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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD133 (Prominin-1) Monoclonal Antibody (13A4), PE, eBioscience™
catalog :
12-1331-80
quantity :
25 µg
price :
US 158
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
13A4
reactivity :
human, mouse, dogs
application :
flow cytometry
more info or order :
citations: 59
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig 2a
Ma Y, Deng M, Zhao X, Liu M. Alternatively Polarized Macrophages Regulate the Growth and Differentiation of Ependymal Stem Cells through the SIRT2 Pathway. Exp Neurobiol. 2020;29:150-163 pubmed publisher
  • flow cytometry; dogs; loading ...
Ito D, Childress M, Mason N, Winter A, O BRIEN T, Henson M, et al. A double blinded, placebo-controlled pilot study to examine reduction of CD34 +/CD117 +/CD133 + lymphoma progenitor cells and duration of remission induced by neoadjuvant valspodar in dogs with large B-cell lymphoma. F1000Res. 2015;4:42 pubmed publisher
  • flow cytometry; human; fig 6a
Jiang F, Li K, Archer M, Mehta M, Jamieson E, Charles A, et al. Differentiation of Islet Progenitors Regulated by Nicotinamide into Transcriptome-Verified β Cells That Ameliorate Diabetes. Stem Cells. 2017;35:1341-1354 pubmed publisher
  • flow cytometry; mouse; fig 3d
Barnett F, Rosenfeld M, Wood M, Kiosses W, Usui Y, Marchetti V, et al. Macrophages form functional vascular mimicry channels in vivo. Sci Rep. 2016;6:36659 pubmed publisher
An H, Seok S, Kwon J, Choudhury A, Oh J, Voon D, et al. The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer. Cell Rep. 2022;41:111878 pubmed publisher
Zhang H, Zhou H, Yuan J, Nan Y, Liu J. Endothelial GABBR2 Regulates Post-ischemic Angiogenesis by Inhibiting the Glycolysis Pathway. Front Cardiovasc Med. 2021;8:696578 pubmed publisher
Yin H, Gao T, Xie J, Huang Z, Zhang X, Yang F, et al. FUBP1 promotes colorectal cancer stemness and metastasis via DVL1-mediated activation of Wnt/β-catenin signaling. Mol Oncol. 2021;: pubmed publisher
Belenguer G, Duart Abadia P, Domingo Muelas A, Morante Redolat J, Farinas I. Cell population analysis of the adult murine subependymal neurogenic lineage by flow cytometry. STAR Protoc. 2021;2:100425 pubmed publisher
Kim I, Wu J, Rahme G, Battaglia S, Dixit A, Gaskell E, et al. Parallel Single-Cell RNA-Seq and Genetic Recording Reveals Lineage Decisions in Developing Embryoid Bodies. Cell Rep. 2020;33:108222 pubmed publisher
Nechama M, Makayes Y, Resnick E, Meir K, Volovelsky O. Rapamycin and dexamethasone during pregnancy prevent tuberous sclerosis complex-associated cystic kidney disease. JCI Insight. 2020;5: pubmed publisher
Gagniac L, Rusidzé M, Boudou F, Cagnet S, Adlanmerini M, Jeannot P, et al. Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium. Development. 2020;147: pubmed publisher
Komabayashi Suzuki M, Yamanishi E, Watanabe C, Okamura M, Tabata H, Iwai R, et al. Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development. Cell Rep. 2019;29:1113-1129.e5 pubmed publisher
Robson J, Remke M, Kool M, Julian E, Korshunov A, Pfister S, et al. Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells. PLoS ONE. 2019;14:e0210665 pubmed publisher
Philippeos C, Telerman S, Oulès B, Pisco A, Shaw T, Elgueta R, et al. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations. J Invest Dermatol. 2018;138:811-825 pubmed publisher
Albert M, Kalebic N, Florio M, Lakshmanaperumal N, Haffner C, Brandl H, et al. Epigenome profiling and editing of neocortical progenitor cells during development. EMBO J. 2017;36:2642-2658 pubmed publisher
Yu L, Chen S, Luo N, He S. The C-terminus domain of the hepatitis B virus x protein stimulates the proliferation of mouse foetal hepatic progenitor cells, although it is not required for the formation of spheroids. Int J Mol Med. 2017;40:400-410 pubmed publisher
Yeh C, Pai M, Shih Y, Shih J, Yeh S. Intravenous Arginine Administration Promotes Proangiogenic Cells Mobilization and Attenuates Lung Injury in Mice with Polymicrobial Sepsis. Nutrients. 2017;9: pubmed publisher
Shang Z, Xu Y, Liang W, Liang K, Hu X, Wang L, et al. Isolation of cancer progenitor cells from cancer stem cells in gastric cancer. Mol Med Rep. 2017;15:3637-3643 pubmed publisher
Yang Y, Magnuson M, Stein R, Wright C. The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation. Development. 2017;144:248-257 pubmed publisher
Weng L, Hu X, Kumar B, García M, Todorov I, Jung X, et al. Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor. Sci Rep. 2016;6:38632 pubmed publisher
Zhu G, Rankin S, Larson J, Zhu X, Chow L, Qu C, et al. PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation. Cancer Res. 2017;77:123-133 pubmed publisher
Le Coz V, Zhu C, Devocelle A, Vazquez A, Boucheix C, Azzi S, et al. IGF-1 contributes to the expansion of melanoma-initiating cells through an epithelial-mesenchymal transition process. Oncotarget. 2016;7:82511-82527 pubmed publisher
Xu K, Shen K, Liang X, Li Y, Nagao N, Li J, et al. MiR-139-5p reverses CD44+/CD133+-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells. Oncotarget. 2016;7:75118-75129 pubmed publisher
Thamm K, Graupner S, Werner C, Huttner W, Corbeil D. Monoclonal Antibodies 13A4 and AC133 Do Not Recognize the Canine Ortholog of Mouse and Human Stem Cell Antigen Prominin-1 (CD133). PLoS ONE. 2016;11:e0164079 pubmed publisher
Walker T, Overall R, Vogler S, Sykes A, Ruhwald S, Lasse D, et al. Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells. Stem Cell Reports. 2016;6:552-565 pubmed publisher
Park J, Park J, Park D, Kim D, Kim H. Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer. Stem Cells. 2016;34:1177-87 pubmed publisher
Loder S, Agarwal S, Sorkin M, Breuler C, Li J, Peterson J, et al. Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification. Ann Surg. 2016;264:1174-1180 pubmed
Siavashi V, Nassiri S, Rahbarghazi R, Vafaei R, Sariri R. ECM-Dependence of Endothelial Progenitor Cell Features. J Cell Biochem. 2016;117:1934-46 pubmed publisher
Luo Y, Coskun V, Liang A, Yu J, Cheng L, Ge W, et al. Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells. Cell. 2015;161:1175-1186 pubmed publisher
Wu C, Wang C, Chang C, Cheng Y, Song J, Jan J, et al. Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors. J Med Chem. 2015;58:1452-65 pubmed publisher
Ubil E, Duan J, Pillai I, Rosa Garrido M, Wu Y, Bargiacchi F, et al. Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature. 2014;514:585-90 pubmed publisher
Nakatsuka R, Matsuoka Y, Uemura Y, Sumide K, Iwaki R, Takahashi M, et al. Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro. Cell Transplant. 2015;24:97-113 pubmed publisher
Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, et al. Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development. PLoS ONE. 2013;8:e75222 pubmed publisher
Adorno M, Sikandar S, Mitra S, Kuo A, Nicolis Di Robilant B, Haro Acosta V, et al. Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature. 2013;501:380-4 pubmed publisher
Tasso R, Ulivi V, Reverberi D, Lo Sicco C, Descalzi F, Cancedda R. In vivo implanted bone marrow-derived mesenchymal stem cells trigger a cascade of cellular events leading to the formation of an ectopic bone regenerative niche. Stem Cells Dev. 2013;22:3178-91 pubmed publisher
Kao C, Hsu Y, Liu J, Lee D, Chung Y, Chiu I. The mood stabilizer valproate activates human FGF1 gene promoter through inhibiting HDAC and GSK-3 activities. J Neurochem. 2013;126:4-18 pubmed publisher
Krelin Y, Berkovich L, Amit M, Gil Z. Association between tumorigenic potential and the fate of cancer cells in a syngeneic melanoma model. PLoS ONE. 2013;8:e62124 pubmed publisher
Roehrich M, Spicher A, Milano G, Vassalli G. Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity. Biomed Res Int. 2013;2013:503047 pubmed publisher
Fujimoto A, Neo S, Ishizuka C, Kato T, Segawa K, Kawarai S, et al. Identification of cell surface antigen expression in canine hepatocellular carcinoma cell lines. J Vet Med Sci. 2013;75:831-5 pubmed
Buono K, Vadlamuri D, Gan Q, Levison S. Leukemia inhibitory factor is essential for subventricular zone neural stem cell and progenitor homeostasis as revealed by a novel flow cytometric analysis. Dev Neurosci. 2012;34:449-62 pubmed publisher
Morrison B, Steel J, Morris J. Sphere culture of murine lung cancer cell lines are enriched with cancer initiating cells. PLoS ONE. 2012;7:e49752 pubmed publisher
Agrawal V, Siu B, Chao H, Hirschi K, Raborn E, Johnson S, et al. Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation. Tissue Eng Part A. 2012;18:1454-63 pubmed publisher
Pei Y, Brun S, Markant S, Lento W, Gibson P, Taketo M, et al. WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development. 2012;139:1724-33 pubmed publisher
Morimoto H, Lee J, Tanaka T, Ishii K, Toyokuni S, Kanatsu Shinohara M, et al. In vitro transformation of mouse testis cells by oncogene transfection. Biol Reprod. 2012;86:148, 1-11 pubmed publisher
Liu L, Liu Z, Chen H, Zhang G, Kong Y, Kang X. Oxidized low-density lipoprotein and ?-glycerophosphate synergistically induce endothelial progenitor cell ossification. Acta Pharmacol Sin. 2011;32:1491-7 pubmed publisher
Nanduri L, Maimets M, Pringle S, van der Zwaag M, van Os R, Coppes R. Regeneration of irradiated salivary glands with stem cell marker expressing cells. Radiother Oncol. 2011;99:367-72 pubmed publisher
Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, et al. Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J Exp Med. 2011;208:949-60 pubmed publisher
Kittrell F, Carletti M, Kerbawy S, Heestand J, Xian W, Zhang M, et al. Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential. Breast Cancer Res. 2011;13:R41 pubmed publisher
Kim M, Koh Y, Kim K, Koh B, Nam D, Alitalo K, et al. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res. 2010;70:10411-21 pubmed publisher
Pfenninger C, Steinhoff C, Hertwig F, Nuber U. Prospectively isolated CD133/CD24-positive ependymal cells from the adult spinal cord and lateral ventricle wall differ in their long-term in vitro self-renewal and in vivo gene expression. Glia. 2011;59:68-81 pubmed publisher
Morris L, Klanke C, Lang S, Pokall S, Maldonado A, Vuletin J, et al. Characterization of endothelial progenitor cells mobilization following cutaneous wounding. Wound Repair Regen. 2010;18:383-90 pubmed publisher
Swijnenburg R, Govaert J, van der Bogt K, Pearl J, Huang M, Stein W, et al. Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction. Circ Cardiovasc Imaging. 2010;3:77-85 pubmed publisher
Burger P, Gupta R, Xiong X, ONTIVEROS C, Salm S, Moscatelli D, et al. High aldehyde dehydrogenase activity: a novel functional marker of murine prostate stem/progenitor cells. Stem Cells. 2009;27:2220-8 pubmed publisher
Santisteban M, Reiman J, Asiedu M, Behrens M, Nassar A, Kalli K, et al. Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res. 2009;69:2887-95 pubmed publisher
Treese C, Mittag A, Lange F, Tarnok A, Loesche A, Emmrich F, et al. Characterization of fibroblasts responsible for cartilage destruction in arthritis. Cytometry A. 2008;73:351-60 pubmed publisher
Pfenninger C, Roschupkina T, Hertwig F, Kottwitz D, Englund E, Bengzon J, et al. CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells. Cancer Res. 2007;67:5727-36 pubmed
Sugiyama T, Rodriguez R, McLean G, Kim S. Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc Natl Acad Sci U S A. 2007;104:175-80 pubmed
Lamerato Kozicki A, Helm K, Jubala C, Cutter G, Modiano J. Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation. Exp Hematol. 2006;34:870-8 pubmed
Lee A, Kessler J, Read T, Kaiser C, Corbeil D, Huttner W, et al. Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci. 2005;8:723-9 pubmed
product information
Product Type :
Antibody
Product Name :
CD133 (Prominin-1) Monoclonal Antibody (13A4), PE, eBioscience™
Catalog # :
12-1331-80
Quantity :
25 µg
Price :
US 158
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Canine, Mouse
Applications :
Flow Cytometry: 1 µg/test
Species :
Canine, Mouse
Clone :
13A4
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
The CD133 (AC133) antigen is a 97 kDa glycoprotein, with 5 transmembrane domains, that shows up as a 120 kDa band on protein gels due to glycosylation. CD133 is a cell surface marker expressed by immature hematopoietic stem cells but not mature blood cells. In addition to hematopoietic stem and progenitor cells, CD133 has been found to be a marker for other stem and progenitor cells including neural and embryonic stem cells. CD133 has been shown to be expressed in cancers, including some leukemias and brain tumors, that may be derived from stem cells. Low level expression could also be detected in the kidney, pancreas, placenta, and fetal liver. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of the CD133 gene is also associated with several types of cancer. CD133 is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner, and multiple transcript variants encoding different isoforms have been found.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test
Aliases :
4932416E19Rik; AC133; antigen AC133; Antigen AC133 homolog; antigen CD133; CD107b; CD133; CORD12; fudenine; hematopoietic stem cell antigen; hProminin; Lamp II; Lamp2; LAMP-2; Lamp-2a; Lamp-2b; Lamp-2c; LGP-96; LGP-B; Mac3; MCDR2; MSTP061; Prom; PROM1; Prom-1; prominin 1; prominin 1.s1; Prominin1; prominin-1; prominin-like 1; Prominin-like protein 1; Proml1; RP41; STGD4
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA