CD158a/h/g Monoclonal Antibody (HP-MA4), PE, eBioscience™ | Invitrogen 12-1589-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD158a/h/g Monoclonal Antibody (HP-MA4), PE, eBioscience™

catalog :

12-1589-41

quantity :

25Tests

price :

US 108

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

HP-MA4

reactivity :

human

application :

flow cytometry

citations: 5

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Sleiman M, Brons N, Kaoma T, Dogu F, Villa Forte A, Lenoble P, et al. NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules. J Immunol. 2014;192:2602-10 pubmed publisher
	Czaja K, Borer A, Schmied L, Terszowski G, Stern M, Gonzalez A. A comprehensive analysis of the binding of anti-KIR antibodies to activating KIRs. Genes Immun. 2014;15:33-7 pubmed publisher
	Brusilovsky M, Cordoba M, Rosental B, Hershkovitz O, Andrake M, Pecherskaya A, et al. Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses. J Immunol. 2013;191:5256-67 pubmed publisher
	Ohira M, Nishida S, Matsuura T, Muraoka I, Tryphonopoulos P, Fan J, et al. Comparative analysis of T-cell depletion method for clinical immunotherapy-anti-hepatitis c effects of natural killer cells via interferon-? production. Transplant Proc. 2013;45:2045-50 pubmed publisher
	So E, Sallin M, Zhang X, Chan S, Sahni L, Schulze D, et al. A high throughput method for enrichment of natural killer cells and lymphocytes and assessment of in vitro cytotoxicity. J Immunol Methods. 2013;394:40-8 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD158a/h/g Monoclonal Antibody (HP-MA4), PE, eBioscience™

Catalog # :

12-1589-41

Quantity :

25Tests

Price :

US 108

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.25 µg)/test

Species :

Human

Clone :

HP-MA4

Isotype :

IgG2b, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.25 µg)/test