product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
NKG2AB6 Monoclonal Antibody (16a11), PE, eBioscience
catalog :
12-5897-81
quantity :
50 ug
price :
US 143.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
16A11
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 27
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 2a
Abadie V, Kim S, Lejeune T, Palanski B, Ernest J, Tastet O, et al. IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease. Nature. 2020;578:600-604 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6e
Bern M, Parikh B, Yang L, Beckman D, Poursine Laurent J, Yokoyama W. Inducible down-regulation of MHC class I results in natural killer cell tolerance. J Exp Med. 2019;216:99-116 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Bern M, Beckman D, Ebihara T, Taffner S, Poursine Laurent J, White J, et al. Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor. Proc Natl Acad Sci U S A. 2017;114:E8440-E8447 pubmed publisher
Han Q, Mu Y, Zhao H, Zhao R, Guo Q, Su Y, et al. Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells. World J Gastroenterol. 2021;27:3581-3594 pubmed publisher
Zhang X, Feng J, Chen S, Yang H, Dong Z. Synergized regulation of NK cell education by NKG2A and specific Ly49 family members. Nat Commun. 2019;10:5010 pubmed publisher
Cong J, Wang X, Zheng X, Wang D, Fu B, Sun R, et al. Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metab. 2018;28:243-255.e5 pubmed publisher
Krzywinska E, Kantari Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, et al. Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis. Nat Commun. 2017;8:1597 pubmed publisher
Krneta T, Gillgrass A, Chew M, Ashkar A. The breast tumor microenvironment alters the phenotype and function of natural killer cells. Cell Mol Immunol. 2016;13:628-39 pubmed publisher
Sullivan R, Fogel L, Leong J, Schneider S, Wong R, Romee R, et al. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013;191:5904-13 pubmed publisher
Ding L, Chen T, Wang X, Zhou L, Shi A, Ning Q. CD69+NK cells contribute to the murine hepatitis virus strain 3-induced murine hepatitis. J Huazhong Univ Sci Technolog Med Sci. 2013;33:505-510 pubmed publisher
Liu R, Engels B, Schreiber K, Ciszewski C, Schietinger A, Schreiber H, et al. IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner. Proc Natl Acad Sci U S A. 2013;110:8158-63 pubmed publisher
Wu X, Chen Y, Wei H, Sun R, Tian Z. Development of murine hepatic NK cells during ontogeny: comparison with spleen NK cells. Clin Dev Immunol. 2012;2012:759765 pubmed publisher
Huarte E, Rynda Apple A, Riccardi C, Skyberg J, Golden S, Rollins M, et al. Tolerogen-induced interferon-producing killer dendritic cells (IKDCs) protect against EAE. J Autoimmun. 2011;37:328-41 pubmed publisher
Barao I, Alvarez M, Ames E, Orr M, Stefanski H, Blazar B, et al. Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC. Blood. 2011;117:7032-41 pubmed publisher
Jonsson A, Yang L, Kim S, Taffner S, Yokoyama W. Effects of MHC class I alleles on licensing of Ly49A+ NK cells. J Immunol. 2010;184:3424-32 pubmed publisher
Chalifour A, Scarpellino L, Back J, Brodin P, Devevre E, Gros F, et al. A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education. Immunity. 2009;30:337-47 pubmed publisher
French J, Roark C, Born W, O Brien R. Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin. J Immunol. 2009;182:1892-900 pubmed publisher
Chen X, Priatel J, Chow M, Teh H. Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice. J Immunol. 2008;180:5973-82 pubmed
Kemball C, Szomolanyi Tsuda E, Lukacher A. Allogeneic differences in the dependence on CD4+ T-cell help for virus-specific CD8+ T-cell differentiation. J Virol. 2007;81:13743-53 pubmed
Rogers S, Rouhi A, Takei F, Mager D. A role for DNA hypomethylation and histone acetylation in maintaining allele-specific expression of mouse NKG2A in developing and mature NK cells. J Immunol. 2006;177:414-21 pubmed
Kemball C, Lee E, Szomolanyi Tsuda E, Pearson T, Larsen C, Lukacher A. Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection. J Immunol. 2006;176:1814-24 pubmed
Fraser K, Gays F, Robinson J, Van Beneden K, Leclercq G, Vance R, et al. NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2. Eur J Immunol. 2002;32:868-78 pubmed
Vance R, Jamieson A, Cado D, Raulet D. Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc Natl Acad Sci U S A. 2002;99:868-73 pubmed
Kraft J, Vance R, Pohl J, Martin A, Raulet D, Jensen P. Analysis of Qa-1(b) peptide binding specificity and the capacity of CD94/NKG2A to discriminate between Qa-1-peptide complexes. J Exp Med. 2000;192:613-24 pubmed
Vance R, Jamieson A, Raulet D. Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J Exp Med. 1999;190:1801-12 pubmed
Vance R, Kraft J, Altman J, Jensen P, Raulet D. Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J Exp Med. 1998;188:1841-8 pubmed
Vance R, Tanamachi D, Hanke T, Raulet D. Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J Immunol. 1997;27:3236-41 pubmed
product information
Product Type :
Antibody
Product Name :
NKG2AB6 Monoclonal Antibody (16a11), PE, eBioscience
Catalog # :
12-5897-81
Quantity :
50 ug
Price :
US 143.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 ug/test
Species :
Mouse
Clone :
16a11
Isotype :
IgG2b, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test
Aliases :
CD159 antigen-like family member A; CD159A; C-lectin type II protein; Cluster of Differentiation 159a; killer cell lectin like receptor C1; killer cell lectin-like receptor subfamily C, member 1; Klrc1; natural killer cell lectin; natural killer group protein 2; NK cell receptor A; NKG2; NKG2-1/B activating NK receptor; NKG2A; NKG2-A/B type II integral membrane protein; NKG2-A/B-activating NK receptor; NKG2-A/NKG2-B type II integral membrane protein; NKG2B; rNKG2A
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA