CD137 Ligand (4-1BB Ligand) Monoclonal Antibody (TKS-1), PE, eBioscience | Invitrogen 12-5901-83 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD137 Ligand (4-1BB Ligand) Monoclonal Antibody (TKS-1), PE, eBioscience

catalog :

12-5901-83

quantity :

200 ug

price :

US 399.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

TKS-1

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 5	Zheng G, Wang B, Chen A. The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. J Immunol. 2004;173:2428-34 pubmed
	Kang S, Lee S, Park S, Kim J, Kim H, Lee H, et al. Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand. Cancer Res. 2017;77:5989-6000 pubmed publisher
	Shrestha S, Noh J, Kim S, Ham H, Kim Y, Yun Y, et al. Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype. Oncoimmunology. 2016;5:e1067744 pubmed
	Madireddi S, Eun S, Lee S, Nemčovičová I, Mehta A, Zajonc D, et al. Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies. J Exp Med. 2014;211:1433-48 pubmed publisher
	Hagman D, Kuzma J, Larson I, Foster Schubert K, Kuan L, Cignarella A, et al. Characterizing and quantifying leukocyte populations in human adipose tissue: impact of enzymatic tissue processing. J Immunol Methods. 2012;386:50-9 pubmed publisher
	Bak S, Barnkob M, Bai A, Higham E, Wittrup K, Chen J. Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells. J Immunol. 2012;189:1708-16 pubmed publisher
	Inamine A, Sakurai D, Horiguchi S, Yonekura S, Hanazawa T, Hosokawa H, et al. Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells. Clin Immunol. 2012;143:170-9 pubmed publisher
	Otani T, Tsuji Takayama K, Okochi A, Yamamoto M, Takeuchi M, Yamasaki F, et al. Stromal cells' B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifunctional regulatory T-cell line. Immunol Cell Biol. 2011;89:246-54 pubmed publisher
	Frasca L, Stonier S, Overwijk W, Schluns K. Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types. J Leukoc Biol. 2010;88:69-78 pubmed publisher
	McWilliams J, Sanchez P, Haluszczak C, Gapin L, Kedl R. Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunity. Vaccine. 2010;28:1468-76 pubmed publisher
	Yan X, Johnson B, Orentas R. Induction of a VLA-2 (CD49b)-expressing effector T cell population by a cell-based neuroblastoma vaccine expressing CD137L. J Immunol. 2008;181:4621-31 pubmed
	Jiang D, Chen Y, Schwarz H. CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol. 2008;181:3923-32 pubmed
	Shao Z, Sun F, Koh D, Schwarz H. Characterisation of soluble murine CD137 and its association with systemic lupus. Mol Immunol. 2008;45:3990-9 pubmed publisher
	He T, Zong S, Wu X, Wei Y, Xiang J. CD4+ T cell acquisition of the bystander pMHC I colocalizing in the same immunological synapse comprising pMHC II and costimulatory CD40, CD54, CD80, OX40L, and 41BBL. Biochem Biophys Res Commun. 2007;362:822-8 pubmed
	Sanchez P, McWilliams J, Haluszczak C, Yagita H, Kedl R. Combined TLR/CD40 stimulation mediates potent cellular immunity by regulating dendritic cell expression of CD70 in vivo. J Immunol. 2007;178:1564-72 pubmed
	Stagg J, Pommey S, Eliopoulos N, Galipeau J. Interferon-gamma-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell. Blood. 2006;107:2570-7 pubmed

product information

Product Type :

Antibody

Product Name :

CD137 Ligand (4-1BB Ligand) Monoclonal Antibody (TKS-1), PE, eBioscience

Catalog # :

12-5901-83

Quantity :

200 ug

Price :

US 399.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 ug/test

Species :

Mouse

Clone :

TKS-1

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/test

Aliases :

4 1 BB Ligand; 4 1 BBL; 41BB Ligand; 4-1BB ligand; 41BBL; 4-1BBL; 4-1BB-L; AI848817; CD 137 Ligand; CD 137L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1BB-L; Ly63l; receptor 4-1BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9

more info or order :

Invitrogen product webpage