This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Ly-49H Monoclonal Antibody (3D10), PE, eBioscience
catalog :
12-5886-82
quantity :
100 ug
price :
US 259.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
3D10

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 18
Reference
Vetters J, van Helden M, De Nolf C, Rennen S, Cloots E, Van De Velde E, et al. Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection. iScience. 2023;26:108570 pubmed publisher
Ro x17e mani x107 C, Lisni x107 B, Pribani x107 Mate x161 i x107 M, Mihali x107 A, Hir x161 l L, Park E, et al. Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells. Nat Commun. 2023;14:6412 pubmed publisher
Li Z, Morman R, Hegermiller E, Sun M, Bartom E, Maienschein Cline M, et al. The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude. J Exp Med. 2021;218: pubmed publisher
Yang E, Singh B, Paustian A, Kambayashi T. Diacylglycerol Kinase ? Is a Target To Enhance NK Cell Function. J Immunol. 2016;197:934-41 pubmed publisher
Sullivan R, Fogel L, Leong J, Schneider S, Wong R, Romee R, et al. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013;191:5904-13 pubmed publisher
Merino E, Abeyweera T, Firth M, Zawislak C, Basu R, Liu X, et al. Protein kinase C-? clustering at immunological synapses amplifies effector responses in NK cells. J Immunol. 2012;189:4859-69 pubmed publisher
Lee G, Liou Y, Wang S, Ko K, Jiang S, Liao N. Different NK cell developmental events require different levels of IL-15 trans-presentation. J Immunol. 2011;187:1212-21 pubmed publisher
Busche A, Schmitz S, Fleige H, Robbins S, Walzer T, Stewart C, et al. Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection. J Immunol. 2011;186:2918-25 pubmed publisher
Eckelhart E, Warsch W, Zebedin E, Simma O, Stoiber D, Kolbe T, et al. A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development. Blood. 2011;117:1565-73 pubmed publisher
Beilke J, Benjamin J, Lanier L. The requirement for NKG2D in NK cell-mediated rejection of parental bone marrow grafts is determined by MHC class I expressed by the graft recipient. Blood. 2010;116:5208-16 pubmed publisher
Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold C, et al. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci U S A. 2010;107:9759-64 pubmed publisher
Fodil Cornu N, Pyzik M, Vidal S. Use of inbred mouse strains to map recognition receptors of MCMV infected cells in the NK cell gene locus. Methods Mol Biol. 2010;612:393-409 pubmed publisher
Orr M, Sun J, Hesslein D, Arase H, Phillips J, Takai T, et al. Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection. J Exp Med. 2009;206:807-17 pubmed publisher
Chen S, Kawashima H, Lowe J, Lanier L, Fukuda M. Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment. J Exp Med. 2005;202:1679-89 pubmed
Caraux A, Kim N, Bell S, Zompi S, Ranson T, Lesjean Pottier S, et al. Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. Blood. 2006;107:994-1002 pubmed
Tassi I, Presti R, Kim S, Yokoyama W, Gilfillan S, Colonna M. Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol. 2005;175:749-54 pubmed
Brown M, Dokun A, Heusel J, Smith H, Beckman D, Blattenberger E, et al. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science. 2001;292:934-7 pubmed
Smith H, Chuang H, Wang L, Salcedo M, Heusel J, Yokoyama W. Nonstochastic coexpression of activation receptors on murine natural killer cells. J Exp Med. 2000;191:1341-54 pubmed
product information
Product Type :
Antibody
Product Name :
Ly-49H Monoclonal Antibody (3D10), PE, eBioscience
Catalog # :
12-5886-82
Quantity :
100 ug
Price :
US 259.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Mouse
Clone :
3D10
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Ly49H is a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly49H, like Ly49D, lacks the characteristic ITAM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly49H is expressed in a subset of NK cells but not NKT (NK1.1/CD3+) cells. Natural killer cells can express several Ly49 proteins.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
Cmv1; Cmv-1; cytomegalovirus resistance 1; killer cell lectin-like receptor 8; killer cell lectin-like receptor, subfamily A, member 8; Klra8; Ly49H; Ly-49h; Ly49-h; Ly49u ; Lymphocyte antigen 49h; T-cell surface glycoprotein Ly-49H
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA