Ly-49A Monoclonal Antibody (A1 (Ly49A)), PE, eBioscience™ | Invitrogen 12-5856-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ly-49A Monoclonal Antibody (A1 (Ly49A)), PE, eBioscience™

catalog :

12-5856-82

quantity :

100 µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

A1 (Ly49A)

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s1a	Abel A, Tiwari A, Gerbec Z, Siebert J, Yang C, Schloemer N, et al. IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells. Front Immunol. 2018;9:1168 pubmed publisher
flow cytometry; mouse; 1:100; loading ...; fig 3d	Ohs I, Van Den Broek M, Nussbaum K, MUNZ C, Arnold S, Quezada S, et al. Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis. Nat Commun. 2016;7:13708 pubmed publisher
	Zhang X, Feng J, Chen S, Yang H, Dong Z. Synergized regulation of NK cell education by NKG2A and specific Ly49 family members. Nat Commun. 2019;10:5010 pubmed publisher
	Yang M, Chen S, Du J, He J, Wang Y, Li Z, et al. NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nat Commun. 2016;7:12730 pubmed publisher
	Sullivan R, Fogel L, Leong J, Schneider S, Wong R, Romee R, et al. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013;191:5904-13 pubmed publisher
	Pyzik M, Charbonneau B, Gendron Pontbriand E, Babic M, Krmpotic A, Jonjic S, et al. Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains. J Exp Med. 2011;208:1105-17 pubmed publisher
	Beldi G, Banz Y, Kroemer A, Sun X, Wu Y, Graubardt N, et al. Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice. Hepatology. 2010;51:1702-11 pubmed publisher
	Croy B, Zhang J, Tayade C, Colucci F, Yadi H, Yamada A. Analysis of uterine natural killer cells in mice. Methods Mol Biol. 2010;612:465-503 pubmed publisher
	Lucas M, Vonarbourg C, Aichele P, Diefenbach A. Studying NK cell/dendritic cell interactions. Methods Mol Biol. 2010;612:97-126 pubmed publisher
	Guo H, Samarakoon A, Vanhaesebroeck B, Malarkannan S. The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation. J Exp Med. 2008;205:2419-35 pubmed publisher
	Malarkannan S, Regunathan J, Chu H, Kutlesa S, Chen Y, Zeng H, et al. Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation. J Immunol. 2007;179:3752-62 pubmed
	Hesslein D, Takaki R, Hermiston M, Weiss A, Lanier L. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc Natl Acad Sci U S A. 2006;103:7012-7 pubmed
	Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, et al. Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr. Blood. 2006;107:3647-55 pubmed
	Robbins S, Tessmer M, Van Kaer L, Brossay L. Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation. Eur J Immunol. 2005;35:757-65 pubmed
	Ortaldo J, Winkler Pickett R, Mason A, Mason L. The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells. J Immunol. 1998;160:1158-65 pubmed
	Mason L, Gosselin P, Anderson S, Fogler W, Ortaldo J, McVicar D. Differential tyrosine phosphorylation of inhibitory versus activating Ly-49 receptor proteins and their recruitment of SHP-1 phosphatase. J Immunol. 1997;159:4187-96 pubmed

product information

Product Type :

Antibody

Product Name :

Ly-49A Monoclonal Antibody (A1 (Ly49A)), PE, eBioscience™

Catalog # :

12-5856-82

Quantity :

100 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Mouse

Clone :

A1 (Ly49A)

Isotype :

IgG2a

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

KLRA1 (also known and Ly49L) is a member of the LY49 family of receptors Natural killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA1 is thought to be an activating receptor, inducing DAP12 phosphorylation in response to antibody-mediated cross-linking of KLRA1 on NK cells. At least three isoforms of KLRA1 are known to exist.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

A1; CH29-493D4.3; class I MHC receptor KLRA22; killer cell lectin like receptor A1, pseudogene; killer cell lectin-like receptor 2; killer cell lectin-like receptor, subfamily A, member 1; killer cell lectin-like receptor, subfamily A, member 2; KLRA#; KLRA1; KLRA1P; Klra2; Klra22; KLRAP1; Ly49; Ly49 inhibitory receptor 8; Ly49a; ly-49a; Ly49i8; LY49L; Ly-49L; Ly49o ; Ly49v; lymphocyte antigen 49a; natural killer cell receptor Ly49A; novel killer cell lectin-like receptor subfamily A protein; t lymphocyte antigen A1; T-cell surface glycoprotein YE1/48

more info or order :

Invitrogen product webpage