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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD309 (FLK1) Monoclonal Antibody (Avas12a1), PE, eBioscience™
catalog :
12-5821-82
quantity :
100 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
Avas12a1
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 59
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s5b
Xu W, Li B, Guan X, Chung S, Wang Y, Yip Y, et al. Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun. 2017;8:14399 pubmed publisher
  • flow cytometry; mouse; loading ...; fig S1
Nasrallah R, Knezevic K, Thai T, Thomas S, Göttgens B, Lacaud G, et al. Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis. Biol Open. 2015;4:819-29 pubmed publisher
  • flow cytometry; mouse
Sheng H, Wang Y, Jin Y, Zhang Q, Zhang Y, Wang L, et al. A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res. 2008;18:846-57 pubmed publisher
Chagraoui H, Kristiansen M, Ruiz J, Serra Barros A, Richter J, Hall Ponsele E, et al. SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells. Nat Commun. 2018;9:5375 pubmed publisher
Bergiers I, Andrews T, Vargel Bölükbaşı Ö, Buness A, Janosz E, Lopez Anguita N, et al. Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis. elife. 2018;7: pubmed publisher
Murray L, Habiel D, Hohmann M, Camelo A, Shang H, Zhou Y, et al. Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis. JCI Insight. 2017;2: pubmed publisher
Secondini C, Coquoz O, Spagnuolo L, Spinetti T, Peyvandi S, Ciarloni L, et al. Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade. Oncoimmunology. 2017;6:e1316437 pubmed publisher
Chen I, Caprioli A, Ohnuki H, Kwak H, Porcher C, Tosato G. EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta. Sci Rep. 2016;6:27195 pubmed publisher
Zhou J, Wu Y, Wang L, Rauova L, Hayes V, Poncz M, et al. The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. J Clin Invest. 2015;125:4391-406 pubmed publisher
Wu L, Wary K, REVSKOY S, Gao X, Tsang K, Komarova Y, et al. Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells. Stem Cell Reports. 2015;5:10-21 pubmed publisher
Wu T, Chan J, Lee C, Leu H, Huang P, Chen J, et al. Rivaroxaban, a factor Xa inhibitor, improves neovascularization in the ischemic hindlimb of streptozotocin-induced diabetic mice. Cardiovasc Diabetol. 2015;14:81 pubmed publisher
Song N, Gao L, Qiu H, Huang C, Cheng H, Zhou H, et al. Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant. Int J Mol Med. 2015;36:139-49 pubmed publisher
Yamamizu K, Schlessinger D, Ko M. SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1). Development. 2014;141:4254-66 pubmed publisher
Ubil E, Duan J, Pillai I, Rosa Garrido M, Wu Y, Bargiacchi F, et al. Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature. 2014;514:585-90 pubmed publisher
Ito K, Yamazaki S, Yamamoto R, Tajima Y, Yanagida A, Kobayashi T, et al. Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice. J Biol Chem. 2014;289:29892-911 pubmed publisher
Cook B, Evans T. BMP signaling balances murine myeloid potential through SMAD-independent p38MAPK and NOTCH pathways. Blood. 2014;124:393-402 pubmed publisher
Behrens A, Zierold C, Shi X, Ren Y, Koyano Nakagawa N, Garry D, et al. Sox7 is regulated by ETV2 during cardiovascular development. Stem Cells Dev. 2014;23:2004-13 pubmed publisher
Shi X, Richard J, Zirbes K, Gong W, Lin G, Kyba M, et al. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Dev Biol. 2014;389:208-18 pubmed publisher
Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, et al. The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids. Nat Immunol. 2014;15:54-62 pubmed publisher
Zhang H, Nieves J, Fraser S, Isern J, Douvaras P, Papatsenko D, et al. Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells. 2014;32:191-203 pubmed publisher
Tornack J, Seiler K, Grützkau A, Grün J, Onodera M, Melchers F, et al. Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis. PLoS ONE. 2013;8:e70116 pubmed publisher
Rasmussen T, Martin C, Walter C, Shi X, Perlingeiro R, Koyano Nakagawa N, et al. Etv2 rescues Flk1 mutant embryoid bodies. Genesis. 2013;51:471-80 pubmed publisher
Roehrich M, Spicher A, Milano G, Vassalli G. Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity. Biomed Res Int. 2013;2013:503047 pubmed publisher
Behrens A, Iacovino M, Lohr J, Ren Y, Zierold C, Harvey R, et al. Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10. Stem Cells Dev. 2013;22:2211-20 pubmed publisher
Rasmussen T, Shi X, Wallis A, Kweon J, Zirbes K, Koyano Nakagawa N, et al. VEGF/Flk1 signaling cascade transactivates Etv2 gene expression. PLoS ONE. 2012;7:e50103 pubmed publisher
Joo H, Choi D, Lim J, Park J, Lee S, Song S, et al. ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell-derived Flk1(+) mesodermal precursor cells. Blood. 2012;120:2733-44 pubmed
Koyano Nakagawa N, Kweon J, Iacovino M, Shi X, Rasmussen T, Borges L, et al. Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells. 2012;30:1611-23 pubmed publisher
Jayaraman P, Parikh F, López Rivera E, Hailemichael Y, Clark A, Ma G, et al. Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol. 2012;188:5365-76 pubmed publisher
Laranjeiro R, Alcobia I, Neves H, Gomes A, Saavedra P, Carvalho C, et al. The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development. PLoS ONE. 2012;7:e34553 pubmed publisher
van den Ameele J, Tiberi L, Bondue A, Paulissen C, Herpoel A, Iacovino M, et al. Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin. EMBO Rep. 2012;13:355-62 pubmed publisher
Nobuhisa I, Yamasaki S, Ramadan A, Taga T. CD45(low)c-Kit(high) cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region. Exp Cell Res. 2012;318:705-15 pubmed publisher
Recalde A, Richart A, Guérin C, Cochain C, Zouggari Y, Yin K, et al. Sympathetic nervous system regulates bone marrow-derived cell egress through endothelial nitric oxide synthase activation: role in postischemic tissue remodeling. Arterioscler Thromb Vasc Biol. 2012;32:643-53 pubmed publisher
van der Bogt K, Hellingman A, Lijkwan M, Bos E, De Vries M, van Rappard J, et al. Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease. JACC Cardiovasc Imaging. 2012;5:46-55 pubmed publisher
Beck B, Driessens G, Goossens S, Youssef K, Kuchnio A, Caauwe A, et al. A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature. 2011;478:399-403 pubmed publisher
Gill J, Langer E, Lindsley R, Cai M, Murphy T, Murphy K. Snail promotes the cell-autonomous generation of Flk1(+) endothelial cells through the repression of the microRNA-200 family. Stem Cells Dev. 2012;21:167-76 pubmed publisher
Warram J, Sorace A, Saini R, Umphrey H, Zinn K, Hoyt K. A triple-targeted ultrasound contrast agent provides improved localization to tumor vasculature. J Ultrasound Med. 2011;30:921-31 pubmed
Joo H, Kim H, Park S, Cho H, Kim H, Lim D, et al. Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells. Blood. 2011;118:2094-104 pubmed publisher
Yu H, Qin H, He F, Wang L, Fu W, Liu D, et al. Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. Hepatology. 2011;54:979-88 pubmed publisher
Gill J, Langer E, Lindsley R, Cai M, Murphy T, Kyba M, et al. Snail and the microRNA-200 family act in opposition to regulate epithelial-to-mesenchymal transition and germ layer fate restriction in differentiating ESCs. Stem Cells. 2011;29:764-76 pubmed publisher
Darabi R, Santos F, Filareto A, Pan W, Koene R, Rudnicki M, et al. Assessment of the myogenic stem cell compartment following transplantation of Pax3/Pax7-induced embryonic stem cell-derived progenitors. Stem Cells. 2011;29:777-90 pubmed publisher
Schenke Layland K, Nsair A, Van Handel B, Angelis E, Gluck J, Votteler M, et al. Recapitulation of the embryonic cardiovascular progenitor cell niche. Biomaterials. 2011;32:2748-56 pubmed publisher
Li F, Liu P, Liu C, Xiang D, Deng L, Li W, et al. Hepatoblast-like progenitor cells derived from embryonic stem cells can repopulate livers of mice. Gastroenterology. 2010;139:2158-2169.e8 pubmed publisher
Ma M, Ding S, Lundqvist A, San H, Fang F, Konoplyannikov M, et al. Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival. Stem Cells. 2010;28:1465-75 pubmed publisher
Morris L, Klanke C, Lang S, Pokall S, Maldonado A, Vuletin J, et al. Characterization of endothelial progenitor cells mobilization following cutaneous wounding. Wound Repair Regen. 2010;18:383-90 pubmed publisher
Paz H, Lynch M, Bogue C, Gasson J. The homeobox gene Hhex regulates the earliest stages of definitive hematopoiesis. Blood. 2010;116:1254-62 pubmed publisher
Reijmers R, Vondenhoff M, Roozendaal R, Kuil A, Li J, Spaargaren M, et al. Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase. J Immunol. 2010;184:3656-64 pubmed publisher
Carmi Y, Voronov E, Dotan S, Lahat N, Rahat M, Fogel M, et al. The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis. J Immunol. 2009;183:4705-14 pubmed publisher
Zhang H, Fraser S, Papazoglu C, Hoatlin M, Baron M. Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells. Stem Cells. 2009;27:2884-95 pubmed publisher
Haddad P, Dussault S, Groleau J, Turgeon J, Michaud S, Ménard C, et al. Nox2-containing NADPH oxidase deficiency confers protection from hindlimb ischemia in conditions of increased oxidative stress. Arterioscler Thromb Vasc Biol. 2009;29:1522-8 pubmed publisher
Senju S, Haruta M, Matsunaga Y, Fukushima S, Ikeda T, Takahashi K, et al. Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells. Stem Cells. 2009;27:1021-31 pubmed publisher
Vondenhoff M, Greuter M, Goverse G, Elewaut D, Dewint P, Ware C, et al. LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. J Immunol. 2009;182:5439-45 pubmed publisher
Asahina K, Tsai S, Li P, Ishii M, Maxson R, Sucov H, et al. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009;49:998-1011 pubmed publisher
Vondenhoff M, van de Pavert S, Dillard M, Greuter M, Goverse G, Oliver G, et al. Lymph sacs are not required for the initiation of lymph node formation. Development. 2009;136:29-34 pubmed publisher
Ajijola O, Dong C, Herderick E, Ma Q, Goldschmidt Clermont P, Yan Z. Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice. Antioxid Redox Signal. 2009;11:15-23 pubmed publisher
Bosnakovski D, Xu Z, Li W, Thet S, Cleaver O, Perlingeiro R, et al. Prospective isolation of skeletal muscle stem cells with a Pax7 reporter. Stem Cells. 2008;26:3194-204 pubmed publisher
Lyshchik A, Fleischer A, Huamani J, Hallahan D, Brissova M, Gore J. Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography. J Ultrasound Med. 2007;26:1575-86 pubmed
Nakano M, Satoh K, Fukumoto Y, Ito Y, Kagaya Y, Ishii N, et al. Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice. Circ Res. 2007;100:662-9 pubmed
Lindsley R, Gill J, Kyba M, Murphy T, Murphy K. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development. 2006;133:3787-96 pubmed
Kano M, Morishita Y, Iwata C, Iwasaka S, Watabe T, Ouchi Y, et al. VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling. J Cell Sci. 2005;118:3759-68 pubmed
product information
Product Type :
Antibody
Product Name :
CD309 (FLK1) Monoclonal Antibody (Avas12a1), PE, eBioscience™
Catalog # :
12-5821-82
Quantity :
100 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Mouse
Clone :
Avas12a1
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
6130401C07; CD309; CD309 antigen; fetal liver kinase 1; fetal liver kinase-1; FLK1; Flk-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); flk-1 type VEGF receptor; KDR; kinase insert domain protein receptor; kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); kinase NYK; Krd-1; Ly73; protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; sVEGFR-2; tyrosine kinase growth factor receptor; vascular endotheial growth factor 2; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR; VEGFR2; VEGFR-2
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA