IRF7 Monoclonal Antibody (MNGPKL), PE, eBioscience | Invitrogen 12-5829-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IRF7 Monoclonal Antibody (MNGPKL), PE, eBioscience

catalog :

12-5829-80

quantity :

25 ug

price :

US 147.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

MNGPKL

reactivity :

mouse

application :

flow cytometry

citations: 5

Reference
Kanno T, Konno R, Miyako K, Nakajima T, Yokoyama S, Sasamoto S, et al. Characterization of proteogenomic signatures of differentiation of CD4+ T cell subsets. DNA Res. 2023;30: pubmed publisher
Kanno T, Miyako K, Nakajima T, Yokoyama S, Sasamoto S, Asou H, et al. SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells. Front Immunol. 2022;13:904875 pubmed publisher
Magen A, Nie J, Ciucci T, Tamoutounour S, Zhao Y, Mehta M, et al. Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells. Cell Rep. 2019;29:3019-3032.e6 pubmed publisher
Ning S, Pagano J, Barber G. IRF7: activation, regulation, modification and function. Genes Immun. 2011;12:399-414 pubmed publisher
Fuchsberger M, Hochrein H, O Keeffe M. Activation of plasmacytoid dendritic cells. Immunol Cell Biol. 2005;83:571-7 pubmed

product information

Product Type :

Antibody

Product Name :

IRF7 Monoclonal Antibody (MNGPKL), PE, eBioscience

Catalog # :

12-5829-80

Quantity :

25 ug

Price :

US 147.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 ug/test

Species :

Mouse

Clone :

MNGPKL

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 ug/test

Aliases :

IMD39; Interferon regulatory factor 7; interferon regulatory factor-7H; Irf7; IRF-7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H