This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
NK1.1 Monoclonal Antibody (PK136), PE, eBioscience™
catalog :
12-5941-63
quantity :
10 µg
price :
US 309.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
PK136
reactivity :
mouse
application :
flow cytometry
citations: 100
Reference
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Kawahara M, Hasegawa N, Takaku H. Murine Splenic Natural Killer Cells Do Not Develop Immunological Memory after Re-Encounter with Mycobacterium bovis BCG. PLoS ONE. 2016;11:e0152051 pubmed publisher
Ren J, Meng S, Yan B, Yu J, Liu J. Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation. Mol Med Rep. 2016;13:3627-38 pubmed publisher
Takeda K, Okumura K. Interferon-γ-Mediated Natural Killer Cell Activation by an Aqueous Panax ginseng Extract. Evid Based Complement Alternat Med. 2015;2015:603198 pubmed publisher
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Bardina S, Michlmayr D, Hoffman K, Obara C, Sum J, Charo I, et al. Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection. J Immunol. 2015;195:4306-18 pubmed publisher
Iwasaki M, LIEDTKE M, Gentles A, Cleary M. CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia. Cell Stem Cell. 2015;17:412-21 pubmed publisher
Krneta T, Gillgrass A, Chew M, Ashkar A. The breast tumor microenvironment alters the phenotype and function of natural killer cells. Cell Mol Immunol. 2016;13:628-39 pubmed publisher
Wu J, Waxman D. Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8+ T-cell responses and immune memory. Oncoimmunology. 2015;4:e1005521 pubmed
Tähtinen S, Kaikkonen S, Merisalo Soikkeli M, Grönberg Vähä Koskela S, Kanerva A, Parviainen S, et al. Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors. PLoS ONE. 2015;10:e0131242 pubmed publisher
Zhang J, Han C, Dai H, Hou J, Dong Y, Cui X, et al. Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury. J Am Soc Nephrol. 2016;27:92-106 pubmed publisher
Oczypok E, Milutinovic P, Alcorn J, Khare A, Crum L, Manni M, et al. Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells. J Allergy Clin Immunol. 2015;136:747-756.e4 pubmed publisher
Habbeddine M, Verbeke P, Karaz S, Bobé P, Kanellopoulos Langevin C. Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface. PLoS ONE. 2014;9:e107267 pubmed publisher
Zhou H, Yan H, Pan H, Hou K, Akk A, Springer L, et al. Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis. J Clin Invest. 2014;124:4363-74 pubmed publisher
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White A, Jenkinson W, Cowan J, Parnell S, Bacon A, Jones N, et al. An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells. J Immunol. 2014;192:2659-66 pubmed publisher
Yamamoto H, Nakamura Y, Sato K, Takahashi Y, Nomura T, Miyasaka T, et al. Defect of CARD9 leads to impaired accumulation of gamma interferon-producing memory phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans. Infect Immun. 2014;82:1606-15 pubmed publisher
Janotová T, Jalovecká M, Auerová M, Svecová I, Bruzlová P, Maierová V, et al. The use of anchored agonists of phagocytic receptors for cancer immunotherapy: B16-F10 murine melanoma model. PLoS ONE. 2014;9:e85222 pubmed publisher
Huang H, Nace G, McDonald K, Tai S, Klune J, Rosborough B, et al. Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection. Hepatology. 2014;59:1984-1997 pubmed publisher
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Rubinstein M, Salem M, Doedens A, Moore C, Chiuzan C, Rivell G, et al. G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses. J Hematol Oncol. 2013;6:75 pubmed publisher
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Gowda N, Wu X, Kumar S, Febbraio M, Gowda D. CD36 contributes to malaria parasite-induced pro-inflammatory cytokine production and NK and T cell activation by dendritic cells. PLoS ONE. 2013;8:e77604 pubmed publisher
Chen Y, Chen T, Pai L, Wesoly J, Bluyssen H, Lee C. A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors. J Exp Med. 2013;210:2515-22 pubmed publisher
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Ballas Z, Buchta C, Rosean T, Heusel J, Shey M. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS ONE. 2013;8:e65599 pubmed publisher
Carmenate T, Pacios A, Enamorado M, Moreno E, García Martínez K, Fuente D, et al. Human IL-2 mutein with higher antitumor efficacy than wild type IL-2. J Immunol. 2013;190:6230-8 pubmed publisher
Ma S, Richardson J, BitMansour A, Solberg T, Pidikiti R, Song K, et al. Partial depletion of regulatory T cells does not influence the inflammation caused by high dose hemi-body irradiation. PLoS ONE. 2013;8:e56607 pubmed publisher
Chamoto K, Gibney B, Lee G, Ackermann M, Konerding M, Tsuda A, et al. Migration of CD11b+ accessory cells during murine lung regeneration. Stem Cell Res. 2013;10:267-77 pubmed publisher
Sun B, Mallampati S, Gong Y, Wang D, Lefebvre V, Sun X. Sox4 is required for the survival of pro-B cells. J Immunol. 2013;190:2080-9 pubmed publisher
Yan X, Shichita T, Katsumata Y, Matsuhashi T, Ito H, Ito K, et al. Deleterious effect of the IL-23/IL-17A axis and ??T cells on left ventricular remodeling after myocardial infarction. J Am Heart Assoc. 2012;1:e004408 pubmed publisher
Cusick M, Libbey J, Patel D, Doty D, Fujinami R. Infiltrating macrophages are key to the development of seizures following virus infection. J Virol. 2013;87:1849-60 pubmed publisher
Sonn C, Choi J, Kim T, Yu Y, Kim K, Shin S, et al. Augmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2. J Radiat Res. 2012;53:823-9 pubmed publisher
Martins V, Ruggiero E, Schlenner S, Madan V, Schmidt M, Fink P, et al. Thymus-autonomous T cell development in the absence of progenitor import. J Exp Med. 2012;209:1409-17 pubmed publisher
Salmond R, Mirchandani A, Besnard A, Bain C, Thomson N, Liew F. IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin. J Allergy Clin Immunol. 2012;130:1159-1166.e6 pubmed publisher
Gowda N, Wu X, Gowda D. TLR9 and MyD88 are crucial for the development of protective immunity to malaria. J Immunol. 2012;188:5073-85 pubmed publisher
Zhang L, Cardinal J, Pan P, Rosborough B, Chang Y, Yan W, et al. Splenocyte apoptosis and autophagy is mediated by interferon regulatory factor 1 during murine endotoxemia. Shock. 2012;37:511-7 pubmed publisher
Doloff J, Waxman D. VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression. Cancer Res. 2012;72:1103-15 pubmed publisher
Rossi L, Avila D, Spallanzani R, Ziblat A, Fuertes M, Lapyckyj L, et al. Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. J Leukoc Biol. 2012;91:321-31 pubmed publisher
Bungartz G, Land H, Scadden D, Emerson S. NF-Y is necessary for hematopoietic stem cell proliferation and survival. Blood. 2012;119:1380-9 pubmed publisher
Whitmarsh R, Gray C, Gregg B, Christian D, May M, Murray P, et al. A critical role for SOCS3 in innate resistance to Toxoplasma gondii. Cell Host Microbe. 2011;10:224-36 pubmed publisher
Gowda N, Wu X, Gowda D. The nucleosome (histone-DNA complex) is the TLR9-specific immunostimulatory component of Plasmodium falciparum that activates DCs. PLoS ONE. 2011;6:e20398 pubmed publisher
Liu Y, Tuve S, Persson J, Beyer I, Yumul R, Li Z, et al. Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models. Cancer Gene Ther. 2011;18:407-18 pubmed publisher
Mortensen M, Soilleux E, Djordjevic G, Tripp R, Lutteropp M, Sadighi Akha E, et al. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med. 2011;208:455-67 pubmed publisher
Subleski J, Hall V, Wolfe T, Scarzello A, Weiss J, Chan T, et al. TCR-dependent and -independent activation underlie liver-specific regulation of NKT cells. J Immunol. 2011;186:838-47 pubmed publisher
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Fang X, Du P, Liu Y, Tang J. Efficient isolation of mouse liver NKT cells by perfusion. PLoS ONE. 2010;5:e10288 pubmed publisher
Nakamura R, Maeda N, Shibata K, Yamada H, Kase T, Yoshikai Y. Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury. J Virol. 2010;84:5574-82 pubmed publisher
Gonzalez M, Plummer E, Rae C, Manchester M. Interaction of Cowpea mosaic virus (CPMV) nanoparticles with antigen presenting cells in vitro and in vivo. PLoS ONE. 2009;4:e7981 pubmed publisher
Kinsey G, Sharma R, Huang L, Li L, Vergis A, Ye H, et al. Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury. J Am Soc Nephrol. 2009;20:1744-53 pubmed publisher
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French J, Roark C, Born W, O Brien R. Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin. J Immunol. 2009;182:1892-900 pubmed publisher
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Wintermeyer P, Cheng C, Gehring S, Hoffman B, Holub M, Brossay L, et al. Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage. Gastroenterology. 2009;136:1048-59 pubmed publisher
Gilfillan S, Chan C, Cella M, Haynes N, Rapaport A, Boles K, et al. DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J Exp Med. 2008;205:2965-73 pubmed publisher
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Lappas C, Day Y, Marshall M, Engelhard V, Linden J. Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. J Exp Med. 2006;203:2639-48 pubmed
Zhang H, Huang W. Fusion proteins of Hsp70 with tumor-associated antigen acting as a potent tumor vaccine and the C-terminal peptide-binding domain of Hsp70 being essential in inducing antigen-independent anti-tumor response in vivo. Cell Stress Chaperones. 2006;11:216-26 pubmed
Wang J, Sun R, Wei H, Dong Z, Gao B, Tian Z. Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism. J Hepatol. 2006;44:446-54 pubmed
French J, Roark C, Born W, O Brien R. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A. 2005;102:14741-6 pubmed
Wu D, Segal N, Sidobre S, Kronenberg M, Chapman P. Cross-presentation of disialoganglioside GD3 to natural killer T cells. J Exp Med. 2003;198:173-81 pubmed
product information
Product Type :
Antibody
Product Name :
NK1.1 Monoclonal Antibody (PK136), PE, eBioscience™
Catalog # :
12-5941-63
Quantity :
10 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Mouse
Clone :
PK136
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
NK1.1 (Killer cell lectin-like receptor subfamily B, member 1, KLRB1, NKR-P1A, CD161, cluster of differentiation 161), refers to Natural Killer (NK) cells, lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
AI462337; CD161; CD161 antigen-like family member B; CD161 antigen-like family member C; CD161b; CD161c; EMBL:AAQ11375.1}; Inhibitory receptor NKR-P1B; killer cell lectin-like receptor subfamily A member 1C; killer cell lectin-like receptor subfamily B member 1B; Killer cell lectin-like receptor subfamily B member 1B allele A; killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1B allele C; killer cell lectin-like receptor subfamily B member 1C; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1F; KLRB1; Klrb1b; klrb1b {ECO:0000312; Klrb1c; Klrb1d; Klrb1f; klrb1f {ECO:0000250; Ly55; Ly-55; Ly55b; ly-55b; Ly55c; Ly-55c; Ly55d; Ly-55d; Ly59; Ly-59; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus C; lymphocyte antigen 55 complex, locus D; lymphocyte antigen 55b; Lymphocyte antigen 55c; lymphocyte antigen 55d; lymphocyte antigen 59; MGC163757; MGC163759; natural killer cell receptor protein NKR-P1B; natural killer cell receptor protein NKR-P1C; natural killer cell receptor-P1; natural killer cell surface protein NKR-P1B allele B6; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele SJL/BALB; natural killer cell surface protein NKR-P1B allele TO; Natural killer cell surface protein NKR-P1F; natural killer cell surface protein P1-40; natural killer cell-associated antigen 1; natural killer cells; nk cells; Nk1; Nk-1; NK1.1; Nk1.2; Nk-1.2; NKRP1; NK-RP1; NKR-P1 34; NKR-P1 40; NKR-P1.9; NKRP140; Nkrp1b; Nkr-p1b; Nkrp1-b; NKR-P1B protein; Nkrp1c; NKR-P1C; Nkrp1d; NKR-P1D; Nkrp1f; NKR-P1F; RGD:2975}; UniProtKB:Q8VD98}
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA