6133-41 pubmed publisher
Tomihara K, Guo M, Shin T, Sun X, Ludwig S, Brumlik M, et al. Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells. J Immunol. 2010;184:6151-60 pubmed publisher
Soudja S, Wehbe M, Mas A, Chasson L, de Tenbossche C, Huijbers I, et al. Tumor-initiated inflammation overrides protective adaptive immunity in an induced melanoma model in mice. Cancer Res. 2010;70:3515-25 pubmed publisher
Mitsui S, Torii K, Fukui H, Tsujimura K, Maeda A, Nose M, et al. The herbal medicine compound falcarindiol from Notopterygii Rhizoma suppresses dendritic cell maturation. J Pharmacol Exp Ther. 2010;333:954-60 pubmed publisher
Ishiwata K, Watanabe N, Guo M, Tomihara K, Brumlik M, Yagita H, et al. Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis. J Immunol. 2010;184:2086-94 pubmed publisher
Akbari O, Stock P, Singh A, Lombardi V, Lee W, Freeman G, et al. PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions. Mucosal Immunol. 2010;3:81-91 pubmed publisher
Colvin B, Sumpter T, Tokita D, Salati J, Mellor A, Thomson A. Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression. Hum Immunol. 2009;70:313-20 pubmed publisher
Siracusa M, Reece J, Urban J, Scott A. Dynamics of lung macrophage activation in response to helminth infection. J Leukoc Biol. 2008;84:1422-33 pubmed publisher
Sheng H, Wang Y, Jin Y, Zhang Q, Zhang Y, Wang L, et al. A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res. 2008;18:846-57 pubmed publisher
Movahedi K, Guilliams M, Van den Bossche J, Van den Bergh R, Gysemans C, Beschin A, et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood. 2008;111:4233-44 pubmed publisher
Stoitzner P, Tripp C, Douillard P, Saeland S, Romani N. Migratory Langerhans cells in mouse lymph nodes in steady state and inflammation. J Invest Dermatol. 2005;125:116-25 pubmed
Shin T, Yoshimura K, Shin T, Crafton E, Tsuchiya H, Housseau F, et al. In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. J Exp Med. 2005;201:1531-41 pubmed
de Heer H, Hammad H, Soullie T, Hijdra D, Vos N, Willart M, et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med. 2004;200:89-98 pubmed
Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, et al. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. J Exp Med. 2003;198:31-8 pubmed

product information

Product Type :

Antibody

Product Name :

CD273 (B7-DC) Monoclonal Antibody (TY25), PE, eBioscience™

Catalog # :

12-5986-83

Quantity :

200 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Mouse

Clone :

TY25

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. [UniProt]

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

B7 dendritic cell molecule; B7DC; B7-DC; bA574F11.2; Btdc; Butyrophilin B7-DC; butyrophilin-like protein; CD273; F730015O22Rik; MGC124039; MGC124040; PD1 ligand 2; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; PDCD1L2; PDCD1LG2; Pdl2; PD-L2; Programmed cell death 1 ligand 2; programmed death ligand 2