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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD206 (MMR) Monoclonal Antibody (19.2), PE, eBioscience
catalog :
12-2069-42
quantity :
100 Tests
price :
US 302.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
19.2
reactivity :
human
application :
flow cytometry
more info or order :
citations: 46
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; 1:100; fig 5a
Beatson R, Tajadura Ortega V, Achkova D, Picco G, Tsourouktsoglou T, Klausing S, et al. The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9. Nat Immunol. 2016;17:1273-1281 pubmed publisher
  • flow cytometry; human; 1.25 ug/ml; fig 2
Su S, Zhao Q, He C, Huang D, Liu J, Chen F, et al. miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nat Commun. 2015;6:8523 pubmed publisher
He P, Dai M, Li Z, Wang X, Liu H, He Y, et al. Effect of connexin 43 in LPS/IL-4-induced macrophage M1/M2 polarization: An observational study. Medicine (Baltimore). 2024;103:e37811 pubmed publisher
Chen S, Chen Y, Li P, Cheng T, Chu Y, Shen Y, et al. Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury. J Biomed Sci. 2024;31:30 pubmed publisher
Yan S, Zhao J, Gao P, Li Z, Li Z, Liu X, et al. Diagnostic potential of NRG1 in benign nerve sheath tumors and its influence on the PI3K-Akt signaling and tumor immunity. Diagn Pathol. 2024;19:28 pubmed publisher
Le Y, Gao H, Le J, Hornick J, Bleday R, Wee J, et al. VentX promotes tumor specific immunity and efficacy of immune checkpoint inhibitors. iScience. 2024;27:108731 pubmed publisher
Park T, Hirday R, Quinn R, Jacob S, Feldman R, Bose D, et al. Differentiation of monocytes and polarized M1/M2 macrophages from human induced pluripotent stem cells. STAR Protoc. 2024;5:102827 pubmed publisher
Guan Y, Chen Q, Xu J, Chen B, Ou B, Liu T, et al. The anti-inflammatory effects of mesenchymal stem cells attenuate diffuse pulmonary hemorrhage. Biotechnol J. 2024;19:e2200632 pubmed publisher
Lang L, Zheng D, Jiang Q, Meng T, Ma X, Yang Y. Uncoupling protein 2 modulates polarization and metabolism of human primary macrophages via glycolysis and the NF‑κB pathway. Exp Ther Med. 2023;26:583 pubmed publisher
Li Y, Yang Y, Guo T, Weng C, Yang Y, Wang Z, et al. Heme oxygenase-1 determines the cell fate of ferroptotic death of alveolar macrophages in COPD. Front Immunol. 2023;14:1162087 pubmed publisher
Zheng Y, Wang N, Wang S, Zhang J, Yang B, Wang Z. Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling. J Exp Clin Cancer Res. 2023;42:129 pubmed publisher
Wang W, Li X, Qin X, Miao Y, Zhang Y, Li S, et al. Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity. Br J Haematol. 2023;202:328-343 pubmed publisher
Liu W, Li K, Zheng M, He L, Chen T. Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia. Antioxidants (Basel). 2022;12: pubmed publisher
He S, Gu X, Yang J, Xu F, Hu J, Wang W, et al. Sphingomyelin synthase 2 is a positive regulator of the CSF1R-STAT3 pathway in pancreatic cancer-associated macrophage. Front Pharmacol. 2022;13:902016 pubmed publisher
Tesoro L, Hern xe1 ndez I, Ram xed rez Carracedo R, D xed ez Mata J, Alcharani N, Jim xe9 nez Guirado B, et al. NIL10: A New IL10-Receptor Binding Nanoparticle That Induces Cardiac Protection in Mice and Pigs Subjected to Acute Myocardial Infarction through STAT3/NF-κB Activation. Pharmaceutics. 2022;14: pubmed publisher
Zhou H, Gan M, Jin X, Dai M, Wang Y, Lei Y, et al. miR‑382 inhibits breast cancer progression and metastasis by affecting the M2 polarization of tumor‑associated macrophages by targeting PGC‑1α. Int J Oncol. 2022;61: pubmed publisher
Zhao G, Ding L, Yu H, Wang W, Wang H, Hu Y, et al. M2-like tumor-associated macrophages transmit exosomal miR-27b-3p and maintain glioblastoma stem-like cell properties. Cell Death Discov. 2022;8:350 pubmed publisher
Liu W, Chen H, Zhu Z, Liu Z, Ma C, Lee Y, et al. Ferroptosis Inducer Improves the Efficacy of Oncolytic Virus-Mediated Cancer Immunotherapy. Biomedicines. 2022;10: pubmed publisher
Lee C, Chiang C, Kuo F, Su S, Huang C, Liu J, et al. High-Molecular-Weight Hyaluronic Acid Inhibits IL-1β-Induced Synovial Inflammation and Macrophage Polarization through the GRP78-NF-κB Signaling Pathway. Int J Mol Sci. 2021;22: pubmed publisher
Liu Y, Huang B, Lin C, Shen C, Lai S, Chen C, et al. Paliperidone Inhibits Glioblastoma Growth in Mouse Brain Tumor Model and Reduces PD-L1 Expression. Cancers (Basel). 2021;13: pubmed publisher
He C, Sun S, Zhang Y, Xie F, Li S. The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer. Oncoimmunology. 2021;10:1897295 pubmed publisher
Li G, Cui L, Wang G. miR-155-5p regulates macrophage M1 polarization and apoptosis in the synovial fluid of patients with knee osteoarthritis. Exp Ther Med. 2021;21:68 pubmed publisher
Poh L, Fann D, Wong P, Lim H, Foo S, Kang S, et al. AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia. Mol Psychiatry. 2021;26:4544-4560 pubmed publisher
Bharat A, Querrey M, Markov N, Kim S, Kurihara C, Garza Castillon R, et al. Lung transplantation for patients with severe COVID-19. Sci Transl Med. 2020;12: pubmed publisher
Zhang G, Jiao Q, Shen C, Song H, Zhang H, Qiu Z, et al. Interleukin 6 regulates the expression of programmed cell death ligand 1 in thyroid cancer. Cancer Sci. 2021;112:997-1010 pubmed publisher
Liu M, Zhong Y, Shao J, Zhang C, Shi C. Tumor-associated macrophages promote human hepatoma Huh-7 cell migration and invasion through the Gli2/IGF-II/ERK1/2 axis by secreting TGF-β1. Cancer Biol Ther. 2020;21:1041-1050 pubmed publisher
Huang B, Liu Y, Lai S, Lin H, Shen C, Yang L, et al. CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions. Int J Mol Sci. 2020;21: pubmed publisher
Liu W, Dai E, Liu Z, Ma C, Guo Z, Bartlett D. In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2. Mol Ther Oncolytics. 2020;17:350-360 pubmed publisher
Schmitz T, Jannasch M, Weigel T, Moseke C, Gbureck U, Groll J, et al. Nanotopographical Coatings Induce an Early Phenotype-Specific Response of Primary Material-Resident M1 and M2 Macrophages. Materials (Basel). 2020;13: pubmed publisher
McArthur S, Juban G, Gobbetti T, Desgeorges T, Theret M, Gondin J, et al. Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation. J Clin Invest. 2020;130:1156-1167 pubmed publisher
Sami E, Paul B, Koziol J, ElShamy W. The Immunosuppressive Microenvironment in BRCA1-IRIS-Overexpressing TNBC Tumors Is Induced by Bidirectional Interaction with Tumor-Associated Macrophages. Cancer Res. 2020;80:1102-1117 pubmed publisher
Bamodu O, Kuo K, Wang C, Huang W, Wu A, Tsai J, et al. Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer. Nutrients. 2019;11: pubmed publisher
Huang D, Mao X, Peng J, Cheng M, Bai T, Du M, et al. Role of adipokine zinc-α2-glycoprotein in coronary heart disease. Am J Physiol Endocrinol Metab. 2019;317:E1055-E1062 pubmed publisher
Sorensen J, Kaluhiokalani J, Hafen P, Deyhle M, Parcell A, Hyldahl R. An altered response in macrophage phenotype following damage in aged human skeletal muscle: implications for skeletal muscle repair. FASEB J. 2019;33:10353-10368 pubmed publisher
Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, d Errico P, et al. A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity. 2019;50:1482-1497.e7 pubmed publisher
Liu R, Tang A, Wang X, Chen X, Zhao L, Xiao Z, et al. Inhibition of lncRNA NEAT1 suppresses the inflammatory response in IBD by modulating the intestinal epithelial barrier and by exosome-mediated polarization of macrophages. Int J Mol Med. 2018;42:2903-2913 pubmed publisher
Guo M, Xiao J, Sheng X, Zhang X, Tie Y, Wang L, et al. Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE-/- Mice by Skewing Macrophages to the M2 Phenotype. Front Pharmacol. 2018;9:464 pubmed publisher
Narasimhan P, Akabas L, Tariq S, Huda N, Bennuru S, Sabzevari H, et al. Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion. PLoS Negl Trop Dis. 2018;12:e0006404 pubmed publisher
Wisgrill L, Wessely I, Spittler A, Forster Waldl E, Berger A, Sadeghi K. Human lactoferrin attenuates the proinflammatory response of neonatal monocyte-derived macrophages. Clin Exp Immunol. 2018;192:315-324 pubmed publisher
Yan J, Tie G, Wang S, Tutto A, DeMarco N, Khair L, et al. Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages. Nat Commun. 2018;9:33 pubmed publisher
Ricklefs I, Barkas I, Duvall M, Cernadas M, Grossman N, Israel E, et al. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2017;2: pubmed publisher
Jannasch M, Gaetzner S, Weigel T, Walles H, Schmitz T, Hansmann J. A comparative multi-parametric in vitro model identifies the power of test conditions to predict the fibrotic tendency of a biomaterial. Sci Rep. 2017;7:1689 pubmed publisher
Chiang C, Chao T, Su Y, Hsu C, Chien C, Chiu K, et al. Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-?B signaling. Oncotarget. 2017;8:20706-20718 pubmed publisher
Jannasch M, Weigel T, Engelhardt L, Wiezoreck J, Gaetzner S, Walles H, et al. In vitro chemotaxis and tissue remodeling assays quantitatively characterize foreign body reaction. ALTEX. 2017;34:253-266 pubmed publisher
Gómez Aristizábal A, Kim K, Viswanathan S. A Systematic Study of the Effect of Different Molecular Weights of Hyaluronic Acid on Mesenchymal Stromal Cell-Mediated Immunomodulation. PLoS ONE. 2016;11:e0147868 pubmed publisher
He L, Marneros A. Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization. J Biol Chem. 2014;289:8019-28 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD206 (MMR) Monoclonal Antibody (19.2), PE, eBioscience
Catalog # :
12-2069-42
Quantity :
100 Tests
Price :
US 302.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.125 ug)/test
Species :
Human
Clone :
19.2
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.125 ug)/test
Aliases :
AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA