product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD195 (CCR5) Monoclonal Antibody (eBioT21/8 (T21/8)), PE, eBioscience
catalog :
12-1957-42
quantity :
100 Tests
price :
US 399.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
eBioT21/8 (T21/8)
reactivity :
human
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human
Kudernatsch R, Letsch A, Guerreiro M, Löbel M, Bauer S, Volk H, et al. Human bone marrow contains a subset of quiescent early memory CD8(+) T cells characterized by high CD127 expression and efflux capacity. Eur J Immunol. 2014;44:3532-42 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD195 (CCR5) Monoclonal Antibody (eBioT21/8 (T21/8)), PE, eBioscience
Catalog # :
12-1957-42
Quantity :
100 Tests
Price :
US 399.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.125 ug)/test
Species :
Human
Clone :
eBioT21/8 (T21/8)
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.125 ug)/test
Aliases :
AM4-7; C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5 (gene/pseudogene); C-C motif chemokine receptor 5 A159A; CCCKR5; CC-CKR-5; Ccr5; CCR-5; CD195; CD195 antigen; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; chemokine receptor CCR5; chemr13; CKR5; CKR-5; Cmkbr5; HIV-1 fusion coreceptor; IDDM22; MIP-1 alpha receptor
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA