CD195 (CCR5) Monoclonal Antibody (HM-CCR5 (7A4)), PE, eBioscience | Invitrogen 12-1951-83 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD195 (CCR5) Monoclonal Antibody (HM-CCR5 (7A4)), PE, eBioscience

catalog :

12-1951-83

quantity :

200 ug

price :

US 380.00

clonality :

monoclonal

host :

hamsters

conjugate :

clone name :

HM-CCR5 (7A4)

reactivity :

mouse

application :

flow cytometry

citations: 18

Reference
Chen K, Lainez N, Nair M, Coss D. Visceral adipose tissue imparts peripheral macrophage influx into the hypothalamus. J Neuroinflammation. 2021;18:140 pubmed publisher
Camps J, Grosemans H, Gijsbers R, Maes C, Sampaolesi M. Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells. Int J Mol Sci. 2019;20: pubmed publisher
Ly C, Nores G, Kataru R, Mehrara B. T helper 2 differentiation is necessary for development of lymphedema. Transl Res. 2019;206:57-70 pubmed publisher
Baur J, Otto C, Steger U, Klein Hessling S, Muhammad K, Pusch T, et al. The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts. Front Immunol. 2018;9:1338 pubmed publisher
García Nores G, Ly C, Cuzzone D, Kataru R, Hespe G, Torrisi J, et al. CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema. Nat Commun. 2018;9:1970 pubmed publisher
Levine A, Mendoza A, Hemmers S, Moltedo B, Niec R, Schizas M, et al. Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017;546:421-425 pubmed publisher
Rowley S, Kuriakose T, Dockery L, Tran Ngyuen T, Gingerich A, Wei L, et al. Tumor progression locus 2 (Tpl2) kinase promotes chemokine receptor expression and macrophage migration during acute inflammation. J Biol Chem. 2014;289:15788-97 pubmed publisher
Chiang Y, Ho K, Sun C, Chiu J, Lee F, Liao F, et al. CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE. 2013;8:e61761 pubmed publisher
Richmond J, Lee J, Green D, Kornfeld H, Cruikshank W. Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells. J Immunol. 2012;189:5886-95 pubmed publisher
Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, et al. Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing. J Clin Invest. 2012;122:711-21 pubmed publisher
Brincks E, Gurung P, Langlois R, Hemann E, Legge K, Griffith T. The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL. J Immunol. 2011;187:4581-8 pubmed publisher
Lee H, Lee H, Kwon Y, Lee J, Kim J, Shin M, et al. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. J Immunol. 2010;185:6698-705 pubmed publisher
Walsh K, Brady M, Finlay C, Boon L, Mills K. Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. J Immunol. 2009;183:1577-86 pubmed publisher
Rahbar R, Murooka T, Fish E. Role for CCR5 in dissemination of vaccinia virus in vivo. J Virol. 2009;83:2226-36 pubmed publisher
Mao A, Paharkova Vatchkova V, Hardy J, Miller M, Kovats S. Estrogen selectively promotes the differentiation of dendritic cells with characteristics of Langerhans cells. J Immunol. 2005;175:5146-51 pubmed
Iwasaki M, Mukai T, Nakajima C, Yang Y, Gao P, Yamaguchi N, et al. A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5. J Immunol. 2001;167:6877-83 pubmed
Zhou Y, Kurihara T, Ryseck R, Yang Y, Ryan C, Loy J, et al. Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J Immunol. 1998;160:4018-25 pubmed
Meyer A, Coyle A, Proudfoot A, Wells T, Power C. Cloning and characterization of a novel murine macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1996;271:14445-51 pubmed

product information

Product Type :

Antibody

Product Name :

CD195 (CCR5) Monoclonal Antibody (HM-CCR5 (7A4)), PE, eBioscience

Catalog # :

12-1951-83

Quantity :

200 ug

Price :

US 380.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 ug/test

Species :

Mouse

Clone :

HM-CCR5 (7A4)

Isotype :

IgG

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/test

Aliases :

AM4-7; C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5 (gene/pseudogene); C-C motif chemokine receptor 5 A159A; CCCKR5; CC-CKR-5; Ccr5; CCR-5; CD195; CD195 antigen; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; chemokine receptor CCR5; chemr13; CKR5; CKR-5; Cmkbr5; HIV-1 fusion coreceptor; IDDM22; MIP-1 alpha receptor