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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD158a/h/g Monoclonal Antibody (HP-MA4), PE, eBioscience™
catalog :
12-1589-42
quantity :
100 Tests
price :
US 319
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
HP-MA4
reactivity :
human
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 6
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human
Sleiman M, Brons N, Kaoma T, Dogu F, Villa Forte A, Lenoble P, et al. NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules. J Immunol. 2014;192:2602-10 pubmed publisher
Chapel A, Garcia Beltran W, Hölzemer A, Ziegler M, Lunemann S, Martrus G, et al. Peptide-specific engagement of the activating NK cell receptor KIR2DS1. Sci Rep. 2017;7:2414 pubmed publisher
Czaja K, Borer A, Schmied L, Terszowski G, Stern M, Gonzalez A. A comprehensive analysis of the binding of anti-KIR antibodies to activating KIRs. Genes Immun. 2014;15:33-7 pubmed publisher
Brusilovsky M, Cordoba M, Rosental B, Hershkovitz O, Andrake M, Pecherskaya A, et al. Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses. J Immunol. 2013;191:5256-67 pubmed publisher
Ohira M, Nishida S, Matsuura T, Muraoka I, Tryphonopoulos P, Fan J, et al. Comparative analysis of T-cell depletion method for clinical immunotherapy-anti-hepatitis c effects of natural killer cells via interferon-? production. Transplant Proc. 2013;45:2045-50 pubmed publisher
So E, Sallin M, Zhang X, Chan S, Sahni L, Schulze D, et al. A high throughput method for enrichment of natural killer cells and lymphocytes and assessment of in vitro cytotoxicity. J Immunol Methods. 2013;394:40-8 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD158a/h/g Monoclonal Antibody (HP-MA4), PE, eBioscience™
Catalog # :
12-1589-42
Quantity :
100 Tests
Price :
US 319
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 µL (0.25 µg)/test
Species :
Human
Clone :
HP-MA4
Isotype :
IgG2b, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.25 µg)/test
Aliases :
183ActI; CD158; CD158 antigen-like family member A; CD158 antigen-like family member G; CD158 antigen-like family member H; CD158 antigen-like family member I; CD158 antigen-like family member J; CD158A; CD158b; CD158B1; CD158G; CD158h; CD158i; CD158J; cl-49; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5; killer cell immunoglobulin-like receptor 2DL1; Killer cell immunoglobulin-like receptor 2DS1; killer cell immunoglobulin-like receptor 2DS2; Killer cell immunoglobulin-like receptor 2DS4; killer cell immunoglobulin-like receptor 2DS5; killer cell immunoglobulin-like receptor KIR2DS2; killer cell immunoglobulin-like receptor KIRDS1; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; killer Ig receptor; killer inhibitory receptor 2-2-1; killer inhibitory receptor 4-1-2; killer-cell Ig-like receptor; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor two domains short tail 2 protein; KIR antigen 2DS4; KIR1D; KIR221; KIR2DL1; KIR2DP1DL1; KIR2DS1; KIR2DS2; KIR-2DS2; KIR2DS4; KIR-2DS4; KIR2DS5; KIR412; KIR-K64; KKA3; MHC class I NK cell receptor; MHC class I NK cell receptor Eb6 ActI; natural killer associated transcript 5; natural killer cell inhibitory receptor; natural killer cell receptor; natural killer-associated transcript 1; Natural killer-associated transcript 5; Natural killer-associated transcript 8; natural killer-associated transcript 9; NK receptor 183 ActI; NKAT; NKAT1; NKAT-1; NKAT5; NKAT-5; NKAT6; NKAT8; NKAT-8; NKAT9; NKAT-9; p50 killer cell activating receptor KAR-K1d; p50.1; p50.3; p58 killer cell inhibitory receptor KIR-K64; p58 killer cell inhibitory receptor KIR-K7a; p58 natural killer cell receptor clone CL-49; P58 natural killer cell receptor clones CL-39/CL-17; p58 natural killer cell receptor clones CL-42/47.11; p58 NK cell inhibitory receptor NKR-K6; p58 NK receptor CL-39/CL-17; p58 NK receptor CL-42/47.11; p58 NK receptor CL-49; p58.1; p58.1 MHC class-I-specific NK receptor; XXbac-BCX195L8.1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA