TCR V alpha 24 J alpha 18 Monoclonal Antibody (6B11), PE, eBioscience™ | Invitrogen 12-5806-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V alpha 24 J alpha 18 Monoclonal Antibody (6B11), PE, eBioscience™

catalog :

12-5806-42

quantity :

100 Tests

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

6B11

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2E	Veinotte L, Gebremeskel S, Johnston B. CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFN? production and tumor control. Oncoimmunology. 2016;5:e1160979 pubmed publisher
flow cytometry; human; fig S2	Ruffell B, Au A, Rugo H, Esserman L, Hwang E, Coussens L. Leukocyte composition of human breast cancer. Proc Natl Acad Sci U S A. 2012;109:2796-801 pubmed publisher
	Zhao M, Svensson M, Venken K, Chawla A, Liang S, Engel I, et al. Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nat Commun. 2018;9:2627 pubmed publisher
	St Louis D, Romero R, Plazyo O, Arenas Hernandez M, Panaitescu B, Xu Y, et al. Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone. J Immunol. 2016;196:1044-59 pubmed publisher
	Servais S, Menten Dedoyart C, Beguin Y, Seidel L, Gothot A, Daulne C, et al. Impact of Pre-Transplant Anti-T Cell Globulin (ATG) on Immune Recovery after Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation. PLoS ONE. 2015;10:e0130026 pubmed publisher
	Lin G, Field J, Yu J, Ken R, Neuberg D, Nathan D, et al. NF-?B is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptors. PLoS ONE. 2013;8:e74664 pubmed publisher
	Venken K, Decruy T, Aspeslagh S, Van Calenbergh S, Lambrecht B, Elewaut D. Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells. J Immunol. 2013;191:2174-83 pubmed publisher
	Zeng S, Ghnewa Y, O Reilly V, Lyons V, Atzberger A, Hogan A, et al. Human invariant NKT cell subsets differentially promote differentiation, antibody production, and T cell stimulation by B cells in vitro. J Immunol. 2013;191:1666-76 pubmed publisher
	Hofmann S, Bosma A, Bruckner Tuderman L, Vukmanovic Stejic M, Jury E, Isenberg D, et al. Invariant natural killer T cells are enriched at the site of cutaneous inflammation in lupus erythematosus. J Dermatol Sci. 2013;71:22-8 pubmed publisher
	Tang X, Jo J, Tan A, Sandalova E, Chia A, Tan K, et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol. 2013;190:3142-52 pubmed publisher
	Field J, Lin G, Okam M, Majerus E, Keefer J, Onyekwere O, et al. Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson. Blood. 2013;121:3329-34 pubmed publisher
	O Reilly V, Zeng S, Bricard G, Atzberger A, Hogan A, Jackson J, et al. Distinct and overlapping effector functions of expanded human CD4+, CD8?+ and CD4-CD8?- invariant natural killer T cells. PLoS ONE. 2011;6:e28648 pubmed publisher
	Kim H, Eyheramonho M, Pichavant M, Gonzalez Cambaceres C, Matangkasombut P, Cervio G, et al. A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans. J Clin Invest. 2011;121:1111-8 pubmed publisher
	Liu L, Lu J, Chao P, Lin L, Zhang Z, Yang T. Lower prevalence of circulating invariant natural killer T (iNKT) cells in patients with acute myocardial infarction undergoing primary coronary stenting. Int Immunopharmacol. 2011;11:480-4 pubmed publisher
	Azakami K, Sato T, Araya N, Utsunomiya A, Kubota R, Suzuki K, et al. Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders. Blood. 2009;114:3208-15 pubmed publisher
	Montoya C, Pollard D, Martinson J, Kumari K, Wasserfall C, Mulder C, et al. Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11. Immunology. 2007;122:1-14 pubmed
	Thomas S, Hou R, Boyson J, Means T, Hess C, Olson D, et al. CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol. 2003;171:2571-80 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V alpha 24 J alpha 18 Monoclonal Antibody (6B11), PE, eBioscience™

Catalog # :

12-5806-42

Quantity :

100 Tests

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.5 µg)/test

Species :

Human

Clone :

6B11

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.5 µg)/test

Aliases :

Va24; Valpha24

more info or order :

Invitrogen product webpage