Ly-49A/D Monoclonal Antibody (eBio12A8 (12A8)), PE, eBioscience | Invitrogen 12-5783-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ly-49A/D Monoclonal Antibody (eBio12A8 (12A8)), PE, eBioscience

catalog :

12-5783-81

quantity :

50 ug

price :

US 146.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

eBio12A8 (12A8)

reactivity :

mouse

application :

flow cytometry

citations: 10

Reference
Ro x17e mani x107 C, Lisni x107 B, Pribani x107 Mate x161 i x107 M, Mihali x107 A, Hir x161 l L, Park E, et al. Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells. Nat Commun. 2023;14:6412 pubmed publisher
Li S, Bern M, Miao B, Fan C, Xing X, Inoue T, et al. The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function. elife. 2022;11: pubmed publisher
Železnjak J, Lisnic V, Popovic B, Lisnić B, Babic M, Halenius A, et al. The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors. J Exp Med. 2019;: pubmed publisher
Pyzik M, Dumaine A, Dumaine A, Charbonneau B, Fodil Cornu N, Jonjic S, et al. Viral MHC class I-like molecule allows evasion of NK cell effector responses in vivo. J Immunol. 2014;193:6061-9 pubmed publisher
Vargas C, Poursine Laurent J, Yang L, Yokoyama W. Development of thymic NK cells from double negative 1 thymocyte precursors. Blood. 2011;118:3570-8 pubmed publisher
Pyzik M, Charbonneau B, Gendron Pontbriand E, Babic M, Krmpotic A, Jonjic S, et al. Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains. J Exp Med. 2011;208:1105-17 pubmed publisher
Croy B, Zhang J, Tayade C, Colucci F, Yadi H, Yamada A. Analysis of uterine natural killer cells in mice. Methods Mol Biol. 2010;612:465-503 pubmed publisher
McNerney M, Lee K, Zhou P, Molinero L, Mashayekhi M, Guzior D, et al. Role of natural killer cell subsets in cardiac allograft rejection. Am J Transplant. 2006;6:505-13 pubmed
Robbins S, Tessmer M, Van Kaer L, Brossay L. Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation. Eur J Immunol. 2005;35:757-65 pubmed
Mason L, Anderson S, Yokoyama W, Smith H, Winkler Pickett R, Ortaldo J. The Ly-49D receptor activates murine natural killer cells. J Exp Med. 1996;184:2119-28 pubmed

product information

Product Type :

Antibody

Product Name :

Ly-49A/D Monoclonal Antibody (eBio12A8 (12A8)), PE, eBioscience

Catalog # :

12-5783-81

Quantity :

50 ug

Price :

US 146.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.125 ug/test

Species :

Mouse

Clone :

eBio12A8 (12A8)

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The Ly-49 family of NK-cell receptors, members of the C-type lectin superfamily, are disulfide-linked type-II transmembrane protein homodimers with extracellular carbohydrate-recognition domains which bind to MHC class I alloantigens. The Ly-49 family members are expressed independently, such that an individual NK or T cell may display more than one class of Ly-49 receptor homodimers. Ly-49D is expressed on subsets of natural killer cells in C57BL/6, C3H/He, and SJL mice, but not DBA/2, AKR, CBA/J, or BALB/c mice. The Ly-49D antigen has not been detected on NK-1.1+ T cells. The Ly-49D receptor has been implicated in mediation of NK cell cytolysis. Ly-49D is an activating receptor while Ly-49A is a inhibitory receptor.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 ug/test

Aliases :

A1; CH29-493D4.3; Chok; class I MHC receptor KLRA22; killer cell lectin-like receptor 4; killer cell lectin-like receptor subfamily A member 32; killer cell lectin-like receptor subfamily A member 33; killer cell lectin-like receptor, subfamily A, member 1; killer cell lectin-like receptor, subfamily A, member 4; Klra1; Klra22; Klra32; Klra33; Klra4; Ly49a; ly-49a; Ly49d; Ly-49d; Ly49-d; Ly49o ; ly49r ; Ly49v; lymphocyte antigen 49a; lymphocyte antigen 49d; natural killer cell receptor Ly49A; novel killer cell lectin-like receptor subfamily A protein; t lymphocyte antigen A1; T-cell surface glycoprotein Ly-49D; T-cell surface glycoprotein YE1/48