product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD183 (CXCR3) Monoclonal Antibody (CXCR3-173), PE, eBioscience
catalog :
12-1831-80
quantity :
25 µg
price :
US 141.00
clonality :
monoclonal
host :
hamsters
conjugate :
PE
clone name :
CXCR3-173
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 46
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig 2g, 3h
Benkhoucha M, Tran N, Breville G, Senoner I, Bradfield P, Papayannopoulou T, et al. CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation. J Neuroinflammation. 2022;19:103 pubmed publisher
Chandana M, Anand A, Ghosh S, Das R, Beura S, Jena S, et al. Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice. Nat Commun. 2022;13:4028 pubmed publisher
Vonderhaar E, Barnekow N, McAllister D, McOlash L, Eid M, Riese M, et al. STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol. 2021;12:41-58 pubmed publisher
Chen J, Chen Y, Shi Y, Ding S, Shen L, Wang R, et al. VX-765 reduces neuroinflammation after spinal cord injury in mice. Neural Regen Res. 2021;16:1836-1847 pubmed publisher
Gu M, Zhou X, Sohn J, Zhu L, Jie Z, Yang J, et al. NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity. Nat Immunol. 2021;22:193-204 pubmed publisher
Ferrere G, Tidjani Alou M, Liu P, Goubet A, Fidelle M, Kepp O, et al. Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade. JCI Insight. 2021;6: pubmed publisher
Zhao K, Tian Y, Wang J, Chen C, Pan B, Yan Z, et al. Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2. Biomed Res Int. 2020;2020:7619849 pubmed publisher
Wang Y, Wang Q, Wang B, Gu Y, Yu H, Yang W, et al. Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells. Cell Death Dis. 2020;11:1024 pubmed publisher
Nguyen H, Ticer T, Bastian D, Kuril S, Li H, Du H, et al. Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease. Cell Rep. 2020;33:108316 pubmed publisher
DiToro D, Harbour S, Bando J, Benavides G, Witte S, Laufer V, et al. Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity. Immunity. 2020;52:650-667.e10 pubmed publisher
Pascual García M, Bonfill Teixidor E, Planas Rigol E, Rubio Perez C, Iurlaro R, Arias A, et al. LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy. Nat Commun. 2019;10:2416 pubmed publisher
Araujo Furlan C, Tosello Boari J, Rodríguez C, Canale F, Fiocca Vernengo F, Boccardo S, et al. Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity. Front Immunol. 2018;9:2555 pubmed publisher
García Nores G, Ly C, Cuzzone D, Kataru R, Hespe G, Torrisi J, et al. CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema. Nat Commun. 2018;9:1970 pubmed publisher
Lindenstrøm T, Moguche A, Damborg M, Agger E, URDAHL K, Andersen P. T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties. EBioMedicine. 2018;27:27-39 pubmed publisher
Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt M, Dhar P, Selvam S, et al. CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metab. 2018;27:85-100.e8 pubmed publisher
Vonk M, Wagenaar L, Pieters R, Knippels L, Willemsen L, Smit J, et al. The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models. Clin Transl Allergy. 2017;7:35 pubmed publisher
Liew P, Kim J, Lee W, Kubes P. Antibody-dependent fragmentation is a newly identified mechanism of cell killing in vivo. Sci Rep. 2017;7:10515 pubmed publisher
Yi P, Liang Y, Yuan D, Jie Z, Kwota Z, Chen Y, et al. A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection. Sci Rep. 2017;7:3857 pubmed publisher
Levine A, Mendoza A, Hemmers S, Moltedo B, Niec R, Schizas M, et al. Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017;546:421-425 pubmed publisher
Young C, Rorke E, Adhikary G, Xu W, Eckert R. Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype. Cell Death Dis. 2017;8:e2840 pubmed publisher
Dang S, Xu H, Xu C, Cai W, Li Q, Cheng Y, et al. Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis. Autophagy. 2014;10:1301-15 pubmed publisher
Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, et al. Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun. 2014;5:3436 pubmed publisher
Roebrock K, Sunderkotter C, Münck N, Wolf M, Nippe N, Barczyk K, et al. Epidermal expression of I-TAC (Cxcl11) instructs adaptive Th2-type immunity. FASEB J. 2014;28:1724-34 pubmed publisher
Chopra M, Lang I, Salzmann S, Pachel C, Kraus S, Bäuerlein C, et al. Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS ONE. 2013;8:e75737 pubmed publisher
Peperzak V, Veraar E, Xiao Y, Babala N, Thiadens K, Brugmans M, et al. CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool. J Immunol. 2013;191:3025-36 pubmed publisher
Radulovic K, Rossini V, Manta C, Holzmann K, Kestler H, Niess J. The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine. PLoS ONE. 2013;8:e65413 pubmed publisher
Breser M, Motrich R, Sanchez L, Mackern Oberti J, Rivero V. Expression of CXCR3 on specific T cells is essential for homing to the prostate gland in an experimental model of chronic prostatitis/chronic pelvic pain syndrome. J Immunol. 2013;190:3121-33 pubmed publisher
Metcalf T, Baxter V, Nilaratanakul V, Griffin D. Recruitment and retention of B cells in the central nervous system in response to alphavirus encephalomyelitis. J Virol. 2013;87:2420-9 pubmed publisher
Zeng R, Oderup C, Yuan R, Lee M, Habtezion A, Hadeiba H, et al. Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells. Mucosal Immunol. 2013;6:847-56 pubmed publisher
Herzig D, Guo Y, Fang G, Toliver Kinsky T, Sherwood E. Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis. Crit Care. 2012;16:R168 pubmed publisher
Piehler D, Grahnert A, Eschke M, Richter T, Kohler G, Stenzel W, et al. T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis. Mucosal Immunol. 2013;6:405-14 pubmed publisher
Choi J, Ziga E, Ritchey J, Collins L, Prior J, Cooper M, et al. IFN?R signaling mediates alloreactive T-cell trafficking and GVHD. Blood. 2012;120:4093-103 pubmed publisher
Domingos Pereira S, Decrausaz L, Derré L, Bobst M, Romero P, Schiller J, et al. Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice. Mucosal Immunol. 2013;6:393-404 pubmed publisher
Shankar S, Wilson M, DiVietro J, Mentink Kane M, Xie Z, Wynn T, et al. RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol. 2012;188:6347-56 pubmed publisher
Sharma A, Chen Q, Nguyen T, Yu Q, Sen J. T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes. J Immunol. 2012;188:3859-68 pubmed publisher
Wilson J, Pack C, Lin E, Frost E, Albrecht J, Hadley A, et al. CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion. J Immunol. 2012;188:4340-8 pubmed publisher
Herzig D, Driver B, Fang G, Toliver Kinsky T, Shute E, Sherwood E. Regulation of lymphocyte trafficking by CXC chemokine receptor 3 during septic shock. Am J Respir Crit Care Med. 2012;185:291-300 pubmed publisher
Gonzaga R, Matzinger P, Perez Diez A. Resident peritoneal NK cells. J Immunol. 2011;187:6235-42 pubmed publisher
Yoshizawa K, Nakajima S, Notake T, Miyagawa S, Hida S, Taki S. IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice. J Immunol. 2011;187:5162-9 pubmed publisher
Brincks E, Gurung P, Langlois R, Hemann E, Legge K, Griffith T. The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL. J Immunol. 2011;187:4581-8 pubmed publisher
Hayakawa Y, Sato Matsushita M, Takeda K, Iwakura Y, Tahara H, Irimura T. Early activation and interferon-? production of tumor-infiltrating mature CD27 high natural killer cells. Cancer Sci. 2011;102:1967-71 pubmed publisher
Qu Y, Taylor J, Bose A, Storkus W. Therapeutic effectiveness of intratumorally delivered dendritic cells engineered to express the pro-inflammatory cytokine, interleukin (IL)-32. Cancer Gene Ther. 2011;18:663-73 pubmed publisher
Haworth O, Cernadas M, Levy B. NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation. J Immunol. 2011;186:6129-35 pubmed publisher
Benson D, Bakan C, Mishra A, Hofmeister C, Efebera Y, Becknell B, et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood. 2010;116:2286-94 pubmed publisher
Sharma R, Sung S, Abaya C, Ju A, Fu S, Ju S. IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation. J Immunol. 2009;183:1065-73 pubmed publisher
Uppaluri R, Sheehan K, Wang L, Bui J, Brotman J, Lu B, et al. Prolongation of cardiac and islet allograft survival by a blocking hamster anti-mouse CXCR3 monoclonal antibody. Transplantation. 2008;86:137-47 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD183 (CXCR3) Monoclonal Antibody (CXCR3-173), PE, eBioscience
Catalog # :
12-1831-80
Quantity :
25 µg
Price :
US 141.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Mouse
Clone :
CXCR3-173
Isotype :
IgG
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
an; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD182; CD183; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; CKR-L2; Cmkar3; CXC; C-X-C chemokine receptor type 3; CXC motif chemokine; C-X-C motif chemokine receptor 3; Cxcr3; CXC-R3; CXCR-3; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP10; IP10 receptor; IP-10 receptor; IP10-R; Mig receptor; MigR; Mig-R
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA