IFNAR1 Monoclonal Antibody (MAR1-5A3), PE, eBioscience™ | Invitrogen 12-5945-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IFNAR1 Monoclonal Antibody (MAR1-5A3), PE, eBioscience™

catalog :

12-5945-80

quantity :

25µg

price :

US 128

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

MAR1-5A3

reactivity :

mouse

application :

flow cytometry

citations: 4

Reference
Mahlakõiv T, Hernandez P, Gronke K, Diefenbach A, Staeheli P. Leukocyte-derived IFN-α/β and epithelial IFN-λ constitute a compartmentalized mucosal defense system that restricts enteric virus infections. PLoS Pathog. 2015;11:e1004782 pubmed publisher
Shahangian A, Chow E, Tian X, Kang J, Ghaffari A, Liu S, et al. Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Invest. 2009;119:1910-20 pubmed publisher
Miller J, Ma Y, Bian J, Sheehan K, Zachary J, Weis J, et al. A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice. J Immunol. 2008;181:8492-503 pubmed
Sheehan K, Lai K, Dunn G, Bruce A, Diamond M, Heutel J, et al. Blocking monoclonal antibodies specific for mouse IFN-alpha/beta receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection. J Interferon Cytokine Res. 2006;26:804-19 pubmed

product information

Product Type :

Antibody

Product Name :

IFNAR1 Monoclonal Antibody (MAR1-5A3), PE, eBioscience™

Catalog # :

12-5945-80

Quantity :

25µg

Price :

US 128

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.125 µg/test

Species :

Mouse

Clone :

MAR1-5A3

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 µg/test