CD366 (TIM3) Monoclonal Antibody (8B.2C12), PE, eBioscience™ | Invitrogen 12-5871-83 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD366 (TIM3) Monoclonal Antibody (8B.2C12), PE, eBioscience™

catalog :

12-5871-83

quantity :

200 µg

price :

US 309.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

8B.2C12

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 1a	Wang H, Zhu X, Qin L, Qian H, Wang Y. Microglia activity modulated by T cell Ig and mucin domain protein 3 (Tim-3). Cell Immunol. 2015;293:49-58 pubmed publisher
flow cytometry; mouse; 1:200	Burton B, Britton G, Fang H, Verhagen J, Smithers B, Sabatos Peyton C, et al. Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy. Nat Commun. 2014;5:4741 pubmed publisher
	Arce Vargas F, Furness A, Litchfield K, Joshi K, Rosenthal R, Ghorani E, et al. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018;33:649-663.e4 pubmed publisher
	Liu Z, Ravindranathan R, Kalinski P, Guo Z, Bartlett D. Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy. Nat Commun. 2017;8:14754 pubmed publisher
	Liu J, Blake S, Harjunpää H, Fairfax K, Yong M, Allen S, et al. Assessing Immune-Related Adverse Events of Efficacious Combination Immunotherapies in Preclinical Models of Cancer. Cancer Res. 2016;76:5288-301 pubmed publisher
	Hou H, Liu W, Wu S, Lu Y, Peng J, Zhu Y, et al. Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock. PLoS ONE. 2014;9:e110585 pubmed publisher
	Deakin A, Duddy G, Wilson S, Harrison S, Latcham J, Fulleylove M, et al. Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target. PLoS ONE. 2014;9:e107490 pubmed publisher
	Frisancho Kiss S, Nyland J, Davis S, Barrett M, Gatewood S, Njoku D, et al. Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J Immunol. 2006;176:6411-5 pubmed
	Beauregard C, Stevens C, Mayhew E, Niederkorn J. Cutting edge: atopy promotes Th2 responses to alloantigens and increases the incidence and tempo of corneal allograft rejection. J Immunol. 2005;174:6577-81 pubmed

product information

Product Type :

Antibody

Product Name :

CD366 (TIM3) Monoclonal Antibody (8B.2C12), PE, eBioscience™

Catalog # :

12-5871-83

Quantity :

200 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.06 µg/test

Species :

Mouse

Clone :

8B.2C12

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.06 µg/test

Aliases :

CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3

more info or order :

Invitrogen product webpage