CD137 (4-1BB) Monoclonal Antibody (4B4 (4B4-1)), PE, eBioscience™ | Invitrogen 12-1379-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD137 (4-1BB) Monoclonal Antibody (4B4 (4B4-1)), PE, eBioscience™

catalog :

12-1379-42

quantity :

100 Tests

price :

US 286

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

4B4 (4B4-1)

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 4b	Komdeur F, Wouters M, Workel H, Tijans A, Terwindt A, Brunekreeft K, et al. CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRÎ±Î²+ CD8Î±Î²+ T cells that can be targeted for cancer immunotherapy. Oncotarget. 2016;7:75130-75144 pubmed publisher
	Schroeder J, Puntigam L, Hofmann L, Jeske S, Beccard I, Doescher J, et al. Circulating Exosomes Inhibit B Cell Proliferation and Activity. Cancers (Basel). 2020;12: pubmed publisher
	Want M, Konstorum A, Huang R, Jain V, Matsueda S, Tsuji T, et al. Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer. Oncoimmunology. 2019;8:e1586042 pubmed publisher
	Guan C, Li Q, Song X, Xu W, Li L, Xu A. Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2. Oxid Med Cell Longev. 2017;2017:9303054 pubmed publisher
	Legat A, Speiser D, Pircher H, Zehn D, Fuertes Marraco S. Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8?T Cells. Front Immunol. 2013;4:455 pubmed publisher
	Hodge G, Hodge S, Reynolds P, Holmes M. Targeting peripheral blood pro-inflammatory CD28null T cells and natural killer T-like cells by inhibiting CD137 expression: possible relevance to treatment of bronchiolitis obliterans syndrome. J Heart Lung Transplant. 2013;32:1081-9 pubmed publisher
	Turcotte S, Gros A, Hogan K, Tran E, Hinrichs C, Wunderlich J, et al. Phenotype and function of T cells infiltrating visceral metastases from gastrointestinal cancers and melanoma: implications for adoptive cell transfer therapy. J Immunol. 2013;191:2217-25 pubmed publisher
	Lee S, Kim Y, Hwang S, Kim Y, Han I, Vinay D, et al. 4-1BB signal stimulates the activation, expansion, and effector functions of ?? T cells in mice and humans. Eur J Immunol. 2013;43:1839-48 pubmed publisher
	Kickler K, Ni Choileain S, Williams A, Richards A, Astier A. Calcitriol modulates the CD46 pathway in T cells. PLoS ONE. 2012;7:e48486 pubmed publisher
	Sumi T, Ishida W, Ebihara N, Fukushima A. T cell-related costimulatory molecules in the conjunctiva of patients with severe allergic conjunctivitis. Cornea. 2010;29:622-7 pubmed publisher
	Cernea S, Herold K. Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies. Clin Immunol. 2010;134:121-9 pubmed publisher
	Houot R, Goldstein M, Kohrt H, Myklebust J, Alizadeh A, Lin J, et al. Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion. Blood. 2009;114:3431-8 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD137 (4-1BB) Monoclonal Antibody (4B4 (4B4-1)), PE, eBioscience™

Catalog # :

12-1379-42

Quantity :

100 Tests

Price :

US 286

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.5 µg)/test

Species :

Human

Clone :

4B4 (4B4-1)

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.5 µg)/test

Aliases :

4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9

more info or order :

Invitrogen product webpage