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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IgA Monoclonal Antibody (mA-6E1), PE, eBioscience
catalog :
12-4204-82
quantity :
100 µg
price :
US 307
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
mA-6E1
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 36
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 3f
Graf R, Seagal J, Otipoby K, Lam K, Ayoub S, Zhang B, et al. BCR-dependent lineage plasticity in mature B cells. Science. 2019;363:748-753 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
Donaldson G, Ladinsky M, Yu K, Sanders J, Yoo B, Chou W, et al. Gut microbiota utilize immunoglobulin A for mucosal colonization. Science. 2018;360:795-800 pubmed publisher
  • flow cytometry; mouse; 1:50; fig 3e
Bemark M, Hazanov H, Strömberg A, Komban R, Holmqvist J, Köster S, et al. Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization. Nat Commun. 2016;7:12698 pubmed publisher
Kordahi M, Delaroque C, Bred xe8 che M, Gewirtz A, Chassaing B. Vaccination against microbiota motility protects mice from the detrimental impact of dietary emulsifier consumption. PLoS Biol. 2023;21:e3002289 pubmed publisher
Vincendeau E, Wei W, Zhang X, Planchais C, Yu W, Lenden Hasse H, et al. SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination. Nat Commun. 2022;13:3707 pubmed publisher
Rice T, Bielecka A, Nguyen M, Rosen C, Song D, Sonnert N, et al. Interspecies commensal interactions have nonlinear impacts on host immunity. Cell Host Microbe. 2022;30:988-1002.e6 pubmed publisher
Xu Y, Zhou H, Post G, Zan H, Casali P. Rad52 mediates class-switch DNA recombination to IgD. Nat Commun. 2022;13:980 pubmed publisher
Tan J, Cho H, Pholcharee T, Pereira L, Doumbo S, Doumtabe D, et al. Functional human IgA targets a conserved site on malaria sporozoites. Sci Transl Med. 2021;13: pubmed publisher
Platt J, de Mattos Barbosa M, Huynh D, Lefferts A, Katta J, Kharas C, et al. TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA. JCI Insight. 2021;6: pubmed publisher
Singh S, Bastos Amador P, Thompson J, Truglio M, Yilmaz B, Cardoso S, et al. Glycan-based shaping of the microbiota during primate evolution. elife. 2021;10: pubmed publisher
Sun X, Liu M, Bai J, Xu J, Zhu C, Dong J, et al. ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage. J Leukoc Biol. 2021;110:1101-1112 pubmed publisher
Prados A, Onder L, Cheng H, Mörbe U, Lütge M, Gil Cruz C, et al. Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity. Nat Immunol. 2021;22:510-519 pubmed publisher
Olivieri M, Cho T, lvarez Quil n A, Li K, Schellenberg M, Zimmermann M, et al. A Genetic Map of the Response to DNA Damage in Human Cells. Cell. 2020;182:481-496.e21 pubmed publisher
Yang D, Sun Y, Chen J, Zhang Y, Fan S, Huang M, et al. REV7 is required for processing AID initiated DNA lesions in activated B cells. Nat Commun. 2020;11:2812 pubmed publisher
Huus K, Bauer K, Brown E, Bozorgmehr T, Woodward S, Serapio Palacios A, et al. Commensal Bacteria Modulate Immunoglobulin A Binding in Response to Host Nutrition. Cell Host Microbe. 2020;27:909-921.e5 pubmed publisher
Yang C, Mogno I, Contijoch E, Borgerding J, Aggarwala V, Li Z, et al. Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation. Cell Host Microbe. 2020;27:467-475.e6 pubmed publisher
Biram A, Winter E, Denton A, Zaretsky I, Dassa B, Bemark M, et al. B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches. Cell Rep. 2020;30:1910-1922.e5 pubmed publisher
Tran H, Ley R, Gewirtz A, Chassaing B. Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases. Nat Commun. 2019;10:5650 pubmed publisher
Lai N, Musser M, Pinho Ribeiro F, Baral P, Jacobson A, Ma P, et al. Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2020;180:33-49.e22 pubmed publisher
Noval Rivas M, Wakita D, Franklin M, Carvalho T, Abolhesn A, Gomez A, et al. Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation. Immunity. 2019;51:508-521.e6 pubmed publisher
Tepper S, Mortusewicz O, Członka E, Bello A, Schmidt A, Jeschke J, et al. Restriction of AID activity and somatic hypermutation by PARP-1. Nucleic Acids Res. 2019;47:7418-7429 pubmed publisher
Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann Kleiter N, et al. CHK1 dosage in germinal center B cells controls humoral immunity. Cell Death Differ. 2019;: pubmed publisher
Melo Gonzalez F, Kammoun H, Evren E, Dutton E, Papadopoulou M, Bradford B, et al. Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria. J Exp Med. 2019;216:728-742 pubmed publisher
Ramakrishnan S, Zhang H, Ma X, Jung I, Schwartz A, Triner D, et al. Intestinal non-canonical NFκB signaling shapes the local and systemic immune response. Nat Commun. 2019;10:660 pubmed publisher
Martínez López M, Iborra S, Conde Garrosa R, Mastrangelo A, Danne C, Mann E, et al. Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity. Immunity. 2019;50:446-461.e9 pubmed publisher
Kiyohara H, Sujino T, Teratani T, Miyamoto K, Arai M, Nomura E, et al. Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells. Cell Mol Gastroenterol Hepatol. 2019;7:135-156 pubmed publisher
Scally S, McLeod B, Bosch A, Miura K, Liang Q, Carroll S, et al. Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25. Nat Commun. 2017;8:1568 pubmed publisher
Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, et al. CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. Nat Commun. 2017;8:14715 pubmed publisher
Kishikawa S, Sato S, Kaneto S, Uchino S, Kohsaka S, Nakamura S, et al. Allograft inflammatory factor 1 is a regulator of transcytosis in M cells. Nat Commun. 2017;8:14509 pubmed publisher
Srikakulapu P, Hu D, Yin C, Mohanta S, Bontha S, Peng L, et al. Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice. Arterioscler Thromb Vasc Biol. 2016;36:1174-85 pubmed publisher
Christensen D, Mortensen R, Rosenkrands I, Dietrich J, Andersen P. Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses. Mucosal Immunol. 2017;10:260-270 pubmed publisher
Davari K, Frankenberger S, Schmidt A, Tomi N, Jungnickel B. Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle. 2014;13:3659-69 pubmed publisher
Kim M, Kim T. IgA+ plasma cells in murine intestinal lamina propria as a positive regulator of Treg differentiation. J Leukoc Biol. 2014;95:461-9 pubmed publisher
Kunisawa J, Gohda M, Hashimoto E, Ishikawa I, Higuchi M, Suzuki Y, et al. Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat Commun. 2013;4:1772 pubmed publisher
Kim M, Kim T. R-phycoerythrin-conjugated antibodies are inappropriate for intracellular staining of murine plasma cells. Cytometry A. 2013;83:452-60 pubmed publisher
Kotani A, Kakazu N, Tsuruyama T, Okazaki I, Muramatsu M, Kinoshita K, et al. Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice. Proc Natl Acad Sci U S A. 2007;104:1616-20 pubmed
product information
Product Type :
Antibody
Product Name :
IgA Monoclonal Antibody (mA-6E1), PE, eBioscience
Catalog # :
12-4204-82
Quantity :
100 µg
Price :
US 307
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.125 µg/test
Species :
Mouse
Clone :
mA-6E1
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Mouse IgA is an immunoglobulin A antibody that is produced by B cells in response to an antigen. It is a crucial component of the mucosal immune system, which protects the body from pathogens that enter through mucosal surfaces such as the respiratory, gastrointestinal, and urogenital tracts. Mouse IgA is composed of two heavy chains and two light chains, and it is the most abundant immunoglobulin in mucosal secretions. It plays a vital role in neutralizing pathogens and preventing their attachment to mucosal surfaces. Mouse IgA is widely used in research and diagnostic applications, including ELISA, Western blotting, and immunohistochemistry.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.125 µg/test
Aliases :
IgA; Igh-2; Igha; immunoglobulin heavy constant alpha; ImmunoglobulinA
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA