CD137 (4-1BB) Monoclonal Antibody (17B5), PE, eBioscience™ | Invitrogen 12-1371-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD137 (4-1BB) Monoclonal Antibody (17B5), PE, eBioscience™

catalog :

12-1371-82

quantity :

100 µg

price :

US 245

clonality :

monoclonal

host :

Syrian golden hamster

conjugate :

clone name :

17B5

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 25

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 3e	Hajaj E, Eisenberg G, Klein S, Frankenburg S, Merims S, Ben David I, et al. SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint. elife. 2020;9: pubmed publisher
flow cytometry; mouse; fig 1	Zheng G, Wang B, Chen A. The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. J Immunol. 2004;173:2428-34 pubmed
	Zahm C, Moseman J, Delmastro L, G Mcneel D. PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy. Oncoimmunology. 2021;10:1912892 pubmed publisher
	Bhatt D, Kang B, Sawant D, Zheng L, PEREZ K, Huang Z, et al. STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets. J Exp Med. 2021;218: pubmed publisher
	Choi H, Deng J, Li S, Silk T, Dong L, Brea E, et al. Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer. Cell Rep. 2019;27:806-819.e5 pubmed publisher
	Buchan S, Fallatah M, Thirdborough S, Taraban V, Rogel A, Thomas L, et al. PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity. Clin Cancer Res. 2018;24:2383-2394 pubmed publisher
	Wu J, Zhang H, Shi X, Xiao X, Fan Y, Minze L, et al. Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction. Immunity. 2017;47:1114-1128.e6 pubmed publisher
	Kang S, Lee S, Park S, Kim J, Kim H, Lee H, et al. Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand. Cancer Res. 2017;77:5989-6000 pubmed publisher
	Zahm C, Colluru V, McNeel D. Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells. Cancer Immunol Res. 2017;5:630-641 pubmed publisher
	Autengruber A, Gereke M, Hansen G, Hennig C, Bruder D. Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function. Eur J Microbiol Immunol (Bp). 2012;2:112-20 pubmed publisher
	Devaud C, Westwood J, John L, Flynn J, Paquet Fifield S, Duong C, et al. Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy. Mol Ther. 2014;22:18-27 pubmed publisher
	Chen Y, Forsberg M, Khaja S, Ciecko A, Hessner M, Geurts A. Gene targeting in NOD mouse embryos using zinc-finger nucleases. Diabetes. 2014;63:68-74 pubmed publisher
	Lee S, Kim Y, Hwang S, Kim Y, Han I, Vinay D, et al. 4-1BB signal stimulates the activation, expansion, and effector functions of ?? T cells in mice and humans. Eur J Immunol. 2013;43:1839-48 pubmed publisher
	Hagman D, Kuzma J, Larson I, Foster Schubert K, Kuan L, Cignarella A, et al. Characterizing and quantifying leukocyte populations in human adipose tissue: impact of enzymatic tissue processing. J Immunol Methods. 2012;386:50-9 pubmed publisher
	Yeo Y, Martínez Gómez J, Croxford J, Gasser S, Ling E, Schwarz H. CD137 ligand activated microglia induces oligodendrocyte apoptosis via reactive oxygen species. J Neuroinflammation. 2012;9:173 pubmed publisher
	Verbrugge I, Hagekyriakou J, Sharp L, Galli M, West A, McLaughlin N, et al. Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies. Cancer Res. 2012;72:3163-74 pubmed publisher
	Osterbur J, Sprague L, Muccioli M, Pate M, Mansfield K, McGinty J, et al. Adhesion to substrates induces dendritic cell endothelization and decreases immunological response. Immunobiology. 2013;218:64-75 pubmed publisher
	Shen C, He Y, Cheng K, Zhang D, Miao S, Zhang A, et al. Killer artificial antigen-presenting cells deplete alloantigen-specific T cells in a murine model of alloskin transplantation. Immunol Lett. 2011;138:144-55 pubmed publisher
	Hamano R, Huang J, Yoshimura T, Oppenheim J, Chen X. TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40. Eur J Immunol. 2011;41:2010-20 pubmed publisher
	Jiang D, Schwarz H. Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein. PLoS ONE. 2010;5:e15565 pubmed publisher
	Gültner S, Kuhlmann T, Hesse A, Weber J, Riemer C, Baier M, et al. Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE. Eur J Immunol. 2010;40:3403-12 pubmed publisher
	Alves B, Leong J, Tamang D, Elliott V, Edelnant J, Redelman D, et al. Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity. J Leukoc Biol. 2009;86:701-12 pubmed publisher
	Abe J, Ueha S, Suzuki J, Tokano Y, Matsushima K, Ishikawa S. Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol. 2008;173:1682-92 pubmed publisher
	Jiang D, Chen Y, Schwarz H. CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol. 2008;181:3923-32 pubmed
	Shao Z, Sun F, Koh D, Schwarz H. Characterisation of soluble murine CD137 and its association with systemic lupus. Mol Immunol. 2008;45:3990-9 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD137 (4-1BB) Monoclonal Antibody (17B5), PE, eBioscience™

Catalog # :

12-1371-82

Quantity :

100 µg

Price :

US 245

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Syrian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

17B5

Isotype :

IgG

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9

more info or order :

Invitrogen product webpage