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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD152 (CTLA-4) Monoclonal Antibody (14D3), PE, eBioscience
catalog :
12-1529-41
quantity :
25 Tests
price :
US 132.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
14D3
reactivity :
human, rhesus macaque
application :
flow cytometry
more info or order :
citations: 49
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; fig 7
Scottà C, Fanelli G, Hoong S, Romano M, Lamperti E, Sukthankar M, et al. Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells. Haematologica. 2016;101:91-100 pubmed publisher
  • flow cytometry; human
Fricke F, Beaudouin J, Eils R, Heilemann M. One, two or three? Probing the stoichiometry of membrane proteins by single-molecule localization microscopy. Sci Rep. 2015;5:14072 pubmed publisher
  • flow cytometry; human
Rueda C, Wells C, Gisslen T, Jobe A, Kallapur S, Chougnet C. Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates. Hum Immunol. 2015;76:65-73 pubmed publisher
  • flow cytometry; human
Bending D, Pesenacker A, Ursu S, Wu Q, Lom H, Thirugnanabalan B, et al. Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis. J Immunol. 2014;193:2699-708 pubmed publisher
Swatler J, Targo x144 ska A, Turos Korgul L, Mosieniak G, Piwocka K. Protocol for isolation of tumor-derived extracellular vesicles and functional studies on human T cell subsets. STAR Protoc. 2024;5:103011 pubmed publisher
Wan Y, Mu X, Zhao J, Li L, Xu W, Zhang M. Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression. Biomed Rep. 2024;20:68 pubmed publisher
Parvini N, Akbari M, Hamidieh A, Fathi F, Amini A, Ebrahimi M, et al. CTLA-4 Blockade of Natural Killer Cells Increases Cytotoxicity against Acute Lymphoid Leukaemia Cells Neda. Cell J. 2024;26:150-157 pubmed publisher
Qiao Y, Chen J, Wang X, Yan S, Tan J, Xia B, et al. Enhancement of CAR-T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins. Cancer Commun (Lond). 2023;43:788-807 pubmed publisher
Trovato F, Mujib S, Jerome E, Cavazza A, Morgan P, Smith J, et al. Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causes. Heliyon. 2022;8:e09733 pubmed publisher
Corgnac S, Damei I, Gros G, Caidi A, Terry S, Chouaib S, et al. Cancer stem-like cells evade CD8+CD103+ tumor-resident memory T (TRM) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model. J Immunother Cancer. 2022;10: pubmed publisher
Piekarska K, Urban Wójciuk Z, Kurkowiak M, Pelikant Małecka I, Schumacher A, Sakowska J, et al. Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity. Nat Commun. 2022;13:856 pubmed publisher
Cho J, Okuma A, Sofjan K, Lee S, Collins J, Wong W. Engineering advanced logic and distributed computing in human CAR immune cells. Nat Commun. 2021;12:792 pubmed publisher
Ye L, Peng W, Niu Y, Xiang X, Wei X, Wang Z, et al. Accumulation of TNFR2-expressing regulatory T cells in malignant pleural effusion of lung cancer patients is associated with poor prognosis. Ann Transl Med. 2020;8:1647 pubmed publisher
Dhariwala M, Karthikeyan D, Vasquez K, Farhat S, Weckel A, Taravati K, et al. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020;1:100132 pubmed publisher
Wierzbinska J, Toth R, Ishaque N, Rippe K, Mallm J, Klett L, et al. Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL. Genome Med. 2020;12:29 pubmed publisher
Lopes D, Oliveira S, Page B, Carvalho L, Carvalho E, Cardoso L. Schistosoma mansoni rSm29 Antigen Induces a Regulatory Phenotype on Dendritic Cells and Lymphocytes From Patients With Cutaneous Leishmaniasis. Front Immunol. 2018;9:3122 pubmed publisher
Tomic S, Ilic N, Kokol V, Gruden Movsesijan A, Mihajlović D, Bekić M, et al. Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells. Int J Nanomedicine. 2018;13:6941-6960 pubmed publisher
Proff J, Brey C, Ensser A, Holter W, Lehner M. Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2-CH3 IgG spacer domains. J Transl Med. 2018;16:26 pubmed publisher
Terranova Barberio M, Thomas S, Ali N, Pawlowska N, Park J, Krings G, et al. HDAC inhibition potentiates immunotherapy in triple negative breast cancer. Oncotarget. 2017;8:114156-114172 pubmed publisher
Raijmakers R, Sprenkeler E, Aleva F, Jacobs C, Kanneganti T, Joosten L, et al. Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics. Sci Rep. 2017;7:11500 pubmed publisher
Geisler K, Markwart R, Requardt R, Weigel C, Schubert K, Scherag A, et al. Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis. PLoS ONE. 2017;12:e0183214 pubmed publisher
Cobb D, Kim O, Golden Mason L, Rosen H, Hahn Y. Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection. Hepatology. 2017;: pubmed publisher
Ehx G, Fransolet G, de Leval L, D Hondt S, Lucas S, Hannon M, et al. Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects. Oncoimmunology. 2017;6:e1314425 pubmed publisher
Zahm C, Colluru V, McNeel D. Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells. Cancer Immunol Res. 2017;5:630-641 pubmed publisher
Siska P, Beckermann K, Mason F, Andrejeva G, Greenplate A, Sendor A, et al. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. JCI Insight. 2017;2: pubmed publisher
Borken F, Markwart R, Requardt R, Schubert K, Spacek M, Verner M, et al. Chronic Critical Illness from Sepsis Is Associated with an Enhanced TCR Response. J Immunol. 2017;198:4781-4791 pubmed publisher
Bending D, Giannakopoulou E, Lom H, Wedderburn L. Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression. J Immunol. 2015;195:5616-24 pubmed publisher
Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed publisher
Thommen D, Schreiner J, Müller P, Herzig P, Roller A, Belousov A, et al. Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors. Cancer Immunol Res. 2015;3:1344-55 pubmed publisher
Cousin C, Aubatin A, le Gouvello S, Apetoh L, Castellano F, Molinier Frenkel V. The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation. Eur J Immunol. 2015;45:1772-82 pubmed publisher
Rodríguez Perea A, Montoya C, Olek S, Chougnet C, Velilla P. Statins increase the frequency of circulating CD4+ FOXP3+ regulatory T cells in healthy individuals. J Immunol Res. 2015;2015:762506 pubmed publisher
Vasco C, Canazza A, Rizzo A, Mossa A, Corsini E, Silvani A, et al. Circulating T regulatory cells migration and phenotype in glioblastoma patients: an in vitro study. J Neurooncol. 2013;115:353-63 pubmed publisher
Ward F, Dahal L, Wijesekera S, Abdul Jawad S, Kaewarpai T, Xu H, et al. The soluble isoform of CTLA-4 as a regulator of T-cell responses. Eur J Immunol. 2013;43:1274-85 pubmed publisher
Koristka S, Cartellieri M, Arndt C, Bippes C, Feldmann A, Michalk I, et al. Retargeting of regulatory T cells to surface-inducible autoantigen La/SS-B. J Autoimmun. 2013;42:105-16 pubmed publisher
Olson B, Jankowska Gan E, Becker J, Vignali D, Burlingham W, McNeel D. Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade. J Immunol. 2012;189:5590-601 pubmed publisher
Presicce P, Moreno Fernandez M, Rusie L, Fichtenbaum C, Chougnet C. In vitro HIV infection impairs the capacity of myeloid dendritic cells to induce regulatory T cells. PLoS ONE. 2012;7:e42802 pubmed publisher
Joffe M, Necula A, Chand R, McWhinney B, Krishnamurthy B, Loudovaris T, et al. Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors. Int Immunol. 2012;24:447-53 pubmed publisher
Khalid M, Yu H, Sauter D, Usmani S, Schmökel J, Feldman J, et al. Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection. J Virol. 2012;86:4906-20 pubmed publisher
Skrindo I, Scheel C, Johansen F, Jahnsen F. Experimentally induced accumulation of Foxp3? T cells in upper airway allergy. Clin Exp Allergy. 2011;41:954-62 pubmed publisher
Schmetterer K, Haiderer D, Leb Reichl V, Neunkirchner A, Jahn Schmid B, Küng H, et al. Bet v 1-specific T-cell receptor/forkhead box protein 3 transgenic T cells suppress Bet v 1-specific T-cell effector function in an activation-dependent manner. J Allergy Clin Immunol. 2011;127:238-45, 245.e1-3 pubmed publisher
Peggs K, Quezada S, Chambers C, Korman A, Allison J. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med. 2009;206:1717-25 pubmed publisher
Horlock C, Stott B, Dyson P, Morishita M, Coombes R, Savage P, et al. The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer. Br J Cancer. 2009;100:1061-7 pubmed publisher
Lages C, Suffia I, Velilla P, Huang B, Warshaw G, Hildeman D, et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol. 2008;181:1835-48 pubmed
Zhang Q, Qian F, Liu H, Zhou L, Huang M, Zhang X, et al. Expression of surface markers on peripheral CD4+CD25high T cells in patients with atopic asthma: role of inhaled corticosteroid. Chin Med J (Engl). 2008;121:205-12 pubmed
Botturi K, Lacoeuille Y, Thomas P, Boniface S, Reynaud Gaubert M, Magnan A. CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients. Eur Respir J. 2008;31:1167-76 pubmed publisher
Saverino D, Brizzolara R, Simone R, Chiappori A, Milintenda Floriani F, Pesce G, et al. Soluble CTLA-4 in autoimmune thyroid diseases: relationship with clinical status and possible role in the immune response dysregulation. Clin Immunol. 2007;123:190-8 pubmed
Matsubar Y, Hori T, Morita R, Sakaguchi S, Uchiyama T. Delineation of immunoregulatory properties of adult T-cell leukemia cells. Int J Hematol. 2006;84:63-9 pubmed
Leong P, Mohammad R, Ibrahim N, Ithnin H, Abdullah M, Davis W, et al. Phenotyping of lymphocytes expressing regulatory and effector markers in infiltrating ductal carcinoma of the breast. Immunol Lett. 2006;102:229-36 pubmed
Bashuda H, Kimikawa M, Seino K, Kato Y, Ono F, Shimizu A, et al. Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. J Clin Invest. 2005;115:1896-902 pubmed
product information
Product Type :
Antibody
Product Name :
CD152 (CTLA-4) Monoclonal Antibody (14D3), PE, eBioscience
Catalog # :
12-1529-41
Quantity :
25 Tests
Price :
US 132.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Rhesus Monkey
Applications :
Flow Cytometry: 5 uL (0.03 ug)/test
Species :
Human, Rhesus Monkey
Clone :
14D3
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.03 ug)/test
Aliases :
ALPS5; CD; CD152; CD152 antigen; CD152 isoform; CD152 protein; CD152 protein precursor; celiac disease 3; CELIAC3; Ctla4; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte associated protein 4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; EGK_04712; GRD4; GSE; ICOS; IDDM12; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; Ly-56; sCTLA4; soluble form; transmembrane form
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA