This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD146 Monoclonal Antibody (P1H12), PE, eBioscience
catalog :
12-1469-42
quantity :
100 Tests
price :
US 329.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
P1H12

The same clone is also sold as:
reactivity :
human, mouse, dogs, domestic rabbit
application :
flow cytometry
citations: 32
Reference
Pei Y, Mikaeiliagah E, Wang B, Zhang X, Pei M. The matrix microenvironment influences but does not dominate tissue-specific stem cell lineage differentiation. Mater Today Bio. 2023;23:100805 pubmed publisher
Gur C, Wang S, Sheban F, Zada M, Li B, Kharouf F, et al. LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma. Cell. 2022;185:1373-1388.e20 pubmed publisher
Al Hosni R, Bozec L, Roberts S, Cheema U. Reprogramming bone progenitor identity and potency through control of collagen density and oxygen tension. iScience. 2022;25:104059 pubmed publisher
Shan Z, Li L, Atkins C, Wang M, Wen Y, Jeong J, et al. Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment. elife. 2021;10: pubmed publisher
Porcelli L, Guida M, De Summa S, Di Fonte R, De Risi I, Garofoli M, et al. uPAR+ extracellular vesicles: a robust biomarker of resistance to checkpoint inhibitor immunotherapy in metastatic melanoma patients. J Immunother Cancer. 2021;9: pubmed publisher
Liu J, Qiu X, Lv Y, Zheng C, Dong Y, Dou G, et al. Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages. Stem Cell Res Ther. 2020;11:507 pubmed publisher
Wang Y, Hu G, Hill R, Dzieciatkowska M, Hansen K, Zhang X, et al. Matrix reverses immortalization-mediated stem cell fate determination. Biomaterials. 2021;265:120387 pubmed publisher
Hartman R, Kapteijn D, Haitjema S, Bekker M, Mokry M, Pasterkamp G, et al. Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets. Sci Rep. 2020;10:12367 pubmed publisher
Li X, Zhang B, Wang H, Zhao X, Zhang Z, Ding G, et al. Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells. J Int Med Res. 2020;48:300060520930853 pubmed publisher
Wang T, Hill R, Dzieciatkowska M, Zhu L, Infante A, Hu G, et al. Site-Dependent Lineage Preference of Adipose Stem Cells. Front Cell Dev Biol. 2020;8:237 pubmed publisher
Wang Y, Fu Y, Yan Z, Zhang X, Pei M. Impact of Fibronectin Knockout on Proliferation and Differentiation of Human Infrapatellar Fat Pad-Derived Stem Cells. Front Bioeng Biotechnol. 2019;7:321 pubmed publisher
Yu B, Li Q, Zhou M. LPS‑induced upregulation of the TLR4 signaling pathway inhibits osteogenic differentiation of human periodontal ligament stem cells under inflammatory conditions. Int J Mol Med. 2019;43:2341-2351 pubmed publisher
Kuryk L, Møller A, Jaderberg M. Combination of immunogenic oncolytic adenovirus ONCOS-102 with anti-PD-1 pembrolizumab exhibits synergistic antitumor effect in humanized A2058 melanoma huNOG mouse model. Oncoimmunology. 2019;8:e1532763 pubmed publisher
Liu W, Zhang L, Xuan K, Hu C, Li L, Zhang Y, et al. Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia. Theranostics. 2018;8:5575-5592 pubmed publisher
Yianni V, Sharpe P. Molecular Programming of Perivascular Stem Cell Precursors. Stem Cells. 2018;36:1890-1904 pubmed publisher
Yu Y, Gool E, Berckmans R, Coumans F, Barendrecht A, Maas C, et al. Extracellular vesicles from human saliva promote hemostasis by delivering coagulant tissue factor to activated platelets. J Thromb Haemost. 2018;16:1153-1163 pubmed publisher
Somasundaram R, Zhang G, Fukunaga Kalabis M, Perego M, Krepler C, Xu X, et al. Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Nat Commun. 2017;8:607 pubmed publisher
Agarwal S, Loder S, Sorkin M, Li S, Shrestha S, Zhao B, et al. Analysis of Bone-Cartilage-Stromal Progenitor Populations in Trauma Induced and Genetic Models of Heterotopic Ossification. Stem Cells. 2016;34:1692-701 pubmed publisher
He X, Shi X, Puthiyakunnon S, Zhang L, Zeng Q, Li Y, et al. CD44-mediated monocyte transmigration across Cryptococcus neoformans-infected brain microvascular endothelial cells is enhanced by HIV-1 gp41-I90 ectodomain. J Biomed Sci. 2016;23:28 pubmed publisher
Yu J, Zhang B, Peng L, Wu C, Cao H, Zhong J, et al. Repositioning of Memantine as a Potential Novel Therapeutic Agent against Meningitic E. coli-Induced Pathogenicities through Disease-Associated Alpha7 Cholinergic Pathway and RNA Sequencing-Based Transcriptome Analysis of Host Inflammatory Responses. PLoS ONE. 2015;10:e0121911 pubmed publisher
Qin Y, Qin J, Zhou C, Li J, Gao W. Generation of embryonic stem cells from mouse adipose-tissue derived cells via somatic cell nuclear transfer. Cell Cycle. 2015;14:1282-90 pubmed publisher
Qin Y, Zhou P, Zhou C, Li J, Gao W. The adipose-derived lineage-negative cells are enriched mesenchymal stem cells and promote limb ischemia recovery in mice. Stem Cells Dev. 2014;23:363-71 pubmed publisher
HUTCHINS N, Wang F, Wang Y, Chung C, Ayala A. Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1. J Leukoc Biol. 2013;94:963-70 pubmed publisher
Kazemnejad S, Zarnani A, Khanmohammadi M, Mobini S. Chondrogenic differentiation of menstrual blood-derived stem cells on nanofibrous scaffolds. Methods Mol Biol. 2013;1058:149-69 pubmed publisher
Moradi I, Behjati M, Kazemi M. Application of anodized titanium for enhanced recruitment of endothelial progenitor cells. Nanoscale Res Lett. 2012;7:298 pubmed publisher
Tasso R, Ilengo C, Quarto R, Cancedda R, Caspi R, Pennesi G. Mesenchymal stem cells induce functionally active T-regulatory lymphocytes in a paracrine fashion and ameliorate experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2012;53:786-93 pubmed publisher
Kita K, Gauglitz G, Phan T, Herndon D, Jeschke M. Isolation and characterization of mesenchymal stem cells from the sub-amniotic human umbilical cord lining membrane. Stem Cells Dev. 2010;19:491-502 pubmed publisher
Lamerato Kozicki A, Helm K, Jubala C, Cutter G, Modiano J. Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation. Exp Hematol. 2006;34:870-8 pubmed
Elshal M, Khan S, Takahashi Y, Solomon M, McCoy J. CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood. Blood. 2005;106:2923-4 pubmed
Wu T, Handa J, Gottsch J. Light-induced oxidative stress in choroidal endothelial cells in mice. Invest Ophthalmol Vis Sci. 2005;46:1117-23 pubmed
Solovey A, Gui L, Chang L, Enenstein J, Browne P, Hebbel R. Identification and functional assessment of endothelial P1H12. J Lab Clin Med. 2001;138:322-31 pubmed
Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel R. Circulating activated endothelial cells in sickle cell anemia. N Engl J Med. 1997;337:1584-90 pubmed
product information
Product Type :
Antibody
Product Name :
CD146 Monoclonal Antibody (P1H12), PE, eBioscience
Catalog # :
12-1469-42
Quantity :
100 Tests
Price :
US 329.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Canine, Human, Mouse, Rabbit
Applications :
Flow Cytometry: 5 uL (0.125 ug)/test
Species :
Canine, Human, Mouse, Rabbit
Clone :
P1H12
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and malignant cell types. In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. CD146 expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Further, CD146 could be an adhesion molecule active in neural crest cells during embryonic development. CD146 acts also as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.125 ug)/test
Aliases :
1-gicerin; AV025631; CD146; CD149; Cell surface glycoprotein MUC18; cell surface glycoprotein P1H12; Gicerin; HEMCAM; l-gicerin; l-gicerin precursor; l-gicerin protein; LOW QUALITY PROTEIN: cell surface glycoprotein MUC18; MCAM; melanoma adhesion molecule; melanoma cell adhesion molecule; Melanoma-associated antigen A32; melanoma-associated antigen MUC18; Muc18; mucin-18; s-endo; S-endo 1 endothelial-associated antigen; s-gicerin; s-gicerin precursor
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA