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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD273 (B7-DC) Monoclonal Antibody (MIH18), PE, eBioscience
catalog :
12-5888-42
quantity :
100 Tests
price :
US 329.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
MIH18
reactivity :
human, mouse
application :
western blot, flow cytometry
more info or order :
Invitrogen product webpage
citations: 39
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human
O Regan N, Steinfelder S, Venugopal G, Rao G, Lucius R, Srikantam A, et al. Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses. PLoS Negl Trop Dis. 2014;8:e3206 pubmed publisher
  • western blot; mouse
Raptopoulou A, Bertsias G, Makrygiannakis D, Verginis P, Kritikos I, Tzardi M, et al. The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis. Arthritis Rheum. 2010;62:1870-80 pubmed publisher
Wan Y, Mu X, Zhao J, Li L, Xu W, Zhang M. Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression. Biomed Rep. 2024;20:68 pubmed publisher
Le Y, Gao H, Le J, Hornick J, Bleday R, Wee J, et al. VentX promotes tumor specific immunity and efficacy of immune checkpoint inhibitors. iScience. 2024;27:108731 pubmed publisher
Ogawa T, Kan O K, Shiota A, Fujita A, Ishii Y, Fukuyama S, et al. Inhibition of PI3Kδ Differentially Regulates Poly I:C- and Human Metapneumovirus-Induced PD-L1 and PD-L2 Expression in Human Bronchial Epithelial Cells. Front Immunol. 2021;12:767666 pubmed publisher
O Connor R, Chauhan V, Mathieson L, Titmarsh H, Koppensteiner L, Young I, et al. T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer. Oncoimmunology. 2021;10:1940675 pubmed publisher
Baruah P, Bullenkamp J, Wilson P, Lee M, Kaski J, Dumitriu I. TLR9 Mediated Tumor-Stroma Interactions in Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinoma Up-Regulate PD-L1 and PD-L2. Front Immunol. 2019;10:1644 pubmed publisher
Bailey K, Julian C, Klinghoffer A, Bernard H, Lucas P, McAllister Lucas L. EWS-FLI1 low Ewing sarcoma cells demonstrate decreased susceptibility to T-cell-mediated tumor cell apoptosis. Oncotarget. 2019;10:3385-3399 pubmed publisher
Ren T, Zheng B, Huang Y, Wang S, Bao X, Liu K, et al. Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways. Cell Death Dis. 2019;10:261 pubmed publisher
Martin A, Nirschl C, Polanczyk M, Bell W, Nirschl T, Harris Bookman S, et al. PD-L1 expression in medulloblastoma: an evaluation by subgroup. Oncotarget. 2018;9:19177-19191 pubmed publisher
Zheng B, Ren T, Huang Y, Sun K, Wang S, Bao X, et al. PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse. J Hematol Oncol. 2018;11:16 pubmed publisher
Kaisar M, Pelgrom L, van der Ham A, Yazdanbakhsh M, Everts B. Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells via both Histone Deacetylase Inhibition and G Protein-Coupled Receptor 109A Signaling. Front Immunol. 2017;8:1429 pubmed publisher
Mladenov R, Hristodorov D, Cremer C, Gresch G, Grieger E, Schenke L, et al. CD64-directed microtubule associated protein tau kills leukemic blasts ex vivo. Oncotarget. 2016;7:67166-67174 pubmed publisher
Martin A, Nirschl T, Nirschl C, Francica B, Kochel C, Van Bokhoven A, et al. Paucity of PD-L1 expression in prostate cancer: innate and adaptive immune resistance. Prostate Cancer Prostatic Dis. 2015;18:325-32 pubmed publisher
Demoulin S, Somja J, Duray A, Guénin S, Roncarati P, Delvenne P, et al. Cervical (pre)neoplastic microenvironment promotes the emergence of tolerogenic dendritic cells via RANKL secretion. Oncoimmunology. 2015;4:e1008334 pubmed
Planès R, BenMohamed L, Leghmari K, Delobel P, Izopet J, Bahraoui E. HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms. J Virol. 2014;88:6672-89 pubmed publisher
Knol A, Nguyen J, Pandolfino M, Quereux G, Brocard A, Peuvrel L, et al. Tissue biomarkers in melanoma patients treated with TIL. PLoS ONE. 2012;7:e48729 pubmed publisher
Frick S, Bacher N, Baier G, Mailänder V, Landfester K, Steinbrink K. Functionalized polystyrene nanoparticles trigger human dendritic cell maturation resulting in enhanced CD4+ T cell activation. Macromol Biosci. 2012;12:1637-47 pubmed publisher
Lichtenegger F, Mueller K, Otte B, Beck B, Hiddemann W, Schendel D, et al. CD86 and IL-12p70 are key players for T helper 1 polarization and natural killer cell activation by Toll-like receptor-induced dendritic cells. PLoS ONE. 2012;7:e44266 pubmed publisher
Kleijwegt F, Laban S, Duinkerken G, Joosten A, Koeleman B, Nikolic T, et al. Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells. J Immunol. 2011;187:6357-64 pubmed publisher
Wang B, Bao J, Wang J, Wang Y, Jiang M, Xing M, et al. Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma. World J Gastroenterol. 2011;17:3322-9 pubmed publisher
Kim Y, Park S, Broxmeyer H. Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction. J Immunol. 2011;187:2291-301 pubmed publisher
Morbach H, Wiegering V, Richl P, Schwarz T, Suffa N, Eichhorn E, et al. Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis. Arthritis Rheum. 2011;63:3458-66 pubmed publisher
Andorsky D, Yamada R, Said J, Pinkus G, Betting D, Timmerman J. Programmed death ligand 1 is expressed by non-hodgkin lymphomas and inhibits the activity of tumor-associated T cells. Clin Cancer Res. 2011;17:4232-44 pubmed publisher
Banerjee S, Lin C, Skinner K, Schiffhauer L, Peacock J, Hicks D, et al. Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression. Cancer Res. 2011;71:318-27 pubmed publisher
Cabezón R, Sintes J, Llinàs L, Benitez Ribas D. Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. Immunol Lett. 2011;134:167-73 pubmed publisher
Hsu M, Hsiao J, Chang K, Wu Y, Su I, Jin Y, et al. Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Mod Pathol. 2010;23:1393-403 pubmed publisher
Alvarez I, Pasquinelli V, Jurado J, Abbate E, Musella R, de la Barrera S, et al. Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis. J Infect Dis. 2010;202:524-32 pubmed publisher
Cavaleiro R, Baptista A, Soares R, Tendeiro R, Foxall R, Gomes P, et al. Major depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV disease. PLoS Pathog. 2009;5:e1000667 pubmed publisher
Leitner J, Klauser C, Pickl W, Stockl J, Majdic O, Bardet A, et al. B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction. Eur J Immunol. 2009;39:1754-64 pubmed publisher
Fourcade J, Kudela P, Sun Z, Shen H, Land S, Lenzner D, et al. PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients. J Immunol. 2009;182:5240-9 pubmed publisher
Kinter A, Godbout E, McNally J, Sereti I, Roby G, O Shea M, et al. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol. 2008;181:6738-46 pubmed
Yang W, Li H, Chen P, Alizadeh H, He Y, Hogan R, et al. PD-L1 expression on human ocular cells and its possible role in regulating immune-mediated ocular inflammation. Invest Ophthalmol Vis Sci. 2009;50:273-80 pubmed publisher
Gröschel S, Piggott K, Vaglio A, Ma Krupa W, Singh K, Goronzy J, et al. TLR-mediated induction of negative regulatory ligands on dendritic cells. J Mol Med (Berl). 2008;86:443-55 pubmed publisher
Waggoner S, Hall C, Hahn Y. HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4+ T cells via suppression of dendritic cell IL-12 production. J Leukoc Biol. 2007;82:1407-19 pubmed
Geng L, Jiang G, Fang Y, Dong S, Xie H, Chen Y, et al. B7-H1 expression is upregulated in peripheral blood CD14+ monocytes of patients with chronic hepatitis B virus infection, which correlates with higher serum IL-10 levels. J Viral Hepat. 2006;13:725-33 pubmed
Pfistershammer K, Klauser C, Pickl W, Stockl J, Leitner J, Zlabinger G, et al. No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. Eur J Immunol. 2006;36:1104-13 pubmed
Methe H, Nugent H, Groothuis A, Seifert P, Sayegh M, Edelman E. Matrix embedding alters the immune response against endothelial cells in vitro and in vivo. Circulation. 2005;112:I89-95 pubmed
Azam P, Peiffer J, Chamousset D, Tissier M, Bonnet P, Vian L, et al. The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers. Toxicol Appl Pharmacol. 2006;212:14-23 pubmed
product information
Product Type :
Antibody
Product Name :
CD273 (B7-DC) Monoclonal Antibody (MIH18), PE, eBioscience
Catalog # :
12-5888-42
Quantity :
100 Tests
Price :
US 329.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.125 ug)/test
Species :
Human
Clone :
MIH18
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Programmed death-ligand 2 (PD-L2), or B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily that, along with programmed death-ligand 1 (PD-L1), acts as a ligand for programmed cell death protein 1 (PD-1). Though expressed primarily in dendritic cells, PD-L2 expression can be induced on a wide variety of immune and non-immune cells depending on the microenvironment. PD-L2 expression is particularly upregulated in the presence of Th2 cytokine, IL-4, as well as Th1 cytokines, TNF-alpha and IFN-gamma to a lesser degree. While generally expressed at lower levels compared to PD-L1, PD-L2 demonstrates a 2 to 6 times higher relative affinity to PD-1 than PD-L1. PD-1 and its ligands are referred to as inhibitory immune checkpoint molecules in that they provide useful negative feedback during physiological homeostasis. Ligation of PD-L2 or PD-L1 inhibits activation, proliferation, and cytokine secretion (e.g. IFN-gamma, IL-10) in T cells, ultimately dampening immune response. Conversely, studies have shown that PD-L2 can also stimulate T cell proliferation and cytokine production, even in PD-1-deficient T cells, suggesting additional receptors. Recent studies have concluded that PD-L2 also binds to a second receptor, repulsive guidance molecule b (RGMb), which was originally identified as a receptor for bone morphogenetic proteins (BMPs). RGMb is expressed in the central nervous system, as well as in macrophages, however, its role in immunity is only beginning to emerge. Interaction between PD-L2 and RGMb regulates the development of respiratory tolerance in the lung through BMP and/or neogenin signaling pathways. The naturally occurring human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.125 ug)/test
Aliases :
B7 dendritic cell molecule; B7DC; B7-DC; bA574F11.2; Btdc; Butyrophilin B7-DC; butyrophilin-like protein; CD273; F730015O22Rik; MGC124039; MGC124040; PD1 ligand 2; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; PDCD1L2; Pdcd1lg2; Pdl2; PD-L2; Programmed cell death 1 ligand 2; programmed death ligand 2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA