CD158f Monoclonal Antibody (UP-R1), PE, eBioscience | Invitrogen 12-1588-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD158f Monoclonal Antibody (UP-R1), PE, eBioscience

catalog :

12-1588-41

quantity :

25 Tests

price :

US 187.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

UP-R1

The same clone is also sold as:

Exbio: 11-774-C100, 1P-774-T100, 11-774-C025, 1P-774-T025, 1A-774-T100
OriGene: AM26776RP-N
BioLegend: 341313, 341307, 341304, 341314, 341309, 341303

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Du Z, Sharma S, Spellman S, Reed E, Rajalingam R. KIR2DL5 alleles mark certain combination of activating KIR genes. Genes Immun. 2008;9:470-80 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD158f Monoclonal Antibody (UP-R1), PE, eBioscience

Catalog # :

12-1588-41

Quantity :

25 Tests

Price :

US 187.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.25 ug)/test

Species :

Human

Clone :

UP-R1

Isotype :

IgG1

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

KIR2DL5A and KIR2DL5B are Killer cell immunoglobulin-like receptors (KIRs), transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. KIR proteins are thought to play an important role in regulation of the immune response. Functionally, KIR2DL5A and KIR2DL5B are receptors on natural killer (NK) cells for HLA-C alleles and prevent cell lysis by inhibiting the activity of NK cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.25 ug)/test

Aliases :

CD158; CD158F; CD158f1; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A; killer cell immunoglobulin-like receptor 2DL5A; killer cell immunoglobulin-like receptor KIR2DL5A; killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 5; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A; killer-cell Ig-like receptor; KIR2DL; KIR2DL5; KIR2DL5.1; KIR2DL5.3; KIR2DL5A; NKAT; NKAT1