CD169 (Siglec-1) Monoclonal Antibody (SER-4), PE, eBioscience | Invitrogen 12-5755-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD169 (Siglec-1) Monoclonal Antibody (SER-4), PE, eBioscience

catalog :

12-5755-80

quantity :

25 ug

price :

US 162.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

SER-4

reactivity :

mouse

application :

flow cytometry

citations: 11

Reference
Zhang L, Feng X, Shen Y, Wang Y, Liu Z, Ma Y, et al. A novel ZsGreen knock-in melanoma cell line reveals the function of CD11b in tumor phagocytosis. Immunol Cell Biol. 2022;100:691-704 pubmed publisher
Serrano López J, Hegde S, Kumar S, Serrano J, Fang J, Wellendorf A, et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. elife. 2021;10: pubmed publisher
Cao Q, Huang Q, Wang Y, Li C. Abraxane-induced bone marrow CD11b+ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with 64Cu-labeled anti-CD11b and prevented by anti-CSF-1. Theranostics. 2021;11:3527-3539 pubmed publisher
Etzerodt A, Moulin M, Doktor T, Delfini M, Mossadegh Keller N, Bajenoff M, et al. Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer. J Exp Med. 2020;217: pubmed publisher
Etzerodt A, Tsalkitzi K, Maniecki M, Damsky W, Delfini M, Baudoin E, et al. Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression. J Exp Med. 2019;216:2394-2411 pubmed publisher
Lai J, Cartier D, Hartholt R, Swystun L, van Velzen A, den Haan J, et al. Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice. J Thromb Haemost. 2018;16:533-545 pubmed publisher
Kawasaki N, VELA J, Nycholat C, Rademacher C, Khurana A, Van Rooijen N, et al. Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. Proc Natl Acad Sci U S A. 2013;110:7826-31 pubmed publisher
Klaas M, Oetke C, Lewis L, Erwig L, Heikema A, Easton A, et al. Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni. J Immunol. 2012;189:2414-22 pubmed publisher
Wu C, Rauch U, Korpos E, Song J, Loser K, Crocker P, et al. Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression. J Immunol. 2009;182:6508-16 pubmed publisher
Oetke C, Vinson M, Jones C, Crocker P. Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels. Mol Cell Biol. 2006;26:1549-57 pubmed
Crocker P, Freeman S, Gordon S, Kelm S. Sialoadhesin binds preferentially to cells of the granulocytic lineage. J Clin Invest. 1995;95:635-43 pubmed

product information

Product Type :

Antibody

Product Name :

CD169 (Siglec-1) Monoclonal Antibody (SER-4), PE, eBioscience

Catalog # :

12-5755-80

Quantity :

25 ug

Price :

US 162.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 ug/test

Species :

Mouse

Clone :

SER-4

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/test

Aliases :

Cd169; dJ1009E24.1; macrophage receptor; p210; pSn; SA; SER; sheep erythrocyte receptor; sialic acid binding Ig like lectin 1; sialic acid binding Ig-like lectin 1, sialoadhesin; Sialic acid-binding Ig-like lectin 1; sialic acid-binding immunoglobulin-like lectin 1; sialoadhesin; SIGLEC1; Siglec-1; SN